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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGAP28
Full Name:
Rho GTPase-activating protein 28
Alias:
Rho-type GTPase-activating protein 28
Type:
Mass (Da):
82029
Number AA:
729
UniProt ID:
Q9P2N2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
D
S
G
G
V
V
L
T
A
Y
H
S
Y
A
R
Site 2
S16
V
V
L
T
A
Y
H
S
Y
A
R
A
Q
P
P
Site 3
Y17
V
L
T
A
Y
H
S
Y
A
R
A
Q
P
P
N
Site 4
S36
C
A
P
R
A
A
A
S
H
P
L
S
R
K
S
Site 5
S40
A
A
A
S
H
P
L
S
R
K
S
I
P
R
C
Site 6
S43
S
H
P
L
S
R
K
S
I
P
R
C
R
R
I
Site 7
S55
R
R
I
N
R
M
L
S
N
E
S
L
H
P
P
Site 8
S58
N
R
M
L
S
N
E
S
L
H
P
P
A
F
S
Site 9
S65
S
L
H
P
P
A
F
S
R
S
N
S
E
A
S
Site 10
S67
H
P
P
A
F
S
R
S
N
S
E
A
S
V
D
Site 11
S69
P
A
F
S
R
S
N
S
E
A
S
V
D
S
A
Site 12
S72
S
R
S
N
S
E
A
S
V
D
S
A
S
M
E
Site 13
S75
N
S
E
A
S
V
D
S
A
S
M
E
D
F
W
Site 14
S77
E
A
S
V
D
S
A
S
M
E
D
F
W
R
E
Site 15
S87
D
F
W
R
E
I
E
S
I
K
D
S
S
M
G
Site 16
S91
E
I
E
S
I
K
D
S
S
M
G
G
Q
E
E
Site 17
T105
E
P
P
P
A
E
V
T
P
V
D
E
G
E
L
Site 18
S127
V
G
L
S
T
L
I
S
G
D
E
E
E
D
G
Site 19
S139
E
D
G
K
A
L
L
S
T
L
T
R
T
Q
A
Site 20
T140
D
G
K
A
L
L
S
T
L
T
R
T
Q
A
A
Site 21
T155
A
V
Q
K
R
Y
H
T
Y
T
Q
T
M
R
K
Site 22
T157
Q
K
R
Y
H
T
Y
T
Q
T
M
R
K
K
D
Site 23
T159
R
Y
H
T
Y
T
Q
T
M
R
K
K
D
K
Q
Site 24
S167
M
R
K
K
D
K
Q
S
I
R
D
V
R
D
I
Site 25
S180
D
I
F
G
V
S
E
S
P
P
R
D
T
C
G
Site 26
T185
S
E
S
P
P
R
D
T
C
G
N
H
T
N
Q
Site 27
T208
E
L
P
R
V
I
K
T
S
G
S
M
P
D
D
Site 28
S209
L
P
R
V
I
K
T
S
G
S
M
P
D
D
A
Site 29
S211
R
V
I
K
T
S
G
S
M
P
D
D
A
S
L
Site 30
S217
G
S
M
P
D
D
A
S
L
N
S
T
T
L
S
Site 31
S220
P
D
D
A
S
L
N
S
T
T
L
S
D
A
S
Site 32
T221
D
D
A
S
L
N
S
T
T
L
S
D
A
S
Q
Site 33
T222
D
A
S
L
N
S
T
T
L
S
D
A
S
Q
D
Site 34
S224
S
L
N
S
T
T
L
S
D
A
S
Q
D
K
E
Site 35
S227
S
T
T
L
S
D
A
S
Q
D
K
E
G
S
F
Site 36
S233
A
S
Q
D
K
E
G
S
F
A
V
P
R
S
D
Site 37
S258
L
P
V
H
S
N
G
S
P
E
P
G
Q
P
V
Site 38
S270
Q
P
V
Q
N
A
I
S
D
D
D
F
L
E
K
Site 39
S287
P
P
E
A
E
E
L
S
F
E
V
S
Y
S
E
Site 40
S291
E
E
L
S
F
E
V
S
Y
S
E
M
V
T
E
Site 41
T297
V
S
Y
S
E
M
V
T
E
A
L
K
R
N
K
Site 42
S308
K
R
N
K
L
K
K
S
E
I
K
K
E
D
Y
Site 43
Y315
S
E
I
K
K
E
D
Y
V
L
T
K
F
N
V
Site 44
T318
K
K
E
D
Y
V
L
T
K
F
N
V
Q
K
T
Site 45
S336
L
T
E
A
G
D
L
S
A
E
D
M
K
K
I
Site 46
S347
M
K
K
I
R
H
L
S
L
I
E
L
T
A
F
Site 47
T352
H
L
S
L
I
E
L
T
A
F
F
D
A
F
G
Site 48
T367
I
Q
L
K
R
N
K
T
E
K
V
K
G
R
D
Site 49
S412
F
F
E
K
V
E
E
S
G
L
E
S
E
G
I
Site 50
S416
V
E
E
S
G
L
E
S
E
G
I
F
R
L
S
Site 51
S423
S
E
G
I
F
R
L
S
G
C
T
A
K
V
K
Site 52
T426
I
F
R
L
S
G
C
T
A
K
V
K
Q
Y
R
Site 53
T516
D
A
A
Q
A
L
M
T
F
F
N
K
V
I
A
Site 54
S531
N
E
S
K
N
R
M
S
L
W
N
I
S
T
V
Site 55
S546
M
A
P
N
L
F
F
S
R
S
K
H
S
D
Y
Site 56
S548
P
N
L
F
F
S
R
S
K
H
S
D
Y
E
E
Site 57
S551
F
F
S
R
S
K
H
S
D
Y
E
E
L
L
L
Site 58
Y553
S
R
S
K
H
S
D
Y
E
E
L
L
L
A
N
Site 59
T585
K
V
P
S
F
L
I
T
Q
V
R
R
M
N
E
Site 60
T594
V
R
R
M
N
E
A
T
M
L
L
K
K
Q
L
Site 61
S603
L
L
K
K
Q
L
P
S
V
R
K
L
L
R
R
Site 62
T612
R
K
L
L
R
R
K
T
L
E
R
E
T
A
S
Site 63
T617
R
K
T
L
E
R
E
T
A
S
P
K
T
S
K
Site 64
S619
T
L
E
R
E
T
A
S
P
K
T
S
K
V
L
Site 65
S623
E
T
A
S
P
K
T
S
K
V
L
Q
K
S
P
Site 66
S629
T
S
K
V
L
Q
K
S
P
S
A
R
R
M
S
Site 67
S631
K
V
L
Q
K
S
P
S
A
R
R
M
S
D
V
Site 68
S636
S
P
S
A
R
R
M
S
D
V
P
E
G
V
I
Site 69
Y674
D
I
L
A
K
F
Q
Y
E
N
S
H
G
S
S
Site 70
S677
A
K
F
Q
Y
E
N
S
H
G
S
S
E
C
I
Site 71
Y692
K
I
Q
N
Q
R
L
Y
E
I
G
G
N
I
G
Site 72
Y713
D
A
Y
I
L
D
V
Y
R
I
N
P
Q
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation