PhosphoNET

           
Protein Info 
   
Short Name:  MBD2
Full Name:  Methyl-CpG-binding domain protein 2
Alias:  Methyl-CpG-binding domain protein 2: Methyl-CpG-binding protein MBD2: Demethylase: Methyl-CpG-binding domain protein 2: Methyl-CpG-binding protein MBD2: Demethylase; Methyl-CpG-binding protein MBD2
Type:  Enzyme, demethylase
Mass (Da):  43255
Number AA:  411
UniProt ID:  Q9UBB5
International Prot ID:  IPI00434623
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005634  GO:0043226  GO:0043227 Uniprot OncoNet
Molecular Function:  GO:0000166  GO:0003676  GO:0003677 PhosphoSite+ KinaseNET
Biological Process:  GO:0000122  GO:0006139  GO:0006350 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S19PEQEEGESAAGGSGA
Site 2S30GSGAGGDSAIEQGGQ
Site 3S44QGSALAPSPVSGVRR
Site 4S47ALAPSPVSGVRREGA
Site 5S99RGRGRPPSGGSGLGG
Site 6S116GGCGGGGSGGGGAPR
Site 7S131REPVPFPSGSAGPGP
Site 8S133PVPFPSGSAGPGPRG
Site 9T144GPRGPRATESGKRMD
Site 10S146RGPRATESGKRMDCP
Site 11S168KEEVIRKSGLSAGKS
Site 12S171VIRKSGLSAGKSDVY
Site 13S175SGLSAGKSDVYYFSP
Site 14Y178SAGKSDVYYFSPSGK
Site 15Y179AGKSDVYYFSPSGKK
Site 16S181KSDVYYFSPSGKKFR
Site 17Y196SKPQLARYLGNTVDL
Site 18T200LARYLGNTVDLSSFD
Site 19S204LGNTVDLSSFDFRTG
Site 20S205GNTVDLSSFDFRTGK
Site 21T210LSSFDFRTGKMMPSK
Site 22T241KGKPDLNTTLPIRQT
Site 23T248TTLPIRQTASIFKQP
Site 24T257SIFKQPVTKVTNHPS
Site 25T260KQPVTKVTNHPSNKV
Site 26S264TKVTNHPSNKVKSDP
Site 27S269HPSNKVKSDPQRMNE
Site 28S291EKRLQGLSASDVTEQ
Site 29S293RLQGLSASDVTEQII
Site 30T296GLSASDVTEQIIKTM
Site 31S316LQGVGPGSNDETLLS
Site 32T320GPGSNDETLLSAVAS
Site 33S393ALMADILSRAADTEE
Site 34T398ILSRAADTEEMDIEM
Site 35S407EMDIEMDSGDEA___
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


2019 Kinexus Bioinformatics Corporation