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Updated November 2019
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Protein Info
Short Name:
ADAMTS9
Full Name:
A disintegrin and metalloproteinase with thrombospondin motifs 9
Alias:
Type:
Mass (Da):
216491
Number AA:
1935
UniProt ID:
Q9P2N4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
R
D
L
A
E
M
G
S
P
D
A
A
A
A
V
Site 2
T65
A
L
G
E
P
F
P
T
N
V
H
F
K
R
T
Site 3
S75
H
F
K
R
T
R
R
S
I
N
S
A
T
D
P
Site 4
S78
R
T
R
R
S
I
N
S
A
T
D
P
W
P
A
Site 5
S88
D
P
W
P
A
F
A
S
S
S
S
S
S
T
S
Site 6
S89
P
W
P
A
F
A
S
S
S
S
S
S
T
S
S
Site 7
S90
W
P
A
F
A
S
S
S
S
S
S
T
S
S
Q
Site 8
S91
P
A
F
A
S
S
S
S
S
S
T
S
S
Q
A
Site 9
S92
A
F
A
S
S
S
S
S
S
T
S
S
Q
A
H
Site 10
S93
F
A
S
S
S
S
S
S
T
S
S
Q
A
H
Y
Site 11
T94
A
S
S
S
S
S
S
T
S
S
Q
A
H
Y
R
Site 12
S95
S
S
S
S
S
S
T
S
S
Q
A
H
Y
R
L
Site 13
S96
S
S
S
S
S
T
S
S
Q
A
H
Y
R
L
S
Site 14
Y100
S
T
S
S
Q
A
H
Y
R
L
S
A
F
G
Q
Site 15
S103
S
Q
A
H
Y
R
L
S
A
F
G
Q
Q
F
L
Site 16
Y155
K
H
C
F
Y
K
G
Y
V
N
T
N
S
E
H
Site 17
T175
L
C
S
G
M
L
G
T
F
R
S
H
D
G
D
Site 18
Y183
F
R
S
H
D
G
D
Y
F
I
E
P
L
Q
S
Site 19
S190
Y
F
I
E
P
L
Q
S
M
D
E
Q
E
D
E
Site 20
Y207
Q
N
K
P
H
I
I
Y
R
R
S
A
P
Q
R
Site 21
S210
P
H
I
I
Y
R
R
S
A
P
Q
R
E
P
S
Site 22
S217
S
A
P
Q
R
E
P
S
T
G
R
H
A
C
D
Site 23
T218
A
P
Q
R
E
P
S
T
G
R
H
A
C
D
T
Site 24
T225
T
G
R
H
A
C
D
T
S
E
H
K
N
R
H
Site 25
S226
G
R
H
A
C
D
T
S
E
H
K
N
R
H
S
Site 26
S233
S
E
H
K
N
R
H
S
K
D
K
K
K
T
R
Site 27
T276
Y
G
N
K
T
D
N
T
R
E
K
R
T
H
R
Site 28
T281
D
N
T
R
E
K
R
T
H
R
R
T
K
R
F
Site 29
T285
E
K
R
T
H
R
R
T
K
R
F
L
S
Y
P
Site 30
S290
R
R
T
K
R
F
L
S
Y
P
R
F
V
E
V
Site 31
Y291
R
T
K
R
F
L
S
Y
P
R
F
V
E
V
L
Site 32
S307
V
A
D
N
R
M
V
S
Y
H
G
E
N
L
Q
Site 33
S357
E
Q
D
G
P
S
I
S
F
N
A
Q
T
T
L
Site 34
T384
P
G
G
I
H
H
D
T
A
V
L
L
T
R
Q
Site 35
T402
R
A
H
D
K
C
D
T
L
G
L
A
E
L
G
Site 36
Y415
L
G
T
I
C
D
P
Y
R
S
C
S
I
S
E
Site 37
S417
T
I
C
D
P
Y
R
S
C
S
I
S
E
D
S
Site 38
S419
C
D
P
Y
R
S
C
S
I
S
E
D
S
G
L
Site 39
S421
P
Y
R
S
C
S
I
S
E
D
S
G
L
S
T
Site 40
S424
S
C
S
I
S
E
D
S
G
L
S
T
A
F
T
Site 41
T428
S
E
D
S
G
L
S
T
A
F
T
I
A
H
E
Site 42
S457
C
K
E
E
G
V
K
S
P
Q
H
V
M
A
P
Site 43
Y482
W
S
K
C
S
R
K
Y
I
T
E
F
L
D
T
Site 44
Y491
T
E
F
L
D
T
G
Y
G
E
C
L
L
N
E
Site 45
S501
C
L
L
N
E
P
E
S
R
P
Y
P
L
P
V
Site 46
Y504
N
E
P
E
S
R
P
Y
P
L
P
V
Q
L
P
Site 47
Y515
V
Q
L
P
G
I
L
Y
N
V
N
K
Q
C
E
Site 48
Y534
P
G
S
Q
V
C
P
Y
M
M
Q
C
R
R
L
Site 49
T558
K
G
C
R
T
Q
H
T
P
W
A
D
G
T
E
Site 50
T564
H
T
P
W
A
D
G
T
E
C
E
P
G
K
H
Site 51
Y574
E
P
G
K
H
C
K
Y
G
F
C
V
P
K
E
Site 52
T587
K
E
M
D
V
P
V
T
D
G
S
W
G
S
W
Site 53
S590
D
V
P
V
T
D
G
S
W
G
S
W
S
P
F
Site 54
S595
D
G
S
W
G
S
W
S
P
F
G
T
C
S
R
Site 55
T599
G
S
W
S
P
F
G
T
C
S
R
T
C
G
G
Site 56
T610
T
C
G
G
G
I
K
T
A
I
R
E
C
N
R
Site 57
Y626
E
P
K
N
G
G
K
Y
C
V
G
R
R
M
K
Site 58
Y677
N
V
R
W
V
P
K
Y
S
G
I
L
M
K
D
Site 59
T709
R
D
R
V
I
D
G
T
P
C
G
Q
D
T
N
Site 60
S750
G
V
C
G
G
D
N
S
S
C
K
T
V
A
G
Site 61
S751
V
C
G
G
D
N
S
S
C
K
T
V
A
G
T
Site 62
T754
G
D
N
S
S
C
K
T
V
A
G
T
F
N
T
Site 63
T758
S
C
K
T
V
A
G
T
F
N
T
V
H
Y
G
Site 64
S785
N
I
D
V
R
Q
H
S
F
S
G
E
T
D
D
Site 65
S787
D
V
R
Q
H
S
F
S
G
E
T
D
D
D
N
Site 66
Y795
G
E
T
D
D
D
N
Y
L
A
L
S
S
S
K
Site 67
S799
D
D
N
Y
L
A
L
S
S
S
K
G
E
F
L
Site 68
S801
N
Y
L
A
L
S
S
S
K
G
E
F
L
L
N
Site 69
S832
A
V
V
E
Y
S
G
S
E
T
A
V
E
R
I
Site 70
T834
V
E
Y
S
G
S
E
T
A
V
E
R
I
N
S
Site 71
S841
T
A
V
E
R
I
N
S
T
D
R
I
E
Q
E
Site 72
Y860
V
L
S
V
G
K
L
Y
N
P
D
V
R
Y
S
Site 73
Y866
L
Y
N
P
D
V
R
Y
S
F
N
I
P
I
E
Site 74
T905
R
K
R
K
L
V
C
T
R
E
S
D
Q
L
T
Site 75
S908
K
L
V
C
T
R
E
S
D
Q
L
T
V
S
D
Site 76
T912
T
R
E
S
D
Q
L
T
V
S
D
Q
R
C
D
Site 77
S914
E
S
D
Q
L
T
V
S
D
Q
R
C
D
R
L
Site 78
S943
D
L
R
W
H
V
A
S
R
S
E
C
S
A
Q
Site 79
Y961
G
Y
R
T
L
D
I
Y
C
A
K
Y
S
R
L
Site 80
Y965
L
D
I
Y
C
A
K
Y
S
R
L
D
G
K
T
Site 81
T972
Y
S
R
L
D
G
K
T
E
K
V
D
D
G
F
Site 82
S981
K
V
D
D
G
F
C
S
S
H
P
K
P
S
N
Site 83
S982
V
D
D
G
F
C
S
S
H
P
K
P
S
N
R
Site 84
S987
C
S
S
H
P
K
P
S
N
R
E
K
C
S
G
Site 85
S993
P
S
N
R
E
K
C
S
G
E
C
N
T
G
G
Site 86
T1017
S
K
S
C
D
G
G
T
Q
R
R
R
A
I
C
Site 87
S1035
R
N
D
V
L
D
D
S
K
C
T
H
Q
E
K
Site 88
T1095
D
R
M
C
D
P
E
T
K
P
T
S
M
Q
T
Site 89
S1099
D
P
E
T
K
P
T
S
M
Q
T
C
Q
Q
P
Site 90
Y1127
S
V
T
C
G
Q
G
Y
Q
L
R
A
V
K
C
Site 91
T1155
C
N
A
A
T
R
P
T
D
T
Q
D
C
E
L
Site 92
T1157
A
A
T
R
P
T
D
T
Q
D
C
E
L
P
S
Site 93
S1164
T
Q
D
C
E
L
P
S
C
H
P
P
P
A
A
Site 94
T1174
P
P
P
A
A
P
E
T
R
R
S
T
Y
S
A
Site 95
S1177
A
A
P
E
T
R
R
S
T
Y
S
A
P
R
T
Site 96
T1178
A
P
E
T
R
R
S
T
Y
S
A
P
R
T
Q
Site 97
Y1179
P
E
T
R
R
S
T
Y
S
A
P
R
T
Q
W
Site 98
S1180
E
T
R
R
S
T
Y
S
A
P
R
T
Q
W
R
Site 99
T1184
S
T
Y
S
A
P
R
T
Q
W
R
F
G
S
W
Site 100
Y1206
G
K
G
T
R
M
R
Y
V
S
C
R
D
E
N
Site 101
S1208
G
T
R
M
R
Y
V
S
C
R
D
E
N
G
S
Site 102
S1215
S
C
R
D
E
N
G
S
V
A
D
E
S
A
C
Site 103
S1220
N
G
S
V
A
D
E
S
A
C
A
T
L
P
R
Site 104
T1224
A
D
E
S
A
C
A
T
L
P
R
P
V
A
K
Site 105
T1237
A
K
E
E
C
S
V
T
P
C
G
Q
W
K
A
Site 106
S1251
A
L
D
W
S
S
C
S
V
T
C
G
Q
G
R
Site 107
T1253
D
W
S
S
C
S
V
T
C
G
Q
G
R
A
T
Site 108
Y1282
R
S
E
C
D
Q
D
Y
I
P
E
T
D
Q
D
Site 109
S1291
P
E
T
D
Q
D
C
S
M
S
P
C
P
Q
R
Site 110
S1293
T
D
Q
D
C
S
M
S
P
C
P
Q
R
T
P
Site 111
T1299
M
S
P
C
P
Q
R
T
P
D
S
G
L
A
Q
Site 112
S1302
C
P
Q
R
T
P
D
S
G
L
A
Q
H
P
F
Site 113
Y1314
H
P
F
Q
N
E
D
Y
R
P
R
S
A
S
P
Site 114
S1318
N
E
D
Y
R
P
R
S
A
S
P
S
R
T
H
Site 115
S1320
D
Y
R
P
R
S
A
S
P
S
R
T
H
V
L
Site 116
S1322
R
P
R
S
A
S
P
S
R
T
H
V
L
G
G
Site 117
T1324
R
S
A
S
P
S
R
T
H
V
L
G
G
N
Q
Site 118
S1341
T
G
P
W
G
A
C
S
S
T
C
A
G
G
S
Site 119
S1342
G
P
W
G
A
C
S
S
T
C
A
G
G
S
Q
Site 120
T1343
P
W
G
A
C
S
S
T
C
A
G
G
S
Q
R
Site 121
S1421
G
E
R
F
P
D
L
S
C
E
I
L
D
K
P
Site 122
T1447
P
H
D
A
A
W
S
T
G
P
W
S
S
C
S
Site 123
S1452
W
S
T
G
P
W
S
S
C
S
V
S
C
G
R
Site 124
S1454
T
G
P
W
S
S
C
S
V
S
C
G
R
G
H
Site 125
S1456
P
W
S
S
C
S
V
S
C
G
R
G
H
K
Q
Site 126
Y1467
G
H
K
Q
R
N
V
Y
C
M
A
K
D
G
S
Site 127
S1478
K
D
G
S
H
L
E
S
D
Y
C
K
H
L
A
Site 128
Y1480
G
S
H
L
E
S
D
Y
C
K
H
L
A
K
P
Site 129
T1535
T
H
K
I
A
R
E
T
E
C
N
P
Y
T
R
Site 130
Y1540
R
E
T
E
C
N
P
Y
T
R
P
E
S
E
R
Site 131
T1541
E
T
E
C
N
P
Y
T
R
P
E
S
E
R
D
Site 132
S1545
N
P
Y
T
R
P
E
S
E
R
D
C
Q
G
P
Site 133
Y1557
Q
G
P
R
C
P
L
Y
T
W
R
A
E
E
W
Site 134
S1575
T
K
T
C
G
E
G
S
R
Y
R
K
V
V
C
Site 135
Y1577
T
C
G
E
G
S
R
Y
R
K
V
V
C
V
D
Site 136
S1598
H
G
A
R
C
D
V
S
K
R
P
V
D
R
E
Site 137
S1606
K
R
P
V
D
R
E
S
C
S
L
Q
P
C
E
Site 138
S1608
P
V
D
R
E
S
C
S
L
Q
P
C
E
Y
V
Site 139
T1627
E
W
S
E
C
S
V
T
C
G
K
G
Y
K
Q
Site 140
Y1632
S
V
T
C
G
K
G
Y
K
Q
R
L
V
S
C
Site 141
S1638
G
Y
K
Q
R
L
V
S
C
S
E
I
Y
T
G
Site 142
S1640
K
Q
R
L
V
S
C
S
E
I
Y
T
G
K
E
Site 143
T1644
V
S
C
S
E
I
Y
T
G
K
E
N
Y
E
Y
Site 144
Y1651
T
G
K
E
N
Y
E
Y
S
Y
Q
T
T
I
N
Site 145
T1662
T
T
I
N
C
P
G
T
Q
P
P
S
V
H
P
Site 146
S1666
C
P
G
T
Q
P
P
S
V
H
P
C
Y
L
R
Site 147
Y1671
P
P
S
V
H
P
C
Y
L
R
D
C
P
V
S
Site 148
T1706
Q
R
S
V
Q
C
L
T
N
E
D
Q
P
S
H
Site 149
S1712
L
T
N
E
D
Q
P
S
H
L
C
H
T
D
L
Site 150
T1726
L
K
P
E
E
R
K
T
C
R
N
V
Y
N
C
Site 151
Y1731
R
K
T
C
R
N
V
Y
N
C
E
L
P
Q
N
Site 152
S1749
V
K
R
L
K
G
A
S
E
D
G
E
Y
F
L
Site 153
Y1754
G
A
S
E
D
G
E
Y
F
L
M
I
R
G
K
Site 154
Y1778
H
S
D
H
P
K
E
Y
V
T
L
V
H
G
D
Site 155
S1786
V
T
L
V
H
G
D
S
E
N
F
S
E
V
Y
Site 156
S1790
H
G
D
S
E
N
F
S
E
V
Y
G
H
R
L
Site 157
Y1793
S
E
N
F
S
E
V
Y
G
H
R
L
H
N
P
Site 158
T1801
G
H
R
L
H
N
P
T
E
C
P
Y
N
G
S
Site 159
Y1819
D
C
Q
C
R
K
D
Y
T
A
A
G
F
S
S
Site 160
S1826
Y
T
A
A
G
F
S
S
F
Q
K
I
R
I
D
Site 161
T1841
L
T
S
M
Q
I
I
T
T
D
L
Q
F
A
R
Site 162
S1850
D
L
Q
F
A
R
T
S
E
G
H
P
V
P
F
Site 163
Y1864
F
A
T
A
G
D
C
Y
S
A
A
K
C
P
Q
Site 164
S1865
A
T
A
G
D
C
Y
S
A
A
K
C
P
Q
G
Site 165
S1875
K
C
P
Q
G
R
F
S
I
N
L
Y
G
T
G
Site 166
Y1879
G
R
F
S
I
N
L
Y
G
T
G
L
S
L
T
Site 167
T1881
F
S
I
N
L
Y
G
T
G
L
S
L
T
E
S
Site 168
S1884
N
L
Y
G
T
G
L
S
L
T
E
S
A
R
W
Site 169
T1886
Y
G
T
G
L
S
L
T
E
S
A
R
W
I
S
Site 170
S1888
T
G
L
S
L
T
E
S
A
R
W
I
S
Q
G
Site 171
S1893
T
E
S
A
R
W
I
S
Q
G
N
Y
A
V
S
Site 172
Y1897
R
W
I
S
Q
G
N
Y
A
V
S
D
I
K
K
Site 173
S1900
S
Q
G
N
Y
A
V
S
D
I
K
K
S
P
D
Site 174
S1905
A
V
S
D
I
K
K
S
P
D
G
T
R
V
V
Site 175
T1909
I
K
K
S
P
D
G
T
R
V
V
G
K
C
G
Site 176
T1923
G
G
Y
C
G
K
C
T
P
S
S
G
T
G
L
Site 177
S1925
Y
C
G
K
C
T
P
S
S
G
T
G
L
E
V
Site 178
S1926
C
G
K
C
T
P
S
S
G
T
G
L
E
V
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation