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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRPC4
Full Name:
Short transient receptor potential channel 4
Alias:
HTrp4; HTrp-4; Transient receptor potential cation channel, subfamily C, member 4; TRP4; Trp-related protein 4
Type:
Channel protein, calcium
Mass (Da):
112101
Number AA:
977
UniProt ID:
Q9UBN4
International Prot ID:
IPI00002689
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030863
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
GO:0015279
PhosphoSite+
KinaseNET
Biological Process:
GO:0006816
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
K
R
N
V
N
A
P
Y
R
D
R
I
P
L
R
Site 2
S27
L
R
I
V
R
A
E
S
E
L
S
P
S
E
K
Site 3
S30
V
R
A
E
S
E
L
S
P
S
E
K
A
Y
L
Site 4
S32
A
E
S
E
L
S
P
S
E
K
A
Y
L
N
A
Site 5
Y36
L
S
P
S
E
K
A
Y
L
N
A
V
E
K
G
Site 6
Y45
N
A
V
E
K
G
D
Y
A
S
V
K
K
S
L
Site 7
S47
V
E
K
G
D
Y
A
S
V
K
K
S
L
E
E
Site 8
S51
D
Y
A
S
V
K
K
S
L
E
E
A
E
I
Y
Site 9
Y58
S
L
E
E
A
E
I
Y
F
K
I
N
I
N
C
Site 10
T140
D
K
Q
F
S
E
F
T
P
D
I
T
P
I
I
Site 11
S184
N
C
V
E
C
V
S
S
S
D
V
D
S
L
R
Site 12
S185
C
V
E
C
V
S
S
S
D
V
D
S
L
R
H
Site 13
S189
V
S
S
S
D
V
D
S
L
R
H
S
R
S
R
Site 14
S193
D
V
D
S
L
R
H
S
R
S
R
L
N
I
Y
Site 15
S195
D
S
L
R
H
S
R
S
R
L
N
I
Y
K
A
Site 16
Y200
S
R
S
R
L
N
I
Y
K
A
L
A
S
P
S
Site 17
T219
S
S
E
D
P
F
L
T
A
F
Q
L
S
W
E
Site 18
S231
S
W
E
L
Q
E
L
S
K
V
E
N
E
F
K
Site 19
S239
K
V
E
N
E
F
K
S
E
Y
E
E
L
S
R
Site 20
Y241
E
N
E
F
K
S
E
Y
E
E
L
S
R
Q
C
Site 21
S245
K
S
E
Y
E
E
L
S
R
Q
C
K
Q
F
A
Site 22
T259
A
K
D
L
L
D
Q
T
R
S
S
R
E
L
E
Site 23
S261
D
L
L
D
Q
T
R
S
S
R
E
L
E
I
I
Site 24
S262
L
L
D
Q
T
R
S
S
R
E
L
E
I
I
L
Site 25
S276
L
N
Y
R
D
D
N
S
L
I
E
E
Q
S
G
Site 26
S282
N
S
L
I
E
E
Q
S
G
N
D
L
A
R
L
Site 27
Y315
Q
L
L
A
S
R
W
Y
D
E
F
P
G
W
R
Site 28
S390
A
S
Q
H
I
D
R
S
D
L
N
R
Q
G
P
Site 29
T400
N
R
Q
G
P
P
P
T
I
V
E
W
M
I
L
Site 30
Y459
K
I
V
A
F
V
K
Y
S
A
L
N
P
R
E
Site 31
T497
L
R
L
I
S
L
F
T
A
N
S
H
L
G
P
Site 32
Y523
I
L
K
F
L
F
I
Y
C
L
V
L
L
A
F
Site 33
Y538
A
N
G
L
N
Q
L
Y
F
Y
Y
E
E
T
K
Site 34
Y540
G
L
N
Q
L
Y
F
Y
Y
E
E
T
K
G
L
Site 35
Y541
L
N
Q
L
Y
F
Y
Y
E
E
T
K
G
L
T
Site 36
S562
E
K
Q
N
N
A
F
S
T
L
F
E
T
L
Q
Site 37
T563
K
Q
N
N
A
F
S
T
L
F
E
T
L
Q
S
Site 38
Y624
I
A
M
M
N
N
S
Y
Q
L
I
A
D
H
A
Site 39
S645
A
R
T
K
L
W
M
S
Y
F
E
E
G
G
T
Site 40
Y646
R
T
K
L
W
M
S
Y
F
E
E
G
G
T
L
Site 41
T652
S
Y
F
E
E
G
G
T
L
P
T
P
F
N
V
Site 42
T655
E
E
G
G
T
L
P
T
P
F
N
V
I
P
S
Site 43
S688
K
M
R
R
K
P
E
S
F
G
T
I
G
R
R
Site 44
T691
R
K
P
E
S
F
G
T
I
G
R
R
A
A
D
Site 45
Y706
N
L
R
R
H
H
Q
Y
Q
E
V
M
R
N
L
Site 46
Y717
M
R
N
L
V
K
R
Y
V
A
A
M
I
R
D
Site 47
T727
A
M
I
R
D
A
K
T
E
E
G
L
T
E
E
Site 48
T732
A
K
T
E
E
G
L
T
E
E
N
F
K
E
L
Site 49
S744
K
E
L
K
Q
D
I
S
S
F
R
F
E
V
L
Site 50
S745
E
L
K
Q
D
I
S
S
F
R
F
E
V
L
G
Site 51
S760
L
L
R
G
S
K
L
S
T
I
Q
S
A
N
A
Site 52
T761
L
R
G
S
K
L
S
T
I
Q
S
A
N
A
S
Site 53
S764
S
K
L
S
T
I
Q
S
A
N
A
S
K
E
S
Site 54
S768
T
I
Q
S
A
N
A
S
K
E
S
S
N
S
A
Site 55
S772
A
N
A
S
K
E
S
S
N
S
A
D
S
D
E
Site 56
S774
A
S
K
E
S
S
N
S
A
D
S
D
E
K
S
Site 57
S777
E
S
S
N
S
A
D
S
D
E
K
S
D
S
E
Site 58
S781
S
A
D
S
D
E
K
S
D
S
E
G
N
S
K
Site 59
S783
D
S
D
E
K
S
D
S
E
G
N
S
K
D
K
Site 60
S787
K
S
D
S
E
G
N
S
K
D
K
K
K
N
F
Site 61
S795
K
D
K
K
K
N
F
S
L
F
D
L
T
T
L
Site 62
S807
T
T
L
I
H
P
R
S
A
A
I
A
S
E
R
Site 63
S812
P
R
S
A
A
I
A
S
E
R
H
N
I
S
N
Site 64
S818
A
S
E
R
H
N
I
S
N
G
S
A
L
V
V
Site 65
S852
F
G
L
F
H
R
R
S
K
Q
N
A
A
E
Q
Site 66
S868
A
N
Q
I
F
S
V
S
E
E
V
A
R
Q
Q
Site 67
S893
L
E
S
R
G
L
A
S
R
G
D
L
S
I
P
Site 68
S898
L
A
S
R
G
D
L
S
I
P
G
L
S
E
Q
Site 69
T916
V
D
H
R
E
R
N
T
D
T
L
G
L
Q
V
Site 70
T918
H
R
E
R
N
T
D
T
L
G
L
Q
V
G
K
Site 71
S932
K
R
V
C
P
F
K
S
E
K
V
V
V
E
D
Site 72
T940
E
K
V
V
V
E
D
T
V
P
I
I
P
K
E
Site 73
S955
K
H
A
K
E
E
D
S
S
I
D
Y
D
L
N
Site 74
S956
H
A
K
E
E
D
S
S
I
D
Y
D
L
N
L
Site 75
Y959
E
E
D
S
S
I
D
Y
D
L
N
L
P
D
T
Site 76
T966
Y
D
L
N
L
P
D
T
V
T
H
E
D
Y
V
Site 77
T968
L
N
L
P
D
T
V
T
H
E
D
Y
V
T
T
Site 78
Y972
D
T
V
T
H
E
D
Y
V
T
T
R
L
_
_
Site 79
T974
V
T
H
E
D
Y
V
T
T
R
L
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation