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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EPS15L1
Full Name:
Epidermal growth factor receptor substrate protein 15R
Alias:
EP15R; Epidermal growth factor receptor pathway substrate 15-like 1; Epidermal growth factor receptor substrate EPS15R; Eps15R; Eps15R protein; Eps15-related protein; EPS15RS; EPS15-RS
Type:
Adapter/scaffold protein, endocytosis vesicle protein
Mass (Da):
94255
Number AA:
864
UniProt ID:
Q9UBC2
International Prot ID:
IPI00163849
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005905
GO:0019898
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005509
GO:0043167
PhosphoSite+
KinaseNET
Biological Process:
GO:0006897
GO:0006897
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
Q
Q
I
P
T
G
N
S
L
Y
E
S
Y
Y
K
Site 2
Y19
I
P
T
G
N
S
L
Y
E
S
Y
Y
K
Q
V
Site 3
S21
T
G
N
S
L
Y
E
S
Y
Y
K
Q
V
D
P
Site 4
Y23
N
S
L
Y
E
S
Y
Y
K
Q
V
D
P
A
Y
Site 5
Y30
Y
K
Q
V
D
P
A
Y
T
G
R
V
G
A
S
Site 6
S49
F
L
K
K
S
G
L
S
D
I
I
L
G
K
I
Site 7
Y74
F
L
D
K
Q
G
F
Y
V
A
L
R
L
V
A
Site 8
S92
S
G
H
E
V
T
L
S
N
L
N
L
S
M
P
Site 9
S97
T
L
S
N
L
N
L
S
M
P
P
P
K
F
H
Site 10
T106
P
P
P
K
F
H
D
T
S
S
P
L
M
V
T
Site 11
S107
P
P
K
F
H
D
T
S
S
P
L
M
V
T
P
Site 12
S108
P
K
F
H
D
T
S
S
P
L
M
V
T
P
P
Site 13
T113
T
S
S
P
L
M
V
T
P
P
S
A
E
A
H
Site 14
S171
L
G
R
V
W
D
L
S
D
I
D
K
D
G
H
Site 15
S207
V
P
S
A
L
P
P
S
L
I
P
P
S
K
R
Site 16
S212
P
P
S
L
I
P
P
S
K
R
K
K
T
V
F
Site 17
T217
P
P
S
K
R
K
K
T
V
F
P
G
A
V
P
Site 18
S229
A
V
P
V
L
P
A
S
P
P
P
K
D
S
L
Site 19
S235
A
S
P
P
P
K
D
S
L
R
S
T
P
S
H
Site 20
S238
P
P
K
D
S
L
R
S
T
P
S
H
G
S
V
Site 21
T239
P
K
D
S
L
R
S
T
P
S
H
G
S
V
S
Site 22
S241
D
S
L
R
S
T
P
S
H
G
S
V
S
S
L
Site 23
S244
R
S
T
P
S
H
G
S
V
S
S
L
N
S
T
Site 24
S246
T
P
S
H
G
S
V
S
S
L
N
S
T
G
S
Site 25
S247
P
S
H
G
S
V
S
S
L
N
S
T
G
S
L
Site 26
S250
G
S
V
S
S
L
N
S
T
G
S
L
S
P
K
Site 27
T251
S
V
S
S
L
N
S
T
G
S
L
S
P
K
H
Site 28
S253
S
S
L
N
S
T
G
S
L
S
P
K
H
S
L
Site 29
S255
L
N
S
T
G
S
L
S
P
K
H
S
L
K
Q
Site 30
S259
G
S
L
S
P
K
H
S
L
K
Q
T
Q
P
T
Site 31
T263
P
K
H
S
L
K
Q
T
Q
P
T
V
N
W
V
Site 32
Y293
T
D
L
D
L
D
G
Y
V
S
G
Q
E
V
K
Site 33
S306
V
K
E
I
F
M
H
S
G
L
T
Q
N
L
L
Site 34
T325
A
L
A
D
T
R
Q
T
G
K
L
S
K
D
Q
Site 35
S355
I
D
P
P
Q
V
L
S
P
D
M
V
P
P
S
Site 36
S362
S
P
D
M
V
P
P
S
E
R
G
T
P
G
P
Site 37
T366
V
P
P
S
E
R
G
T
P
G
P
D
S
S
G
Site 38
S371
R
G
T
P
G
P
D
S
S
G
S
L
G
S
G
Site 39
S372
G
T
P
G
P
D
S
S
G
S
L
G
S
G
E
Site 40
S374
P
G
P
D
S
S
G
S
L
G
S
G
E
F
T
Site 41
S377
D
S
S
G
S
L
G
S
G
E
F
T
G
V
K
Site 42
T381
S
L
G
S
G
E
F
T
G
V
K
E
L
D
D
Site 43
S390
V
K
E
L
D
D
I
S
Q
E
I
A
Q
L
Q
Site 44
Y401
A
Q
L
Q
R
E
K
Y
S
L
E
Q
D
I
R
Site 45
T418
E
E
A
I
R
Q
K
T
S
E
V
Q
E
L
Q
Site 46
T432
Q
N
D
L
D
R
E
T
S
S
L
Q
E
L
E
Site 47
S433
N
D
L
D
R
E
T
S
S
L
Q
E
L
E
A
Site 48
S434
D
L
D
R
E
T
S
S
L
Q
E
L
E
A
Q
Site 49
S464
A
K
L
R
D
M
L
S
D
V
R
Q
K
C
Q
Site 50
T474
R
Q
K
C
Q
D
E
T
Q
M
I
S
S
L
K
Site 51
T482
Q
M
I
S
S
L
K
T
Q
I
Q
S
Q
E
S
Site 52
S486
S
L
K
T
Q
I
Q
S
Q
E
S
D
L
K
S
Site 53
S489
T
Q
I
Q
S
Q
E
S
D
L
K
S
Q
E
D
Site 54
S493
S
Q
E
S
D
L
K
S
Q
E
D
D
L
N
R
Site 55
S503
D
D
L
N
R
A
K
S
E
L
N
R
L
Q
Q
Site 56
T528
A
G
R
V
Q
L
E
T
I
I
K
S
L
K
S
Site 57
S532
Q
L
E
T
I
I
K
S
L
K
S
T
Q
D
E
Site 58
S535
T
I
I
K
S
L
K
S
T
Q
D
E
I
N
Q
Site 59
T536
I
I
K
S
L
K
S
T
Q
D
E
I
N
Q
A
Site 60
S548
N
Q
A
R
S
K
L
S
Q
L
H
E
S
R
Q
Site 61
S560
S
R
Q
E
A
H
R
S
L
E
Q
Y
D
Q
V
Site 62
Y564
A
H
R
S
L
E
Q
Y
D
Q
V
L
D
G
A
Site 63
T577
G
A
H
G
A
S
L
T
D
L
A
N
L
S
E
Site 64
S587
A
N
L
S
E
G
V
S
L
A
E
R
G
S
F
Site 65
S593
V
S
L
A
E
R
G
S
F
G
A
M
D
D
P
Site 66
T612
A
L
L
F
S
N
N
T
Q
E
L
H
P
D
P
Site 67
T622
L
H
P
D
P
F
Q
T
E
D
P
F
K
S
D
Site 68
S628
Q
T
E
D
P
F
K
S
D
P
F
K
G
A
D
Site 69
T653
P
F
A
E
Q
Q
T
T
S
T
D
P
F
G
G
Site 70
S654
F
A
E
Q
Q
T
T
S
T
D
P
F
G
G
D
Site 71
S666
G
G
D
P
F
K
E
S
D
P
F
R
G
S
A
Site 72
S672
E
S
D
P
F
R
G
S
A
T
D
D
F
F
K
Site 73
T688
Q
T
K
N
D
P
F
T
S
D
P
F
T
K
N
Site 74
S689
T
K
N
D
P
F
T
S
D
P
F
T
K
N
P
Site 75
T693
P
F
T
S
D
P
F
T
K
N
P
S
L
P
S
Site 76
S697
D
P
F
T
K
N
P
S
L
P
S
K
L
D
P
Site 77
S707
S
K
L
D
P
F
E
S
S
D
P
F
S
S
S
Site 78
S708
K
L
D
P
F
E
S
S
D
P
F
S
S
S
S
Site 79
S712
F
E
S
S
D
P
F
S
S
S
S
V
S
S
K
Site 80
S713
E
S
S
D
P
F
S
S
S
S
V
S
S
K
G
Site 81
S714
S
S
D
P
F
S
S
S
S
V
S
S
K
G
S
Site 82
S715
S
D
P
F
S
S
S
S
V
S
S
K
G
S
D
Site 83
S717
P
F
S
S
S
S
V
S
S
K
G
S
D
P
F
Site 84
S718
F
S
S
S
S
V
S
S
K
G
S
D
P
F
G
Site 85
S721
S
S
V
S
S
K
G
S
D
P
F
G
T
L
D
Site 86
T726
K
G
S
D
P
F
G
T
L
D
P
F
G
S
G
Site 87
S732
G
T
L
D
P
F
G
S
G
S
F
N
S
A
E
Site 88
S734
L
D
P
F
G
S
G
S
F
N
S
A
E
G
F
Site 89
S737
F
G
S
G
S
F
N
S
A
E
G
F
A
D
F
Site 90
S745
A
E
G
F
A
D
F
S
Q
M
S
K
P
P
P
Site 91
S748
F
A
D
F
S
Q
M
S
K
P
P
P
S
G
P
Site 92
S753
Q
M
S
K
P
P
P
S
G
P
F
T
S
S
L
Site 93
T757
P
P
P
S
G
P
F
T
S
S
L
G
G
A
G
Site 94
S758
P
P
S
G
P
F
T
S
S
L
G
G
A
G
F
Site 95
S759
P
S
G
P
F
T
S
S
L
G
G
A
G
F
S
Site 96
S766
S
L
G
G
A
G
F
S
D
D
P
F
K
S
K
Site 97
S772
F
S
D
D
P
F
K
S
K
Q
D
T
P
A
L
Site 98
T776
P
F
K
S
K
Q
D
T
P
A
L
P
P
K
K
Site 99
S793
P
P
R
P
K
P
P
S
G
K
S
T
P
V
S
Site 100
S796
P
K
P
P
S
G
K
S
T
P
V
S
Q
L
G
Site 101
T797
K
P
P
S
G
K
S
T
P
V
S
Q
L
G
S
Site 102
S800
S
G
K
S
T
P
V
S
Q
L
G
S
A
D
F
Site 103
S804
T
P
V
S
Q
L
G
S
A
D
F
P
E
A
P
Site 104
S821
F
Q
P
L
G
A
D
S
G
D
P
F
Q
S
K
Site 105
S827
D
S
G
D
P
F
Q
S
K
K
G
F
G
D
P
Site 106
S836
K
G
F
G
D
P
F
S
G
K
D
P
F
V
P
Site 107
S844
G
K
D
P
F
V
P
S
S
A
A
K
P
S
K
Site 108
S845
K
D
P
F
V
P
S
S
A
A
K
P
S
K
A
Site 109
S850
P
S
S
A
A
K
P
S
K
A
S
A
S
G
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation