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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ANKFY1
Full Name:
Ankyrin repeat and FYVE domain-containing protein 1
Alias:
ANFY1; ANKHZN; Ankyrin repeat and FYVE domain containing 1; Ankyrin repeat and FYVE domain-containing 1; Ankyrin repeats hooked to a zinc finger motif; KIAA1255; Rabankyrin-5; ZFYVE14
Type:
Mass (Da):
128399
Number AA:
1169
UniProt ID:
Q9P2R3
International Prot ID:
IPI00159899
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005768
GO:0010008
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
L
M
L
L
R
Q
E
Y
V
K
L
Q
K
K
L
Site 2
S45
A
A
Q
A
N
K
E
S
S
S
E
S
F
I
S
Site 3
S47
Q
A
N
K
E
S
S
S
E
S
F
I
S
R
L
Site 4
S49
N
K
E
S
S
S
E
S
F
I
S
R
L
L
A
Site 5
Y62
L
A
I
V
A
D
L
Y
E
Q
E
Q
Y
S
D
Site 6
Y67
D
L
Y
E
Q
E
Q
Y
S
D
L
K
I
K
V
Site 7
S80
K
V
G
D
R
H
I
S
A
H
K
F
V
L
A
Site 8
S90
K
F
V
L
A
A
R
S
D
S
W
S
L
A
N
Site 9
S94
A
A
R
S
D
S
W
S
L
A
N
L
S
S
T
Site 10
S100
W
S
L
A
N
L
S
S
T
K
E
L
D
L
S
Site 11
S107
S
T
K
E
L
D
L
S
D
A
N
P
E
V
T
Site 12
Y122
M
T
M
L
R
W
I
Y
T
D
E
L
E
F
R
Site 13
T136
R
E
D
D
V
F
L
T
E
L
M
K
L
A
N
Site 14
Y171
V
R
N
C
I
R
F
Y
Q
T
A
E
E
L
N
Site 15
S180
T
A
E
E
L
N
A
S
T
L
M
N
Y
C
A
Site 16
S203
D
L
R
K
E
D
F
S
S
M
S
A
Q
L
L
Site 17
S204
L
R
K
E
D
F
S
S
M
S
A
Q
L
L
Y
Site 18
Y211
S
M
S
A
Q
L
L
Y
K
M
I
K
S
K
T
Site 19
S216
L
L
Y
K
M
I
K
S
K
T
E
Y
P
L
H
Site 20
T218
Y
K
M
I
K
S
K
T
E
Y
P
L
H
K
A
Site 21
Y220
M
I
K
S
K
T
E
Y
P
L
H
K
A
I
K
Site 22
Y237
R
E
D
V
V
F
L
Y
L
I
E
M
D
S
Q
Site 23
S243
L
Y
L
I
E
M
D
S
Q
L
P
G
K
L
N
Site 24
T273
R
R
L
E
S
I
A
T
T
L
V
S
H
K
A
Site 25
T274
R
L
E
S
I
A
T
T
L
V
S
H
K
A
D
Site 26
S288
D
V
D
M
V
D
K
S
G
W
S
L
L
H
K
Site 27
Y333
P
L
H
L
V
A
L
Y
S
S
K
K
H
S
A
Site 28
S334
L
H
L
V
A
L
Y
S
S
K
K
H
S
A
D
Site 29
S339
L
Y
S
S
K
K
H
S
A
D
V
M
S
E
M
Site 30
S344
K
H
S
A
D
V
M
S
E
M
A
Q
I
A
E
Site 31
S365
A
N
P
N
M
Q
D
S
K
G
R
T
P
L
H
Site 32
T369
M
Q
D
S
K
G
R
T
P
L
H
V
S
I
M
Site 33
S384
A
G
N
E
Y
V
F
S
Q
L
L
Q
C
K
Q
Site 34
S415
A
V
Q
H
I
T
V
S
S
D
Q
S
V
N
P
Site 35
S419
I
T
V
S
S
D
Q
S
V
N
P
F
E
D
V
Site 36
S433
V
P
V
V
N
G
T
S
F
D
E
N
S
F
A
Site 37
S438
G
T
S
F
D
E
N
S
F
A
A
R
L
I
Q
Site 38
S448
A
R
L
I
Q
R
G
S
H
T
D
A
P
D
T
Site 39
T450
L
I
Q
R
G
S
H
T
D
A
P
D
T
A
T
Site 40
T455
S
H
T
D
A
P
D
T
A
T
G
N
C
L
L
Site 41
T457
T
D
A
P
D
T
A
T
G
N
C
L
L
Q
R
Site 42
T493
H
R
N
K
W
G
E
T
P
L
H
T
A
C
R
Site 43
T497
W
G
E
T
P
L
H
T
A
C
R
H
G
L
A
Site 44
S533
P
L
P
K
E
A
A
S
L
T
S
L
A
D
S
Site 45
S583
L
Q
I
I
P
D
F
S
L
K
D
S
R
D
Q
Site 46
S587
P
D
F
S
L
K
D
S
R
D
Q
T
V
L
G
Site 47
T591
L
K
D
S
R
D
Q
T
V
L
G
L
A
L
W
Site 48
T618
S
G
A
A
I
N
D
T
M
S
D
G
Q
T
L
Site 49
S620
A
A
I
N
D
T
M
S
D
G
Q
T
L
L
H
Site 50
T624
D
T
M
S
D
G
Q
T
L
L
H
M
A
I
Q
Site 51
S637
I
Q
R
Q
D
S
K
S
A
L
F
L
L
E
H
Site 52
S682
C
T
R
G
A
D
M
S
V
P
D
E
K
G
N
Site 53
S705
N
N
L
E
D
I
A
S
T
L
V
R
H
G
C
Site 54
T715
V
R
H
G
C
D
A
T
C
W
G
P
G
P
G
Site 55
S753
R
S
G
C
D
V
N
S
P
R
Q
P
G
A
N
Site 56
T772
E
E
A
R
D
G
Q
T
P
L
H
L
A
A
S
Site 57
T805
A
Q
D
A
E
G
R
T
P
I
H
V
A
I
S
Site 58
T839
V
R
D
R
Q
G
L
T
P
F
A
C
A
M
T
Site 59
S852
M
T
F
K
N
N
K
S
A
E
A
I
L
K
R
Site 60
S861
E
A
I
L
K
R
E
S
G
A
A
E
Q
V
D
Site 61
S905
N
S
R
V
Q
D
A
S
K
L
T
P
L
H
L
Site 62
T941
E
L
T
K
H
R
Q
T
A
L
H
L
A
A
Q
Site 63
S1008
A
F
N
L
R
G
Q
S
P
L
H
I
L
G
Q
Site 64
Y1035
F
L
E
C
M
P
G
Y
P
L
D
K
P
D
A
Site 65
Y1052
S
T
V
L
L
L
A
Y
M
K
G
N
A
N
L
Site 66
Y1083
Q
G
V
N
I
F
N
Y
Q
V
A
T
K
Q
L
Site 67
S1099
F
R
L
L
D
M
L
S
K
E
P
P
W
C
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation