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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYOT
Full Name:
Myotilin
Alias:
LGMD1; LGMD1A; Myofibrillar titin-like Ig domains; MYOTI; Titin immunoglobulin domain protein; TTID
Type:
Cytoskeletal protein
Mass (Da):
55395
Number AA:
498
UniProt ID:
Q9UBF9
International Prot ID:
IPI00009551
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030018
GO:0015629
GO:0042383
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0008307
PhosphoSite+
KinaseNET
Biological Process:
GO:0006936
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
R
P
K
H
F
I
Q
S
Q
N
P
C
G
S
R
Site 2
S19
Q
S
Q
N
P
C
G
S
R
L
Q
P
P
G
P
Site 3
T28
L
Q
P
P
G
P
E
T
S
S
F
S
S
Q
T
Site 4
S29
Q
P
P
G
P
E
T
S
S
F
S
S
Q
T
K
Site 5
S30
P
P
G
P
E
T
S
S
F
S
S
Q
T
K
Q
Site 6
S32
G
P
E
T
S
S
F
S
S
Q
T
K
Q
S
S
Site 7
S33
P
E
T
S
S
F
S
S
Q
T
K
Q
S
S
I
Site 8
T35
T
S
S
F
S
S
Q
T
K
Q
S
S
I
I
I
Site 9
T48
I
I
Q
P
R
Q
C
T
E
Q
R
F
S
A
S
Site 10
S53
Q
C
T
E
Q
R
F
S
A
S
S
T
L
S
S
Site 11
S55
T
E
Q
R
F
S
A
S
S
T
L
S
S
H
I
Site 12
S56
E
Q
R
F
S
A
S
S
T
L
S
S
H
I
T
Site 13
T57
Q
R
F
S
A
S
S
T
L
S
S
H
I
T
M
Site 14
S59
F
S
A
S
S
T
L
S
S
H
I
T
M
S
S
Site 15
S60
S
A
S
S
T
L
S
S
H
I
T
M
S
S
S
Site 16
T63
S
T
L
S
S
H
I
T
M
S
S
S
A
F
P
Site 17
S66
S
S
H
I
T
M
S
S
S
A
F
P
A
S
P
Site 18
S67
S
H
I
T
M
S
S
S
A
F
P
A
S
P
Q
Site 19
S72
S
S
S
A
F
P
A
S
P
Q
Q
H
A
G
S
Site 20
S79
S
P
Q
Q
H
A
G
S
N
P
G
Q
R
V
T
Site 21
T86
S
N
P
G
Q
R
V
T
T
T
Y
N
Q
S
P
Site 22
T87
N
P
G
Q
R
V
T
T
T
Y
N
Q
S
P
A
Site 23
T88
P
G
Q
R
V
T
T
T
Y
N
Q
S
P
A
S
Site 24
Y89
G
Q
R
V
T
T
T
Y
N
Q
S
P
A
S
F
Site 25
S92
V
T
T
T
Y
N
Q
S
P
A
S
F
L
S
S
Site 26
S95
T
Y
N
Q
S
P
A
S
F
L
S
S
I
L
P
Site 27
S98
Q
S
P
A
S
F
L
S
S
I
L
P
S
Q
P
Site 28
S99
S
P
A
S
F
L
S
S
I
L
P
S
Q
P
D
Site 29
S103
F
L
S
S
I
L
P
S
Q
P
D
Y
N
S
S
Site 30
Y107
I
L
P
S
Q
P
D
Y
N
S
S
K
I
P
S
Site 31
S109
P
S
Q
P
D
Y
N
S
S
K
I
P
S
A
M
Site 32
S110
S
Q
P
D
Y
N
S
S
K
I
P
S
A
M
D
Site 33
S114
Y
N
S
S
K
I
P
S
A
M
D
S
N
Y
Q
Site 34
S118
K
I
P
S
A
M
D
S
N
Y
Q
Q
S
S
A
Site 35
Y120
P
S
A
M
D
S
N
Y
Q
Q
S
S
A
G
Q
Site 36
T145
N
A
K
P
I
P
R
T
P
D
H
E
I
Q
G
Site 37
S153
P
D
H
E
I
Q
G
S
K
E
A
L
I
Q
D
Site 38
T170
R
K
L
K
C
K
D
T
L
L
H
N
G
N
Q
Site 39
T180
H
N
G
N
Q
R
L
T
Y
E
E
K
M
A
R
Site 40
Y181
N
G
N
Q
R
L
T
Y
E
E
K
M
A
R
R
Site 41
S205
V
F
Q
A
Q
D
D
S
G
A
Q
D
S
Q
Q
Site 42
S210
D
D
S
G
A
Q
D
S
Q
Q
H
N
S
E
H
Site 43
S215
Q
D
S
Q
Q
H
N
S
E
H
A
R
L
Q
V
Site 44
T224
H
A
R
L
Q
V
P
T
S
Q
V
R
S
R
S
Site 45
S225
A
R
L
Q
V
P
T
S
Q
V
R
S
R
S
T
Site 46
S229
V
P
T
S
Q
V
R
S
R
S
T
S
R
G
D
Site 47
S231
T
S
Q
V
R
S
R
S
T
S
R
G
D
V
N
Site 48
T232
S
Q
V
R
S
R
S
T
S
R
G
D
V
N
D
Site 49
S233
Q
V
R
S
R
S
T
S
R
G
D
V
N
D
Q
Site 50
Y248
D
A
I
Q
E
K
F
Y
P
P
R
F
I
Q
V
Site 51
S282
G
L
P
A
P
D
V
S
W
Y
L
N
G
R
T
Site 52
Y284
P
A
P
D
V
S
W
Y
L
N
G
R
T
V
Q
Site 53
S292
L
N
G
R
T
V
Q
S
D
D
L
H
K
M
I
Site 54
Y321
R
A
S
D
A
G
A
Y
A
C
V
A
K
N
R
Site 55
T333
K
N
R
A
G
E
A
T
F
T
V
Q
L
D
V
Site 56
Y353
K
R
A
P
M
F
I
Y
K
P
Q
S
K
K
V
Site 57
S357
M
F
I
Y
K
P
Q
S
K
K
V
L
E
G
D
Site 58
S365
K
K
V
L
E
G
D
S
V
K
L
E
C
Q
I
Site 59
S397
Q
F
N
T
D
R
I
S
L
Y
Q
D
N
T
G
Site 60
Y399
N
T
D
R
I
S
L
Y
Q
D
N
T
G
R
V
Site 61
T403
I
S
L
Y
Q
D
N
T
G
R
V
T
L
L
I
Site 62
T407
Q
D
N
T
G
R
V
T
L
L
I
K
D
V
N
Site 63
T422
K
K
D
A
G
W
Y
T
V
S
A
V
N
E
A
Site 64
T432
A
V
N
E
A
G
V
T
T
C
N
T
R
L
D
Site 65
T441
C
N
T
R
L
D
V
T
A
R
P
N
Q
T
L
Site 66
T459
K
Q
L
R
V
R
P
T
F
S
K
Y
L
A
L
Site 67
Y463
V
R
P
T
F
S
K
Y
L
A
L
N
G
K
G
Site 68
S490
F
Q
R
L
A
A
Q
S
G
L
Y
E
S
E
E
Site 69
Y493
L
A
A
Q
S
G
L
Y
E
S
E
E
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation