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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARPP-21
Full Name:
cAMP-regulated phosphoprotein 21
Alias:
ARP21
Type:
Inhibitor protein
Mass (Da):
89196
Number AA:
812
UniProt ID:
Q9UBL0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
E
G
G
T
E
Q
E
T
A
T
P
E
N
G
I
Site 2
T23
G
T
E
Q
E
T
A
T
P
E
N
G
I
V
K
Site 3
S31
P
E
N
G
I
V
K
S
E
S
L
D
E
E
E
Site 4
S33
N
G
I
V
K
S
E
S
L
D
E
E
E
K
L
Site 5
S56
Q
N
Q
E
R
R
K
S
K
S
G
A
G
K
G
Site 6
S58
Q
E
R
R
K
S
K
S
G
A
G
K
G
K
L
Site 7
S68
G
K
G
K
L
T
R
S
L
A
V
C
E
E
S
Site 8
S75
S
L
A
V
C
E
E
S
S
A
R
P
G
G
E
Site 9
S76
L
A
V
C
E
E
S
S
A
R
P
G
G
E
S
Site 10
S83
S
A
R
P
G
G
E
S
L
Q
D
Q
E
S
I
Site 11
S89
E
S
L
Q
D
Q
E
S
I
H
L
Q
L
S
S
Site 12
S95
E
S
I
H
L
Q
L
S
S
F
S
S
L
Q
E
Site 13
S96
S
I
H
L
Q
L
S
S
F
S
S
L
Q
E
E
Site 14
S99
L
Q
L
S
S
F
S
S
L
Q
E
E
D
K
S
Site 15
S106
S
L
Q
E
E
D
K
S
R
K
D
D
S
E
R
Site 16
S111
D
K
S
R
K
D
D
S
E
R
E
K
E
K
D
Site 17
T124
K
D
K
N
K
D
K
T
S
E
K
P
K
I
R
Site 18
S125
D
K
N
K
D
K
T
S
E
K
P
K
I
R
M
Site 19
S134
K
P
K
I
R
M
L
S
K
D
C
S
Q
E
Y
Site 20
S138
R
M
L
S
K
D
C
S
Q
E
Y
T
D
S
T
Site 21
Y141
S
K
D
C
S
Q
E
Y
T
D
S
T
G
I
D
Site 22
T142
K
D
C
S
Q
E
Y
T
D
S
T
G
I
D
L
Site 23
S144
C
S
Q
E
Y
T
D
S
T
G
I
D
L
H
E
Site 24
T145
S
Q
E
Y
T
D
S
T
G
I
D
L
H
E
F
Site 25
T156
L
H
E
F
L
I
N
T
L
K
N
N
S
R
D
Site 26
Y194
K
F
P
Q
M
S
S
Y
Q
R
M
L
V
H
R
Site 27
S218
N
V
D
Q
T
G
K
S
V
I
I
N
K
T
S
Site 28
S225
S
V
I
I
N
K
T
S
S
T
R
I
P
E
Q
Site 29
S226
V
I
I
N
K
T
S
S
T
R
I
P
E
Q
R
Site 30
S246
K
D
E
K
G
E
E
S
Q
K
R
F
I
L
K
Site 31
S257
F
I
L
K
R
D
N
S
S
I
D
K
E
D
N
Site 32
S258
I
L
K
R
D
N
S
S
I
D
K
E
D
N
Q
Site 33
S278
P
F
R
D
D
R
R
S
K
S
I
E
E
R
E
Site 34
S280
R
D
D
R
R
S
K
S
I
E
E
R
E
E
E
Site 35
Y288
I
E
E
R
E
E
E
Y
Q
R
V
R
E
R
I
Site 36
S300
E
R
I
F
A
H
D
S
V
C
S
Q
E
S
L
Site 37
S303
F
A
H
D
S
V
C
S
Q
E
S
L
F
V
E
Site 38
S306
D
S
V
C
S
Q
E
S
L
F
V
E
N
S
R
Site 39
S318
N
S
R
L
L
E
D
S
N
I
C
N
E
T
Y
Site 40
Y325
S
N
I
C
N
E
T
Y
K
K
R
Q
L
F
R
Site 41
S338
F
R
G
N
R
D
G
S
G
R
T
S
G
S
R
Site 42
S342
R
D
G
S
G
R
T
S
G
S
R
Q
S
S
S
Site 43
S344
G
S
G
R
T
S
G
S
R
Q
S
S
S
E
N
Site 44
S347
R
T
S
G
S
R
Q
S
S
S
E
N
E
L
K
Site 45
S348
T
S
G
S
R
Q
S
S
S
E
N
E
L
K
W
Site 46
S349
S
G
S
R
Q
S
S
S
E
N
E
L
K
W
S
Site 47
S363
S
D
H
Q
R
A
W
S
S
T
D
S
D
S
S
Site 48
S364
D
H
Q
R
A
W
S
S
T
D
S
D
S
S
N
Site 49
T365
H
Q
R
A
W
S
S
T
D
S
D
S
S
N
R
Site 50
S367
R
A
W
S
S
T
D
S
D
S
S
N
R
N
L
Site 51
S369
W
S
S
T
D
S
D
S
S
N
R
N
L
K
P
Site 52
S370
S
S
T
D
S
D
S
S
N
R
N
L
K
P
A
Site 53
T379
R
N
L
K
P
A
M
T
K
T
A
S
F
G
G
Site 54
T381
L
K
P
A
M
T
K
T
A
S
F
G
G
I
T
Site 55
S383
P
A
M
T
K
T
A
S
F
G
G
I
T
V
L
Site 56
T391
F
G
G
I
T
V
L
T
R
G
D
S
T
S
S
Site 57
S395
T
V
L
T
R
G
D
S
T
S
S
T
R
S
T
Site 58
S397
L
T
R
G
D
S
T
S
S
T
R
S
T
G
K
Site 59
S398
T
R
G
D
S
T
S
S
T
R
S
T
G
K
L
Site 60
T399
R
G
D
S
T
S
S
T
R
S
T
G
K
L
S
Site 61
S401
D
S
T
S
S
T
R
S
T
G
K
L
S
K
A
Site 62
T402
S
T
S
S
T
R
S
T
G
K
L
S
K
A
G
Site 63
S406
T
R
S
T
G
K
L
S
K
A
G
S
E
S
S
Site 64
S410
G
K
L
S
K
A
G
S
E
S
S
S
S
A
G
Site 65
S412
L
S
K
A
G
S
E
S
S
S
S
A
G
S
S
Site 66
S413
S
K
A
G
S
E
S
S
S
S
A
G
S
S
G
Site 67
S414
K
A
G
S
E
S
S
S
S
A
G
S
S
G
S
Site 68
S415
A
G
S
E
S
S
S
S
A
G
S
S
G
S
L
Site 69
S418
E
S
S
S
S
A
G
S
S
G
S
L
S
R
T
Site 70
S419
S
S
S
S
A
G
S
S
G
S
L
S
R
T
H
Site 71
S421
S
S
A
G
S
S
G
S
L
S
R
T
H
P
P
Site 72
S423
A
G
S
S
G
S
L
S
R
T
H
P
P
L
Q
Site 73
T425
S
S
G
S
L
S
R
T
H
P
P
L
Q
S
T
Site 74
S431
R
T
H
P
P
L
Q
S
T
P
L
V
S
G
V
Site 75
Y448
G
S
P
G
C
V
P
Y
P
E
N
G
I
G
G
Site 76
T486
S
I
L
L
N
P
H
T
G
Q
P
F
V
N
P
Site 77
T496
P
F
V
N
P
D
G
T
P
A
I
Y
N
P
P
Site 78
Y500
P
D
G
T
P
A
I
Y
N
P
P
T
S
Q
Q
Site 79
T504
P
A
I
Y
N
P
P
T
S
Q
Q
P
L
R
S
Site 80
S505
A
I
Y
N
P
P
T
S
Q
Q
P
L
R
S
A
Site 81
S511
T
S
Q
Q
P
L
R
S
A
M
V
G
Q
S
Q
Site 82
S517
R
S
A
M
V
G
Q
S
Q
Q
Q
P
P
Q
Q
Site 83
S527
Q
P
P
Q
Q
Q
P
S
P
Q
P
Q
Q
Q
V
Site 84
T554
T
Q
R
D
D
V
A
T
Q
F
G
Q
M
T
L
Site 85
T560
A
T
Q
F
G
Q
M
T
L
S
R
Q
S
S
G
Site 86
S562
Q
F
G
Q
M
T
L
S
R
Q
S
S
G
E
T
Site 87
S565
Q
M
T
L
S
R
Q
S
S
G
E
T
P
E
P
Site 88
S566
M
T
L
S
R
Q
S
S
G
E
T
P
E
P
P
Site 89
T569
S
R
Q
S
S
G
E
T
P
E
P
P
S
G
P
Site 90
S574
G
E
T
P
E
P
P
S
G
P
V
Y
P
S
S
Site 91
Y578
E
P
P
S
G
P
V
Y
P
S
S
L
M
P
Q
Site 92
S580
P
S
G
P
V
Y
P
S
S
L
M
P
Q
P
A
Site 93
S581
S
G
P
V
Y
P
S
S
L
M
P
Q
P
A
Q
Site 94
S591
P
Q
P
A
Q
Q
P
S
Y
V
I
A
S
T
G
Site 95
Y592
Q
P
A
Q
Q
P
S
Y
V
I
A
S
T
G
Q
Site 96
T603
S
T
G
Q
Q
L
P
T
G
G
F
S
G
S
G
Site 97
S607
Q
L
P
T
G
G
F
S
G
S
G
P
P
I
S
Site 98
S609
P
T
G
G
F
S
G
S
G
P
P
I
S
Q
Q
Site 99
S614
S
G
S
G
P
P
I
S
Q
Q
V
L
Q
P
P
Site 100
S623
Q
V
L
Q
P
P
P
S
P
Q
G
F
V
Q
Q
Site 101
Y639
P
P
A
Q
M
P
V
Y
Y
Y
P
S
G
Q
Y
Site 102
Y640
P
A
Q
M
P
V
Y
Y
Y
P
S
G
Q
Y
P
Site 103
Y641
A
Q
M
P
V
Y
Y
Y
P
S
G
Q
Y
P
T
Site 104
Y646
Y
Y
Y
P
S
G
Q
Y
P
T
S
T
T
Q
Q
Site 105
S649
P
S
G
Q
Y
P
T
S
T
T
Q
Q
Y
R
P
Site 106
Y662
R
P
M
A
P
V
Q
Y
N
A
Q
R
S
Q
Q
Site 107
Y679
Q
A
A
Q
Q
A
G
Y
Q
P
V
L
S
G
Q
Site 108
S684
A
G
Y
Q
P
V
L
S
G
Q
Q
G
F
Q
G
Site 109
S701
G
V
Q
Q
P
P
Q
S
Q
N
V
I
N
N
Q
Site 110
S715
Q
Q
G
T
P
V
Q
S
V
M
V
S
Y
P
T
Site 111
S719
P
V
Q
S
V
M
V
S
Y
P
T
M
S
S
Y
Site 112
Y720
V
Q
S
V
M
V
S
Y
P
T
M
S
S
Y
Q
Site 113
S725
V
S
Y
P
T
M
S
S
Y
Q
V
P
M
T
Q
Site 114
Y726
S
Y
P
T
M
S
S
Y
Q
V
P
M
T
Q
G
Site 115
T731
S
S
Y
Q
V
P
M
T
Q
G
S
Q
G
L
P
Site 116
S741
S
Q
G
L
P
Q
Q
S
Y
Q
Q
P
I
M
L
Site 117
Y742
Q
G
L
P
Q
Q
S
Y
Q
Q
P
I
M
L
P
Site 118
S756
P
N
Q
A
G
Q
G
S
L
P
A
T
G
M
P
Site 119
T760
G
Q
G
S
L
P
A
T
G
M
P
V
Y
C
N
Site 120
T769
M
P
V
Y
C
N
V
T
P
P
T
P
Q
N
N
Site 121
T772
Y
C
N
V
T
P
P
T
P
Q
N
N
L
R
L
Site 122
T788
G
P
H
C
P
S
S
T
V
P
V
M
S
A
S
Site 123
S793
S
S
T
V
P
V
M
S
A
S
C
R
T
N
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation