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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HECW2
Full Name:
E3 ubiquitin-protein ligase HECW2
Alias:
E3 ubiquitin-protein ligase HECW2; EC 6.3.2.-; HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2; KIAA1301; NEDD4-related E3 ubiquitin ligase NEDL2; NEDL2
Type:
Ligase; EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system
Mass (Da):
175769
Number AA:
1572
UniProt ID:
Q9P2P5
International Prot ID:
IPI00017163
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0016881
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0006464
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
R
N
P
Q
M
R
Y
T
L
S
P
E
N
L
Q
Site 2
S24
P
Q
M
R
Y
T
L
S
P
E
N
L
Q
S
L
Site 3
S30
L
S
P
E
N
L
Q
S
L
A
A
Q
S
S
M
Site 4
S36
Q
S
L
A
A
Q
S
S
M
P
E
N
M
T
L
Site 5
T42
S
S
M
P
E
N
M
T
L
Q
R
A
N
S
D
Site 6
S48
M
T
L
Q
R
A
N
S
D
T
D
L
V
T
S
Site 7
T50
L
Q
R
A
N
S
D
T
D
L
V
T
S
E
S
Site 8
T54
N
S
D
T
D
L
V
T
S
E
S
R
S
S
L
Site 9
S55
S
D
T
D
L
V
T
S
E
S
R
S
S
L
T
Site 10
S57
T
D
L
V
T
S
E
S
R
S
S
L
T
A
S
Site 11
S59
L
V
T
S
E
S
R
S
S
L
T
A
S
M
Y
Site 12
S60
V
T
S
E
S
R
S
S
L
T
A
S
M
Y
E
Site 13
S64
S
R
S
S
L
T
A
S
M
Y
E
Y
T
L
G
Site 14
Y66
S
S
L
T
A
S
M
Y
E
Y
T
L
G
Q
A
Site 15
Y68
L
T
A
S
M
Y
E
Y
T
L
G
Q
A
Q
N
Site 16
Y95
P
S
D
W
I
G
L
Y
H
I
D
E
N
S
P
Site 17
S108
S
P
A
N
F
W
D
S
K
N
R
G
V
T
G
Site 18
T114
D
S
K
N
R
G
V
T
G
T
Q
K
G
Q
I
Site 19
T116
K
N
R
G
V
T
G
T
Q
K
G
Q
I
V
W
Site 20
Y130
W
R
I
E
P
G
P
Y
F
M
E
P
E
I
K
Site 21
S176
E
G
M
E
G
G
A
S
G
N
L
H
S
R
K
Site 22
S181
G
A
S
G
N
L
H
S
R
K
L
V
S
F
T
Site 23
S186
L
H
S
R
K
L
V
S
F
T
L
S
D
L
R
Site 24
Y208
M
F
F
N
P
D
P
Y
L
K
M
S
I
Q
P
Site 25
S212
P
D
P
Y
L
K
M
S
I
Q
P
G
K
K
S
Site 26
S219
S
I
Q
P
G
K
K
S
S
F
P
T
C
A
H
Site 27
S220
I
Q
P
G
K
K
S
S
F
P
T
C
A
H
H
Site 28
T223
G
K
K
S
S
F
P
T
C
A
H
H
G
Q
E
Site 29
S233
H
H
G
Q
E
R
R
S
T
I
I
S
N
T
T
Site 30
T234
H
G
Q
E
R
R
S
T
I
I
S
N
T
T
N
Site 31
S237
E
R
R
S
T
I
I
S
N
T
T
N
P
I
W
Site 32
T239
R
S
T
I
I
S
N
T
T
N
P
I
W
H
R
Site 33
Y249
P
I
W
H
R
E
K
Y
S
F
F
A
L
L
T
Site 34
S270
I
K
D
K
F
A
K
S
R
P
I
I
K
R
F
Site 35
S300
A
I
G
D
Q
M
L
S
Y
N
L
G
R
R
L
Site 36
Y301
I
G
D
Q
M
L
S
Y
N
L
G
R
R
L
P
Site 37
Y315
P
A
D
H
V
S
G
Y
L
Q
F
K
V
E
V
Site 38
S325
F
K
V
E
V
T
S
S
V
H
E
D
A
S
P
Site 39
S331
S
S
V
H
E
D
A
S
P
E
A
V
G
T
I
Site 40
S350
S
V
N
G
D
L
G
S
P
S
D
D
E
D
M
Site 41
S352
N
G
D
L
G
S
P
S
D
D
E
D
M
P
G
Site 42
S360
D
D
E
D
M
P
G
S
H
H
D
S
Q
V
C
Site 43
S364
M
P
G
S
H
H
D
S
Q
V
C
S
N
G
P
Site 44
S368
H
H
D
S
Q
V
C
S
N
G
P
V
S
E
D
Site 45
S373
V
C
S
N
G
P
V
S
E
D
S
A
A
D
G
Site 46
S376
N
G
P
V
S
E
D
S
A
A
D
G
T
P
K
Site 47
T381
E
D
S
A
A
D
G
T
P
K
H
S
F
R
T
Site 48
S385
A
D
G
T
P
K
H
S
F
R
T
S
S
T
L
Site 49
S389
P
K
H
S
F
R
T
S
S
T
L
E
I
D
T
Site 50
S390
K
H
S
F
R
T
S
S
T
L
E
I
D
T
E
Site 51
T396
S
S
T
L
E
I
D
T
E
E
L
T
S
T
S
Site 52
T400
E
I
D
T
E
E
L
T
S
T
S
S
R
T
S
Site 53
S401
I
D
T
E
E
L
T
S
T
S
S
R
T
S
P
Site 54
T402
D
T
E
E
L
T
S
T
S
S
R
T
S
P
P
Site 55
S403
T
E
E
L
T
S
T
S
S
R
T
S
P
P
R
Site 56
S404
E
E
L
T
S
T
S
S
R
T
S
P
P
R
G
Site 57
S407
T
S
T
S
S
R
T
S
P
P
R
G
R
Q
D
Site 58
S415
P
P
R
G
R
Q
D
S
L
N
D
Y
L
D
A
Site 59
Y419
R
Q
D
S
L
N
D
Y
L
D
A
I
E
H
N
Site 60
T433
N
G
H
S
R
P
G
T
A
T
C
S
E
R
S
Site 61
T435
H
S
R
P
G
T
A
T
C
S
E
R
S
M
G
Site 62
S437
R
P
G
T
A
T
C
S
E
R
S
M
G
A
S
Site 63
S440
T
A
T
C
S
E
R
S
M
G
A
S
P
K
L
Site 64
S444
S
E
R
S
M
G
A
S
P
K
L
R
S
S
F
Site 65
S450
A
S
P
K
L
R
S
S
F
P
T
D
T
R
L
Site 66
T453
K
L
R
S
S
F
P
T
D
T
R
L
N
A
M
Site 67
S465
N
A
M
L
H
I
D
S
D
E
E
D
H
E
F
Site 68
Y478
E
F
Q
Q
D
L
G
Y
P
S
S
L
E
E
E
Site 69
S481
Q
D
L
G
Y
P
S
S
L
E
E
E
G
G
L
Site 70
S492
E
G
G
L
I
M
F
S
R
A
S
R
A
D
D
Site 71
S495
L
I
M
F
S
R
A
S
R
A
D
D
G
S
L
Site 72
S501
A
S
R
A
D
D
G
S
L
T
S
Q
T
K
L
Site 73
T503
R
A
D
D
G
S
L
T
S
Q
T
K
L
E
D
Site 74
T520
V
E
N
E
E
A
S
T
H
E
A
A
S
F
E
Site 75
S525
A
S
T
H
E
A
A
S
F
E
D
K
P
E
N
Site 76
S539
N
L
P
E
L
A
E
S
S
L
P
A
G
P
A
Site 77
S540
L
P
E
L
A
E
S
S
L
P
A
G
P
A
P
Site 78
S559
G
G
P
E
P
Q
P
S
A
D
Q
G
S
A
E
Site 79
S564
Q
P
S
A
D
Q
G
S
A
E
L
C
G
S
Q
Site 80
S570
G
S
A
E
L
C
G
S
Q
E
V
D
Q
P
T
Site 81
S578
Q
E
V
D
Q
P
T
S
G
A
D
T
G
T
S
Site 82
T582
Q
P
T
S
G
A
D
T
G
T
S
D
A
S
G
Site 83
T584
T
S
G
A
D
T
G
T
S
D
A
S
G
G
S
Site 84
S585
S
G
A
D
T
G
T
S
D
A
S
G
G
S
R
Site 85
S588
D
T
G
T
S
D
A
S
G
G
S
R
R
A
V
Site 86
S591
T
S
D
A
S
G
G
S
R
R
A
V
S
E
T
Site 87
S596
G
G
S
R
R
A
V
S
E
T
E
S
L
D
Q
Site 88
T598
S
R
R
A
V
S
E
T
E
S
L
D
Q
G
S
Site 89
S600
R
A
V
S
E
T
E
S
L
D
Q
G
S
E
P
Site 90
S605
T
E
S
L
D
Q
G
S
E
P
S
Q
V
S
S
Site 91
S608
L
D
Q
G
S
E
P
S
Q
V
S
S
E
T
E
Site 92
S611
G
S
E
P
S
Q
V
S
S
E
T
E
P
S
D
Site 93
S612
S
E
P
S
Q
V
S
S
E
T
E
P
S
D
P
Site 94
S617
V
S
S
E
T
E
P
S
D
P
A
R
T
E
S
Site 95
T622
E
P
S
D
P
A
R
T
E
S
V
S
E
A
S
Site 96
S624
S
D
P
A
R
T
E
S
V
S
E
A
S
T
R
Site 97
S626
P
A
R
T
E
S
V
S
E
A
S
T
R
P
E
Site 98
S629
T
E
S
V
S
E
A
S
T
R
P
E
G
E
S
Site 99
T630
E
S
V
S
E
A
S
T
R
P
E
G
E
S
D
Site 100
S636
S
T
R
P
E
G
E
S
D
L
E
C
A
D
S
Site 101
S643
S
D
L
E
C
A
D
S
S
C
N
E
S
V
T
Site 102
S644
D
L
E
C
A
D
S
S
C
N
E
S
V
T
T
Site 103
S648
A
D
S
S
C
N
E
S
V
T
T
Q
L
S
S
Site 104
T650
S
S
C
N
E
S
V
T
T
Q
L
S
S
V
D
Site 105
T651
S
C
N
E
S
V
T
T
Q
L
S
S
V
D
T
Site 106
S654
E
S
V
T
T
Q
L
S
S
V
D
T
R
C
S
Site 107
S655
S
V
T
T
Q
L
S
S
V
D
T
R
C
S
S
Site 108
T658
T
Q
L
S
S
V
D
T
R
C
S
S
L
E
S
Site 109
S661
S
S
V
D
T
R
C
S
S
L
E
S
A
R
F
Site 110
S662
S
V
D
T
R
C
S
S
L
E
S
A
R
F
P
Site 111
S665
T
R
C
S
S
L
E
S
A
R
F
P
E
T
P
Site 112
T671
E
S
A
R
F
P
E
T
P
A
F
S
S
Q
E
Site 113
S676
P
E
T
P
A
F
S
S
Q
E
E
E
D
G
A
Site 114
S690
A
C
A
A
E
P
T
S
S
G
P
A
E
G
S
Site 115
S691
C
A
A
E
P
T
S
S
G
P
A
E
G
S
Q
Site 116
S697
S
S
G
P
A
E
G
S
Q
E
S
V
C
T
A
Site 117
S700
P
A
E
G
S
Q
E
S
V
C
T
A
G
S
L
Site 118
S714
L
P
V
V
Q
V
P
S
G
E
D
E
G
P
G
Site 119
T726
G
P
G
A
E
S
A
T
V
P
D
Q
E
E
L
Site 120
S742
E
V
W
Q
R
R
G
S
L
E
G
A
A
A
A
Site 121
S752
G
A
A
A
A
A
E
S
P
P
Q
E
E
G
S
Site 122
T766
S
A
G
E
A
Q
G
T
C
E
G
A
T
A
Q
Site 123
S791
N
G
H
Q
P
L
R
S
L
P
S
V
R
Q
D
Site 124
S794
Q
P
L
R
S
L
P
S
V
R
Q
D
V
S
R
Site 125
S800
P
S
V
R
Q
D
V
S
R
Y
Q
R
V
D
E
Site 126
Y802
V
R
Q
D
V
S
R
Y
Q
R
V
D
E
A
L
Site 127
Y825
D
S
H
G
R
I
F
Y
V
D
H
V
N
R
T
Site 128
T833
V
D
H
V
N
R
T
T
T
W
Q
R
P
T
A
Site 129
T834
D
H
V
N
R
T
T
T
W
Q
R
P
T
A
P
Site 130
T839
T
T
T
W
Q
R
P
T
A
P
P
A
P
Q
V
Site 131
S852
Q
V
L
Q
R
S
N
S
I
Q
Q
M
E
Q
L
Site 132
Y863
M
E
Q
L
N
R
R
Y
Q
S
I
R
R
T
M
Site 133
S865
Q
L
N
R
R
Y
Q
S
I
R
R
T
M
T
N
Site 134
T869
R
Y
Q
S
I
R
R
T
M
T
N
E
R
P
E
Site 135
T871
Q
S
I
R
R
T
M
T
N
E
R
P
E
E
N
Site 136
T879
N
E
R
P
E
E
N
T
N
A
I
D
G
A
G
Site 137
S895
E
A
D
F
H
Q
A
S
A
D
F
R
R
E
N
Site 138
S907
R
E
N
I
L
P
H
S
T
S
R
S
R
I
T
Site 139
S909
N
I
L
P
H
S
T
S
R
S
R
I
T
L
L
Site 140
S911
L
P
H
S
T
S
R
S
R
I
T
L
L
L
Q
Site 141
T914
S
T
S
R
S
R
I
T
L
L
L
Q
S
P
P
Site 142
S936
E
F
F
T
V
L
H
S
N
P
S
A
Y
R
M
Site 143
S939
T
V
L
H
S
N
P
S
A
Y
R
M
F
T
N
Site 144
T955
T
C
L
K
H
M
I
T
K
V
R
R
D
T
H
Site 145
T961
I
T
K
V
R
R
D
T
H
H
F
E
R
Y
Q
Site 146
T1011
V
D
H
N
S
R
T
T
T
F
I
D
P
R
L
Site 147
T1012
D
H
N
S
R
T
T
T
F
I
D
P
R
L
P
Site 148
S1022
D
P
R
L
P
L
Q
S
S
R
P
T
S
A
L
Site 149
S1023
P
R
L
P
L
Q
S
S
R
P
T
S
A
L
V
Site 150
T1026
P
L
Q
S
S
R
P
T
S
A
L
V
H
R
Q
Site 151
S1027
L
Q
S
S
R
P
T
S
A
L
V
H
R
Q
H
Site 152
T1036
L
V
H
R
Q
H
L
T
R
Q
R
S
H
S
A
Site 153
S1040
Q
H
L
T
R
Q
R
S
H
S
A
G
E
V
G
Site 154
S1042
L
T
R
Q
R
S
H
S
A
G
E
V
G
E
D
Site 155
S1050
A
G
E
V
G
E
D
S
R
H
A
G
P
P
V
Site 156
S1062
P
P
V
L
P
R
P
S
S
T
F
N
T
V
S
Site 157
S1063
P
V
L
P
R
P
S
S
T
F
N
T
V
S
R
Site 158
T1064
V
L
P
R
P
S
S
T
F
N
T
V
S
R
P
Site 159
T1067
R
P
S
S
T
F
N
T
V
S
R
P
Q
Y
Q
Site 160
Y1073
N
T
V
S
R
P
Q
Y
Q
D
M
V
P
V
A
Site 161
T1106
Q
E
R
Q
P
D
L
T
R
N
H
S
L
R
E
Site 162
S1110
P
D
L
T
R
N
H
S
L
R
E
K
I
Q
F
Site 163
T1123
Q
F
I
R
T
E
G
T
P
G
L
V
R
L
S
Site 164
S1159
P
H
A
L
L
H
P
S
Y
C
Q
S
P
R
G
Site 165
Y1160
H
A
L
L
H
P
S
Y
C
Q
S
P
R
G
S
Site 166
S1163
L
H
P
S
Y
C
Q
S
P
R
G
S
P
V
S
Site 167
S1167
Y
C
Q
S
P
R
G
S
P
V
S
S
P
Q
N
Site 168
S1170
S
P
R
G
S
P
V
S
S
P
Q
N
S
P
G
Site 169
S1171
P
R
G
S
P
V
S
S
P
Q
N
S
P
G
T
Site 170
S1175
P
V
S
S
P
Q
N
S
P
G
T
Q
R
A
N
Site 171
T1178
S
P
Q
N
S
P
G
T
Q
R
A
N
A
R
A
Site 172
Y1189
N
A
R
A
P
A
P
Y
K
R
D
F
E
A
K
Site 173
Y1201
E
A
K
L
R
N
F
Y
R
K
L
E
T
K
G
Site 174
Y1209
R
K
L
E
T
K
G
Y
G
Q
G
P
G
K
L
Site 175
Y1236
A
F
N
Q
I
M
G
Y
S
R
K
D
L
Q
R
Site 176
Y1247
D
L
Q
R
N
K
L
Y
V
T
F
V
G
E
E
Site 177
T1249
Q
R
N
K
L
Y
V
T
F
V
G
E
E
G
L
Site 178
Y1258
V
G
E
E
G
L
D
Y
S
G
P
S
R
E
F
Site 179
S1259
G
E
E
G
L
D
Y
S
G
P
S
R
E
F
F
Site 180
S1270
R
E
F
F
F
L
V
S
R
E
L
F
N
P
Y
Site 181
Y1277
S
R
E
L
F
N
P
Y
Y
G
L
F
E
Y
S
Site 182
Y1278
R
E
L
F
N
P
Y
Y
G
L
F
E
Y
S
A
Site 183
Y1283
P
Y
Y
G
L
F
E
Y
S
A
N
D
T
Y
T
Site 184
T1288
F
E
Y
S
A
N
D
T
Y
T
V
Q
I
S
P
Site 185
Y1289
E
Y
S
A
N
D
T
Y
T
V
Q
I
S
P
M
Site 186
T1290
Y
S
A
N
D
T
Y
T
V
Q
I
S
P
M
S
Site 187
Y1348
C
D
L
S
D
L
E
Y
L
D
E
E
F
H
Q
Site 188
T1398
G
G
A
N
I
P
V
T
E
K
N
K
K
E
Y
Site 189
S1424
G
V
V
Q
Q
T
E
S
L
V
R
G
F
Y
E
Site 190
S1459
G
T
A
E
I
D
L
S
D
W
R
N
N
T
E
Site 191
Y1467
D
W
R
N
N
T
E
Y
R
G
G
Y
H
D
N
Site 192
Y1471
N
T
E
Y
R
G
G
Y
H
D
N
H
I
V
I
Site 193
Y1508
T
G
T
S
S
I
P
Y
E
G
F
A
S
L
R
Site 194
S1513
I
P
Y
E
G
F
A
S
L
R
G
S
N
G
P
Site 195
S1517
G
F
A
S
L
R
G
S
N
G
P
R
R
F
C
Site 196
T1539
T
A
L
P
R
A
H
T
C
F
N
R
L
D
L
Site 197
Y1549
N
R
L
D
L
P
P
Y
P
S
F
S
M
L
Y
Site 198
S1551
L
D
L
P
P
Y
P
S
F
S
M
L
Y
E
K
Site 199
T1561
M
L
Y
E
K
L
L
T
A
V
E
E
T
S
T
Site 200
T1568
T
A
V
E
E
T
S
T
F
G
L
E
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation