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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ASH2L
Full Name:
Set1/Ash2 histone methyltransferase complex subunit ASH2
Alias:
ASH2L1; ASH2L2; ASH2-like; ASH2-like protein
Type:
Transcription factor
Mass (Da):
68723
Number AA:
628
UniProt ID:
Q9UBL3
International Prot ID:
IPI00328658
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0032991
GO:0034708
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006351
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S48
A
P
P
G
E
G
I
S
A
A
P
T
V
E
P
Site 2
T52
E
G
I
S
A
A
P
T
V
E
P
S
S
G
E
Site 3
S57
A
P
T
V
E
P
S
S
G
E
A
E
G
G
E
Site 4
S71
E
A
N
L
V
D
V
S
G
G
L
E
T
E
S
Site 5
S78
S
G
G
L
E
T
E
S
S
N
G
K
D
T
L
Site 6
S79
G
G
L
E
T
E
S
S
N
G
K
D
T
L
E
Site 7
T84
E
S
S
N
G
K
D
T
L
E
G
A
G
D
T
Site 8
T97
D
T
S
E
V
M
D
T
Q
A
G
S
V
D
E
Site 9
S101
V
M
D
T
Q
A
G
S
V
D
E
E
N
G
R
Site 10
T128
T
K
W
F
T
A
D
T
F
G
I
D
T
S
S
Site 11
Y157
C
H
H
S
G
N
T
Y
F
L
R
K
Q
A
N
Site 12
T177
L
S
A
L
A
N
L
T
W
Q
S
R
T
Q
D
Site 13
T189
T
Q
D
E
H
P
K
T
M
F
S
K
D
K
D
Site 14
Y204
I
I
P
F
I
D
K
Y
W
E
C
M
T
T
R
Site 15
T218
R
Q
R
P
G
K
M
T
W
P
N
N
I
V
K
Site 16
S228
N
N
I
V
K
T
M
S
K
E
R
D
V
F
L
Site 17
S244
K
E
H
P
D
P
G
S
K
D
P
E
E
D
Y
Site 18
Y251
S
K
D
P
E
E
D
Y
P
K
F
G
L
L
D
Site 19
S262
G
L
L
D
Q
D
L
S
N
I
G
P
A
Y
D
Site 20
Y268
L
S
N
I
G
P
A
Y
D
N
Q
K
Q
S
S
Site 21
S274
A
Y
D
N
Q
K
Q
S
S
A
V
S
T
S
G
Site 22
S278
Q
K
Q
S
S
A
V
S
T
S
G
N
L
N
G
Site 23
T279
K
Q
S
S
A
V
S
T
S
G
N
L
N
G
G
Site 24
S280
Q
S
S
A
V
S
T
S
G
N
L
N
G
G
I
Site 25
S291
N
G
G
I
A
A
G
S
S
G
K
G
R
G
A
Site 26
S292
G
G
I
A
A
G
S
S
G
K
G
R
G
A
K
Site 27
S316
G
T
T
K
K
A
R
S
D
P
L
F
S
A
Q
Site 28
S321
A
R
S
D
P
L
F
S
A
Q
R
L
P
P
H
Site 29
Y330
Q
R
L
P
P
H
G
Y
P
L
E
H
P
F
N
Site 30
Y341
H
P
F
N
K
D
G
Y
R
Y
I
L
A
E
P
Site 31
Y373
K
P
I
P
G
D
L
Y
R
A
C
L
Y
E
R
Site 32
S395
R
A
P
Q
L
K
I
S
D
D
R
L
T
V
V
Site 33
T400
K
I
S
D
D
R
L
T
V
V
G
E
K
G
Y
Site 34
Y407
T
V
V
G
E
K
G
Y
S
M
V
R
A
S
H
Site 35
S408
V
V
G
E
K
G
Y
S
M
V
R
A
S
H
G
Site 36
S413
G
Y
S
M
V
R
A
S
H
G
V
R
K
G
A
Site 37
Y422
G
V
R
K
G
A
W
Y
F
E
I
T
V
D
E
Site 38
T434
V
D
E
M
P
P
D
T
A
A
R
L
G
W
S
Site 39
Y453
N
L
Q
A
P
L
G
Y
D
K
F
S
Y
S
W
Site 40
S457
P
L
G
Y
D
K
F
S
Y
S
W
R
S
K
K
Site 41
Y458
L
G
Y
D
K
F
S
Y
S
W
R
S
K
K
G
Site 42
S459
G
Y
D
K
F
S
Y
S
W
R
S
K
K
G
T
Site 43
T466
S
W
R
S
K
K
G
T
K
F
H
Q
S
I
G
Site 44
S471
K
G
T
K
F
H
Q
S
I
G
K
H
Y
S
S
Site 45
S477
Q
S
I
G
K
H
Y
S
S
G
Y
G
Q
G
D
Site 46
S478
S
I
G
K
H
Y
S
S
G
Y
G
Q
G
D
V
Site 47
Y489
Q
G
D
V
L
G
F
Y
I
N
L
P
E
D
T
Site 48
T498
N
L
P
E
D
T
E
T
A
K
S
L
P
D
T
Site 49
S501
E
D
T
E
T
A
K
S
L
P
D
T
Y
K
D
Site 50
T505
T
A
K
S
L
P
D
T
Y
K
D
K
A
L
I
Site 51
Y506
A
K
S
L
P
D
T
Y
K
D
K
A
L
I
K
Site 52
S516
K
A
L
I
K
F
K
S
Y
L
Y
F
E
E
K
Site 53
Y517
A
L
I
K
F
K
S
Y
L
Y
F
E
E
K
D
Site 54
Y519
I
K
F
K
S
Y
L
Y
F
E
E
K
D
F
V
Site 55
S532
F
V
D
K
A
E
K
S
L
K
Q
T
P
H
S
Site 56
T536
A
E
K
S
L
K
Q
T
P
H
S
E
I
I
F
Site 57
S539
S
L
K
Q
T
P
H
S
E
I
I
F
Y
K
N
Site 58
Y544
P
H
S
E
I
I
F
Y
K
N
G
V
N
Q
G
Site 59
Y584
N
F
G
P
C
F
K
Y
P
P
K
D
L
T
Y
Site 60
T590
K
Y
P
P
K
D
L
T
Y
R
P
M
S
D
M
Site 61
Y591
Y
P
P
K
D
L
T
Y
R
P
M
S
D
M
G
Site 62
S595
D
L
T
Y
R
P
M
S
D
M
G
W
G
A
V
Site 63
Y612
H
T
L
A
D
V
L
Y
H
V
E
T
E
V
D
Site 64
S623
T
E
V
D
G
R
R
S
P
P
W
E
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation