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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDP2
Full Name:
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial
Alias:
Pyruvate dehydrogenase phosphatase catalytic subunit 2
Type:
Mass (Da):
59978
Number AA:
529
UniProt ID:
Q9P2J9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
S
S
T
V
S
Y
W
I
L
N
S
T
R
Site 2
S12
V
S
Y
W
I
L
N
S
T
R
N
S
I
A
T
Site 3
S16
I
L
N
S
T
R
N
S
I
A
T
L
Q
G
G
Site 4
T19
S
T
R
N
S
I
A
T
L
Q
G
G
R
R
L
Site 5
Y27
L
Q
G
G
R
R
L
Y
S
R
Y
V
S
N
R
Site 6
S28
Q
G
G
R
R
L
Y
S
R
Y
V
S
N
R
N
Site 7
Y30
G
R
R
L
Y
S
R
Y
V
S
N
R
N
K
L
Site 8
S32
R
L
Y
S
R
Y
V
S
N
R
N
K
L
K
W
Site 9
S43
K
L
K
W
R
L
F
S
R
V
P
P
T
L
N
Site 10
T48
L
F
S
R
V
P
P
T
L
N
S
S
P
C
G
Site 11
S51
R
V
P
P
T
L
N
S
S
P
C
G
G
F
T
Site 12
T58
S
S
P
C
G
G
F
T
L
C
K
A
Y
R
H
Site 13
T66
L
C
K
A
Y
R
H
T
S
T
E
E
D
D
F
Site 14
S67
C
K
A
Y
R
H
T
S
T
E
E
D
D
F
H
Site 15
S78
D
D
F
H
L
Q
L
S
P
E
Q
I
N
E
V
Site 16
S100
H
K
I
L
D
L
E
S
R
V
P
N
S
V
L
Site 17
S105
L
E
S
R
V
P
N
S
V
L
R
F
E
S
N
Site 18
S111
N
S
V
L
R
F
E
S
N
Q
L
A
A
N
S
Site 19
S118
S
N
Q
L
A
A
N
S
P
V
E
D
R
R
G
Site 20
S128
E
D
R
R
G
V
A
S
C
L
Q
T
N
G
L
Site 21
S179
H
M
E
G
A
M
E
S
M
K
P
L
L
P
I
Site 22
Y198
K
H
P
G
D
S
I
Y
K
D
V
T
S
V
H
Site 23
T202
D
S
I
Y
K
D
V
T
S
V
H
L
D
H
L
Site 24
S203
S
I
Y
K
D
V
T
S
V
H
L
D
H
L
R
Site 25
Y212
H
L
D
H
L
R
V
Y
W
Q
E
L
L
D
L
Site 26
Y233
S
I
E
E
A
L
M
Y
S
F
Q
R
L
D
S
Site 27
S234
I
E
E
A
L
M
Y
S
F
Q
R
L
D
S
D
Site 28
S240
Y
S
F
Q
R
L
D
S
D
I
S
L
E
I
Q
Site 29
S243
Q
R
L
D
S
D
I
S
L
E
I
Q
A
P
L
Site 30
T255
A
P
L
E
D
E
V
T
R
N
L
S
L
Q
V
Site 31
S259
D
E
V
T
R
N
L
S
L
Q
V
A
F
S
G
Site 32
S327
L
K
R
E
H
P
E
S
E
D
R
T
I
I
M
Site 33
T331
H
P
E
S
E
D
R
T
I
I
M
E
D
R
L
Site 34
S362
W
S
K
E
L
Q
R
S
I
L
E
R
G
F
N
Site 35
Y376
N
T
E
A
L
N
I
Y
Q
F
T
P
P
H
Y
Site 36
T379
A
L
N
I
Y
Q
F
T
P
P
H
Y
Y
T
P
Site 37
Y383
Y
Q
F
T
P
P
H
Y
Y
T
P
P
Y
L
T
Site 38
Y384
Q
F
T
P
P
H
Y
Y
T
P
P
Y
L
T
A
Site 39
T385
F
T
P
P
H
Y
Y
T
P
P
Y
L
T
A
E
Site 40
Y388
P
H
Y
Y
T
P
P
Y
L
T
A
E
P
E
V
Site 41
T390
Y
Y
T
P
P
Y
L
T
A
E
P
E
V
T
Y
Site 42
T396
L
T
A
E
P
E
V
T
Y
H
R
L
R
P
Q
Site 43
Y397
T
A
E
P
E
V
T
Y
H
R
L
R
P
Q
D
Site 44
S419
D
G
L
W
D
M
L
S
N
E
D
V
V
R
L
Site 45
S461
L
L
L
Q
R
K
A
S
G
L
H
E
A
D
Q
Site 46
Y506
P
E
D
L
A
R
M
Y
R
D
D
I
T
V
T
Site 47
T511
R
M
Y
R
D
D
I
T
V
T
V
V
Y
F
N
Site 48
T513
Y
R
D
D
I
T
V
T
V
V
Y
F
N
S
E
Site 49
Y525
N
S
E
S
I
G
A
Y
Y
K
G
G
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation