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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLK
Full Name:
DNA polymerase kappa
Alias:
DINB; DINB1; DINP; EC 2.7.7.7; POLQ; Polymerase (DNA directed) kappa; Polymerase (DNA-directed) kappa
Type:
DNA replication
Mass (Da):
98809
Number AA:
870
UniProt ID:
Q9UBT6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003887
GO:0003684
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
GO:0006260
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
S
T
K
E
K
C
D
S
Y
K
D
D
L
L
L
Site 2
Y11
T
K
E
K
C
D
S
Y
K
D
D
L
L
L
R
Site 3
T44
N
K
I
I
M
E
A
T
K
G
S
R
F
Y
G
Site 4
Y50
A
T
K
G
S
R
F
Y
G
N
E
L
K
K
E
Site 5
S96
F
A
M
E
L
E
Q
S
R
N
L
S
N
T
I
Site 6
S100
L
E
Q
S
R
N
L
S
N
T
I
V
H
I
D
Site 7
T102
Q
S
R
N
L
S
N
T
I
V
H
I
D
M
D
Site 8
Y112
H
I
D
M
D
A
F
Y
A
A
V
E
M
R
D
Site 9
S137
V
G
S
M
S
M
L
S
T
S
N
Y
H
A
R
Site 10
T138
G
S
M
S
M
L
S
T
S
N
Y
H
A
R
R
Site 11
Y141
S
M
L
S
T
S
N
Y
H
A
R
R
F
G
V
Site 12
Y174
V
P
P
N
F
D
K
Y
R
A
V
S
K
E
V
Site 13
S178
F
D
K
Y
R
A
V
S
K
E
V
K
E
I
L
Site 14
Y201
A
M
S
L
D
E
A
Y
L
N
I
T
K
H
L
Site 15
Y221
W
P
E
D
K
R
R
Y
F
I
K
M
G
S
S
Site 16
S228
Y
F
I
K
M
G
S
S
V
E
N
D
N
P
G
Site 17
S242
G
K
E
V
N
K
L
S
E
H
E
R
S
I
S
Site 18
S247
K
L
S
E
H
E
R
S
I
S
P
L
L
F
E
Site 19
S249
S
E
H
E
R
S
I
S
P
L
L
F
E
E
S
Site 20
S256
S
P
L
L
F
E
E
S
P
S
D
V
Q
P
P
Site 21
S258
L
L
F
E
E
S
P
S
D
V
Q
P
P
G
D
Site 22
T305
R
F
R
I
E
Q
K
T
T
L
T
A
S
A
G
Site 23
T306
F
R
I
E
Q
K
T
T
L
T
A
S
A
G
I
Site 24
S324
T
M
L
A
K
V
C
S
D
K
N
K
P
N
G
Site 25
S355
D
L
P
I
R
K
V
S
G
I
G
K
V
T
E
Site 26
T372
L
K
A
L
G
I
I
T
C
T
E
L
Y
Q
Q
Site 27
S384
Y
Q
Q
R
A
L
L
S
L
L
F
S
E
T
S
Site 28
Y394
F
S
E
T
S
W
H
Y
F
L
H
I
S
L
G
Site 29
T408
G
L
G
S
T
H
L
T
R
D
G
E
R
K
S
Site 30
S415
T
R
D
G
E
R
K
S
M
S
V
E
R
T
F
Site 31
S417
D
G
E
R
K
S
M
S
V
E
R
T
F
S
E
Site 32
T421
K
S
M
S
V
E
R
T
F
S
E
I
N
K
A
Site 33
S423
M
S
V
E
R
T
F
S
E
I
N
K
A
E
E
Site 34
S433
N
K
A
E
E
Q
Y
S
L
C
Q
E
L
C
S
Site 35
T455
K
E
R
L
K
G
R
T
V
T
I
K
L
K
N
Site 36
T457
R
L
K
G
R
T
V
T
I
K
L
K
N
V
N
Site 37
T469
N
V
N
F
E
V
K
T
R
A
S
T
V
S
S
Site 38
S472
F
E
V
K
T
R
A
S
T
V
S
S
V
V
S
Site 39
T473
E
V
K
T
R
A
S
T
V
S
S
V
V
S
T
Site 40
S475
K
T
R
A
S
T
V
S
S
V
V
S
T
A
E
Site 41
S476
T
R
A
S
T
V
S
S
V
V
S
T
A
E
E
Site 42
S479
S
T
V
S
S
V
V
S
T
A
E
E
I
F
A
Site 43
T494
I
A
K
E
L
L
K
T
E
I
D
A
D
F
P
Site 44
S514
R
L
M
G
V
R
I
S
S
F
P
N
E
E
D
Site 45
S515
L
M
G
V
R
I
S
S
F
P
N
E
E
D
R
Site 46
S528
D
R
K
H
Q
Q
R
S
I
I
G
F
L
Q
A
Site 47
S541
Q
A
G
N
Q
A
L
S
A
T
E
C
T
L
E
Site 48
S562
F
V
K
P
L
E
M
S
H
K
K
S
F
F
D
Site 49
S566
L
E
M
S
H
K
K
S
F
F
D
K
K
R
S
Site 50
S573
S
F
F
D
K
K
R
S
E
R
K
W
S
H
Q
Site 51
S578
K
R
S
E
R
K
W
S
H
Q
D
T
F
K
C
Site 52
S592
C
E
A
V
N
K
Q
S
F
Q
T
S
Q
P
F
Site 53
S596
N
K
Q
S
F
Q
T
S
Q
P
F
Q
V
L
K
Site 54
S613
M
N
E
N
L
E
I
S
E
N
S
D
D
C
Q
Site 55
S635
F
R
A
Q
G
C
I
S
L
E
A
L
N
K
H
Site 56
S653
C
L
D
G
P
S
I
S
E
N
F
K
M
F
S
Site 57
S660
S
E
N
F
K
M
F
S
C
S
H
V
S
A
T
Site 58
S678
K
K
E
N
V
P
A
S
S
L
C
E
K
Q
D
Site 59
S679
K
E
N
V
P
A
S
S
L
C
E
K
Q
D
Y
Site 60
Y686
S
L
C
E
K
Q
D
Y
E
A
H
P
K
I
K
Site 61
S710
L
V
D
T
I
D
N
S
S
K
A
E
S
I
D
Site 62
S711
V
D
T
I
D
N
S
S
K
A
E
S
I
D
A
Site 63
S715
D
N
S
S
K
A
E
S
I
D
A
L
S
N
K
Site 64
S720
A
E
S
I
D
A
L
S
N
K
H
S
K
E
E
Site 65
S724
D
A
L
S
N
K
H
S
K
E
E
C
S
S
L
Site 66
S729
K
H
S
K
E
E
C
S
S
L
P
S
K
S
F
Site 67
S730
H
S
K
E
E
C
S
S
L
P
S
K
S
F
N
Site 68
S733
E
E
C
S
S
L
P
S
K
S
F
N
I
E
H
Site 69
S735
C
S
S
L
P
S
K
S
F
N
I
E
H
C
H
Site 70
S745
I
E
H
C
H
Q
N
S
S
S
T
V
S
L
E
Site 71
S746
E
H
C
H
Q
N
S
S
S
T
V
S
L
E
N
Site 72
S747
H
C
H
Q
N
S
S
S
T
V
S
L
E
N
E
Site 73
S750
Q
N
S
S
S
T
V
S
L
E
N
E
D
V
G
Site 74
S758
L
E
N
E
D
V
G
S
F
R
Q
E
Y
R
Q
Site 75
Y763
V
G
S
F
R
Q
E
Y
R
Q
P
Y
L
C
E
Site 76
Y767
R
Q
E
Y
R
Q
P
Y
L
C
E
V
K
T
G
Site 77
S789
C
N
V
E
Q
K
T
S
D
L
T
L
F
N
V
Site 78
T792
E
Q
K
T
S
D
L
T
L
F
N
V
H
V
D
Site 79
S805
V
D
V
C
L
N
K
S
F
I
Q
E
L
R
K
Site 80
S824
P
V
N
Q
P
K
E
S
S
R
S
T
G
S
S
Site 81
S825
V
N
Q
P
K
E
S
S
R
S
T
G
S
S
S
Site 82
S827
Q
P
K
E
S
S
R
S
T
G
S
S
S
G
V
Site 83
T828
P
K
E
S
S
R
S
T
G
S
S
S
G
V
Q
Site 84
S830
E
S
S
R
S
T
G
S
S
S
G
V
Q
K
A
Site 85
S831
S
S
R
S
T
G
S
S
S
G
V
Q
K
A
V
Site 86
S832
S
R
S
T
G
S
S
S
G
V
Q
K
A
V
T
Site 87
T839
S
G
V
Q
K
A
V
T
R
T
K
R
P
G
L
Site 88
T841
V
Q
K
A
V
T
R
T
K
R
P
G
L
M
T
Site 89
T848
T
K
R
P
G
L
M
T
K
Y
S
T
S
K
K
Site 90
Y850
R
P
G
L
M
T
K
Y
S
T
S
K
K
I
K
Site 91
S851
P
G
L
M
T
K
Y
S
T
S
K
K
I
K
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation