KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
KLHL14
Full Name:
Kelch-like protein 14
Alias:
Type:
Mass (Da):
70714
Number AA:
628
UniProt ID:
Q9P2G3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
S
R
S
G
D
R
T
S
T
F
D
P
S
H
Site 2
S9
S
R
S
G
D
R
T
S
T
F
D
P
S
H
S
Site 3
T10
R
S
G
D
R
T
S
T
F
D
P
S
H
S
D
Site 4
S14
R
T
S
T
F
D
P
S
H
S
D
N
L
L
H
Site 5
S16
S
T
F
D
P
S
H
S
D
N
L
L
H
G
L
Site 6
T36
K
Q
L
F
C
D
V
T
L
T
A
Q
G
Q
Q
Site 7
S60
S
C
S
Q
Y
F
R
S
L
F
S
S
H
P
P
Site 8
S63
Q
Y
F
R
S
L
F
S
S
H
P
P
L
G
G
Site 9
S64
Y
F
R
S
L
F
S
S
H
P
P
L
G
G
G
Site 10
S93
Q
P
P
Q
Q
Q
P
S
Q
Q
Q
Q
P
P
P
Site 11
T106
P
P
Q
E
E
P
G
T
P
S
S
S
P
D
D
Site 12
S109
E
E
P
G
T
P
S
S
S
P
D
D
K
L
L
Site 13
S110
E
P
G
T
P
S
S
S
P
D
D
K
L
L
T
Site 14
T117
S
P
D
D
K
L
L
T
S
P
R
A
I
N
N
Site 15
S118
P
D
D
K
L
L
T
S
P
R
A
I
N
N
L
Site 16
Y186
D
Q
I
S
V
Q
N
Y
K
Q
V
C
K
I
A
Site 17
S227
E
M
R
A
L
L
D
S
L
P
P
P
V
E
S
Site 18
Y256
D
R
E
T
R
M
Q
Y
A
P
D
L
M
K
R
Site 19
S280
E
L
V
E
R
V
Q
S
V
D
F
M
R
T
D
Site 20
S312
F
R
Q
H
C
R
Q
S
L
A
S
R
I
R
S
Site 21
S315
H
C
R
Q
S
L
A
S
R
I
R
S
N
K
K
Site 22
S319
S
L
A
S
R
I
R
S
N
K
K
M
L
L
L
Site 23
S339
P
G
P
D
R
L
P
S
N
L
V
Q
Y
Y
D
Site 24
Y345
P
S
N
L
V
Q
Y
Y
D
D
E
K
K
T
W
Site 25
T356
K
K
T
W
K
I
L
T
I
M
P
Y
N
S
A
Site 26
T391
N
P
N
G
K
H
S
T
N
F
V
S
R
Y
D
Site 27
Y397
S
T
N
F
V
S
R
Y
D
P
R
F
N
S
W
Site 28
S416
P
M
Q
E
R
R
A
S
F
Y
A
C
R
L
D
Site 29
Y418
Q
E
R
R
A
S
F
Y
A
C
R
L
D
K
H
Site 30
Y427
C
R
L
D
K
H
L
Y
V
I
G
G
R
N
E
Site 31
T435
V
I
G
G
R
N
E
T
G
Y
L
S
S
V
E
Site 32
Y437
G
G
R
N
E
T
G
Y
L
S
S
V
E
C
Y
Site 33
S440
N
E
T
G
Y
L
S
S
V
E
C
Y
N
L
E
Site 34
Y444
Y
L
S
S
V
E
C
Y
N
L
E
T
N
E
W
Site 35
Y453
L
E
T
N
E
W
R
Y
V
S
S
L
P
Q
P
Site 36
S455
T
N
E
W
R
Y
V
S
S
L
P
Q
P
L
A
Site 37
Y474
A
V
H
N
G
K
I
Y
I
S
G
G
V
H
N
Site 38
Y484
G
G
V
H
N
G
E
Y
V
P
W
L
Y
C
Y
Site 39
T506
A
R
K
Q
D
M
N
T
K
R
A
I
H
T
L
Site 40
Y542
D
V
M
L
V
E
C
Y
D
P
K
G
D
Q
W
Site 41
T554
D
Q
W
N
I
L
Q
T
P
I
L
E
G
R
S
Site 42
S581
L
V
G
G
Y
S
W
S
M
G
A
Y
K
S
S
Site 43
Y585
Y
S
W
S
M
G
A
Y
K
S
S
T
I
C
Y
Site 44
Y592
Y
K
S
S
T
I
C
Y
C
P
E
K
G
T
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation