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Updated November 2019
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Protein Info
Short Name:
ARHGAP20
Full Name:
Rho GTPase-activating protein 20
Alias:
Type:
Mass (Da):
132608
Number AA:
1191
UniProt ID:
Q9P2F6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
L
G
G
Q
P
G
R
S
S
S
L
T
G
V
S
Site 2
S19
G
G
Q
P
G
R
S
S
S
L
T
G
V
S
R
Site 3
S20
G
Q
P
G
R
S
S
S
L
T
G
V
S
R
L
Site 4
T22
P
G
R
S
S
S
L
T
G
V
S
R
L
A
G
Site 5
S31
V
S
R
L
A
G
G
S
C
T
K
K
K
M
K
Site 6
T39
C
T
K
K
K
M
K
T
L
A
E
R
R
R
S
Site 7
S46
T
L
A
E
R
R
R
S
A
P
S
L
I
L
D
Site 8
S49
E
R
R
R
S
A
P
S
L
I
L
D
K
A
L
Site 9
T61
K
A
L
Q
K
R
P
T
T
R
D
S
P
S
A
Site 10
T62
A
L
Q
K
R
P
T
T
R
D
S
P
S
A
S
Site 11
S65
K
R
P
T
T
R
D
S
P
S
A
S
V
D
T
Site 12
S67
P
T
T
R
D
S
P
S
A
S
V
D
T
C
T
Site 13
S69
T
R
D
S
P
S
A
S
V
D
T
C
T
F
L
Site 14
Y119
F
V
V
A
K
I
K
Y
N
N
N
F
K
I
K
Site 15
T166
P
T
V
N
F
V
A
T
F
S
S
P
E
Q
K
Site 16
S169
N
F
V
A
T
F
S
S
P
E
Q
K
D
K
W
Site 17
Y192
N
L
E
K
E
K
D
Y
P
K
S
I
P
L
K
Site 18
S195
K
E
K
D
Y
P
K
S
I
P
L
K
I
F
A
Site 19
T213
G
N
C
A
Y
S
K
T
I
T
V
M
N
S
D
Site 20
T215
C
A
Y
S
K
T
I
T
V
M
N
S
D
T
A
Site 21
S219
K
T
I
T
V
M
N
S
D
T
A
N
E
V
I
Site 22
S238
P
M
L
G
I
T
G
S
E
R
D
Y
Q
L
W
Site 23
Y242
I
T
G
S
E
R
D
Y
Q
L
W
V
N
S
G
Site 24
S248
D
Y
Q
L
W
V
N
S
G
K
E
E
A
P
Y
Site 25
Y255
S
G
K
E
E
A
P
Y
P
L
I
G
H
E
Y
Site 26
Y262
Y
P
L
I
G
H
E
Y
P
Y
G
I
K
M
S
Site 27
Y264
L
I
G
H
E
Y
P
Y
G
I
K
M
S
H
L
Site 28
S269
Y
P
Y
G
I
K
M
S
H
L
R
D
S
A
L
Site 29
S274
K
M
S
H
L
R
D
S
A
L
L
T
P
G
S
Site 30
T278
L
R
D
S
A
L
L
T
P
G
S
K
D
S
T
Site 31
S281
S
A
L
L
T
P
G
S
K
D
S
T
T
P
F
Site 32
S284
L
T
P
G
S
K
D
S
T
T
P
F
N
L
Q
Site 33
T285
T
P
G
S
K
D
S
T
T
P
F
N
L
Q
E
Site 34
T286
P
G
S
K
D
S
T
T
P
F
N
L
Q
E
P
Site 35
S321
L
A
A
A
Q
Q
L
S
D
S
G
H
K
T
F
Site 36
S323
A
A
Q
Q
L
S
D
S
G
H
K
T
F
K
R
Site 37
T327
L
S
D
S
G
H
K
T
F
K
R
R
R
S
I
Site 38
S333
K
T
F
K
R
R
R
S
I
I
N
W
A
F
W
Site 39
S352
T
H
L
D
N
L
P
S
S
P
T
S
P
M
P
Site 40
S353
H
L
D
N
L
P
S
S
P
T
S
P
M
P
G
Site 41
S356
N
L
P
S
S
P
T
S
P
M
P
G
Q
L
F
Site 42
T394
L
N
Q
K
G
P
L
T
K
G
I
F
R
Q
S
Site 43
S401
T
K
G
I
F
R
Q
S
A
N
V
K
S
C
R
Site 44
S406
R
Q
S
A
N
V
K
S
C
R
E
L
K
E
K
Site 45
S416
E
L
K
E
K
L
N
S
G
V
E
V
H
L
D
Site 46
T469
N
D
E
E
K
I
N
T
V
Q
R
L
L
D
Q
Site 47
T505
H
S
S
S
N
Q
M
T
A
F
N
L
A
V
C
Site 48
S523
S
I
L
W
P
P
A
S
S
S
P
E
L
E
N
Site 49
S525
L
W
P
P
A
S
S
S
P
E
L
E
N
E
F
Site 50
T533
P
E
L
E
N
E
F
T
K
K
V
S
L
L
I
Site 51
S563
T
S
L
F
R
E
V
S
V
R
C
D
T
R
E
Site 52
T568
E
V
S
V
R
C
D
T
R
E
N
A
S
D
I
Site 53
S583
S
C
F
Q
L
N
D
S
S
Y
D
S
L
E
N
Site 54
S584
C
F
Q
L
N
D
S
S
Y
D
S
L
E
N
E
Site 55
Y585
F
Q
L
N
D
S
S
Y
D
S
L
E
N
E
L
Site 56
S587
L
N
D
S
S
Y
D
S
L
E
N
E
L
N
E
Site 57
S601
E
D
V
D
A
P
C
S
D
L
V
K
K
L
G
Site 58
S611
V
K
K
L
G
Q
G
S
R
S
M
D
S
V
L
Site 59
S613
K
L
G
Q
G
S
R
S
M
D
S
V
L
T
L
Site 60
S616
Q
G
S
R
S
M
D
S
V
L
T
L
S
D
Y
Site 61
T619
R
S
M
D
S
V
L
T
L
S
D
Y
D
L
D
Site 62
S621
M
D
S
V
L
T
L
S
D
Y
D
L
D
Q
P
Site 63
Y623
S
V
L
T
L
S
D
Y
D
L
D
Q
P
E
V
Site 64
S644
S
D
F
D
L
A
H
S
K
D
E
D
V
Q
M
Site 65
S657
Q
M
K
R
P
L
E
S
K
P
V
N
I
L
V
Site 66
S678
R
D
H
A
R
A
P
S
A
M
C
T
P
S
Y
Site 67
T682
R
A
P
S
A
M
C
T
P
S
Y
L
S
T
A
Site 68
T688
C
T
P
S
Y
L
S
T
A
A
A
N
A
A
K
Site 69
S696
A
A
A
N
A
A
K
S
L
R
R
H
R
R
C
Site 70
S704
L
R
R
H
R
R
C
S
E
P
S
I
D
Y
L
Site 71
S707
H
R
R
C
S
E
P
S
I
D
Y
L
D
S
K
Site 72
Y710
C
S
E
P
S
I
D
Y
L
D
S
K
L
S
Y
Site 73
S713
P
S
I
D
Y
L
D
S
K
L
S
Y
L
R
E
Site 74
S716
D
Y
L
D
S
K
L
S
Y
L
R
E
F
Y
Q
Site 75
Y717
Y
L
D
S
K
L
S
Y
L
R
E
F
Y
Q
K
Site 76
Y722
L
S
Y
L
R
E
F
Y
Q
K
K
L
R
K
S
Site 77
S729
Y
Q
K
K
L
R
K
S
S
C
D
A
I
L
S
Site 78
S730
Q
K
K
L
R
K
S
S
C
D
A
I
L
S
Q
Site 79
S736
S
S
C
D
A
I
L
S
Q
K
D
E
D
Y
L
Site 80
Y742
L
S
Q
K
D
E
D
Y
L
K
Q
N
Q
P
L
Site 81
T755
P
L
Q
E
E
G
K
T
C
F
K
Q
S
L
V
Site 82
S760
G
K
T
C
F
K
Q
S
L
V
T
G
T
D
V
Site 83
S768
L
V
T
G
T
D
V
S
K
K
N
A
T
T
Q
Site 84
T777
K
N
A
T
T
Q
N
T
K
K
K
S
L
S
G
Site 85
S781
T
Q
N
T
K
K
K
S
L
S
G
S
E
G
N
Site 86
S783
N
T
K
K
K
S
L
S
G
S
E
G
N
H
V
Site 87
S785
K
K
K
S
L
S
G
S
E
G
N
H
V
K
L
Site 88
S802
K
S
K
P
V
A
I
S
V
A
S
Y
S
P
M
Site 89
Y806
V
A
I
S
V
A
S
Y
S
P
M
S
S
Q
D
Site 90
S807
A
I
S
V
A
S
Y
S
P
M
S
S
Q
D
H
Site 91
S810
V
A
S
Y
S
P
M
S
S
Q
D
H
S
K
N
Site 92
S811
A
S
Y
S
P
M
S
S
Q
D
H
S
K
N
Q
Site 93
S815
P
M
S
S
Q
D
H
S
K
N
Q
P
F
D
V
Site 94
T824
N
Q
P
F
D
V
N
T
S
G
Y
S
P
P
H
Site 95
S825
Q
P
F
D
V
N
T
S
G
Y
S
P
P
H
T
Site 96
Y827
F
D
V
N
T
S
G
Y
S
P
P
H
T
A
D
Site 97
S828
D
V
N
T
S
G
Y
S
P
P
H
T
A
D
A
Site 98
T832
S
G
Y
S
P
P
H
T
A
D
A
L
K
G
P
Site 99
T841
D
A
L
K
G
P
R
T
H
R
R
C
S
E
P
Site 100
S846
P
R
T
H
R
R
C
S
E
P
N
I
E
D
Q
Site 101
T858
E
D
Q
N
R
K
L
T
Y
L
R
G
I
Y
S
Site 102
Y859
D
Q
N
R
K
L
T
Y
L
R
G
I
Y
S
K
Site 103
Y864
L
T
Y
L
R
G
I
Y
S
K
K
Q
H
K
T
Site 104
S865
T
Y
L
R
G
I
Y
S
K
K
Q
H
K
T
S
Site 105
T871
Y
S
K
K
Q
H
K
T
S
C
E
A
G
L
L
Site 106
S872
S
K
K
Q
H
K
T
S
C
E
A
G
L
L
H
Site 107
Y884
L
L
H
G
E
E
D
Y
L
K
R
H
K
S
L
Site 108
S890
D
Y
L
K
R
H
K
S
L
Q
M
E
G
Q
K
Site 109
S912
M
G
I
E
V
G
K
S
S
A
T
N
Q
N
T
Site 110
T919
S
S
A
T
N
Q
N
T
E
K
V
L
P
P
R
Site 111
T933
R
L
N
L
C
P
R
T
S
Y
S
S
L
S
S
Site 112
S934
L
N
L
C
P
R
T
S
Y
S
S
L
S
S
P
Site 113
Y935
N
L
C
P
R
T
S
Y
S
S
L
S
S
P
G
Site 114
S936
L
C
P
R
T
S
Y
S
S
L
S
S
P
G
T
Site 115
S937
C
P
R
T
S
Y
S
S
L
S
S
P
G
T
S
Site 116
S939
R
T
S
Y
S
S
L
S
S
P
G
T
S
P
S
Site 117
S940
T
S
Y
S
S
L
S
S
P
G
T
S
P
S
G
Site 118
T943
S
S
L
S
S
P
G
T
S
P
S
G
S
S
V
Site 119
S944
S
L
S
S
P
G
T
S
P
S
G
S
S
V
S
Site 120
S946
S
S
P
G
T
S
P
S
G
S
S
V
S
S
Q
Site 121
S948
P
G
T
S
P
S
G
S
S
V
S
S
Q
D
S
Site 122
S949
G
T
S
P
S
G
S
S
V
S
S
Q
D
S
A
Site 123
S951
S
P
S
G
S
S
V
S
S
Q
D
S
A
F
S
Site 124
S952
P
S
G
S
S
V
S
S
Q
D
S
A
F
S
Q
Site 125
S955
S
S
V
S
S
Q
D
S
A
F
S
Q
I
S
E
Site 126
S958
S
S
Q
D
S
A
F
S
Q
I
S
E
H
S
V
Site 127
S961
D
S
A
F
S
Q
I
S
E
H
S
V
F
T
P
Site 128
T967
I
S
E
H
S
V
F
T
P
T
E
T
S
S
P
Site 129
T969
E
H
S
V
F
T
P
T
E
T
S
S
P
I
D
Site 130
S973
F
T
P
T
E
T
S
S
P
I
D
C
T
F
Q
Site 131
T978
T
S
S
P
I
D
C
T
F
Q
A
Q
R
K
R
Site 132
S989
Q
R
K
R
E
D
L
S
P
D
F
S
N
A
S
Site 133
S993
E
D
L
S
P
D
F
S
N
A
S
H
V
S
G
Site 134
S996
S
P
D
F
S
N
A
S
H
V
S
G
M
P
G
Site 135
S999
F
S
N
A
S
H
V
S
G
M
P
G
P
S
S
Site 136
S1006
S
G
M
P
G
P
S
S
G
Q
A
C
S
R
P
Site 137
S1011
P
S
S
G
Q
A
C
S
R
P
A
Y
T
K
K
Site 138
Y1015
Q
A
C
S
R
P
A
Y
T
K
K
D
T
M
E
Site 139
T1031
H
S
Q
M
H
S
V
T
L
H
P
S
T
W
L
Site 140
S1035
H
S
V
T
L
H
P
S
T
W
L
R
N
G
V
Site 141
T1036
S
V
T
L
H
P
S
T
W
L
R
N
G
V
A
Site 142
S1044
W
L
R
N
G
V
A
S
L
K
N
W
S
L
K
Site 143
S1066
P
E
E
E
K
I
A
S
P
K
G
P
L
E
P
Site 144
S1078
L
E
P
P
P
H
A
S
G
V
P
E
A
N
S
Site 145
S1085
S
G
V
P
E
A
N
S
L
Q
E
E
Q
K
D
Site 146
S1102
L
R
A
A
E
G
L
S
P
V
Q
S
A
Q
R
Site 147
S1106
E
G
L
S
P
V
Q
S
A
Q
R
C
S
S
S
Site 148
S1111
V
Q
S
A
Q
R
C
S
S
S
P
F
Q
D
S
Site 149
S1112
Q
S
A
Q
R
C
S
S
S
P
F
Q
D
S
E
Site 150
S1113
S
A
Q
R
C
S
S
S
P
F
Q
D
S
E
R
Site 151
S1118
S
S
S
P
F
Q
D
S
E
R
H
C
S
S
P
Site 152
S1123
Q
D
S
E
R
H
C
S
S
P
F
S
L
V
E
Site 153
S1124
D
S
E
R
H
C
S
S
P
F
S
L
V
E
S
Site 154
S1127
R
H
C
S
S
P
F
S
L
V
E
S
R
L
K
Site 155
S1139
R
L
K
L
C
M
K
S
H
E
E
I
E
P
G
Site 156
S1147
H
E
E
I
E
P
G
S
Q
S
S
S
G
S
L
Site 157
S1149
E
I
E
P
G
S
Q
S
S
S
G
S
L
P
W
Site 158
S1151
E
P
G
S
Q
S
S
S
G
S
L
P
W
E
R
Site 159
S1153
G
S
Q
S
S
S
G
S
L
P
W
E
R
A
S
Site 160
S1160
S
L
P
W
E
R
A
S
A
S
S
W
T
L
E
Site 161
S1163
W
E
R
A
S
A
S
S
W
T
L
E
D
A
T
Site 162
T1170
S
W
T
L
E
D
A
T
S
P
D
S
G
P
T
Site 163
S1171
W
T
L
E
D
A
T
S
P
D
S
G
P
T
V
Site 164
S1174
E
D
A
T
S
P
D
S
G
P
T
V
V
C
D
Site 165
Y1186
V
C
D
I
E
D
R
Y
L
T
K
D
I
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation