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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRWD1
Full Name:
LEUCINE-RICH REPEAT AND WD REPEAT-CONTAINING PROTEIN 1.
Alias:
DKFZp434K1815; Leucine-rich repeat and WD repeat-containing protein 1; Leucine-rich repeats and WD repeat domain containing 1
Type:
Mass (Da):
70861
Number AA:
647
UniProt ID:
Q9UFC0
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
M
Q
R
G
R
P
K
S
D
R
L
G
K
I
R
Site 2
S25
D
R
L
G
K
I
R
S
L
D
L
S
G
L
E
Site 3
S29
K
I
R
S
L
D
L
S
G
L
E
L
L
S
E
Site 4
S35
L
S
G
L
E
L
L
S
E
H
L
D
P
K
L
Site 5
S55
Q
L
Q
E
L
D
L
S
N
N
H
L
E
T
L
Site 6
T61
L
S
N
N
H
L
E
T
L
P
D
N
L
G
L
Site 7
S97
F
P
K
L
E
E
L
S
L
E
G
N
P
F
L
Site 8
T105
L
E
G
N
P
F
L
T
V
N
D
N
L
K
V
Site 9
T118
K
V
S
F
L
L
P
T
L
R
K
V
N
G
K
Site 10
S128
K
V
N
G
K
D
A
S
S
T
Y
S
Q
V
E
Site 11
S129
V
N
G
K
D
A
S
S
T
Y
S
Q
V
E
N
Site 12
T130
N
G
K
D
A
S
S
T
Y
S
Q
V
E
N
L
Site 13
S132
K
D
A
S
S
T
Y
S
Q
V
E
N
L
N
R
Site 14
T142
E
N
L
N
R
E
L
T
S
R
V
T
A
H
W
Site 15
T146
R
E
L
T
S
R
V
T
A
H
W
E
K
F
M
Site 16
T155
H
W
E
K
F
M
A
T
L
G
P
E
E
E
A
Site 17
S172
A
Q
A
D
F
V
K
S
A
V
R
D
V
R
Y
Site 18
Y179
S
A
V
R
D
V
R
Y
G
P
E
S
L
S
E
Site 19
S183
D
V
R
Y
G
P
E
S
L
S
E
F
T
Q
W
Site 20
S185
R
Y
G
P
E
S
L
S
E
F
T
Q
W
R
V
Site 21
S196
Q
W
R
V
R
M
I
S
E
E
L
V
A
A
S
Site 22
S212
T
Q
V
Q
K
A
N
S
P
E
K
P
P
E
A
Site 23
S241
R
P
D
D
V
P
L
S
L
S
P
S
K
R
A
Site 24
S243
D
D
V
P
L
S
L
S
P
S
K
R
A
C
A
Site 25
S245
V
P
L
S
L
S
P
S
K
R
A
C
A
S
P
Site 26
S251
P
S
K
R
A
C
A
S
P
S
A
Q
V
E
G
Site 27
S253
K
R
A
C
A
S
P
S
A
Q
V
E
G
S
P
Site 28
S259
P
S
A
Q
V
E
G
S
P
V
A
G
S
D
G
Site 29
S264
E
G
S
P
V
A
G
S
D
G
S
Q
P
A
V
Site 30
S267
P
V
A
G
S
D
G
S
Q
P
A
V
K
L
E
Site 31
S287
Q
C
H
S
K
N
N
S
P
Q
D
L
E
T
Q
Site 32
T293
N
S
P
Q
D
L
E
T
Q
L
W
A
C
A
F
Site 33
S310
A
W
E
E
G
A
T
S
Q
T
V
A
T
C
G
Site 34
T312
E
E
G
A
T
S
Q
T
V
A
T
C
G
G
E
Site 35
Y335
T
G
I
V
L
H
K
Y
K
A
P
G
E
E
F
Site 36
S363
A
G
H
K
K
R
W
S
V
L
A
A
A
G
L
Site 37
Y429
I
G
V
P
N
Q
D
Y
E
F
Q
A
S
Q
L
Site 38
S434
Q
D
Y
E
F
Q
A
S
Q
L
L
T
L
D
T
Site 39
S490
C
E
V
E
F
V
F
S
E
G
S
E
A
S
G
Site 40
S493
E
F
V
F
S
E
G
S
E
A
S
G
R
R
V
Site 41
S496
F
S
E
G
S
E
A
S
G
R
R
V
D
G
L
Site 42
S513
V
N
E
D
I
V
A
S
K
G
S
G
L
G
T
Site 43
T520
S
K
G
S
G
L
G
T
I
C
L
W
S
W
R
Site 44
S535
Q
T
W
G
G
R
G
S
Q
S
T
V
A
V
V
Site 45
S551
L
A
R
L
Q
W
S
S
T
E
L
A
Y
F
S
Site 46
T552
A
R
L
Q
W
S
S
T
E
L
A
Y
F
S
L
Site 47
S558
S
T
E
L
A
Y
F
S
L
S
A
C
P
D
K
Site 48
Y580
E
E
G
N
V
W
L
Y
D
V
S
N
I
L
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation