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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HDAC6
Full Name:
Histone deacetylase 6
Alias:
FLJ16239; HD6; HDA6; JM21; KIAA0901
Type:
Deacetylase; EC 3.5.1.98; Ubiquitin conjugating system
Mass (Da):
131419
Number AA:
1215
UniProt ID:
Q9UBN7
International Prot ID:
IPI00005711
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016235
GO:0005901
GO:0031252
Uniprot
OncoNet
Molecular Function:
GO:0051879
GO:0003779
GO:0043014
PhosphoSite+
KinaseNET
Biological Process:
GO:0070846
GO:0070842
GO:0070301
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
T
S
T
G
Q
D
S
T
T
Site 2
S8
M
T
S
T
G
Q
D
S
T
T
T
R
Q
R
R
Site 3
T9
T
S
T
G
Q
D
S
T
T
T
R
Q
R
R
S
Site 4
T10
S
T
G
Q
D
S
T
T
T
R
Q
R
R
S
R
Site 5
S16
T
T
T
R
Q
R
R
S
R
Q
N
P
Q
S
P
Site 6
S22
R
S
R
Q
N
P
Q
S
P
P
Q
D
S
S
V
Site 7
S27
P
Q
S
P
P
Q
D
S
S
V
T
S
K
R
N
Site 8
S28
Q
S
P
P
Q
D
S
S
V
T
S
K
R
N
I
Site 9
T30
P
P
Q
D
S
S
V
T
S
K
R
N
I
K
K
Site 10
S31
P
Q
D
S
S
V
T
S
K
R
N
I
K
K
G
Site 11
S43
K
K
G
A
V
P
R
S
I
P
N
L
A
E
V
Site 12
Y158
D
L
M
E
T
T
Q
Y
M
N
E
G
E
L
R
Site 13
T170
E
L
R
V
L
A
D
T
Y
D
S
V
Y
L
H
Site 14
Y171
L
R
V
L
A
D
T
Y
D
S
V
Y
L
H
P
Site 15
S173
V
L
A
D
T
Y
D
S
V
Y
L
H
P
N
S
Site 16
Y175
A
D
T
Y
D
S
V
Y
L
H
P
N
S
Y
S
Site 17
S182
Y
L
H
P
N
S
Y
S
C
A
C
L
A
S
G
Site 18
T263
H
G
Q
G
T
Q
F
T
F
D
Q
D
P
S
V
Site 19
Y272
D
Q
D
P
S
V
L
Y
F
S
I
H
R
Y
E
Site 20
S274
D
P
S
V
L
Y
F
S
I
H
R
Y
E
Q
G
Site 21
Y278
L
Y
F
S
I
H
R
Y
E
Q
G
R
F
W
P
Site 22
S293
H
L
K
A
S
N
W
S
T
T
G
F
G
Q
G
Site 23
T294
L
K
A
S
N
W
S
T
T
G
F
G
Q
G
Q
Site 24
Y303
G
F
G
Q
G
Q
G
Y
T
I
N
V
P
W
N
Site 25
T359
P
K
G
E
M
A
A
T
P
A
G
F
A
Q
L
Site 26
S412
D
P
C
P
M
L
E
S
P
G
A
P
C
R
S
Site 27
S419
S
P
G
A
P
C
R
S
A
Q
A
S
V
S
C
Site 28
T442
W
E
V
L
V
R
S
T
E
T
V
E
R
D
N
Site 29
S458
E
E
D
N
V
E
E
S
E
E
E
G
P
W
E
Site 30
Y485
Q
S
R
T
G
L
V
Y
D
Q
N
M
M
N
H
Site 31
T527
A
G
R
C
L
T
L
T
P
R
P
A
T
E
A
Site 32
T532
T
L
T
P
R
P
A
T
E
A
E
L
L
T
C
Site 33
Y544
L
T
C
H
S
A
E
Y
V
G
H
L
R
A
T
Site 34
T551
Y
V
G
H
L
R
A
T
E
K
M
K
T
R
E
Site 35
T556
R
A
T
E
K
M
K
T
R
E
L
H
R
E
S
Site 36
S563
T
R
E
L
H
R
E
S
S
N
F
D
S
I
Y
Site 37
S564
R
E
L
H
R
E
S
S
N
F
D
S
I
Y
I
Site 38
S568
R
E
S
S
N
F
D
S
I
Y
I
C
P
S
T
Site 39
Y570
S
S
N
F
D
S
I
Y
I
C
P
S
T
F
A
Site 40
S665
H
M
F
E
D
D
P
S
V
L
Y
V
S
L
H
Site 41
Y668
E
D
D
P
S
V
L
Y
V
S
L
H
R
Y
D
Site 42
S670
D
P
S
V
L
Y
V
S
L
H
R
Y
D
H
G
Site 43
Y674
L
Y
V
S
L
H
R
Y
D
H
G
T
F
F
P
Site 44
S689
M
G
D
E
G
A
S
S
Q
I
G
R
A
A
G
Site 45
Y715
P
R
M
G
D
A
D
Y
L
A
A
W
H
R
L
Site 46
S755
P
L
G
G
C
Q
V
S
P
E
G
Y
A
H
L
Site 47
S786
E
G
G
Y
N
L
T
S
I
S
E
S
M
A
A
Site 48
S790
N
L
T
S
I
S
E
S
M
A
A
C
T
R
S
Site 49
S797
S
M
A
A
C
T
R
S
L
L
G
D
P
P
P
Site 50
T807
G
D
P
P
P
L
L
T
L
P
R
P
P
L
S
Site 51
T823
A
L
A
S
I
T
E
T
I
Q
V
H
R
R
Y
Site 52
Y830
T
I
Q
V
H
R
R
Y
W
R
S
L
R
V
M
Site 53
S846
V
E
D
R
E
G
P
S
S
S
K
L
V
T
K
Site 54
S847
E
D
R
E
G
P
S
S
S
K
L
V
T
K
K
Site 55
T852
P
S
S
S
K
L
V
T
K
K
A
P
Q
P
A
Site 56
T868
P
R
L
A
E
R
M
T
T
R
E
K
K
V
L
Site 57
T869
R
L
A
E
R
M
T
T
R
E
K
K
V
L
E
Site 58
S884
A
G
M
G
K
V
T
S
A
S
F
G
E
E
S
Site 59
S886
M
G
K
V
T
S
A
S
F
G
E
E
S
T
P
Site 60
S891
S
A
S
F
G
E
E
S
T
P
G
Q
T
N
S
Site 61
T892
A
S
F
G
E
E
S
T
P
G
Q
T
N
S
E
Site 62
S898
S
T
P
G
Q
T
N
S
E
T
A
V
V
A
L
Site 63
T900
P
G
Q
T
N
S
E
T
A
V
V
A
L
T
Q
Site 64
S911
A
L
T
Q
D
Q
P
S
E
A
A
T
G
G
A
Site 65
T915
D
Q
P
S
E
A
A
T
G
G
A
T
L
A
Q
Site 66
T947
E
E
A
V
G
G
A
T
P
D
Q
T
T
S
E
Site 67
T951
G
G
A
T
P
D
Q
T
T
S
E
E
T
V
G
Site 68
S953
A
T
P
D
Q
T
T
S
E
E
T
V
G
G
A
Site 69
T965
G
G
A
I
L
D
Q
T
T
S
E
D
A
V
G
Site 70
S967
A
I
L
D
Q
T
T
S
E
D
A
V
G
G
A
Site 71
S981
A
T
L
G
Q
T
T
S
E
E
A
V
G
G
A
Site 72
T1007
E
G
A
T
L
D
Q
T
T
S
E
E
A
P
G
Site 73
S1009
A
T
L
D
Q
T
T
S
E
E
A
P
G
G
T
Site 74
T1021
G
G
T
E
L
I
Q
T
P
L
A
S
S
T
D
Site 75
T1031
A
S
S
T
D
H
Q
T
P
P
T
S
P
V
Q
Site 76
S1035
D
H
Q
T
P
P
T
S
P
V
Q
G
T
T
P
Site 77
T1041
T
S
P
V
Q
G
T
T
P
Q
I
S
P
S
T
Site 78
S1045
Q
G
T
T
P
Q
I
S
P
S
T
L
I
G
S
Site 79
S1047
T
T
P
Q
I
S
P
S
T
L
I
G
S
L
R
Site 80
T1048
T
P
Q
I
S
P
S
T
L
I
G
S
L
R
T
Site 81
S1062
T
L
E
L
G
S
E
S
Q
G
A
S
E
S
Q
Site 82
S1066
G
S
E
S
Q
G
A
S
E
S
Q
A
P
G
E
Site 83
S1068
E
S
Q
G
A
S
E
S
Q
A
P
G
E
E
N
Site 84
S1089
G
G
Q
D
M
A
D
S
M
L
M
Q
G
S
R
Site 85
T1099
M
Q
G
S
R
G
L
T
D
Q
A
I
F
Y
A
Site 86
Y1156
Y
Q
V
Y
C
G
R
Y
I
N
G
H
M
L
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation