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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLIP2
Full Name:
ISOFORM 1 OF CAP-GLY DOMAIN-CONTAINING LINKER PROTEIN 2.
Alias:
CLIP; CLIP-115; Cytoplasmic linker 2; Cytoplasmic linker protein 2; WBSCR4; WSCR4
Type:
Scaffolding protein, cyclin
Mass (Da):
115837
Number AA:
1046
UniProt ID:
Q9UDT6
International Prot ID:
IPI00019642
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005875
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
P
G
R
G
G
K
H
S
S
P
M
G
R
T
S
Site 2
S18
G
R
G
G
K
H
S
S
P
M
G
R
T
S
T
Site 3
S24
S
S
P
M
G
R
T
S
T
G
S
A
S
S
S
Site 4
T25
S
P
M
G
R
T
S
T
G
S
A
S
S
S
A
Site 5
S27
M
G
R
T
S
T
G
S
A
S
S
S
A
A
V
Site 6
S29
R
T
S
T
G
S
A
S
S
S
A
A
V
A
A
Site 7
S38
S
A
A
V
A
A
S
S
K
E
G
S
P
L
H
Site 8
S42
A
A
S
S
K
E
G
S
P
L
H
K
Q
S
S
Site 9
S48
G
S
P
L
H
K
Q
S
S
G
P
S
S
S
P
Site 10
S49
S
P
L
H
K
Q
S
S
G
P
S
S
S
P
A
Site 11
S52
H
K
Q
S
S
G
P
S
S
S
P
A
A
A
A
Site 12
S53
K
Q
S
S
G
P
S
S
S
P
A
A
A
A
A
Site 13
S54
Q
S
S
G
P
S
S
S
P
A
A
A
A
A
P
Site 14
Y129
G
A
V
G
G
V
R
Y
F
E
C
P
A
L
Q
Site 15
T140
P
A
L
Q
G
I
F
T
R
P
S
K
L
T
R
Site 16
S143
Q
G
I
F
T
R
P
S
K
L
T
R
Q
P
T
Site 17
T146
F
T
R
P
S
K
L
T
R
Q
P
T
A
E
G
Site 18
T150
S
K
L
T
R
Q
P
T
A
E
G
S
G
S
D
Site 19
S154
R
Q
P
T
A
E
G
S
G
S
D
A
H
S
V
Site 20
S156
P
T
A
E
G
S
G
S
D
A
H
S
V
E
S
Site 21
S160
G
S
G
S
D
A
H
S
V
E
S
L
T
A
Q
Site 22
S163
S
D
A
H
S
V
E
S
L
T
A
Q
N
L
S
Site 23
S170
S
L
T
A
Q
N
L
S
L
H
S
G
T
A
T
Site 24
T177
S
L
H
S
G
T
A
T
P
P
L
T
S
R
V
Site 25
T181
G
T
A
T
P
P
L
T
S
R
V
I
P
L
R
Site 26
S190
R
V
I
P
L
R
E
S
V
L
N
S
S
V
K
Site 27
S194
L
R
E
S
V
L
N
S
S
V
K
T
G
N
E
Site 28
T198
V
L
N
S
S
V
K
T
G
N
E
S
G
S
N
Site 29
S202
S
V
K
T
G
N
E
S
G
S
N
L
S
D
S
Site 30
S204
K
T
G
N
E
S
G
S
N
L
S
D
S
G
S
Site 31
S207
N
E
S
G
S
N
L
S
D
S
G
S
V
K
R
Site 32
S209
S
G
S
N
L
S
D
S
G
S
V
K
R
G
E
Site 33
S211
S
N
L
S
D
S
G
S
V
K
R
G
E
K
D
Site 34
Y237
T
K
T
G
V
V
R
Y
V
G
E
T
D
F
A
Site 35
T241
V
V
R
Y
V
G
E
T
D
F
A
K
G
E
W
Site 36
Y269
G
A
V
A
G
T
R
Y
F
Q
C
P
P
K
F
Site 37
S292
V
I
R
I
G
F
P
S
T
S
P
A
K
A
K
Site 38
T293
I
R
I
G
F
P
S
T
S
P
A
K
A
K
K
Site 39
S294
R
I
G
F
P
S
T
S
P
A
K
A
K
K
T
Site 40
T301
S
P
A
K
A
K
K
T
K
R
M
A
M
G
V
Site 41
T312
A
M
G
V
S
A
L
T
H
S
P
S
S
S
S
Site 42
S314
G
V
S
A
L
T
H
S
P
S
S
S
S
I
S
Site 43
S316
S
A
L
T
H
S
P
S
S
S
S
I
S
S
V
Site 44
S317
A
L
T
H
S
P
S
S
S
S
I
S
S
V
S
Site 45
S318
L
T
H
S
P
S
S
S
S
I
S
S
V
S
S
Site 46
S319
T
H
S
P
S
S
S
S
I
S
S
V
S
S
V
Site 47
S321
S
P
S
S
S
S
I
S
S
V
S
S
V
A
S
Site 48
S322
P
S
S
S
S
I
S
S
V
S
S
V
A
S
S
Site 49
S328
S
S
V
S
S
V
A
S
S
V
G
G
R
P
S
Site 50
S329
S
V
S
S
V
A
S
S
V
G
G
R
P
S
R
Site 51
S335
S
S
V
G
G
R
P
S
R
S
G
L
L
T
E
Site 52
S337
V
G
G
R
P
S
R
S
G
L
L
T
E
T
S
Site 53
T341
P
S
R
S
G
L
L
T
E
T
S
S
R
Y
A
Site 54
T343
R
S
G
L
L
T
E
T
S
S
R
Y
A
R
K
Site 55
S344
S
G
L
L
T
E
T
S
S
R
Y
A
R
K
I
Site 56
S345
G
L
L
T
E
T
S
S
R
Y
A
R
K
I
S
Site 57
Y347
L
T
E
T
S
S
R
Y
A
R
K
I
S
G
T
Site 58
S352
S
R
Y
A
R
K
I
S
G
T
T
A
L
Q
E
Site 59
T354
Y
A
R
K
I
S
G
T
T
A
L
Q
E
A
L
Site 60
T355
A
R
K
I
S
G
T
T
A
L
Q
E
A
L
K
Site 61
Y406
L
K
A
Q
H
E
Q
Y
V
A
E
A
E
E
K
Site 62
S423
R
A
R
L
L
V
E
S
V
R
K
E
K
V
D
Site 63
S432
R
K
E
K
V
D
L
S
N
Q
L
E
E
E
R
Site 64
S453
Q
F
R
V
E
E
E
S
I
T
K
G
D
L
E
Site 65
T455
R
V
E
E
E
S
I
T
K
G
D
L
E
T
Q
Site 66
S476
R
I
G
E
L
E
Q
S
L
L
L
E
K
A
Q
Site 67
T497
E
L
A
D
N
R
L
T
T
V
A
E
K
S
R
Site 68
T498
L
A
D
N
R
L
T
T
V
A
E
K
S
R
V
Site 69
S503
L
T
T
V
A
E
K
S
R
V
L
Q
L
E
E
Site 70
T513
L
Q
L
E
E
E
L
T
L
R
R
G
E
I
E
Site 71
S529
L
Q
Q
C
L
L
H
S
G
P
P
P
P
D
H
Site 72
S551
R
L
R
E
R
L
L
S
A
S
K
E
H
Q
R
Site 73
S553
R
E
R
L
L
S
A
S
K
E
H
Q
R
E
S
Site 74
S560
S
K
E
H
Q
R
E
S
G
V
L
R
D
K
Y
Site 75
Y567
S
G
V
L
R
D
K
Y
E
K
A
L
K
A
Y
Site 76
S604
D
K
V
Q
Q
A
T
S
E
N
M
G
L
M
D
Site 77
S615
G
L
M
D
N
W
K
S
K
L
D
S
L
A
S
Site 78
S619
N
W
K
S
K
L
D
S
L
A
S
D
H
Q
K
Site 79
S622
S
K
L
D
S
L
A
S
D
H
Q
K
S
L
E
Site 80
S627
L
A
S
D
H
Q
K
S
L
E
D
L
K
A
T
Site 81
S712
A
Q
L
E
V
Q
A
S
Q
H
R
L
E
L
Q
Site 82
Y742
L
E
K
L
D
V
E
Y
R
G
Q
A
Q
A
I
Site 83
S757
E
F
L
K
E
Q
I
S
L
A
E
K
K
M
L
Site 84
Y766
A
E
K
K
M
L
D
Y
E
R
L
Q
R
A
E
Site 85
S782
Q
G
K
Q
E
V
E
S
L
R
E
K
L
L
V
Site 86
T806
A
L
C
S
S
Q
H
T
H
M
I
E
S
N
D
Site 87
S815
M
I
E
S
N
D
I
S
E
E
T
I
R
T
K
Site 88
T821
I
S
E
E
T
I
R
T
K
E
T
V
E
G
L
Site 89
T824
E
T
I
R
T
K
E
T
V
E
G
L
Q
D
K
Site 90
T840
N
K
R
D
K
E
V
T
A
L
T
S
Q
T
E
Site 91
S844
K
E
V
T
A
L
T
S
Q
T
E
M
L
R
A
Site 92
S854
E
M
L
R
A
Q
V
S
A
L
E
S
K
C
K
Site 93
S858
A
Q
V
S
A
L
E
S
K
C
K
S
G
E
K
Site 94
S862
A
L
E
S
K
C
K
S
G
E
K
K
V
D
A
Site 95
T883
R
L
E
A
E
L
E
T
V
S
R
K
T
H
D
Site 96
T888
L
E
T
V
S
R
K
T
H
D
A
S
G
Q
L
Site 97
S892
S
R
K
T
H
D
A
S
G
Q
L
V
L
I
S
Site 98
S899
S
G
Q
L
V
L
I
S
Q
E
L
L
R
K
E
Site 99
S908
E
L
L
R
K
E
R
S
L
N
E
L
R
V
L
Site 100
S923
L
L
E
A
N
R
H
S
P
G
P
E
R
D
L
Site 101
S931
P
G
P
E
R
D
L
S
R
E
V
H
K
A
E
Site 102
T958
R
G
L
R
E
K
L
T
G
L
D
K
E
K
S
Site 103
S965
T
G
L
D
K
E
K
S
L
S
D
Q
R
R
Y
Site 104
S967
L
D
K
E
K
S
L
S
D
Q
R
R
Y
S
L
Site 105
Y972
S
L
S
D
Q
R
R
Y
S
L
I
D
R
S
S
Site 106
S973
L
S
D
Q
R
R
Y
S
L
I
D
R
S
S
A
Site 107
S978
R
Y
S
L
I
D
R
S
S
A
P
E
L
L
R
Site 108
S979
Y
S
L
I
D
R
S
S
A
P
E
L
L
R
L
Site 109
S1016
K
L
M
E
A
M
R
S
C
P
D
K
A
Q
T
Site 110
T1023
S
C
P
D
K
A
Q
T
I
G
N
S
G
S
A
Site 111
S1027
K
A
Q
T
I
G
N
S
G
S
A
N
G
I
H
Site 112
S1029
Q
T
I
G
N
S
G
S
A
N
G
I
H
Q
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation