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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ONECUT1
Full Name:
Hepatocyte nuclear factor 6
Alias:
One cut domain family member 1;One cut homeobox 1
Type:
Mass (Da):
51023
Number AA:
465
UniProt ID:
Q9UBC0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
I
G
E
L
H
G
V
S
H
E
P
V
P
A
P
Site 2
S31
P
A
D
L
L
G
G
S
P
H
A
R
S
S
V
Site 3
S36
G
G
S
P
H
A
R
S
S
V
A
H
R
G
S
Site 4
S37
G
S
P
H
A
R
S
S
V
A
H
R
G
S
H
Site 5
S43
S
S
V
A
H
R
G
S
H
L
P
P
A
H
P
Site 6
S57
P
R
S
M
G
M
A
S
L
L
D
G
G
S
G
Site 7
S63
A
S
L
L
D
G
G
S
G
G
G
D
Y
H
H
Site 8
Y68
G
G
S
G
G
G
D
Y
H
H
H
H
R
A
P
Site 9
S78
H
H
R
A
P
E
H
S
L
A
G
P
L
H
P
Site 10
T88
G
P
L
H
P
T
M
T
M
A
C
E
T
P
P
Site 11
T93
T
M
T
M
A
C
E
T
P
P
G
M
S
M
P
Site 12
T102
P
G
M
S
M
P
T
T
Y
T
T
L
T
P
L
Site 13
Y103
G
M
S
M
P
T
T
Y
T
T
L
T
P
L
Q
Site 14
T105
S
M
P
T
T
Y
T
T
L
T
P
L
Q
P
L
Site 15
T107
P
T
T
Y
T
T
L
T
P
L
Q
P
L
P
P
Site 16
S116
L
Q
P
L
P
P
I
S
T
V
S
D
K
F
P
Site 17
T117
Q
P
L
P
P
I
S
T
V
S
D
K
F
P
H
Site 18
S119
L
P
P
I
S
T
V
S
D
K
F
P
H
H
H
Site 19
S146
Q
R
L
A
G
N
V
S
G
S
F
T
L
M
R
Site 20
S148
L
A
G
N
V
S
G
S
F
T
L
M
R
D
E
Site 21
T150
G
N
V
S
G
S
F
T
L
M
R
D
E
R
G
Site 22
S160
R
D
E
R
G
L
A
S
M
N
N
L
Y
T
P
Site 23
Y165
L
A
S
M
N
N
L
Y
T
P
Y
H
K
D
V
Site 24
T166
A
S
M
N
N
L
Y
T
P
Y
H
K
D
V
A
Site 25
S178
D
V
A
G
M
G
Q
S
L
S
P
L
S
S
S
Site 26
S183
G
Q
S
L
S
P
L
S
S
S
G
L
G
S
I
Site 27
S184
Q
S
L
S
P
L
S
S
S
G
L
G
S
I
H
Site 28
S185
S
L
S
P
L
S
S
S
G
L
G
S
I
H
N
Site 29
S189
L
S
S
S
G
L
G
S
I
H
N
S
Q
Q
G
Site 30
S193
G
L
G
S
I
H
N
S
Q
Q
G
L
P
H
Y
Site 31
Y200
S
Q
Q
G
L
P
H
Y
A
H
P
G
A
A
M
Site 32
T214
M
P
T
D
K
M
L
T
P
N
G
F
E
A
H
Site 33
T235
R
H
G
E
Q
H
L
T
P
T
S
A
G
M
V
Site 34
S238
E
Q
H
L
T
P
T
S
A
G
M
V
P
I
N
Site 35
T267
G
H
G
Q
L
L
G
T
A
R
E
P
N
P
S
Site 36
S274
T
A
R
E
P
N
P
S
V
T
G
A
Q
V
S
Site 37
S281
S
V
T
G
A
Q
V
S
N
G
S
N
S
G
Q
Site 38
T294
G
Q
M
E
E
I
N
T
K
E
V
A
Q
R
I
Site 39
T302
K
E
V
A
Q
R
I
T
T
E
L
K
R
Y
S
Site 40
T303
E
V
A
Q
R
I
T
T
E
L
K
R
Y
S
I
Site 41
Y308
I
T
T
E
L
K
R
Y
S
I
P
Q
A
I
F
Site 42
S309
T
T
E
L
K
R
Y
S
I
P
Q
A
I
F
A
Site 43
S323
A
Q
R
V
L
C
R
S
Q
G
T
L
S
D
L
Site 44
T326
V
L
C
R
S
Q
G
T
L
S
D
L
L
R
N
Site 45
S328
C
R
S
Q
G
T
L
S
D
L
L
R
N
P
K
Site 46
S338
L
R
N
P
K
P
W
S
K
L
K
S
G
R
E
Site 47
S342
K
P
W
S
K
L
K
S
G
R
E
T
F
R
R
Site 48
T346
K
L
K
S
G
R
E
T
F
R
R
M
W
K
W
Site 49
S363
E
P
E
F
Q
R
M
S
A
L
R
L
A
A
C
Site 50
T384
H
G
K
D
R
G
N
T
P
K
K
P
R
L
V
Site 51
T399
F
T
D
V
Q
R
R
T
L
H
A
I
F
K
E
Site 52
S411
F
K
E
N
K
R
P
S
K
E
L
Q
I
T
I
Site 53
T417
P
S
K
E
L
Q
I
T
I
S
Q
Q
L
G
L
Site 54
S419
K
E
L
Q
I
T
I
S
Q
Q
L
G
L
E
L
Site 55
S440
F
M
N
A
R
R
R
S
L
D
K
W
Q
D
E
Site 56
S449
D
K
W
Q
D
E
G
S
S
N
S
G
N
S
S
Site 57
S450
K
W
Q
D
E
G
S
S
N
S
G
N
S
S
S
Site 58
S452
Q
D
E
G
S
S
N
S
G
N
S
S
S
S
S
Site 59
S455
G
S
S
N
S
G
N
S
S
S
S
S
S
T
C
Site 60
S456
S
S
N
S
G
N
S
S
S
S
S
S
T
C
T
Site 61
S457
S
N
S
G
N
S
S
S
S
S
S
T
C
T
K
Site 62
S458
N
S
G
N
S
S
S
S
S
S
T
C
T
K
A
Site 63
S459
S
G
N
S
S
S
S
S
S
T
C
T
K
A
_
Site 64
S460
G
N
S
S
S
S
S
S
T
C
T
K
A
_
_
Site 65
T461
N
S
S
S
S
S
S
T
C
T
K
A
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation