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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
JARID1B
Full Name:
Lysine-specific demethylase 5B
Alias:
Cancer/testis antigen 31; CT31; JAD1B; Jumonji, AT rich interactive domain 1B (RBP2-like); KDM5B; Lysine (K)-specific demethylase 5B; PLU-1; PUT1; RB-binding protein; RBBP2H1A; Retinoblastoma-binding protein 2 homolog 1
Type:
EC 1.14.11.-; Oxidoreductase; Demethylase; Transcription, coactivator/corepressor
Mass (Da):
175645
Number AA:
1544
UniProt ID:
Q9UGL1
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005506
GO:0016702
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0045892
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
E
A
A
T
T
L
H
P
G
P
R
P
Site 2
S38
E
C
P
V
F
E
P
S
W
E
E
F
A
D
P
Site 3
T84
D
V
D
K
L
H
F
T
P
R
I
Q
R
L
N
Site 4
Y110
F
L
D
Q
I
A
K
Y
W
E
L
Q
G
S
T
Site 5
S116
K
Y
W
E
L
Q
G
S
T
L
K
I
P
H
V
Site 6
S169
A
P
G
K
A
V
G
S
H
I
R
G
H
Y
E
Site 7
Y175
G
S
H
I
R
G
H
Y
E
R
I
L
N
P
Y
Site 8
Y182
Y
E
R
I
L
N
P
Y
N
L
F
L
S
G
D
Site 9
S187
N
P
Y
N
L
F
L
S
G
D
S
L
R
C
L
Site 10
S190
N
L
F
L
S
G
D
S
L
R
C
L
Q
K
P
Site 11
Y208
T
D
T
K
D
K
E
Y
K
P
H
D
I
P
Q
Site 12
S218
H
D
I
P
Q
R
Q
S
V
Q
P
S
E
T
C
Site 13
S222
Q
R
Q
S
V
Q
P
S
E
T
C
P
P
A
R
Site 14
T248
I
K
I
E
P
E
E
T
T
E
A
R
T
H
N
Site 15
T264
R
R
R
M
G
C
P
T
P
K
C
E
N
E
K
Site 16
S275
E
N
E
K
E
M
K
S
S
I
K
Q
E
P
I
Site 17
S276
N
E
K
E
M
K
S
S
I
K
Q
E
P
I
E
Site 18
Y287
E
P
I
E
R
K
D
Y
I
V
E
N
E
K
E
Site 19
S298
N
E
K
E
K
P
K
S
R
S
K
K
A
T
N
Site 20
T304
K
S
R
S
K
K
A
T
N
A
V
D
L
Y
V
Site 21
S362
K
C
L
A
Q
E
C
S
K
P
Q
E
A
F
G
Site 22
Y377
F
E
Q
A
A
R
D
Y
T
L
R
T
F
G
E
Site 23
T378
E
Q
A
A
R
D
Y
T
L
R
T
F
G
E
M
Site 24
T381
A
R
D
Y
T
L
R
T
F
G
E
M
A
D
A
Site 25
Y393
A
D
A
F
K
S
D
Y
F
N
M
P
V
H
M
Site 26
S415
K
E
F
W
R
L
V
S
T
I
E
E
D
V
T
Site 27
T422
S
T
I
E
E
D
V
T
V
E
Y
G
A
D
I
Site 28
Y425
E
E
D
V
T
V
E
Y
G
A
D
I
A
S
K
Site 29
S431
E
Y
G
A
D
I
A
S
K
E
F
G
S
G
F
Site 30
S436
I
A
S
K
E
F
G
S
G
F
P
V
R
D
G
Site 31
S448
R
D
G
K
I
K
L
S
P
E
E
E
E
Y
L
Site 32
Y454
L
S
P
E
E
E
E
Y
L
D
S
G
W
N
L
Site 33
S457
E
E
E
E
Y
L
D
S
G
W
N
L
N
N
M
Site 34
T476
Q
S
V
L
A
H
I
T
A
D
I
C
G
M
K
Site 35
Y520
W
G
E
P
K
T
W
Y
G
V
P
G
Y
A
A
Site 36
Y525
T
W
Y
G
V
P
G
Y
A
A
E
Q
L
E
N
Site 37
Y569
M
T
H
E
V
P
V
Y
R
T
N
Q
C
A
G
Site 38
Y586
V
I
T
F
P
R
A
Y
H
S
G
F
N
Q
G
Site 39
Y624
H
Y
R
L
L
H
R
Y
C
V
F
S
H
D
E
Site 40
T668
D
E
K
A
L
R
E
T
V
R
K
L
G
V
I
Site 41
S677
R
K
L
G
V
I
D
S
E
R
M
D
F
E
L
Site 42
Y728
E
L
C
S
C
P
P
Y
K
Y
K
L
R
Y
R
Site 43
Y730
C
S
C
P
P
Y
K
Y
K
L
R
Y
R
Y
T
Site 44
Y734
P
Y
K
Y
K
L
R
Y
R
Y
T
L
D
D
L
Site 45
Y736
K
Y
K
L
R
Y
R
Y
T
L
D
D
L
Y
P
Site 46
T737
Y
K
L
R
Y
R
Y
T
L
D
D
L
Y
P
M
Site 47
Y742
R
Y
T
L
D
D
L
Y
P
M
M
N
A
L
K
Site 48
S754
A
L
K
L
R
A
E
S
Y
N
E
W
A
L
N
Site 49
Y755
L
K
L
R
A
E
S
Y
N
E
W
A
L
N
V
Site 50
T771
E
A
L
E
A
K
I
T
K
K
K
S
L
V
S
Site 51
S775
A
K
I
T
K
K
K
S
L
V
S
F
K
A
L
Site 52
S778
T
K
K
K
S
L
V
S
F
K
A
L
I
E
E
Site 53
T804
L
R
H
L
R
L
V
T
Q
D
A
E
K
C
A
Site 54
S812
Q
D
A
E
K
C
A
S
V
A
Q
Q
L
L
N
Site 55
T824
L
L
N
G
K
R
Q
T
R
Y
R
S
G
G
G
Site 56
Y826
N
G
K
R
Q
T
R
Y
R
S
G
G
G
K
S
Site 57
S828
K
R
Q
T
R
Y
R
S
G
G
G
K
S
Q
N
Site 58
S833
Y
R
S
G
G
G
K
S
Q
N
Q
L
T
V
N
Site 59
T838
G
K
S
Q
N
Q
L
T
V
N
E
L
R
Q
F
Site 60
S876
V
E
D
F
Q
Q
H
S
Q
K
L
L
S
E
E
Site 61
S881
Q
H
S
Q
K
L
L
S
E
E
T
P
S
A
A
Site 62
T884
Q
K
L
L
S
E
E
T
P
S
A
A
E
L
Q
Site 63
S886
L
L
S
E
E
T
P
S
A
A
E
L
Q
D
L
Site 64
S932
Q
A
C
L
D
P
S
S
L
T
L
D
D
M
R
Site 65
T966
A
R
L
Q
E
L
L
T
V
S
E
H
W
D
D
Site 66
S977
H
W
D
D
K
A
K
S
L
L
K
A
R
P
R
Site 67
S986
L
K
A
R
P
R
H
S
L
N
S
L
A
T
A
Site 68
S989
R
P
R
H
S
L
N
S
L
A
T
A
V
K
E
Site 69
S1013
N
G
A
A
L
K
D
S
V
Q
R
A
R
D
W
Site 70
S1048
E
L
V
T
R
G
R
S
I
P
V
H
L
N
S
Site 71
T1076
W
K
E
C
A
V
N
T
F
L
T
E
N
S
P
Site 72
S1082
N
T
F
L
T
E
N
S
P
Y
S
L
L
E
V
Site 73
S1119
L
P
N
G
K
K
K
S
T
K
L
E
S
L
S
Site 74
T1120
P
N
G
K
K
K
S
T
K
L
E
S
L
S
D
Site 75
S1124
K
K
S
T
K
L
E
S
L
S
D
L
E
R
A
Site 76
S1126
S
T
K
L
E
S
L
S
D
L
E
R
A
L
T
Site 77
T1133
S
D
L
E
R
A
L
T
E
S
K
E
T
A
S
Site 78
S1135
L
E
R
A
L
T
E
S
K
E
T
A
S
A
M
Site 79
T1144
E
T
A
S
A
M
A
T
L
G
E
A
R
L
R
Site 80
S1158
R
E
M
E
A
L
Q
S
L
R
L
A
N
E
G
Site 81
S1169
A
N
E
G
K
L
L
S
P
L
Q
D
V
D
I
Site 82
S1224
L
C
P
H
C
R
R
S
E
K
P
P
L
E
K
Site 83
S1284
F
V
Q
D
R
V
G
S
G
L
L
Y
S
R
W
Site 84
Y1288
R
V
G
S
G
L
L
Y
S
R
W
Q
A
S
A
Site 85
S1289
V
G
S
G
L
L
Y
S
R
W
Q
A
S
A
G
Site 86
S1299
Q
A
S
A
G
Q
V
S
D
T
N
K
V
S
Q
Site 87
T1301
S
A
G
Q
V
S
D
T
N
K
V
S
Q
P
P
Site 88
S1305
V
S
D
T
N
K
V
S
Q
P
P
G
T
T
S
Site 89
T1310
K
V
S
Q
P
P
G
T
T
S
F
S
L
P
D
Site 90
S1312
S
Q
P
P
G
T
T
S
F
S
L
P
D
D
W
Site 91
S1314
P
P
G
T
T
S
F
S
L
P
D
D
W
D
N
Site 92
T1323
P
D
D
W
D
N
R
T
S
Y
L
H
S
P
F
Site 93
S1324
D
D
W
D
N
R
T
S
Y
L
H
S
P
F
S
Site 94
Y1325
D
W
D
N
R
T
S
Y
L
H
S
P
F
S
T
Site 95
S1328
N
R
T
S
Y
L
H
S
P
F
S
T
G
R
S
Site 96
S1331
S
Y
L
H
S
P
F
S
T
G
R
S
C
I
P
Site 97
T1332
Y
L
H
S
P
F
S
T
G
R
S
C
I
P
L
Site 98
T1369
E
I
Q
E
L
Y
Q
T
L
L
A
K
P
S
P
Site 99
S1375
Q
T
L
L
A
K
P
S
P
A
Q
Q
T
D
R
Site 100
T1380
K
P
S
P
A
Q
Q
T
D
R
S
S
P
V
R
Site 101
S1383
P
A
Q
Q
T
D
R
S
S
P
V
R
P
S
S
Site 102
S1384
A
Q
Q
T
D
R
S
S
P
V
R
P
S
S
E
Site 103
S1389
R
S
S
P
V
R
P
S
S
E
K
N
D
C
C
Site 104
S1390
S
S
P
V
R
P
S
S
E
K
N
D
C
C
R
Site 105
S1405
G
K
R
D
G
I
N
S
L
E
R
K
L
K
R
Site 106
S1421
L
E
R
E
G
L
S
S
E
R
W
E
R
V
K
Site 107
T1432
E
R
V
K
K
M
R
T
P
K
K
K
K
I
K
Site 108
S1441
K
K
K
K
I
K
L
S
H
P
K
D
M
N
N
Site 109
S1456
F
K
L
E
R
E
R
S
Y
E
L
V
R
S
A
Site 110
Y1457
K
L
E
R
E
R
S
Y
E
L
V
R
S
A
E
Site 111
S1462
R
S
Y
E
L
V
R
S
A
E
T
H
S
L
P
Site 112
S1467
V
R
S
A
E
T
H
S
L
P
S
D
T
S
Y
Site 113
S1470
A
E
T
H
S
L
P
S
D
T
S
Y
S
E
Q
Site 114
S1473
H
S
L
P
S
D
T
S
Y
S
E
Q
E
D
S
Site 115
Y1474
S
L
P
S
D
T
S
Y
S
E
Q
E
D
S
E
Site 116
S1475
L
P
S
D
T
S
Y
S
E
Q
E
D
S
E
D
Site 117
S1480
S
Y
S
E
Q
E
D
S
E
D
E
D
A
I
C
Site 118
S1521
H
Q
V
C
V
G
V
S
P
E
M
A
E
K
E
Site 119
Y1530
E
M
A
E
K
E
D
Y
I
C
V
R
C
T
V
Site 120
T1536
D
Y
I
C
V
R
C
T
V
K
D
A
P
S
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation