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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIK4CB
Full Name:
Phosphatidylinositol 4-kinase, catalytic beta
Alias:
EC 2.7.1.67; NPIK; PI4K92; PI4KB; PI4Kbeta; PI4K-beta
Type:
Kinase, lipid, inositol phosphate metabolism
Mass (Da):
91379
Number AA:
816
UniProt ID:
Q9UBF8
International Prot ID:
IPI00002591
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0012505
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0004430
GO:0005524
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006661
GO:0046854
GO:0048015
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
E
P
A
P
L
K
P
T
S
E
P
T
S
G
P
Site 2
S15
P
A
P
L
K
P
T
S
E
P
T
S
G
P
P
Site 3
S19
K
P
T
S
E
P
T
S
G
P
P
G
N
N
G
Site 4
S69
L
H
G
G
V
A
V
S
S
R
G
T
P
L
E
Site 5
S85
V
N
G
D
G
V
D
S
E
I
R
C
L
D
D
Site 6
S110
E
M
G
A
A
V
A
S
G
T
A
K
G
A
R
Site 7
S124
R
R
R
R
Q
N
N
S
A
K
Q
S
W
L
L
Site 8
S128
Q
N
N
S
A
K
Q
S
W
L
L
R
L
F
E
Site 9
S146
F
D
I
S
M
A
I
S
Y
L
Y
N
S
K
E
Site 10
Y147
D
I
S
M
A
I
S
Y
L
Y
N
S
K
E
P
Site 11
Y149
S
M
A
I
S
Y
L
Y
N
S
K
E
P
G
V
Site 12
Y175
R
N
E
D
V
D
F
Y
L
P
Q
L
L
N
M
Site 13
Y197
V
G
D
A
I
K
P
Y
I
V
H
R
C
R
Q
Site 14
S205
I
V
H
R
C
R
Q
S
I
N
F
S
L
Q
C
Site 15
S209
C
R
Q
S
I
N
F
S
L
Q
C
A
L
L
L
Site 16
S226
Y
S
S
D
M
H
I
S
T
Q
R
H
S
R
G
Site 17
T227
S
S
D
M
H
I
S
T
Q
R
H
S
R
G
T
Site 18
S231
H
I
S
T
Q
R
H
S
R
G
T
K
L
R
K
Site 19
T234
T
Q
R
H
S
R
G
T
K
L
R
K
L
I
L
Site 20
S242
K
L
R
K
L
I
L
S
D
E
L
K
P
A
H
Site 21
S256
H
R
K
R
E
L
P
S
L
S
P
A
P
D
T
Site 22
S258
K
R
E
L
P
S
L
S
P
A
P
D
T
G
L
Site 23
T263
S
L
S
P
A
P
D
T
G
L
S
P
S
K
R
Site 24
S266
P
A
P
D
T
G
L
S
P
S
K
R
T
H
Q
Site 25
S268
P
D
T
G
L
S
P
S
K
R
T
H
Q
R
S
Site 26
T271
G
L
S
P
S
K
R
T
H
Q
R
S
K
S
D
Site 27
S275
S
K
R
T
H
Q
R
S
K
S
D
A
T
A
S
Site 28
S277
R
T
H
Q
R
S
K
S
D
A
T
A
S
I
S
Site 29
T280
Q
R
S
K
S
D
A
T
A
S
I
S
L
S
S
Site 30
S282
S
K
S
D
A
T
A
S
I
S
L
S
S
N
L
Site 31
S284
S
D
A
T
A
S
I
S
L
S
S
N
L
K
R
Site 32
S286
A
T
A
S
I
S
L
S
S
N
L
K
R
T
A
Site 33
S294
S
N
L
K
R
T
A
S
N
P
K
V
E
N
E
Site 34
S306
E
N
E
D
E
E
L
S
S
S
T
E
S
I
D
Site 35
S307
N
E
D
E
E
L
S
S
S
T
E
S
I
D
N
Site 36
S308
E
D
E
E
L
S
S
S
T
E
S
I
D
N
S
Site 37
S311
E
L
S
S
S
T
E
S
I
D
N
S
F
S
S
Site 38
S315
S
T
E
S
I
D
N
S
F
S
S
P
V
R
L
Site 39
S317
E
S
I
D
N
S
F
S
S
P
V
R
L
A
P
Site 40
S318
S
I
D
N
S
F
S
S
P
V
R
L
A
P
E
Site 41
S331
P
E
R
E
F
I
K
S
L
M
A
I
G
K
R
Site 42
T341
A
I
G
K
R
L
A
T
L
P
T
K
E
Q
K
Site 43
T349
L
P
T
K
E
Q
K
T
Q
R
L
I
S
E
L
Site 44
S354
Q
K
T
Q
R
L
I
S
E
L
S
L
L
N
H
Site 45
S357
Q
R
L
I
S
E
L
S
L
L
N
H
K
L
P
Site 46
T411
L
E
C
E
N
F
D
T
T
S
V
P
A
R
I
Site 47
T412
E
C
E
N
F
D
T
T
S
V
P
A
R
I
P
Site 48
S413
C
E
N
F
D
T
T
S
V
P
A
R
I
P
E
Site 49
S425
I
P
E
N
R
I
R
S
T
R
S
V
E
N
L
Site 50
T426
P
E
N
R
I
R
S
T
R
S
V
E
N
L
P
Site 51
S428
N
R
I
R
S
T
R
S
V
E
N
L
P
E
C
Site 52
T438
N
L
P
E
C
G
I
T
H
E
Q
R
A
G
S
Site 53
S445
T
H
E
Q
R
A
G
S
F
S
T
V
P
N
Y
Site 54
S447
E
Q
R
A
G
S
F
S
T
V
P
N
Y
D
N
Site 55
Y452
S
F
S
T
V
P
N
Y
D
N
D
D
E
A
W
Site 56
S460
D
N
D
D
E
A
W
S
V
D
D
I
G
E
L
Site 57
T476
V
E
L
P
E
V
H
T
N
S
C
D
N
I
S
Site 58
S478
L
P
E
V
H
T
N
S
C
D
N
I
S
Q
F
Site 59
S483
T
N
S
C
D
N
I
S
Q
F
S
V
D
S
I
Site 60
S486
C
D
N
I
S
Q
F
S
V
D
S
I
T
S
Q
Site 61
S489
I
S
Q
F
S
V
D
S
I
T
S
Q
E
S
K
Site 62
T491
Q
F
S
V
D
S
I
T
S
Q
E
S
K
E
P
Site 63
S495
D
S
I
T
S
Q
E
S
K
E
P
V
F
I
A
Site 64
S511
G
D
I
R
R
R
L
S
E
Q
L
A
H
T
P
Site 65
T517
L
S
E
Q
L
A
H
T
P
T
A
F
K
R
D
Site 66
T519
E
Q
L
A
H
T
P
T
A
F
K
R
D
P
E
Site 67
S548
V
R
R
I
R
E
G
S
P
Y
G
H
L
P
N
Site 68
Y550
R
I
R
E
G
S
P
Y
G
H
L
P
N
W
R
Site 69
S584
Q
V
L
K
Q
L
Q
S
I
W
E
Q
E
R
V
Site 70
S626
I
H
Q
V
K
K
Q
S
Q
L
S
L
L
D
Y
Site 71
Y633
S
Q
L
S
L
L
D
Y
F
L
Q
E
H
G
S
Site 72
S640
Y
F
L
Q
E
H
G
S
Y
T
T
E
A
F
L
Site 73
Y641
F
L
Q
E
H
G
S
Y
T
T
E
A
F
L
S
Site 74
T642
L
Q
E
H
G
S
Y
T
T
E
A
F
L
S
A
Site 75
S648
Y
T
T
E
A
F
L
S
A
Q
R
N
F
V
Q
Site 76
S706
R
N
L
G
F
E
T
S
A
F
K
L
T
T
E
Site 77
T712
T
S
A
F
K
L
T
T
E
F
V
D
V
M
G
Site 78
Y728
L
D
G
D
M
F
N
Y
Y
K
M
L
M
L
Q
Site 79
Y729
D
G
D
M
F
N
Y
Y
K
M
L
M
L
Q
G
Site 80
S767
L
P
C
F
H
G
S
S
T
I
R
N
L
K
E
Site 81
T768
P
C
F
H
G
S
S
T
I
R
N
L
K
E
R
Site 82
S779
L
K
E
R
F
H
M
S
M
T
E
E
Q
L
Q
Site 83
S796
V
E
Q
M
V
D
G
S
M
R
S
I
T
T
K
Site 84
S799
M
V
D
G
S
M
R
S
I
T
T
K
L
Y
D
Site 85
T801
D
G
S
M
R
S
I
T
T
K
L
Y
D
G
F
Site 86
Y805
R
S
I
T
T
K
L
Y
D
G
F
Q
Y
L
T
Site 87
Y810
K
L
Y
D
G
F
Q
Y
L
T
N
G
I
M
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation