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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UBA2
Full Name:
SUMO-activating enzyme subunit 2
Alias:
ANTHRACYCLINE-associated resistance ARX; ARX; FLJ13058; HRIHFB2115; SAE2; SUMO-1 activating enzyme subunit 2; UBA2, ubiquitin-activating enzyme E1; Ubiquitin-like modifier activating enzyme 2; UBLE1B; ULE1B
Type:
Ligase; EC 6.3.2.-; Ubiquitin ligase
Mass (Da):
71224
Number AA:
640
UniProt ID:
Q9UBT2
International Prot ID:
IPI00023234
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008047
GO:0016874
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0006464
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S55
D
L
D
T
I
D
V
S
N
L
N
R
Q
F
L
Site 2
Y84
K
E
S
V
L
Q
F
Y
P
K
A
N
I
V
A
Site 3
Y92
P
K
A
N
I
V
A
Y
H
D
S
I
M
N
P
Site 4
Y101
D
S
I
M
N
P
D
Y
N
V
E
F
F
R
Q
Site 5
Y159
K
K
G
V
T
E
C
Y
E
C
H
P
K
P
T
Site 6
T166
Y
E
C
H
P
K
P
T
Q
R
T
F
P
G
C
Site 7
T169
H
P
K
P
T
Q
R
T
F
P
G
C
T
I
R
Site 8
T174
Q
R
T
F
P
G
C
T
I
R
N
T
P
S
E
Site 9
T178
P
G
C
T
I
R
N
T
P
S
E
P
I
H
C
Site 10
S207
E
D
A
D
Q
E
V
S
P
D
R
A
D
P
E
Site 11
S229
A
E
A
R
A
R
A
S
N
E
D
G
D
I
K
Site 12
S239
D
G
D
I
K
R
I
S
T
K
E
W
A
K
S
Site 13
T240
G
D
I
K
R
I
S
T
K
E
W
A
K
S
T
Site 14
S246
S
T
K
E
W
A
K
S
T
G
Y
D
P
V
K
Site 15
Y249
E
W
A
K
S
T
G
Y
D
P
V
K
L
F
T
Site 16
Y265
L
F
K
D
D
I
R
Y
L
L
T
M
D
K
L
Site 17
T268
D
D
I
R
Y
L
L
T
M
D
K
L
W
R
K
Site 18
S289
L
D
W
A
E
V
Q
S
Q
G
E
E
T
N
A
Site 19
S297
Q
G
E
E
T
N
A
S
D
Q
Q
N
E
P
Q
Site 20
S317
Q
Q
V
L
D
V
K
S
Y
A
R
L
F
S
K
Site 21
Y318
Q
V
L
D
V
K
S
Y
A
R
L
F
S
K
S
Site 22
S323
K
S
Y
A
R
L
F
S
K
S
I
E
T
L
R
Site 23
S325
Y
A
R
L
F
S
K
S
I
E
T
L
R
V
H
Site 24
T328
L
F
S
K
S
I
E
T
L
R
V
H
L
A
E
Site 25
S378
K
S
R
F
D
I
K
S
M
A
G
N
I
I
P
Site 26
S407
L
E
G
L
K
I
L
S
G
K
I
D
Q
C
R
Site 27
Y442
D
P
P
N
P
N
C
Y
V
C
A
S
K
P
E
Site 28
T451
C
A
S
K
P
E
V
T
V
R
L
N
V
H
K
Site 29
T460
R
L
N
V
H
K
V
T
V
L
T
L
Q
D
K
Site 30
S492
G
K
G
T
I
L
I
S
S
E
E
G
E
T
E
Site 31
S493
K
G
T
I
L
I
S
S
E
E
G
E
T
E
A
Site 32
T498
I
S
S
E
E
G
E
T
E
A
N
N
H
K
K
Site 33
S507
A
N
N
H
K
K
L
S
E
F
G
I
R
N
G
Site 34
S515
E
F
G
I
R
N
G
S
R
L
Q
A
D
D
F
Site 35
S565
Q
A
E
D
A
A
K
S
I
T
N
G
S
D
D
Site 36
S570
A
K
S
I
T
N
G
S
D
D
G
A
Q
P
S
Site 37
S577
S
D
D
G
A
Q
P
S
T
S
T
A
Q
E
Q
Site 38
T578
D
D
G
A
Q
P
S
T
S
T
A
Q
E
Q
D
Site 39
S592
D
D
V
L
I
V
D
S
D
E
E
D
S
S
N
Site 40
S598
D
S
D
E
E
D
S
S
N
N
A
D
V
S
E
Site 41
S604
S
S
N
N
A
D
V
S
E
E
E
R
S
R
K
Site 42
S609
D
V
S
E
E
E
R
S
R
K
R
K
L
D
E
Site 43
S621
L
D
E
K
E
N
L
S
A
K
R
S
R
I
E
Site 44
S625
E
N
L
S
A
K
R
S
R
I
E
Q
K
E
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation