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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CGN
Full Name:
Cingulin
Alias:
CING; cingulin; KIAA1319; KIAA1319, cingulin
Type:
Adapter/scaffold protein
Mass (Da):
136386
Number AA:
1197
UniProt ID:
Q9P2M7
International Prot ID:
IPI00515042
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016459
GO:0005923
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0003774
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T28
V
S
G
A
E
M
G
T
L
R
R
G
G
R
R
Site 2
S43
P
A
K
D
A
R
A
S
T
Y
G
V
A
V
R
Site 3
T44
A
K
D
A
R
A
S
T
Y
G
V
A
V
R
V
Site 4
Y45
K
D
A
R
A
S
T
Y
G
V
A
V
R
V
Q
Site 5
S64
Q
P
F
V
V
L
N
S
G
E
K
G
G
D
S
Site 6
S71
S
G
E
K
G
G
D
S
F
G
V
Q
I
K
G
Site 7
S89
Q
G
A
S
G
A
L
S
S
D
L
E
L
P
E
Site 8
S90
G
A
S
G
A
L
S
S
D
L
E
L
P
E
N
Site 9
Y99
L
E
L
P
E
N
P
Y
S
Q
V
K
G
F
P
Site 10
S100
E
L
P
E
N
P
Y
S
Q
V
K
G
F
P
A
Site 11
S109
V
K
G
F
P
A
P
S
Q
S
S
T
S
D
E
Site 12
S111
G
F
P
A
P
S
Q
S
S
T
S
D
E
E
P
Site 13
S112
F
P
A
P
S
Q
S
S
T
S
D
E
E
P
G
Site 14
T113
P
A
P
S
Q
S
S
T
S
D
E
E
P
G
A
Site 15
S114
A
P
S
Q
S
S
T
S
D
E
E
P
G
A
Y
Site 16
Y121
S
D
E
E
P
G
A
Y
W
N
G
K
L
L
R
Site 17
S129
W
N
G
K
L
L
R
S
H
S
Q
A
S
L
A
Site 18
S131
G
K
L
L
R
S
H
S
Q
A
S
L
A
G
P
Site 19
S134
L
R
S
H
S
Q
A
S
L
A
G
P
G
P
V
Site 20
S144
G
P
G
P
V
D
P
S
N
R
S
N
S
M
L
Site 21
S147
P
V
D
P
S
N
R
S
N
S
M
L
E
L
A
Site 22
S149
D
P
S
N
R
S
N
S
M
L
E
L
A
P
K
Site 23
S159
E
L
A
P
K
V
A
S
P
G
S
T
I
D
T
Site 24
S162
P
K
V
A
S
P
G
S
T
I
D
T
A
P
L
Site 25
T163
K
V
A
S
P
G
S
T
I
D
T
A
P
L
S
Site 26
T166
S
P
G
S
T
I
D
T
A
P
L
S
S
V
D
Site 27
S174
A
P
L
S
S
V
D
S
L
I
N
K
F
D
S
Site 28
S181
S
L
I
N
K
F
D
S
Q
L
G
G
Q
A
R
Site 29
T191
G
G
Q
A
R
G
R
T
G
R
R
T
R
M
L
Site 30
T195
R
G
R
T
G
R
R
T
R
M
L
P
P
E
Q
Site 31
S206
P
P
E
Q
R
K
R
S
K
S
L
D
S
R
L
Site 32
S208
E
Q
R
K
R
S
K
S
L
D
S
R
L
P
R
Site 33
S211
K
R
S
K
S
L
D
S
R
L
P
R
D
T
F
Site 34
T217
D
S
R
L
P
R
D
T
F
E
E
R
E
R
Q
Site 35
S225
F
E
E
R
E
R
Q
S
T
N
H
W
T
S
S
Site 36
T226
E
E
R
E
R
Q
S
T
N
H
W
T
S
S
T
Site 37
Y235
H
W
T
S
S
T
K
Y
D
N
H
V
G
T
S
Site 38
S248
T
S
K
Q
P
A
Q
S
Q
N
L
S
P
L
S
Site 39
S252
P
A
Q
S
Q
N
L
S
P
L
S
G
F
S
R
Site 40
S255
S
Q
N
L
S
P
L
S
G
F
S
R
S
R
Q
Site 41
S258
L
S
P
L
S
G
F
S
R
S
R
Q
T
Q
D
Site 42
S260
P
L
S
G
F
S
R
S
R
Q
T
Q
D
W
V
Site 43
T263
G
F
S
R
S
R
Q
T
Q
D
W
V
L
Q
S
Site 44
S270
T
Q
D
W
V
L
Q
S
F
E
E
P
R
R
S
Site 45
S277
S
F
E
E
P
R
R
S
A
Q
D
P
T
M
L
Site 46
T282
R
R
S
A
Q
D
P
T
M
L
Q
F
K
S
T
Site 47
S288
P
T
M
L
Q
F
K
S
T
P
D
L
L
R
D
Site 48
T289
T
M
L
Q
F
K
S
T
P
D
L
L
R
D
Q
Site 49
S304
Q
E
A
A
P
P
G
S
V
D
H
M
K
A
T
Site 50
Y313
D
H
M
K
A
T
I
Y
G
I
L
R
E
G
S
Site 51
S320
Y
G
I
L
R
E
G
S
S
E
S
E
T
S
V
Site 52
S321
G
I
L
R
E
G
S
S
E
S
E
T
S
V
R
Site 53
S323
L
R
E
G
S
S
E
S
E
T
S
V
R
R
K
Site 54
T325
E
G
S
S
E
S
E
T
S
V
R
R
K
V
S
Site 55
S326
G
S
S
E
S
E
T
S
V
R
R
K
V
S
L
Site 56
S332
T
S
V
R
R
K
V
S
L
V
L
E
K
M
Q
Site 57
S382
K
R
Q
K
L
E
P
S
Q
V
G
L
E
R
Q
Site 58
T394
E
R
Q
L
E
E
K
T
E
E
C
S
R
L
Q
Site 59
S414
R
K
G
E
A
Q
Q
S
N
K
E
L
Q
N
M
Site 60
T437
D
L
R
H
G
L
E
T
Q
V
M
E
L
Q
N
Site 61
T492
R
L
R
E
R
E
L
T
A
L
K
G
A
L
K
Site 62
S504
A
L
K
E
E
V
A
S
R
D
Q
E
V
E
H
Site 63
Y516
V
E
H
V
R
Q
Q
Y
Q
R
D
T
E
Q
L
Site 64
T520
R
Q
Q
Y
Q
R
D
T
E
Q
L
R
R
S
M
Site 65
S526
D
T
E
Q
L
R
R
S
M
Q
D
A
T
Q
D
Site 66
T531
R
R
S
M
Q
D
A
T
Q
D
H
A
V
L
E
Site 67
T558
L
Q
R
E
L
E
E
T
S
E
E
T
G
H
W
Site 68
T579
N
K
E
D
L
R
A
T
K
Q
E
L
L
Q
L
Site 69
S614
E
L
E
Q
A
R
A
S
A
G
D
T
R
Q
V
Site 70
T618
A
R
A
S
A
G
D
T
R
Q
V
E
V
L
K
Site 71
T631
L
K
K
E
L
L
R
T
Q
E
E
L
K
E
L
Site 72
S644
E
L
Q
A
E
R
Q
S
Q
E
V
A
G
R
H
Site 73
T683
Q
N
L
Q
L
Q
K
T
L
Q
Q
L
R
Q
D
Site 74
T706
M
V
A
E
A
E
A
T
V
L
G
Q
R
R
A
Site 75
T717
Q
R
R
A
A
V
E
T
T
L
R
E
T
Q
E
Site 76
T718
R
R
A
A
V
E
T
T
L
R
E
T
Q
E
E
Site 77
T722
V
E
T
T
L
R
E
T
Q
E
E
N
D
E
F
Site 78
S778
L
E
E
A
L
N
A
S
Q
E
E
E
G
S
L
Site 79
S784
A
S
Q
E
E
E
G
S
L
A
A
A
K
R
A
Site 80
T844
Q
K
R
L
L
D
R
T
V
D
R
L
N
K
E
Site 81
Y873
L
Q
A
Q
L
E
D
Y
K
E
K
A
R
R
E
Site 82
S893
R
Q
A
K
D
W
A
S
E
A
E
K
T
S
G
Site 83
T898
W
A
S
E
A
E
K
T
S
G
G
L
S
R
L
Site 84
S903
E
K
T
S
G
G
L
S
R
L
Q
D
E
I
Q
Site 85
T925
A
S
Q
A
E
R
D
T
A
R
L
D
K
E
L
Site 86
S950
E
A
E
N
K
K
R
S
Q
D
D
R
A
R
Q
Site 87
S966
K
G
L
E
E
K
V
S
R
L
E
T
E
L
D
Site 88
T970
E
K
V
S
R
L
E
T
E
L
D
E
E
K
N
Site 89
T978
E
L
D
E
E
K
N
T
V
E
L
L
T
D
R
Site 90
T983
K
N
T
V
E
L
L
T
D
R
V
N
R
G
R
Site 91
S1005
T
E
L
M
Q
E
R
S
A
R
Q
D
L
E
C
Site 92
S1016
D
L
E
C
D
K
I
S
L
E
R
Q
N
K
D
Site 93
T1026
R
Q
N
K
D
L
K
T
R
L
A
S
S
E
G
Site 94
S1030
D
L
K
T
R
L
A
S
S
E
G
F
Q
K
P
Site 95
S1038
S
E
G
F
Q
K
P
S
A
S
L
S
Q
L
E
Site 96
S1040
G
F
Q
K
P
S
A
S
L
S
Q
L
E
S
Q
Site 97
S1042
Q
K
P
S
A
S
L
S
Q
L
E
S
Q
N
Q
Site 98
S1046
A
S
L
S
Q
L
E
S
Q
N
Q
L
L
Q
E
Site 99
T1063
Q
A
E
E
R
E
K
T
V
L
Q
S
T
N
R
Site 100
S1067
R
E
K
T
V
L
Q
S
T
N
R
K
L
E
R
Site 101
T1068
E
K
T
V
L
Q
S
T
N
R
K
L
E
R
K
Site 102
S1098
N
D
Q
K
D
Q
L
S
L
R
V
K
A
L
K
Site 103
S1145
Q
L
Q
A
R
I
K
S
L
E
K
D
S
W
R
Site 104
S1150
I
K
S
L
E
K
D
S
W
R
K
A
S
R
S
Site 105
S1155
K
D
S
W
R
K
A
S
R
S
A
A
E
S
A
Site 106
S1157
S
W
R
K
A
S
R
S
A
A
E
S
A
L
K
Site 107
S1161
A
S
R
S
A
A
E
S
A
L
K
N
E
G
L
Site 108
S1170
L
K
N
E
G
L
S
S
D
E
E
F
D
S
V
Site 109
S1176
S
S
D
E
E
F
D
S
V
Y
D
P
S
S
I
Site 110
Y1178
D
E
E
F
D
S
V
Y
D
P
S
S
I
A
S
Site 111
S1182
D
S
V
Y
D
P
S
S
I
A
S
L
L
T
E
Site 112
S1185
Y
D
P
S
S
I
A
S
L
L
T
E
S
N
L
Site 113
T1188
S
S
I
A
S
L
L
T
E
S
N
L
Q
T
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation