KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
WDR35
Full Name:
WD repeat-containing protein 35
Alias:
Type:
Mass (Da):
133547
Number AA:
1181
UniProt ID:
Q9P2L0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
F
Y
L
S
K
K
I
S
I
P
N
N
V
K
L
Site 2
T47
V
L
K
L
E
T
Q
T
D
D
A
K
L
R
G
Site 3
S62
L
A
A
P
S
N
L
S
M
N
Q
T
L
E
G
Site 4
T66
S
N
L
S
M
N
Q
T
L
E
G
H
S
G
S
Site 5
S73
T
L
E
G
H
S
G
S
V
Q
V
V
T
W
N
Site 6
S89
Q
Y
Q
K
L
T
T
S
D
E
N
G
L
I
I
Site 7
S120
R
N
K
S
V
V
R
S
M
S
W
N
A
D
G
Site 8
S122
K
S
V
V
R
S
M
S
W
N
A
D
G
Q
K
Site 9
S160
D
L
K
G
I
Q
L
S
H
V
T
W
S
A
D
Site 10
Y183
A
N
G
E
I
H
I
Y
D
N
Q
G
N
F
M
Site 11
Y213
S
I
A
G
I
H
W
Y
H
G
T
E
G
Y
V
Site 12
T298
P
F
G
E
H
L
G
T
L
K
V
P
G
K
E
Site 13
S307
K
V
P
G
K
E
I
S
A
L
S
W
E
G
G
Site 14
S310
G
K
E
I
S
A
L
S
W
E
G
G
G
L
K
Site 15
Y348
S
N
T
V
V
Y
A
Y
T
R
P
D
R
P
E
Site 16
Y356
T
R
P
D
R
P
E
Y
C
V
V
F
W
D
T
Site 17
Y369
D
T
K
N
N
E
K
Y
V
K
Y
V
K
G
L
Site 18
Y372
N
N
E
K
Y
V
K
Y
V
K
G
L
I
S
I
Site 19
T451
A
S
K
E
A
F
Y
T
W
Q
Y
R
V
A
K
Site 20
Y480
K
E
G
R
E
R
I
Y
H
V
D
D
T
P
S
Site 21
T485
R
I
Y
H
V
D
D
T
P
S
G
S
M
D
G
Site 22
S489
V
D
D
T
P
S
G
S
M
D
G
V
L
D
Y
Site 23
Y496
S
M
D
G
V
L
D
Y
S
K
T
I
Q
G
T
Site 24
S497
M
D
G
V
L
D
Y
S
K
T
I
Q
G
T
R
Site 25
T499
G
V
L
D
Y
S
K
T
I
Q
G
T
R
D
P
Site 26
T511
R
D
P
I
C
A
I
T
A
S
D
K
I
L
I
Site 27
S523
I
L
I
V
G
R
E
S
G
T
I
Q
R
Y
S
Site 28
Y529
E
S
G
T
I
Q
R
Y
S
L
P
N
V
G
L
Site 29
Y547
Y
S
L
N
C
R
A
Y
Q
L
S
L
N
C
N
Site 30
S550
N
C
R
A
Y
Q
L
S
L
N
C
N
S
S
R
Site 31
S564
R
L
A
I
I
D
I
S
G
V
L
T
F
F
D
Site 32
T568
I
D
I
S
G
V
L
T
F
F
D
L
D
A
R
Site 33
T577
F
D
L
D
A
R
V
T
D
S
T
G
Q
Q
V
Site 34
S579
L
D
A
R
V
T
D
S
T
G
Q
Q
V
V
G
Site 35
T580
D
A
R
V
T
D
S
T
G
Q
Q
V
V
G
E
Site 36
Y618
M
M
E
K
T
R
M
Y
V
F
R
N
L
D
P
Site 37
T631
D
P
E
E
P
I
Q
T
S
G
Y
I
C
N
F
Site 38
Y634
E
P
I
Q
T
S
G
Y
I
C
N
F
E
D
L
Site 39
Y662
P
E
H
P
N
K
D
Y
L
I
N
F
E
I
R
Site 40
S670
L
I
N
F
E
I
R
S
L
R
D
S
R
A
L
Site 41
S674
E
I
R
S
L
R
D
S
R
A
L
I
E
K
V
Site 42
S687
K
V
G
I
K
D
A
S
Q
F
I
E
D
N
P
Site 43
Y725
A
F
V
R
C
K
D
Y
Q
G
I
K
F
V
K
Site 44
S739
K
R
L
G
K
L
L
S
E
S
M
K
Q
A
E
Site 45
Y750
K
Q
A
E
V
V
G
Y
F
G
R
F
E
E
A
Site 46
T760
R
F
E
E
A
E
R
T
Y
L
E
M
D
R
R
Site 47
Y761
F
E
E
A
E
R
T
Y
L
E
M
D
R
R
D
Site 48
T789
R
V
L
Q
L
L
K
T
G
S
G
D
A
D
D
Site 49
S791
L
Q
L
L
K
T
G
S
G
D
A
D
D
S
L
Site 50
S797
G
S
G
D
A
D
D
S
L
L
E
Q
A
N
N
Site 51
Y809
A
N
N
A
I
G
D
Y
F
A
D
R
Q
K
W
Site 52
Y822
K
W
L
N
A
V
Q
Y
Y
V
Q
G
R
N
Q
Site 53
Y823
W
L
N
A
V
Q
Y
Y
V
Q
G
R
N
Q
E
Site 54
Y836
Q
E
R
L
A
E
C
Y
Y
M
L
E
D
Y
E
Site 55
Y837
E
R
L
A
E
C
Y
Y
M
L
E
D
Y
E
G
Site 56
Y842
C
Y
Y
M
L
E
D
Y
E
G
L
E
N
L
A
Site 57
S915
H
S
M
K
E
I
G
S
L
L
A
R
Y
A
S
Site 58
S922
S
L
L
A
R
Y
A
S
H
L
L
E
K
N
K
Site 59
T930
H
L
L
E
K
N
K
T
L
D
A
I
E
L
Y
Site 60
Y942
E
L
Y
R
K
A
N
Y
F
F
D
A
A
K
L
Site 61
Y981
S
A
L
L
I
E
Q
Y
H
E
Q
M
K
N
A
Site 62
S997
R
G
K
V
K
G
K
S
S
E
A
T
S
A
L
Site 63
S998
G
K
V
K
G
K
S
S
E
A
T
S
A
L
A
Site 64
T1001
K
G
K
S
S
E
A
T
S
A
L
A
G
L
L
Site 65
S1002
G
K
S
S
E
A
T
S
A
L
A
G
L
L
E
Site 66
S1014
L
L
E
E
E
V
L
S
T
T
D
R
F
T
D
Site 67
T1015
L
E
E
E
V
L
S
T
T
D
R
F
T
D
N
Site 68
T1020
L
S
T
T
D
R
F
T
D
N
A
W
R
G
A
Site 69
Y1058
T
A
L
H
L
K
D
Y
E
D
I
I
P
P
V
Site 70
S1085
S
R
A
F
G
T
C
S
K
A
F
I
K
L
K
Site 71
S1093
K
A
F
I
K
L
K
S
L
E
T
L
S
S
E
Site 72
T1096
I
K
L
K
S
L
E
T
L
S
S
E
Q
K
Q
Site 73
S1099
K
S
L
E
T
L
S
S
E
Q
K
Q
Q
Y
E
Site 74
Y1105
S
S
E
Q
K
Q
Q
Y
E
D
L
A
L
E
I
Site 75
S1128
N
R
K
P
E
L
D
S
L
M
E
G
G
E
G
Site 76
T1139
G
G
E
G
K
L
P
T
C
V
A
T
G
S
P
Site 77
S1145
P
T
C
V
A
T
G
S
P
I
T
E
Y
Q
F
Site 78
Y1150
T
G
S
P
I
T
E
Y
Q
F
W
M
C
S
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation