KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TBC1D14
Full Name:
TBC1 domain family member 14
Alias:
KIAA1322; TBC1 domain family, member 14; TBC14
Type:
GTPase activating protein, Rab
Mass (Da):
78137
Number AA:
678
UniProt ID:
Q9P2M4
International Prot ID:
IPI00002347
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005097
PhosphoSite+
KinaseNET
Biological Process:
GO:0032313
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T2
_
_
_
_
_
_
M
T
D
G
K
L
S
T
S
Site 2
S7
_
M
T
D
G
K
L
S
T
S
T
N
G
V
A
Site 3
T8
M
T
D
G
K
L
S
T
S
T
N
G
V
A
F
Site 4
S42
L
K
A
P
R
L
L
S
A
P
E
Y
G
P
K
Site 5
Y46
R
L
L
S
A
P
E
Y
G
P
K
L
K
L
R
Site 6
S60
R
A
L
E
D
R
H
S
L
Q
S
V
D
S
G
Site 7
S63
E
D
R
H
S
L
Q
S
V
D
S
G
I
P
T
Site 8
S66
H
S
L
Q
S
V
D
S
G
I
P
T
L
E
I
Site 9
T70
S
V
D
S
G
I
P
T
L
E
I
G
N
P
E
Site 10
S82
N
P
E
P
V
P
C
S
A
V
H
V
R
R
K
Site 11
S91
V
H
V
R
R
K
Q
S
D
S
D
L
I
P
E
Site 12
S93
V
R
R
K
Q
S
D
S
D
L
I
P
E
R
A
Site 13
S117
C
A
P
P
A
P
S
S
T
E
R
E
Q
S
V
Site 14
T118
A
P
P
A
P
S
S
T
E
R
E
Q
S
V
R
Site 15
S123
S
S
T
E
R
E
Q
S
V
R
K
S
S
T
F
Site 16
S127
R
E
Q
S
V
R
K
S
S
T
F
P
R
T
G
Site 17
S128
E
Q
S
V
R
K
S
S
T
F
P
R
T
G
Y
Site 18
T129
Q
S
V
R
K
S
S
T
F
P
R
T
G
Y
D
Site 19
T133
K
S
S
T
F
P
R
T
G
Y
D
S
V
K
L
Site 20
Y135
S
T
F
P
R
T
G
Y
D
S
V
K
L
Y
S
Site 21
S137
F
P
R
T
G
Y
D
S
V
K
L
Y
S
P
T
Site 22
Y141
G
Y
D
S
V
K
L
Y
S
P
T
S
K
A
L
Site 23
S142
Y
D
S
V
K
L
Y
S
P
T
S
K
A
L
T
Site 24
S145
V
K
L
Y
S
P
T
S
K
A
L
T
R
S
D
Site 25
T149
S
P
T
S
K
A
L
T
R
S
D
D
V
S
V
Site 26
S151
T
S
K
A
L
T
R
S
D
D
V
S
V
C
S
Site 27
S158
S
D
D
V
S
V
C
S
V
S
S
L
G
T
E
Site 28
S167
S
S
L
G
T
E
L
S
T
T
L
S
V
S
N
Site 29
T169
L
G
T
E
L
S
T
T
L
S
V
S
N
E
D
Site 30
S171
T
E
L
S
T
T
L
S
V
S
N
E
D
I
L
Site 31
T191
S
S
S
S
A
I
V
T
L
E
N
D
D
D
P
Site 32
S206
Q
F
T
N
V
T
L
S
S
I
K
E
T
R
G
Site 33
S249
N
L
L
A
R
K
Q
S
A
R
L
D
K
H
N
Site 34
S276
R
E
N
A
Q
K
D
S
K
R
I
Q
K
E
Y
Site 35
Y283
S
K
R
I
Q
K
E
Y
E
D
K
A
G
R
P
Site 36
S291
E
D
K
A
G
R
P
S
K
P
P
S
P
K
Q
Site 37
S295
G
R
P
S
K
P
P
S
P
K
Q
N
V
R
K
Site 38
Y338
A
Q
K
H
R
Q
Q
Y
E
E
M
V
V
Q
A
Site 39
S439
R
A
K
E
R
W
R
S
L
S
T
G
G
S
E
Site 40
S441
K
E
R
W
R
S
L
S
T
G
G
S
E
V
E
Site 41
S445
R
S
L
S
T
G
G
S
E
V
E
N
E
D
A
Site 42
S462
S
A
A
D
R
E
A
S
L
E
L
I
K
L
D
Site 43
T578
H
F
K
K
N
N
L
T
P
D
I
Y
L
I
D
Site 44
T643
I
H
M
A
Q
F
L
T
R
L
P
E
D
L
P
Site 45
S688
S
R
E
M
E
K
G
S
P
S
L
R
H
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation