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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DNMT3B
Full Name:
DNA (cytosine-5)-methyltransferase 3B
Alias:
2.1.1.37; DNA cytosine-5 methyltransferase 3 beta; DNA methyltransferase HsaIIIB; DNA MTase HsaIIIB; DNM3B; EC 2.1.1.37; ICF
Type:
Enzyme - Methyltransferase; Nucleus
Mass (Da):
95751
Number AA:
853
UniProt ID:
Q9UBC3
International Prot ID:
IPI00012593
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003714
GO:0008270
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051573
GO:0010628
GO:0051571
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
D
A
G
G
R
E
D
S
I
L
V
N
G
A
C
Site 2
S28
I
L
V
N
G
A
C
S
D
Q
S
S
D
S
P
Site 3
S31
N
G
A
C
S
D
Q
S
S
D
S
P
P
I
L
Site 4
S32
G
A
C
S
D
Q
S
S
D
S
P
P
I
L
E
Site 5
S34
C
S
D
Q
S
S
D
S
P
P
I
L
E
A
I
Site 6
T43
P
I
L
E
A
I
R
T
P
E
I
R
G
R
R
Site 7
S51
P
E
I
R
G
R
R
S
S
S
R
L
S
K
R
Site 8
S52
E
I
R
G
R
R
S
S
S
R
L
S
K
R
E
Site 9
S53
I
R
G
R
R
S
S
S
R
L
S
K
R
E
V
Site 10
S56
R
R
S
S
S
R
L
S
K
R
E
V
S
S
L
Site 11
S61
R
L
S
K
R
E
V
S
S
L
L
S
Y
T
Q
Site 12
S62
L
S
K
R
E
V
S
S
L
L
S
Y
T
Q
D
Site 13
S65
R
E
V
S
S
L
L
S
Y
T
Q
D
L
T
G
Site 14
Y66
E
V
S
S
L
L
S
Y
T
Q
D
L
T
G
D
Site 15
T71
L
S
Y
T
Q
D
L
T
G
D
G
D
G
E
D
Site 16
S82
D
G
E
D
G
D
G
S
D
T
P
V
M
P
K
Site 17
T84
E
D
G
D
G
S
D
T
P
V
M
P
K
L
F
Site 18
T94
M
P
K
L
F
R
E
T
R
T
R
S
E
S
P
Site 19
T96
K
L
F
R
E
T
R
T
R
S
E
S
P
A
V
Site 20
S98
F
R
E
T
R
T
R
S
E
S
P
A
V
R
T
Site 21
S100
E
T
R
T
R
S
E
S
P
A
V
R
T
R
N
Site 22
T105
S
E
S
P
A
V
R
T
R
N
N
N
S
V
S
Site 23
S110
V
R
T
R
N
N
N
S
V
S
S
R
E
R
H
Site 24
S112
T
R
N
N
N
S
V
S
S
R
E
R
H
R
P
Site 25
S113
R
N
N
N
S
V
S
S
R
E
R
H
R
P
S
Site 26
S120
S
R
E
R
H
R
P
S
P
R
S
T
R
G
R
Site 27
S123
R
H
R
P
S
P
R
S
T
R
G
R
Q
G
R
Site 28
T124
H
R
P
S
P
R
S
T
R
G
R
Q
G
R
N
Site 29
S136
G
R
N
H
V
D
E
S
P
V
E
F
P
A
T
Site 30
T143
S
P
V
E
F
P
A
T
R
S
L
R
R
R
A
Site 31
S145
V
E
F
P
A
T
R
S
L
R
R
R
A
T
A
Site 32
T151
R
S
L
R
R
R
A
T
A
S
A
G
T
P
W
Site 33
S153
L
R
R
R
A
T
A
S
A
G
T
P
W
P
S
Site 34
T156
R
A
T
A
S
A
G
T
P
W
P
S
P
P
S
Site 35
S160
S
A
G
T
P
W
P
S
P
P
S
S
Y
L
T
Site 36
S163
T
P
W
P
S
P
P
S
S
Y
L
T
I
D
L
Site 37
S164
P
W
P
S
P
P
S
S
Y
L
T
I
D
L
T
Site 38
T167
S
P
P
S
S
Y
L
T
I
D
L
T
D
D
T
Site 39
T171
S
Y
L
T
I
D
L
T
D
D
T
E
D
T
H
Site 40
T174
T
I
D
L
T
D
D
T
E
D
T
H
G
T
P
Site 41
T180
D
T
E
D
T
H
G
T
P
Q
S
S
S
T
P
Site 42
S183
D
T
H
G
T
P
Q
S
S
S
T
P
Y
A
R
Site 43
S185
H
G
T
P
Q
S
S
S
T
P
Y
A
R
L
A
Site 44
T186
G
T
P
Q
S
S
S
T
P
Y
A
R
L
A
Q
Site 45
Y188
P
Q
S
S
S
T
P
Y
A
R
L
A
Q
D
S
Site 46
S195
Y
A
R
L
A
Q
D
S
Q
Q
G
G
M
E
S
Site 47
S202
S
Q
Q
G
G
M
E
S
P
Q
V
E
A
D
S
Site 48
S209
S
P
Q
V
E
A
D
S
G
D
G
D
S
S
E
Site 49
S214
A
D
S
G
D
G
D
S
S
E
Y
Q
D
G
K
Site 50
S215
D
S
G
D
G
D
S
S
E
Y
Q
D
G
K
E
Site 51
Y217
G
D
G
D
S
S
E
Y
Q
D
G
K
E
F
G
Site 52
S250
V
V
S
W
K
A
T
S
K
R
Q
A
M
S
G
Site 53
T291
S
Q
H
F
N
L
A
T
F
N
K
L
V
S
Y
Site 54
T316
A
R
V
R
A
G
K
T
F
P
S
S
P
G
D
Site 55
S319
R
A
G
K
T
F
P
S
S
P
G
D
S
L
E
Site 56
S320
A
G
K
T
F
P
S
S
P
G
D
S
L
E
D
Site 57
S324
F
P
S
S
P
G
D
S
L
E
D
Q
L
K
P
Site 58
T353
E
G
L
K
P
N
N
T
Q
P
V
V
N
K
S
Site 59
S360
T
Q
P
V
V
N
K
S
K
V
R
R
A
G
S
Site 60
S367
S
K
V
R
R
A
G
S
R
K
L
E
S
R
K
Site 61
Y375
R
K
L
E
S
R
K
Y
E
N
K
T
R
R
R
Site 62
T379
S
R
K
Y
E
N
K
T
R
R
R
T
A
D
D
Site 63
T383
E
N
K
T
R
R
R
T
A
D
D
S
A
T
S
Site 64
S387
R
R
R
T
A
D
D
S
A
T
S
D
Y
C
P
Site 65
T389
R
T
A
D
D
S
A
T
S
D
Y
C
P
A
P
Site 66
Y392
D
D
S
A
T
S
D
Y
C
P
A
P
K
R
L
Site 67
T401
P
A
P
K
R
L
K
T
N
C
Y
N
N
G
K
Site 68
Y404
K
R
L
K
T
N
C
Y
N
N
G
K
D
R
G
Site 69
S416
D
R
G
D
E
D
Q
S
R
E
Q
M
A
S
D
Site 70
S422
Q
S
R
E
Q
M
A
S
D
V
A
N
N
K
S
Site 71
S430
D
V
A
N
N
K
S
S
L
E
D
G
C
L
S
Site 72
S437
S
L
E
D
G
C
L
S
C
G
R
K
N
P
V
Site 73
S445
C
G
R
K
N
P
V
S
F
H
P
L
F
E
G
Site 74
Y467
D
R
F
L
E
L
F
Y
M
Y
D
D
D
G
Y
Site 75
Y469
F
L
E
L
F
Y
M
Y
D
D
D
G
Y
Q
S
Site 76
Y474
Y
M
Y
D
D
D
G
Y
Q
S
Y
C
T
V
C
Site 77
Y477
D
D
D
G
Y
Q
S
Y
C
T
V
C
C
E
G
Site 78
T510
C
L
E
V
L
V
G
T
G
T
A
A
E
A
K
Site 79
T551
V
R
L
Q
A
F
F
T
S
D
T
G
L
E
Y
Site 80
S552
R
L
Q
A
F
F
T
S
D
T
G
L
E
Y
E
Site 81
Y558
T
S
D
T
G
L
E
Y
E
A
P
K
L
Y
P
Site 82
Y564
E
Y
E
A
P
K
L
Y
P
A
I
P
A
A
R
Site 83
S579
R
R
P
I
R
V
L
S
L
F
D
G
I
A
T
Site 84
Y588
F
D
G
I
A
T
G
Y
L
V
L
K
E
L
G
Site 85
Y601
L
G
I
K
V
G
K
Y
V
A
S
E
V
C
E
Site 86
Y624
K
H
E
G
N
I
K
Y
V
N
D
V
R
N
I
Site 87
T632
V
N
D
V
R
N
I
T
K
K
N
I
E
E
W
Site 88
S649
F
D
L
V
I
G
G
S
P
C
N
D
L
S
N
Site 89
S655
G
S
P
C
N
D
L
S
N
V
N
P
A
R
K
Site 90
Y665
N
P
A
R
K
G
L
Y
E
G
T
G
R
L
F
Site 91
T668
R
K
G
L
Y
E
G
T
G
R
L
F
F
E
F
Site 92
Y676
G
R
L
F
F
E
F
Y
H
L
L
N
Y
S
R
Site 93
Y681
E
F
Y
H
L
L
N
Y
S
R
P
K
E
G
D
Site 94
S682
F
Y
H
L
L
N
Y
S
R
P
K
E
G
D
D
Site 95
S711
V
G
D
K
R
D
I
S
R
F
L
E
C
N
P
Site 96
Y734
S
A
A
H
R
A
R
Y
F
W
G
N
L
P
G
Site 97
S749
M
N
R
P
V
I
A
S
K
N
D
K
L
E
L
Site 98
Y762
E
L
Q
D
C
L
E
Y
N
R
I
A
K
L
K
Site 99
T773
A
K
L
K
K
V
Q
T
I
T
T
K
S
N
S
Site 100
T776
K
K
V
Q
T
I
T
T
K
S
N
S
I
K
Q
Site 101
S778
V
Q
T
I
T
T
K
S
N
S
I
K
Q
G
K
Site 102
S780
T
I
T
T
K
S
N
S
I
K
Q
G
K
N
Q
Site 103
Y815
I
F
G
F
P
V
H
Y
T
D
V
S
N
M
G
Site 104
T816
F
G
F
P
V
H
Y
T
D
V
S
N
M
G
R
Site 105
S819
P
V
H
Y
T
D
V
S
N
M
G
R
G
A
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation