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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
APEX2
Full Name:
DNA-(apurinic or apyrimidinic site) lyase 2
Alias:
AP endonuclease 2; AP endonuclease XTH2; APE2; APEX nuclease (apurinic/apyrimidinic endonuclease) 2; APEXL2; XTH2
Type:
Lyase; EC 4.2.99.18; Mitochondrial
Mass (Da):
57400
Number AA:
UniProt ID:
Q9UBZ4
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003906
GO:0004519
PhosphoSite+
KinaseNET
Biological Process:
GO:0006281
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y66
P
L
A
I
V
E
G
Y
N
S
Y
F
S
F
S
Site 2
S68
A
I
V
E
G
Y
N
S
Y
F
S
F
S
R
N
Site 3
Y69
I
V
E
G
Y
N
S
Y
F
S
F
S
R
N
R
Site 4
S71
E
G
Y
N
S
Y
F
S
F
S
R
N
R
S
G
Site 5
S73
Y
N
S
Y
F
S
F
S
R
N
R
S
G
Y
S
Site 6
S77
F
S
F
S
R
N
R
S
G
Y
S
G
V
A
T
Site 7
Y79
F
S
R
N
R
S
G
Y
S
G
V
A
T
F
C
Site 8
T84
S
G
Y
S
G
V
A
T
F
C
K
D
N
A
T
Site 9
T91
T
F
C
K
D
N
A
T
P
V
A
A
E
E
G
Site 10
T120
Y
G
N
M
D
E
F
T
Q
E
E
L
R
A
L
Site 11
S129
E
E
L
R
A
L
D
S
E
G
R
A
L
L
T
Site 12
T136
S
E
G
R
A
L
L
T
Q
H
K
I
R
T
W
Site 13
T149
T
W
E
G
K
E
K
T
L
T
L
I
N
V
Y
Site 14
T151
E
G
K
E
K
T
L
T
L
I
N
V
Y
C
P
Site 15
T200
I
I
L
G
D
L
N
T
A
H
R
P
I
D
H
Site 16
S227
P
G
R
K
W
M
D
S
L
L
S
N
L
G
C
Site 17
S230
K
W
M
D
S
L
L
S
N
L
G
C
Q
S
A
Site 18
Y247
V
G
P
F
I
D
S
Y
R
C
F
Q
P
K
Q
Site 19
T259
P
K
Q
E
G
A
F
T
C
W
S
A
V
T
G
Site 20
Y272
T
G
A
R
H
L
N
Y
G
S
R
L
D
Y
V
Site 21
Y278
N
Y
G
S
R
L
D
Y
V
L
G
D
R
T
L
Site 22
S349
F
L
V
P
L
E
Q
S
P
V
L
E
Q
S
T
Site 23
T367
N
N
Q
T
R
V
Q
T
C
Q
N
K
A
Q
V
Site 24
S376
Q
N
K
A
Q
V
R
S
T
R
P
Q
P
S
Q
Site 25
T377
N
K
A
Q
V
R
S
T
R
P
Q
P
S
Q
V
Site 26
S382
R
S
T
R
P
Q
P
S
Q
V
G
S
S
R
G
Site 27
S386
P
Q
P
S
Q
V
G
S
S
R
G
Q
K
N
L
Site 28
S395
R
G
Q
K
N
L
K
S
Y
F
Q
P
S
P
S
Site 29
Y396
G
Q
K
N
L
K
S
Y
F
Q
P
S
P
S
C
Site 30
S400
L
K
S
Y
F
Q
P
S
P
S
C
P
Q
A
S
Site 31
S402
S
Y
F
Q
P
S
P
S
C
P
Q
A
S
P
D
Site 32
S407
S
P
S
C
P
Q
A
S
P
D
I
E
L
P
S
Site 33
T423
P
L
M
S
A
L
M
T
P
K
T
P
E
E
K
Site 34
T426
S
A
L
M
T
P
K
T
P
E
E
K
A
V
A
Site 35
S454
D
E
K
E
L
R
T
S
F
W
K
S
V
L
A
Site 36
S458
L
R
T
S
F
W
K
S
V
L
A
G
P
L
R
Site 37
T480
R
E
P
C
V
M
R
T
V
K
K
P
G
P
N
Site 38
Y493
P
N
L
G
R
R
F
Y
M
C
A
R
P
R
G
Site 39
T503
A
R
P
R
G
P
P
T
D
P
S
S
R
C
N
Site 40
S506
R
G
P
P
T
D
P
S
S
R
C
N
F
F
L
Site 41
S507
G
P
P
T
D
P
S
S
R
C
N
F
F
L
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation