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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BIN2
Full Name:
Bridging integrator 2
Alias:
BRAP-1; Breast cancer associated protein BRAP1; Breast cancer-associated protein 1
Type:
Adaptor/scaffold
Mass (Da):
61874
Number AA:
565
UniProt ID:
Q9UBW5
International Prot ID:
IPI00550792
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S48
E
R
F
E
Q
S
A
S
N
F
Y
Q
Q
Q
A
Site 2
S69
K
D
L
K
N
F
L
S
A
V
K
V
M
H
E
Site 3
S77
A
V
K
V
M
H
E
S
S
K
R
V
S
E
T
Site 4
S78
V
K
V
M
H
E
S
S
K
R
V
S
E
T
L
Site 5
S82
H
E
S
S
K
R
V
S
E
T
L
Q
E
I
Y
Site 6
T84
S
S
K
R
V
S
E
T
L
Q
E
I
Y
S
S
Site 7
S90
E
T
L
Q
E
I
Y
S
S
E
W
D
G
H
E
Site 8
S91
T
L
Q
E
I
Y
S
S
E
W
D
G
H
E
E
Site 9
Y113
N
D
L
L
W
E
D
Y
E
E
K
L
A
D
Q
Site 10
T124
L
A
D
Q
A
V
R
T
M
E
I
Y
V
A
Q
Site 11
S133
E
I
Y
V
A
Q
F
S
E
I
K
E
R
I
A
Site 12
Y149
R
G
R
K
L
V
D
Y
D
S
A
R
H
H
L
Site 13
S151
R
K
L
V
D
Y
D
S
A
R
H
H
L
E
A
Site 14
T182
E
E
F
N
K
A
Q
T
V
F
E
D
L
N
Q
Site 15
Y221
S
N
L
R
D
V
F
Y
R
E
M
S
K
L
N
Site 16
Y232
S
K
L
N
H
N
L
Y
E
V
M
S
K
L
E
Site 17
S236
H
N
L
Y
E
V
M
S
K
L
E
K
Q
H
S
Site 18
S243
S
K
L
E
K
Q
H
S
N
K
V
F
V
V
K
Site 19
S256
V
K
G
L
S
S
S
S
R
R
S
L
V
I
S
Site 20
S259
L
S
S
S
S
R
R
S
L
V
I
S
P
P
V
Site 21
S263
S
R
R
S
L
V
I
S
P
P
V
R
T
A
T
Site 22
T268
V
I
S
P
P
V
R
T
A
T
V
S
S
P
L
Site 23
T270
S
P
P
V
R
T
A
T
V
S
S
P
L
T
S
Site 24
S272
P
V
R
T
A
T
V
S
S
P
L
T
S
P
T
Site 25
S273
V
R
T
A
T
V
S
S
P
L
T
S
P
T
S
Site 26
T276
A
T
V
S
S
P
L
T
S
P
T
S
P
S
T
Site 27
S277
T
V
S
S
P
L
T
S
P
T
S
P
S
T
L
Site 28
T279
S
S
P
L
T
S
P
T
S
P
S
T
L
S
L
Site 29
S280
S
P
L
T
S
P
T
S
P
S
T
L
S
L
K
Site 30
S282
L
T
S
P
T
S
P
S
T
L
S
L
K
S
E
Site 31
T283
T
S
P
T
S
P
S
T
L
S
L
K
S
E
S
Site 32
S285
P
T
S
P
S
T
L
S
L
K
S
E
S
E
S
Site 33
S288
P
S
T
L
S
L
K
S
E
S
E
S
V
S
A
Site 34
S290
T
L
S
L
K
S
E
S
E
S
V
S
A
T
E
Site 35
S292
S
L
K
S
E
S
E
S
V
S
A
T
E
D
L
Site 36
S294
K
S
E
S
E
S
V
S
A
T
E
D
L
A
P
Site 37
T296
E
S
E
S
V
S
A
T
E
D
L
A
P
D
A
Site 38
S310
A
A
Q
G
E
D
N
S
E
I
K
E
L
L
E
Site 39
S326
E
E
I
E
K
E
G
S
E
A
S
S
S
E
E
Site 40
S330
K
E
G
S
E
A
S
S
S
E
E
D
E
P
L
Site 41
S331
E
G
S
E
A
S
S
S
E
E
D
E
P
L
P
Site 42
S349
G
P
A
Q
A
Q
P
S
P
T
T
E
R
A
K
Site 43
T352
Q
A
Q
P
S
P
T
T
E
R
A
K
S
Q
E
Site 44
S357
P
T
T
E
R
A
K
S
Q
E
E
V
L
P
S
Site 45
S364
S
Q
E
E
V
L
P
S
S
T
T
P
S
P
G
Site 46
S365
Q
E
E
V
L
P
S
S
T
T
P
S
P
G
G
Site 47
T366
E
E
V
L
P
S
S
T
T
P
S
P
G
G
A
Site 48
T367
E
V
L
P
S
S
T
T
P
S
P
G
G
A
L
Site 49
S369
L
P
S
S
T
T
P
S
P
G
G
A
L
S
P
Site 50
S375
P
S
P
G
G
A
L
S
P
S
G
Q
P
S
S
Site 51
S377
P
G
G
A
L
S
P
S
G
Q
P
S
S
S
A
Site 52
S381
L
S
P
S
G
Q
P
S
S
S
A
T
E
V
V
Site 53
S382
S
P
S
G
Q
P
S
S
S
A
T
E
V
V
L
Site 54
S383
P
S
G
Q
P
S
S
S
A
T
E
V
V
L
R
Site 55
T385
G
Q
P
S
S
S
A
T
E
V
V
L
R
T
R
Site 56
T393
E
V
V
L
R
T
R
T
A
S
E
G
S
E
Q
Site 57
S395
V
L
R
T
R
T
A
S
E
G
S
E
Q
P
K
Site 58
S398
T
R
T
A
S
E
G
S
E
Q
P
K
K
R
A
Site 59
S406
E
Q
P
K
K
R
A
S
I
Q
R
T
S
A
P
Site 60
T410
K
R
A
S
I
Q
R
T
S
A
P
P
S
R
P
Site 61
S411
R
A
S
I
Q
R
T
S
A
P
P
S
R
P
P
Site 62
S415
Q
R
T
S
A
P
P
S
R
P
P
P
P
R
A
Site 63
T423
R
P
P
P
P
R
A
T
A
S
P
R
P
S
S
Site 64
S425
P
P
P
R
A
T
A
S
P
R
P
S
S
G
N
Site 65
S429
A
T
A
S
P
R
P
S
S
G
N
I
P
S
S
Site 66
S430
T
A
S
P
R
P
S
S
G
N
I
P
S
S
P
Site 67
S435
P
S
S
G
N
I
P
S
S
P
T
A
S
G
G
Site 68
S436
S
S
G
N
I
P
S
S
P
T
A
S
G
G
G
Site 69
T438
G
N
I
P
S
S
P
T
A
S
G
G
G
S
P
Site 70
S440
I
P
S
S
P
T
A
S
G
G
G
S
P
T
S
Site 71
S444
P
T
A
S
G
G
G
S
P
T
S
P
R
A
S
Site 72
T446
A
S
G
G
G
S
P
T
S
P
R
A
S
L
G
Site 73
S447
S
G
G
G
S
P
T
S
P
R
A
S
L
G
T
Site 74
S451
S
P
T
S
P
R
A
S
L
G
T
G
T
A
S
Site 75
T454
S
P
R
A
S
L
G
T
G
T
A
S
P
R
T
Site 76
T456
R
A
S
L
G
T
G
T
A
S
P
R
T
S
L
Site 77
S458
S
L
G
T
G
T
A
S
P
R
T
S
L
E
V
Site 78
T461
T
G
T
A
S
P
R
T
S
L
E
V
S
P
N
Site 79
S462
G
T
A
S
P
R
T
S
L
E
V
S
P
N
P
Site 80
S466
P
R
T
S
L
E
V
S
P
N
P
E
P
P
E
Site 81
T478
P
P
E
K
P
V
R
T
P
E
A
K
E
N
E
Site 82
T497
Q
N
P
E
E
L
C
T
S
P
T
L
M
T
S
Site 83
S498
N
P
E
E
L
C
T
S
P
T
L
M
T
S
Q
Site 84
S504
T
S
P
T
L
M
T
S
Q
V
A
S
E
P
G
Site 85
S508
L
M
T
S
Q
V
A
S
E
P
G
E
A
K
K
Site 86
S527
E
K
D
N
K
L
I
S
A
N
S
S
E
G
Q
Site 87
S530
N
K
L
I
S
A
N
S
S
E
G
Q
D
Q
L
Site 88
S531
K
L
I
S
A
N
S
S
E
G
Q
D
Q
L
Q
Site 89
S540
G
Q
D
Q
L
Q
V
S
M
V
P
E
N
N
N
Site 90
S558
P
E
P
Q
E
E
V
S
T
S
E
N
P
Q
L
Site 91
T559
E
P
Q
E
E
V
S
T
S
E
N
P
Q
L
_
Site 92
S560
P
Q
E
E
V
S
T
S
E
N
P
Q
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation