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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP35
Full Name:
Ubiquitin carboxyl-terminal hydrolase 35
Alias:
Deubiquitinating enzyme 35; EC 3.1.2.15; Ubiquitin specific peptidase 35; Ubiquitin thioesterase 35; Ubiquitin-specific-processing protease 35; UBP35; USP34
Type:
Phosphoprotein
Mass (Da):
113348
Number AA:
1017
UniProt ID:
Q9P2H5
International Prot ID:
IPI00001726
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008234
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
E
A
V
V
T
S
S
Y
P
V
S
V
K
Q
G
Site 2
S16
V
T
S
S
Y
P
V
S
V
K
Q
G
L
V
R
Site 3
T131
L
R
R
E
V
L
R
T
V
C
E
R
P
G
P
Site 4
S222
K
E
L
F
A
V
I
S
C
E
E
E
P
P
S
Site 5
S229
S
C
E
E
E
P
P
S
S
A
L
A
S
V
V
Site 6
S230
C
E
E
E
P
P
S
S
A
L
A
S
V
V
Q
Site 7
S252
D
G
V
V
R
N
L
S
N
D
D
S
V
T
D
Site 8
S256
R
N
L
S
N
D
D
S
V
T
D
S
Q
M
L
Site 9
T258
L
S
N
D
D
S
V
T
D
S
Q
M
L
T
A
Site 10
S260
N
D
D
S
V
T
D
S
Q
M
L
T
A
I
S
Site 11
S356
H
I
P
P
M
V
A
S
L
V
K
E
D
S
N
Site 12
S362
A
S
L
V
K
E
D
S
N
S
G
T
S
C
L
Site 13
S364
L
V
K
E
D
S
N
S
G
T
S
C
L
E
Q
Site 14
T366
K
E
D
S
N
S
G
T
S
C
L
E
Q
L
A
Site 15
T418
L
L
G
Q
D
A
W
T
S
Q
K
S
E
L
A
Site 16
S419
L
G
Q
D
A
W
T
S
Q
K
S
E
L
A
G
Site 17
Y428
K
S
E
L
A
G
F
Y
P
R
L
M
A
K
S
Site 18
S435
Y
P
R
L
M
A
K
S
D
T
G
K
I
G
L
Site 19
T437
R
L
M
A
K
S
D
T
G
K
I
G
L
I
N
Site 20
T472
R
H
C
V
L
R
L
T
E
N
N
S
Q
P
L
Site 21
S476
L
R
L
T
E
N
N
S
Q
P
L
M
T
K
L
Site 22
S493
L
F
G
F
L
E
H
S
Q
R
P
A
I
S
P
Site 23
S499
H
S
Q
R
P
A
I
S
P
E
N
F
L
S
A
Site 24
S507
P
E
N
F
L
S
A
S
W
T
P
W
F
S
P
Site 25
T509
N
F
L
S
A
S
W
T
P
W
F
S
P
G
T
Site 26
T516
T
P
W
F
S
P
G
T
Q
Q
D
C
S
E
Y
Site 27
S521
P
G
T
Q
Q
D
C
S
E
Y
L
K
Y
L
L
Site 28
Y523
T
Q
Q
D
C
S
E
Y
L
K
Y
L
L
D
R
Site 29
Y526
D
C
S
E
Y
L
K
Y
L
L
D
R
L
H
E
Site 30
T537
R
L
H
E
E
E
K
T
G
T
R
I
C
Q
K
Site 31
S548
I
C
Q
K
L
K
Q
S
S
S
P
S
P
P
E
Site 32
S550
Q
K
L
K
Q
S
S
S
P
S
P
P
E
E
P
Site 33
S552
L
K
Q
S
S
S
P
S
P
P
E
E
P
P
A
Site 34
S562
E
E
P
P
A
P
S
S
T
S
V
E
K
M
F
Site 35
S564
P
P
A
P
S
S
T
S
V
E
K
M
F
G
G
Site 36
T593
S
S
R
E
E
A
F
T
D
L
S
L
A
F
P
Site 37
S596
E
E
A
F
T
D
L
S
L
A
F
P
P
P
E
Site 38
S612
C
R
R
R
R
L
G
S
V
M
R
P
T
E
D
Site 39
T617
L
G
S
V
M
R
P
T
E
D
I
T
A
R
E
Site 40
T621
M
R
P
T
E
D
I
T
A
R
E
L
P
P
P
Site 41
T629
A
R
E
L
P
P
P
T
S
A
Q
G
P
G
R
Site 42
S630
R
E
L
P
P
P
T
S
A
Q
G
P
G
R
V
Site 43
T648
R
Q
R
K
H
C
I
T
E
D
T
P
P
T
S
Site 44
T651
K
H
C
I
T
E
D
T
P
P
T
S
L
Y
I
Site 45
S655
T
E
D
T
P
P
T
S
L
Y
I
E
G
L
D
Site 46
Y657
D
T
P
P
T
S
L
Y
I
E
G
L
D
S
K
Site 47
S663
L
Y
I
E
G
L
D
S
K
E
A
G
G
Q
S
Site 48
S671
K
E
A
G
G
Q
S
S
Q
E
E
R
I
E
R
Site 49
S698
E
V
G
E
E
E
E
S
T
R
G
E
G
E
R
Site 50
T699
V
G
E
E
E
E
S
T
R
G
E
G
E
R
E
Site 51
S734
E
Q
E
K
E
E
D
S
L
G
A
G
T
H
P
Site 52
S747
H
P
D
A
A
I
P
S
G
E
R
T
C
G
S
Site 53
T751
A
I
P
S
G
E
R
T
C
G
S
E
G
S
R
Site 54
S754
S
G
E
R
T
C
G
S
E
G
S
R
S
V
L
Site 55
S759
C
G
S
E
G
S
R
S
V
L
D
L
V
N
Y
Site 56
S769
D
L
V
N
Y
F
L
S
P
E
K
L
T
A
E
Site 57
Y779
K
L
T
A
E
N
R
Y
Y
C
E
S
C
A
S
Site 58
Y780
L
T
A
E
N
R
Y
Y
C
E
S
C
A
S
L
Site 59
S786
Y
Y
C
E
S
C
A
S
L
Q
D
A
E
K
V
Site 60
T816
R
F
S
F
D
L
R
T
M
R
R
R
K
I
L
Site 61
S857
V
V
H
S
G
V
S
S
E
S
G
H
Y
Y
C
Site 62
Y862
V
S
S
E
S
G
H
Y
Y
C
Y
A
R
E
G
Site 63
Y863
S
S
E
S
G
H
Y
Y
C
Y
A
R
E
G
A
Site 64
Y865
E
S
G
H
Y
Y
C
Y
A
R
E
G
A
A
R
Site 65
Y890
P
E
P
E
N
Q
W
Y
L
F
N
D
T
R
V
Site 66
S898
L
F
N
D
T
R
V
S
F
S
S
F
E
S
V
Site 67
S900
N
D
T
R
V
S
F
S
S
F
E
S
V
S
N
Site 68
S901
D
T
R
V
S
F
S
S
F
E
S
V
S
N
V
Site 69
S910
E
S
V
S
N
V
T
S
F
F
P
K
D
T
A
Site 70
T916
T
S
F
F
P
K
D
T
A
Y
V
L
F
Y
R
Site 71
Y918
F
F
P
K
D
T
A
Y
V
L
F
Y
R
Q
R
Site 72
S936
G
P
E
A
E
L
G
S
S
R
V
R
T
E
P
Site 73
S937
P
E
A
E
L
G
S
S
R
V
R
T
E
P
T
Site 74
T941
L
G
S
S
R
V
R
T
E
P
T
L
H
K
D
Site 75
S954
K
D
L
M
E
A
I
S
K
D
N
I
L
Y
L
Site 76
Y960
I
S
K
D
N
I
L
Y
L
Q
E
Q
E
K
E
Site 77
Y974
E
A
R
S
R
A
A
Y
I
S
A
L
P
T
S
Site 78
S976
R
S
R
A
A
Y
I
S
A
L
P
T
S
P
H
Site 79
T980
A
Y
I
S
A
L
P
T
S
P
H
W
G
R
G
Site 80
S981
Y
I
S
A
L
P
T
S
P
H
W
G
R
G
F
Site 81
S998
D
K
D
E
D
E
G
S
P
G
G
C
N
P
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation