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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTCHD2
Full Name:
Patched domain-containing protein 2
Alias:
Protein dispatched homolog 3
Type:
Mass (Da):
153048
Number AA:
1392
UniProt ID:
Q9P2K9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T24
E
Q
E
E
E
E
A
T
G
E
T
F
L
G
A
Site 2
S53
W
R
H
W
P
L
A
S
R
P
P
A
S
G
F
Site 3
S58
L
A
S
R
P
P
A
S
G
F
W
S
T
L
G
Site 4
S104
P
P
L
D
I
D
I
S
Y
N
A
F
E
I
R
Site 5
Y105
P
L
D
I
D
I
S
Y
N
A
F
E
I
R
N
Site 6
S116
E
I
R
N
H
E
A
S
Q
R
F
D
A
L
T
Site 7
T123
S
Q
R
F
D
A
L
T
L
A
L
K
S
Q
F
Site 8
S128
A
L
T
L
A
L
K
S
Q
F
G
S
W
G
R
Site 9
S132
A
L
K
S
Q
F
G
S
W
G
R
N
R
R
D
Site 10
T144
R
R
D
L
A
D
F
T
S
E
T
L
Q
R
L
Site 11
S145
R
D
L
A
D
F
T
S
E
T
L
Q
R
L
I
Site 12
T147
L
A
D
F
T
S
E
T
L
Q
R
L
I
S
E
Site 13
S153
E
T
L
Q
R
L
I
S
E
Q
L
Q
Q
L
H
Site 14
S165
Q
L
H
L
G
N
R
S
R
Q
A
S
R
A
P
Site 15
S169
G
N
R
S
R
Q
A
S
R
A
P
R
V
I
P
Site 16
T189
G
P
G
P
Y
R
D
T
S
A
A
Q
K
P
T
Site 17
S190
P
G
P
Y
R
D
T
S
A
A
Q
K
P
T
A
Site 18
S200
Q
K
P
T
A
N
R
S
G
R
L
R
R
E
T
Site 19
T207
S
G
R
L
R
R
E
T
P
P
L
E
D
L
A
Site 20
S218
E
D
L
A
A
N
Q
S
E
D
P
R
N
Q
R
Site 21
S227
D
P
R
N
Q
R
L
S
K
N
G
R
Y
Q
P
Site 22
Y232
R
L
S
K
N
G
R
Y
Q
P
S
I
P
P
H
Site 23
S235
K
N
G
R
Y
Q
P
S
I
P
P
H
A
A
V
Site 24
S247
A
A
V
A
A
N
Q
S
R
A
R
R
G
A
S
Site 25
S254
S
R
A
R
R
G
A
S
R
W
D
Y
S
R
A
Site 26
Y258
R
G
A
S
R
W
D
Y
S
R
A
Y
V
S
A
Site 27
S259
G
A
S
R
W
D
Y
S
R
A
Y
V
S
A
N
Site 28
Y262
R
W
D
Y
S
R
A
Y
V
S
A
N
T
Q
T
Site 29
S292
A
E
R
N
I
F
T
S
E
R
L
V
T
I
H
Site 30
T297
F
T
S
E
R
L
V
T
I
H
E
I
E
R
K
Site 31
S329
L
K
D
L
P
L
G
S
Y
S
Y
C
S
P
P
Site 32
Y330
K
D
L
P
L
G
S
Y
S
Y
C
S
P
P
S
Site 33
S331
D
L
P
L
G
S
Y
S
Y
C
S
P
P
S
S
Site 34
Y332
L
P
L
G
S
Y
S
Y
C
S
P
P
S
S
L
Site 35
S334
L
G
S
Y
S
Y
C
S
P
P
S
S
L
M
T
Site 36
S338
S
Y
C
S
P
P
S
S
L
M
T
Y
F
F
P
Site 37
T341
S
P
P
S
S
L
M
T
Y
F
F
P
T
E
R
Site 38
Y342
P
P
S
S
L
M
T
Y
F
F
P
T
E
R
G
Site 39
T346
L
M
T
Y
F
F
P
T
E
R
G
G
K
I
Y
Site 40
Y353
T
E
R
G
G
K
I
Y
Y
D
G
M
G
Q
D
Site 41
Y354
E
R
G
G
K
I
Y
Y
D
G
M
G
Q
D
L
Site 42
S367
D
L
A
D
I
R
G
S
L
E
L
A
M
T
H
Site 43
T373
G
S
L
E
L
A
M
T
H
P
E
F
Y
W
Y
Site 44
Y378
A
M
T
H
P
E
F
Y
W
Y
V
D
E
G
L
Site 45
Y380
T
H
P
E
F
Y
W
Y
V
D
E
G
L
S
A
Site 46
S386
W
Y
V
D
E
G
L
S
A
D
N
L
K
S
S
Site 47
S392
L
S
A
D
N
L
K
S
S
L
L
R
S
E
I
Site 48
S393
S
A
D
N
L
K
S
S
L
L
R
S
E
I
L
Site 49
Y408
F
G
A
P
L
P
N
Y
Y
S
V
D
D
R
W
Site 50
S410
A
P
L
P
N
Y
Y
S
V
D
D
R
W
E
E
Site 51
S424
E
Q
R
A
K
F
Q
S
F
V
V
T
Y
V
A
Site 52
Y453
G
G
T
D
L
F
D
Y
E
V
R
R
T
F
N
Site 53
T545
I
N
T
Y
R
Q
A
T
H
L
E
D
P
Q
L
Site 54
T557
P
Q
L
R
M
I
H
T
V
Q
T
A
G
K
A
Site 55
S625
L
Y
L
A
P
L
E
S
S
C
Q
T
S
C
H
Site 56
S626
Y
L
A
P
L
E
S
S
C
Q
T
S
C
H
Q
Site 57
T639
H
Q
N
C
S
R
K
T
S
L
H
F
P
G
D
Site 58
S640
Q
N
C
S
R
K
T
S
L
H
F
P
G
D
V
Site 59
S657
A
P
E
Q
V
G
G
S
P
A
Q
G
P
I
P
Site 60
S681
E
V
E
E
E
P
V
S
L
E
L
G
D
V
S
Site 61
S701
P
E
G
L
Q
P
A
S
N
T
G
S
R
G
H
Site 62
S705
Q
P
A
S
N
T
G
S
R
G
H
L
I
V
Q
Site 63
S754
A
S
R
L
R
P
A
S
R
A
P
L
L
F
R
Site 64
S796
L
F
Q
E
K
P
H
S
L
Q
N
N
I
R
T
Site 65
S804
L
Q
N
N
I
R
T
S
L
E
K
K
R
R
G
Site 66
S812
L
E
K
K
R
R
G
S
G
V
P
W
A
S
R
Site 67
S818
G
S
G
V
P
W
A
S
R
P
E
A
T
L
Q
Site 68
T830
T
L
Q
D
F
P
G
T
V
Y
I
S
K
V
K
Site 69
Y832
Q
D
F
P
G
T
V
Y
I
S
K
V
K
S
Q
Site 70
S834
F
P
G
T
V
Y
I
S
K
V
K
S
Q
G
H
Site 71
S838
V
Y
I
S
K
V
K
S
Q
G
H
P
A
V
Y
Site 72
S852
Y
R
L
S
L
N
A
S
L
P
A
P
W
Q
A
Site 73
S861
P
A
P
W
Q
A
V
S
P
G
D
G
E
V
P
Site 74
S869
P
G
D
G
E
V
P
S
F
Q
V
Y
R
A
P
Site 75
Y873
E
V
P
S
F
Q
V
Y
R
A
P
F
G
N
F
Site 76
T906
P
S
R
K
W
M
L
T
T
L
A
C
D
A
K
Site 77
Y923
W
K
F
D
F
S
F
Y
V
A
T
K
E
Q
Q
Site 78
Y936
Q
Q
H
T
R
K
L
Y
F
A
Q
S
H
K
P
Site 79
S940
R
K
L
Y
F
A
Q
S
H
K
P
P
F
H
G
Site 80
S959
A
P
P
G
C
L
L
S
S
S
P
D
G
P
T
Site 81
S960
P
P
G
C
L
L
S
S
S
P
D
G
P
T
K
Site 82
S961
P
G
C
L
L
S
S
S
P
D
G
P
T
K
G
Site 83
T966
S
S
S
P
D
G
P
T
K
G
F
F
F
V
P
Site 84
S983
K
V
P
K
A
R
L
S
A
T
F
G
F
N
P
Site 85
Y1039
G
D
P
G
S
V
V
Y
D
S
S
F
D
L
F
Site 86
S1041
P
G
S
V
V
Y
D
S
S
F
D
L
F
K
E
Site 87
S1082
P
S
G
Y
S
I
S
S
F
L
Q
M
L
H
P
Site 88
S1105
N
L
L
P
G
Q
L
S
H
G
A
V
G
V
R
Site 89
S1120
E
G
R
V
Q
W
I
S
M
A
F
E
S
T
T
Site 90
Y1128
M
A
F
E
S
T
T
Y
K
G
K
S
S
F
Q
Site 91
S1132
S
T
T
Y
K
G
K
S
S
F
Q
T
Y
S
D
Site 92
S1133
T
T
Y
K
G
K
S
S
F
Q
T
Y
S
D
Y
Site 93
T1136
K
G
K
S
S
F
Q
T
Y
S
D
Y
L
R
W
Site 94
S1138
K
S
S
F
Q
T
Y
S
D
Y
L
R
W
E
S
Site 95
Y1140
S
F
Q
T
Y
S
D
Y
L
R
W
E
S
F
L
Site 96
S1145
S
D
Y
L
R
W
E
S
F
L
Q
Q
Q
L
Q
Site 97
S1158
L
Q
A
L
P
E
G
S
V
L
R
R
G
F
Q
Site 98
T1276
H
Q
A
E
D
A
R
T
Q
R
Q
W
R
T
L
Site 99
S1348
L
G
I
M
A
P
S
S
F
T
R
T
R
T
S
Site 100
T1352
A
P
S
S
F
T
R
T
R
T
S
F
L
K
A
Site 101
T1354
S
S
F
T
R
T
R
T
S
F
L
K
A
L
G
Site 102
S1355
S
F
T
R
T
R
T
S
F
L
K
A
L
G
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation