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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPAST
Full Name:
Spastin
Alias:
ADPSP; FSP2; KIAA1083; SPG4
Type:
Cytoskeletal protein
Mass (Da):
67197
Number AA:
616
UniProt ID:
Q9UBP0
International Prot ID:
IPI00002707
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005783
GO:0005768
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0043014
GO:0048487
PhosphoSite+
KinaseNET
Biological Process:
GO:0006888
GO:0007049
GO:0008219
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
G
R
G
K
K
K
G
S
G
G
A
S
N
P
V
Site 2
S17
K
K
G
S
G
G
A
S
N
P
V
P
P
R
P
Site 3
S44
G
P
A
P
P
P
E
S
P
H
K
R
N
L
Y
Site 4
Y51
S
P
H
K
R
N
L
Y
Y
F
S
Y
P
L
F
Site 5
Y52
P
H
K
R
N
L
Y
Y
F
S
Y
P
L
F
V
Site 6
S93
L
M
A
A
K
R
S
S
G
A
A
P
A
P
A
Site 7
S101
G
A
A
P
A
P
A
S
A
S
A
P
A
P
V
Site 8
S103
A
P
A
P
A
S
A
S
A
P
A
P
V
P
G
Site 9
S128
K
Q
A
F
E
Y
I
S
I
A
L
R
I
D
E
Site 10
T165
K
G
I
A
V
I
V
T
G
Q
G
E
Q
C
E
Site 11
S205
M
Q
P
V
L
P
F
S
K
S
Q
T
D
V
Y
Site 12
S207
P
V
L
P
F
S
K
S
Q
T
D
V
Y
N
D
Site 13
T209
L
P
F
S
K
S
Q
T
D
V
Y
N
D
S
T
Site 14
Y212
S
K
S
Q
T
D
V
Y
N
D
S
T
N
L
A
Site 15
S227
C
R
N
G
H
L
Q
S
E
S
G
A
V
P
K
Site 16
T240
P
K
R
K
D
P
L
T
H
T
S
N
S
L
P
Site 17
T242
R
K
D
P
L
T
H
T
S
N
S
L
P
R
S
Site 18
S243
K
D
P
L
T
H
T
S
N
S
L
P
R
S
K
Site 19
S245
P
L
T
H
T
S
N
S
L
P
R
S
K
T
V
Site 20
S249
T
S
N
S
L
P
R
S
K
T
V
M
K
T
G
Site 21
T251
N
S
L
P
R
S
K
T
V
M
K
T
G
S
A
Site 22
T255
R
S
K
T
V
M
K
T
G
S
A
G
L
S
G
Site 23
S257
K
T
V
M
K
T
G
S
A
G
L
S
G
H
H
Site 24
S261
K
T
G
S
A
G
L
S
G
H
H
R
A
P
S
Site 25
S268
S
G
H
H
R
A
P
S
Y
S
G
L
S
M
V
Site 26
Y269
G
H
H
R
A
P
S
Y
S
G
L
S
M
V
S
Site 27
S270
H
H
R
A
P
S
Y
S
G
L
S
M
V
S
G
Site 28
S273
A
P
S
Y
S
G
L
S
M
V
S
G
V
K
Q
Site 29
S276
Y
S
G
L
S
M
V
S
G
V
K
Q
G
S
G
Site 30
S282
V
S
G
V
K
Q
G
S
G
P
A
P
T
T
H
Site 31
T288
G
S
G
P
A
P
T
T
H
K
G
T
P
K
T
Site 32
T292
A
P
T
T
H
K
G
T
P
K
T
N
R
T
N
Site 33
T295
T
H
K
G
T
P
K
T
N
R
T
N
K
P
S
Site 34
T298
G
T
P
K
T
N
R
T
N
K
P
S
T
P
T
Site 35
S302
T
N
R
T
N
K
P
S
T
P
T
T
A
T
R
Site 36
T303
N
R
T
N
K
P
S
T
P
T
T
A
T
R
K
Site 37
T305
T
N
K
P
S
T
P
T
T
A
T
R
K
K
K
Site 38
T306
N
K
P
S
T
P
T
T
A
T
R
K
K
K
D
Site 39
T369
S
L
R
P
E
L
F
T
G
L
R
A
P
A
R
Site 40
Y415
A
A
S
L
T
S
K
Y
V
G
E
G
E
K
L
Site 41
S445
I
F
I
D
E
V
D
S
L
L
C
E
R
R
E
Site 42
S458
R
E
G
E
H
D
A
S
R
R
L
K
T
E
F
Site 43
T463
D
A
S
R
R
L
K
T
E
F
L
I
E
F
D
Site 44
T486
R
V
L
V
M
G
A
T
N
R
P
Q
E
L
D
Site 45
Y505
R
R
F
I
K
R
V
Y
V
S
L
P
N
E
E
Site 46
S527
N
L
L
C
K
Q
G
S
P
L
T
Q
K
E
L
Site 47
T541
L
A
Q
L
A
R
M
T
D
G
Y
S
G
S
D
Site 48
Y544
L
A
R
M
T
D
G
Y
S
G
S
D
L
T
A
Site 49
S545
A
R
M
T
D
G
Y
S
G
S
D
L
T
A
L
Site 50
S547
M
T
D
G
Y
S
G
S
D
L
T
A
L
A
K
Site 51
T550
G
Y
S
G
S
D
L
T
A
L
A
K
D
A
A
Site 52
S575
Q
V
K
N
M
S
A
S
E
M
R
N
I
R
L
Site 53
S583
E
M
R
N
I
R
L
S
D
F
T
E
S
L
K
Site 54
T586
N
I
R
L
S
D
F
T
E
S
L
K
K
I
K
Site 55
S588
R
L
S
D
F
T
E
S
L
K
K
I
K
R
S
Site 56
S595
S
L
K
K
I
K
R
S
V
S
P
Q
T
L
E
Site 57
S597
K
K
I
K
R
S
V
S
P
Q
T
L
E
A
Y
Site 58
T600
K
R
S
V
S
P
Q
T
L
E
A
Y
I
R
W
Site 59
Y604
S
P
Q
T
L
E
A
Y
I
R
W
N
K
D
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation