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Updated November 2019
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Protein Info
Short Name:
FRMD4A
Full Name:
FERM domain-containing protein 4A
Alias:
BA295P9.4; FERM domain containing 4A; FLJ10210; FRM4A; FRMD4; KIAA1294
Type:
Unknown function
Mass (Da):
115458
Number AA:
1039
UniProt ID:
Q9P2Q2
International Prot ID:
IPI00644865
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S51
E
L
L
D
L
V
A
S
H
F
N
L
K
E
K
Site 2
Y60
F
N
L
K
E
K
E
Y
F
G
I
A
F
T
D
Site 3
T66
E
Y
F
G
I
A
F
T
D
E
T
G
H
L
N
Site 4
T69
G
I
A
F
T
D
E
T
G
H
L
N
W
L
Q
Site 5
S90
E
H
D
F
P
K
K
S
G
P
V
V
L
Y
F
Site 6
S107
R
F
Y
I
E
S
I
S
Y
L
K
D
N
A
T
Site 7
S155
E
A
K
G
D
F
S
S
N
E
V
V
R
S
D
Site 8
S161
S
S
N
E
V
V
R
S
D
L
K
K
L
P
A
Site 9
T171
K
K
L
P
A
L
P
T
Q
A
L
K
E
H
P
Site 10
S179
Q
A
L
K
E
H
P
S
L
A
Y
C
E
D
R
Site 11
Y191
E
D
R
V
I
E
H
Y
K
K
L
N
G
Q
T
Site 12
Y206
R
G
Q
A
I
V
N
Y
M
S
I
V
E
S
L
Site 13
S212
N
Y
M
S
I
V
E
S
L
P
T
Y
G
V
H
Site 14
Y216
I
V
E
S
L
P
T
Y
G
V
H
Y
Y
A
V
Site 15
Y220
L
P
T
Y
G
V
H
Y
Y
A
V
K
D
K
Q
Site 16
Y221
P
T
Y
G
V
H
Y
Y
A
V
K
D
K
Q
G
Site 17
Y237
P
W
W
L
G
L
S
Y
K
G
I
F
Q
Y
D
Site 18
Y243
S
Y
K
G
I
F
Q
Y
D
Y
H
D
K
V
K
Site 19
Y245
K
G
I
F
Q
Y
D
Y
H
D
K
V
K
P
R
Site 20
Y264
W
R
Q
L
E
N
L
Y
F
R
E
K
K
F
S
Site 21
S271
Y
F
R
E
K
K
F
S
V
E
V
H
D
P
R
Site 22
S281
V
H
D
P
R
R
A
S
V
T
R
R
T
F
G
Site 23
T283
D
P
R
R
A
S
V
T
R
R
T
F
G
H
S
Site 24
T286
R
A
S
V
T
R
R
T
F
G
H
S
G
I
A
Site 25
Y318
A
I
S
Q
H
Q
F
Y
L
D
R
K
Q
S
K
Site 26
S324
F
Y
L
D
R
K
Q
S
K
S
K
I
H
A
A
Site 27
S326
L
D
R
K
Q
S
K
S
K
I
H
A
A
R
S
Site 28
S333
S
K
I
H
A
A
R
S
L
S
E
I
A
I
D
Site 29
S335
I
H
A
A
R
S
L
S
E
I
A
I
D
L
T
Site 30
T342
S
E
I
A
I
D
L
T
E
T
G
T
L
K
T
Site 31
T346
I
D
L
T
E
T
G
T
L
K
T
S
K
L
A
Site 32
S357
S
K
L
A
N
M
G
S
K
G
K
I
I
S
G
Site 33
S363
G
S
K
G
K
I
I
S
G
S
S
G
S
L
L
Site 34
S365
K
G
K
I
I
S
G
S
S
G
S
L
L
S
S
Site 35
S371
G
S
S
G
S
L
L
S
S
G
S
Q
E
S
D
Site 36
S372
S
S
G
S
L
L
S
S
G
S
Q
E
S
D
S
Site 37
S374
G
S
L
L
S
S
G
S
Q
E
S
D
S
S
Q
Site 38
S377
L
S
S
G
S
Q
E
S
D
S
S
Q
S
A
K
Site 39
S379
S
G
S
Q
E
S
D
S
S
Q
S
A
K
K
D
Site 40
S380
G
S
Q
E
S
D
S
S
Q
S
A
K
K
D
M
Site 41
S393
D
M
L
A
A
L
K
S
R
Q
E
A
L
E
E
Site 42
T401
R
Q
E
A
L
E
E
T
L
R
Q
R
L
E
E
Site 43
T420
C
L
R
E
A
E
L
T
G
K
L
P
V
E
Y
Site 44
Y427
T
G
K
L
P
V
E
Y
P
L
D
P
G
E
E
Site 45
T444
I
V
R
R
R
I
G
T
A
F
K
L
D
E
Q
Site 46
S473
E
R
E
F
A
I
Q
S
Q
I
T
E
A
A
R
Site 47
S484
E
A
A
R
R
L
A
S
D
P
N
V
S
K
K
Site 48
T498
K
L
K
K
Q
R
K
T
S
Y
L
N
A
L
K
Site 49
S499
L
K
K
Q
R
K
T
S
Y
L
N
A
L
K
K
Site 50
Y500
K
K
Q
R
K
T
S
Y
L
N
A
L
K
K
L
Site 51
S521
I
N
E
N
R
I
K
S
G
K
K
P
T
Q
R
Site 52
T526
I
K
S
G
K
K
P
T
Q
R
A
S
L
I
I
Site 53
S530
K
K
P
T
Q
R
A
S
L
I
I
D
D
G
N
Site 54
S540
I
D
D
G
N
I
A
S
E
D
S
S
L
S
D
Site 55
S546
A
S
E
D
S
S
L
S
D
A
L
V
L
E
D
Site 56
S556
L
V
L
E
D
E
D
S
Q
V
T
S
T
I
S
Site 57
T559
E
D
E
D
S
Q
V
T
S
T
I
S
P
L
H
Site 58
S560
D
E
D
S
Q
V
T
S
T
I
S
P
L
H
S
Site 59
T561
E
D
S
Q
V
T
S
T
I
S
P
L
H
S
P
Site 60
S563
S
Q
V
T
S
T
I
S
P
L
H
S
P
H
K
Site 61
S567
S
T
I
S
P
L
H
S
P
H
K
G
L
P
P
Site 62
S578
G
L
P
P
R
P
P
S
H
N
R
P
P
P
P
Site 63
S587
N
R
P
P
P
P
Q
S
L
E
G
L
R
Q
M
Site 64
Y596
E
G
L
R
Q
M
H
Y
H
R
N
D
Y
D
K
Site 65
Y601
M
H
Y
H
R
N
D
Y
D
K
S
P
I
K
P
Site 66
S604
H
R
N
D
Y
D
K
S
P
I
K
P
K
M
W
Site 67
S612
P
I
K
P
K
M
W
S
E
S
S
L
D
E
P
Site 68
S614
K
P
K
M
W
S
E
S
S
L
D
E
P
Y
E
Site 69
S615
P
K
M
W
S
E
S
S
L
D
E
P
Y
E
K
Site 70
Y620
E
S
S
L
D
E
P
Y
E
K
V
K
K
R
S
Site 71
S627
Y
E
K
V
K
K
R
S
S
H
S
H
S
S
S
Site 72
S628
E
K
V
K
K
R
S
S
H
S
H
S
S
S
H
Site 73
S630
V
K
K
R
S
S
H
S
H
S
S
S
H
K
R
Site 74
S632
K
R
S
S
H
S
H
S
S
S
H
K
R
F
P
Site 75
S633
R
S
S
H
S
H
S
S
S
H
K
R
F
P
S
Site 76
S634
S
S
H
S
H
S
S
S
H
K
R
F
P
S
T
Site 77
S640
S
S
H
K
R
F
P
S
T
G
S
C
A
E
A
Site 78
T641
S
H
K
R
F
P
S
T
G
S
C
A
E
A
G
Site 79
S643
K
R
F
P
S
T
G
S
C
A
E
A
G
G
G
Site 80
S653
E
A
G
G
G
S
N
S
L
Q
N
S
P
I
R
Site 81
S657
G
S
N
S
L
Q
N
S
P
I
R
G
L
P
H
Site 82
S667
R
G
L
P
H
W
N
S
Q
S
S
M
P
S
T
Site 83
S669
L
P
H
W
N
S
Q
S
S
M
P
S
T
P
D
Site 84
S670
P
H
W
N
S
Q
S
S
M
P
S
T
P
D
L
Site 85
S673
N
S
Q
S
S
M
P
S
T
P
D
L
R
V
R
Site 86
T674
S
Q
S
S
M
P
S
T
P
D
L
R
V
R
S
Site 87
S681
T
P
D
L
R
V
R
S
P
H
Y
V
H
S
T
Site 88
Y684
L
R
V
R
S
P
H
Y
V
H
S
T
R
S
V
Site 89
S687
R
S
P
H
Y
V
H
S
T
R
S
V
D
I
S
Site 90
T688
S
P
H
Y
V
H
S
T
R
S
V
D
I
S
P
Site 91
S690
H
Y
V
H
S
T
R
S
V
D
I
S
P
T
R
Site 92
S694
S
T
R
S
V
D
I
S
P
T
R
L
H
S
L
Site 93
T696
R
S
V
D
I
S
P
T
R
L
H
S
L
A
L
Site 94
S700
I
S
P
T
R
L
H
S
L
A
L
H
F
R
H
Site 95
S709
A
L
H
F
R
H
R
S
S
S
L
E
S
Q
G
Site 96
S710
L
H
F
R
H
R
S
S
S
L
E
S
Q
G
K
Site 97
S711
H
F
R
H
R
S
S
S
L
E
S
Q
G
K
L
Site 98
S714
H
R
S
S
S
L
E
S
Q
G
K
L
L
G
S
Site 99
S721
S
Q
G
K
L
L
G
S
E
N
D
T
G
S
P
Site 100
T725
L
L
G
S
E
N
D
T
G
S
P
D
F
Y
T
Site 101
S727
G
S
E
N
D
T
G
S
P
D
F
Y
T
P
R
Site 102
Y731
D
T
G
S
P
D
F
Y
T
P
R
T
R
S
S
Site 103
T732
T
G
S
P
D
F
Y
T
P
R
T
R
S
S
N
Site 104
T735
P
D
F
Y
T
P
R
T
R
S
S
N
G
S
D
Site 105
S737
F
Y
T
P
R
T
R
S
S
N
G
S
D
P
M
Site 106
S738
Y
T
P
R
T
R
S
S
N
G
S
D
P
M
D
Site 107
S741
R
T
R
S
S
N
G
S
D
P
M
D
D
C
S
Site 108
S748
S
D
P
M
D
D
C
S
S
C
T
S
H
S
S
Site 109
S749
D
P
M
D
D
C
S
S
C
T
S
H
S
S
S
Site 110
T751
M
D
D
C
S
S
C
T
S
H
S
S
S
E
H
Site 111
S752
D
D
C
S
S
C
T
S
H
S
S
S
E
H
Y
Site 112
S754
C
S
S
C
T
S
H
S
S
S
E
H
Y
Y
P
Site 113
S756
S
C
T
S
H
S
S
S
E
H
Y
Y
P
A
Q
Site 114
Y759
S
H
S
S
S
E
H
Y
Y
P
A
Q
M
N
A
Site 115
Y760
H
S
S
S
E
H
Y
Y
P
A
Q
M
N
A
N
Site 116
Y768
P
A
Q
M
N
A
N
Y
S
T
L
A
E
D
S
Site 117
S769
A
Q
M
N
A
N
Y
S
T
L
A
E
D
S
P
Site 118
S775
Y
S
T
L
A
E
D
S
P
S
K
A
R
Q
R
Site 119
S777
T
L
A
E
D
S
P
S
K
A
R
Q
R
Q
R
Site 120
S795
R
A
A
G
A
L
G
S
A
S
S
G
S
M
P
Site 121
S797
A
G
A
L
G
S
A
S
S
G
S
M
P
N
L
Site 122
S798
G
A
L
G
S
A
S
S
G
S
M
P
N
L
A
Site 123
S800
L
G
S
A
S
S
G
S
M
P
N
L
A
A
R
Site 124
Y821
G
G
A
G
G
G
V
Y
L
H
S
Q
S
Q
P
Site 125
S824
G
G
G
V
Y
L
H
S
Q
S
Q
P
S
S
Q
Site 126
S826
G
V
Y
L
H
S
Q
S
Q
P
S
S
Q
Y
R
Site 127
S830
H
S
Q
S
Q
P
S
S
Q
Y
R
I
K
E
Y
Site 128
Y837
S
Q
Y
R
I
K
E
Y
P
L
Y
I
E
G
G
Site 129
Y840
R
I
K
E
Y
P
L
Y
I
E
G
G
A
T
P
Site 130
S852
A
T
P
V
V
V
R
S
L
E
S
D
Q
E
G
Site 131
Y861
E
S
D
Q
E
G
H
Y
S
V
K
A
Q
F
K
Site 132
S862
S
D
Q
E
G
H
Y
S
V
K
A
Q
F
K
T
Site 133
S870
V
K
A
Q
F
K
T
S
N
S
Y
T
A
G
G
Site 134
S872
A
Q
F
K
T
S
N
S
Y
T
A
G
G
L
F
Site 135
Y873
Q
F
K
T
S
N
S
Y
T
A
G
G
L
F
K
Site 136
T874
F
K
T
S
N
S
Y
T
A
G
G
L
F
K
E
Site 137
S882
A
G
G
L
F
K
E
S
W
R
G
G
G
G
D
Site 138
T893
G
G
G
D
E
G
D
T
G
R
L
T
P
S
R
Site 139
T897
E
G
D
T
G
R
L
T
P
S
R
S
Q
I
L
Site 140
S899
D
T
G
R
L
T
P
S
R
S
Q
I
L
R
T
Site 141
S901
G
R
L
T
P
S
R
S
Q
I
L
R
T
P
S
Site 142
T906
S
R
S
Q
I
L
R
T
P
S
L
G
R
E
G
Site 143
S908
S
Q
I
L
R
T
P
S
L
G
R
E
G
A
H
Site 144
S925
G
A
G
R
A
A
V
S
D
E
L
R
Q
W
Y
Site 145
Y932
S
D
E
L
R
Q
W
Y
Q
R
S
T
A
S
H
Site 146
T936
R
Q
W
Y
Q
R
S
T
A
S
H
K
E
H
S
Site 147
S943
T
A
S
H
K
E
H
S
R
L
S
H
T
S
S
Site 148
S946
H
K
E
H
S
R
L
S
H
T
S
S
T
S
S
Site 149
T948
E
H
S
R
L
S
H
T
S
S
T
S
S
D
S
Site 150
S949
H
S
R
L
S
H
T
S
S
T
S
S
D
S
G
Site 151
S950
S
R
L
S
H
T
S
S
T
S
S
D
S
G
S
Site 152
T951
R
L
S
H
T
S
S
T
S
S
D
S
G
S
Q
Site 153
S952
L
S
H
T
S
S
T
S
S
D
S
G
S
Q
Y
Site 154
S953
S
H
T
S
S
T
S
S
D
S
G
S
Q
Y
S
Site 155
S955
T
S
S
T
S
S
D
S
G
S
Q
Y
S
T
S
Site 156
S957
S
T
S
S
D
S
G
S
Q
Y
S
T
S
S
Q
Site 157
Y959
S
S
D
S
G
S
Q
Y
S
T
S
S
Q
S
T
Site 158
S960
S
D
S
G
S
Q
Y
S
T
S
S
Q
S
T
F
Site 159
T961
D
S
G
S
Q
Y
S
T
S
S
Q
S
T
F
V
Site 160
S962
S
G
S
Q
Y
S
T
S
S
Q
S
T
F
V
A
Site 161
S963
G
S
Q
Y
S
T
S
S
Q
S
T
F
V
A
H
Site 162
S965
Q
Y
S
T
S
S
Q
S
T
F
V
A
H
S
R
Site 163
T966
Y
S
T
S
S
Q
S
T
F
V
A
H
S
R
V
Site 164
S990
T
S
A
A
L
P
Q
S
Q
R
S
S
T
P
S
Site 165
S993
A
L
P
Q
S
Q
R
S
S
T
P
S
S
E
I
Site 166
S994
L
P
Q
S
Q
R
S
S
T
P
S
S
E
I
G
Site 167
T995
P
Q
S
Q
R
S
S
T
P
S
S
E
I
G
A
Site 168
S997
S
Q
R
S
S
T
P
S
S
E
I
G
A
T
P
Site 169
S998
Q
R
S
S
T
P
S
S
E
I
G
A
T
P
P
Site 170
T1003
P
S
S
E
I
G
A
T
P
P
S
S
P
H
H
Site 171
S1006
E
I
G
A
T
P
P
S
S
P
H
H
I
L
T
Site 172
S1007
I
G
A
T
P
P
S
S
P
H
H
I
L
T
W
Site 173
T1013
S
S
P
H
H
I
L
T
W
Q
T
G
E
A
T
Site 174
T1016
H
H
I
L
T
W
Q
T
G
E
A
T
E
N
S
Site 175
S1023
T
G
E
A
T
E
N
S
P
I
L
D
G
S
E
Site 176
S1029
N
S
P
I
L
D
G
S
E
S
P
P
H
Q
S
Site 177
S1031
P
I
L
D
G
S
E
S
P
P
H
Q
S
T
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation