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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KCNN3
Full Name:
Small conductance calcium-activated potassium channel protein 3
Alias:
K3; KCa2.3; SK3; SKCa3
Type:
Membrane, Integral membrane protein
Mass (Da):
82026
Number AA:
736
UniProt ID:
Q9UGI6
International Prot ID:
IPI00032465
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005516
GO:0016286
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
T
S
G
H
F
H
D
S
G
V
G
D
L
D
E
Site 2
S26
P
K
C
P
C
P
S
S
G
D
E
Q
Q
Q
Q
Site 3
S58
P
Q
Q
P
L
G
P
S
L
Q
P
Q
P
P
Q
Site 4
S91
Q
Q
P
P
H
P
L
S
Q
L
A
Q
L
Q
S
Site 5
S98
S
Q
L
A
Q
L
Q
S
Q
P
V
H
P
G
L
Site 6
S109
H
P
G
L
L
H
S
S
P
T
A
F
R
A
P
Site 7
T111
G
L
L
H
S
S
P
T
A
F
R
A
P
P
S
Site 8
S118
T
A
F
R
A
P
P
S
S
N
S
T
A
I
L
Site 9
S119
A
F
R
A
P
P
S
S
N
S
T
A
I
L
H
Site 10
S121
R
A
P
P
S
S
N
S
T
A
I
L
H
P
S
Site 11
T122
A
P
P
S
S
N
S
T
A
I
L
H
P
S
S
Site 12
S128
S
T
A
I
L
H
P
S
S
R
Q
G
S
Q
L
Site 13
S129
T
A
I
L
H
P
S
S
R
Q
G
S
Q
L
N
Site 14
S133
H
P
S
S
R
Q
G
S
Q
L
N
L
N
D
H
Site 15
S145
N
D
H
L
L
G
H
S
P
S
S
T
A
T
S
Site 16
S147
H
L
L
G
H
S
P
S
S
T
A
T
S
G
P
Site 17
S148
L
L
G
H
S
P
S
S
T
A
T
S
G
P
G
Site 18
T149
L
G
H
S
P
S
S
T
A
T
S
G
P
G
G
Site 19
T151
H
S
P
S
S
T
A
T
S
G
P
G
G
G
S
Site 20
S152
S
P
S
S
T
A
T
S
G
P
G
G
G
S
R
Site 21
S158
T
S
G
P
G
G
G
S
R
H
R
Q
A
S
P
Site 22
S164
G
S
R
H
R
Q
A
S
P
L
V
H
R
R
D
Site 23
S172
P
L
V
H
R
R
D
S
N
P
F
T
E
I
A
Site 24
T176
R
R
D
S
N
P
F
T
E
I
A
M
S
S
C
Site 25
S181
P
F
T
E
I
A
M
S
S
C
K
Y
S
G
G
Site 26
Y185
I
A
M
S
S
C
K
Y
S
G
G
V
M
K
P
Site 27
S186
A
M
S
S
C
K
Y
S
G
G
V
M
K
P
L
Site 28
S194
G
G
V
M
K
P
L
S
R
L
S
A
S
R
R
Site 29
S197
M
K
P
L
S
R
L
S
A
S
R
R
N
L
I
Site 30
S199
P
L
S
R
L
S
A
S
R
R
N
L
I
E
A
Site 31
S217
G
Q
P
L
Q
L
F
S
P
S
N
P
P
E
I
Site 32
S227
N
P
P
E
I
V
I
S
S
R
E
D
N
H
A
Site 33
T253
H
N
H
Q
H
A
G
T
T
A
S
S
T
T
F
Site 34
S256
Q
H
A
G
T
T
A
S
S
T
T
F
P
K
A
Site 35
T258
A
G
T
T
A
S
S
T
T
F
P
K
A
N
K
Site 36
T259
G
T
T
A
S
S
T
T
F
P
K
A
N
K
R
Site 37
Y273
R
K
N
Q
N
I
G
Y
K
L
G
H
R
R
A
Site 38
S289
F
E
K
R
K
R
L
S
D
Y
A
L
I
F
G
Site 39
Y291
K
R
K
R
L
S
D
Y
A
L
I
F
G
M
F
Site 40
S310
M
V
I
E
T
E
L
S
W
G
L
Y
S
K
D
Site 41
Y314
T
E
L
S
W
G
L
Y
S
K
D
S
M
F
S
Site 42
S315
E
L
S
W
G
L
Y
S
K
D
S
M
F
S
L
Site 43
S318
W
G
L
Y
S
K
D
S
M
F
S
L
A
L
K
Site 44
Y365
D
W
R
I
A
M
T
Y
E
R
I
L
Y
I
S
Site 45
S398
W
T
A
R
L
A
F
S
Y
T
P
S
R
A
E
Site 46
T400
A
R
L
A
F
S
Y
T
P
S
R
A
E
A
D
Site 47
S402
L
A
F
S
Y
T
P
S
R
A
E
A
D
V
D
Site 48
T435
L
L
H
S
K
L
F
T
D
A
S
S
R
S
I
Site 49
S438
S
K
L
F
T
D
A
S
S
R
S
I
G
A
L
Site 50
S439
K
L
F
T
D
A
S
S
R
S
I
G
A
L
N
Site 51
Y489
T
V
R
V
C
E
R
Y
H
D
Q
Q
D
V
T
Site 52
T522
Y
G
D
M
V
P
H
T
Y
C
G
K
G
V
C
Site 53
T554
V
A
R
K
L
E
L
T
K
A
E
K
H
V
H
Site 54
T584
A
A
N
V
L
R
E
T
W
L
I
Y
K
H
T
Site 55
S618
Q
A
I
H
Q
L
R
S
V
K
M
E
Q
R
K
Site 56
S627
K
M
E
Q
R
K
L
S
D
Q
A
N
T
L
V
Site 57
Y644
S
K
M
Q
N
V
M
Y
D
L
I
T
E
L
N
Site 58
S663
D
L
E
K
Q
I
G
S
L
E
S
K
L
E
H
Site 59
T672
E
S
K
L
E
H
L
T
A
S
F
N
S
L
P
Site 60
T685
L
P
L
L
I
A
D
T
L
R
Q
Q
Q
Q
Q
Site 61
S715
G
T
T
H
T
P
I
S
D
S
P
I
G
V
S
Site 62
S717
T
H
T
P
I
S
D
S
P
I
G
V
S
S
T
Site 63
S722
S
D
S
P
I
G
V
S
S
T
S
F
P
T
P
Site 64
S723
D
S
P
I
G
V
S
S
T
S
F
P
T
P
Y
Site 65
T724
S
P
I
G
V
S
S
T
S
F
P
T
P
Y
T
Site 66
S725
P
I
G
V
S
S
T
S
F
P
T
P
Y
T
S
Site 67
T728
V
S
S
T
S
F
P
T
P
Y
T
S
S
S
S
Site 68
Y730
S
T
S
F
P
T
P
Y
T
S
S
S
S
C
_
Site 69
T731
T
S
F
P
T
P
Y
T
S
S
S
S
C
_
_
Site 70
S732
S
F
P
T
P
Y
T
S
S
S
S
C
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation