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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHL13
Full Name:
Kelch-like protein 13
Alias:
Bklhd2; Flj10262; Kelch-like 13
Type:
Uncharacterized protein
Mass (Da):
68187
Number AA:
604
UniProt ID:
Q9P2N7
International Prot ID:
IPI00002398
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
P
L
K
W
K
T
S
S
P
A
I
W
K
F
P
Site 2
T22
F
P
V
P
V
L
K
T
S
R
S
T
P
L
S
Site 3
S23
P
V
P
V
L
K
T
S
R
S
T
P
L
S
P
Site 4
S25
P
V
L
K
T
S
R
S
T
P
L
S
P
A
Y
Site 5
T26
V
L
K
T
S
R
S
T
P
L
S
P
A
Y
I
Site 6
Y32
S
T
P
L
S
P
A
Y
I
S
L
V
E
E
E
Site 7
S34
P
L
S
P
A
Y
I
S
L
V
E
E
E
D
Q
Site 8
S46
E
D
Q
H
M
K
L
S
L
G
G
S
E
M
G
Site 9
S50
M
K
L
S
L
G
G
S
E
M
G
L
S
S
H
Site 10
S55
G
G
S
E
M
G
L
S
S
H
L
Q
S
S
K
Site 11
S56
G
S
E
M
G
L
S
S
H
L
Q
S
S
K
A
Site 12
S60
G
L
S
S
H
L
Q
S
S
K
A
G
P
T
R
Site 13
S61
L
S
S
H
L
Q
S
S
K
A
G
P
T
R
I
Site 14
T70
A
G
P
T
R
I
F
T
S
N
T
H
S
S
V
Site 15
S71
G
P
T
R
I
F
T
S
N
T
H
S
S
V
V
Site 16
T73
T
R
I
F
T
S
N
T
H
S
S
V
V
L
Q
Site 17
S76
F
T
S
N
T
H
S
S
V
V
L
Q
G
F
D
Site 18
T101
V
T
L
M
P
G
D
T
D
D
A
F
P
V
H
Site 19
T167
N
M
D
N
L
Q
D
T
L
E
A
A
S
F
L
Site 20
Y206
V
G
R
I
A
N
T
Y
N
L
T
E
V
D
K
Site 21
Y214
N
L
T
E
V
D
K
Y
V
N
S
F
V
L
K
Site 22
S217
E
V
D
K
Y
V
N
S
F
V
L
K
N
F
P
Site 23
S245
E
R
L
A
F
V
L
S
S
N
S
L
K
H
C
Site 24
T288
N
I
R
F
P
L
M
T
P
Q
E
L
I
N
Y
Site 25
Y295
T
P
Q
E
L
I
N
Y
V
Q
T
V
D
F
M
Site 26
T307
D
F
M
R
T
D
N
T
C
V
N
L
L
L
E
Site 27
Y318
L
L
L
E
A
S
N
Y
Q
M
M
P
Y
M
Q
Site 28
S330
Y
M
Q
P
V
M
Q
S
D
R
T
A
I
R
S
Site 29
T333
P
V
M
Q
S
D
R
T
A
I
R
S
D
T
T
Site 30
S337
S
D
R
T
A
I
R
S
D
T
T
H
L
V
T
Site 31
T339
R
T
A
I
R
S
D
T
T
H
L
V
T
L
G
Site 32
Y362
V
S
K
E
L
R
M
Y
D
E
K
A
H
E
W
Site 33
S371
E
K
A
H
E
W
K
S
L
A
P
M
D
A
P
Site 34
Y400
V
V
G
G
Q
S
N
Y
D
T
K
G
K
T
A
Site 35
T402
G
G
Q
S
N
Y
D
T
K
G
K
T
A
V
D
Site 36
T410
K
G
K
T
A
V
D
T
V
F
R
F
D
P
R
Site 37
Y418
V
F
R
F
D
P
R
Y
N
K
W
M
Q
V
A
Site 38
T432
A
S
L
N
E
K
R
T
F
F
H
L
S
A
L
Site 39
S437
K
R
T
F
F
H
L
S
A
L
K
G
Y
L
Y
Site 40
Y444
S
A
L
K
G
Y
L
Y
A
V
G
G
R
N
A
Site 41
Y461
E
L
P
T
V
E
C
Y
N
P
R
T
N
E
W
Site 42
T469
N
P
R
T
N
E
W
T
Y
V
A
K
M
S
E
Site 43
Y470
P
R
T
N
E
W
T
Y
V
A
K
M
S
E
P
Site 44
Y479
A
K
M
S
E
P
H
Y
G
H
A
G
T
V
Y
Site 45
T497
M
Y
I
S
G
G
I
T
H
D
T
F
Q
K
E
Site 46
T500
S
G
G
I
T
H
D
T
F
Q
K
E
L
M
C
Site 47
T522
W
I
Q
K
A
P
M
T
T
V
R
G
L
H
C
Site 48
T548
G
G
N
H
F
R
G
T
S
D
Y
D
D
V
L
Site 49
S549
G
N
H
F
R
G
T
S
D
Y
D
D
V
L
S
Site 50
Y551
H
F
R
G
T
S
D
Y
D
D
V
L
S
C
E
Site 51
S556
S
D
Y
D
D
V
L
S
C
E
Y
Y
S
P
I
Site 52
Y559
D
D
V
L
S
C
E
Y
Y
S
P
I
L
D
Q
Site 53
Y560
D
V
L
S
C
E
Y
Y
S
P
I
L
D
Q
W
Site 54
Y609
M
V
E
I
V
Q
K
Y
D
P
D
K
D
E
W
Site 55
T635
G
I
R
A
C
T
L
T
V
F
P
P
E
E
T
Site 56
T643
V
F
P
P
E
E
T
T
P
S
P
S
R
E
S
Site 57
S645
P
P
E
E
T
T
P
S
P
S
R
E
S
P
L
Site 58
S647
E
E
T
T
P
S
P
S
R
E
S
P
L
S
A
Site 59
S650
T
P
S
P
S
R
E
S
P
L
S
A
P
_
_
Site 60
S653
P
S
R
E
S
P
L
S
A
P
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation