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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PARP2
Full Name:
Poly [ADP-ribose] polymerase 2
Alias:
EC 2.4.2.30; HPARP-2; NAD(+) ADP-ribosyltransferase 2; PADPRT-2; PARP-2; Poly[ADP-ribose] synthetase 2
Type:
Nucleus protein
Mass (Da):
66206
Number AA:
583
UniProt ID:
Q9UGN5
International Prot ID:
IPI00026497
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0005654
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003950
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006471
GO:0006259
GO:0006281
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
A
R
R
R
R
S
T
G
G
G
R
A
R
Site 2
T9
A
A
R
R
R
R
S
T
G
G
G
R
A
R
A
Site 3
S20
R
A
R
A
L
N
E
S
K
R
V
N
N
G
N
Site 4
S34
N
T
A
P
E
D
S
S
P
A
K
K
T
R
R
Site 5
T39
D
S
S
P
A
K
K
T
R
R
C
Q
R
Q
E
Site 6
S47
R
R
C
Q
R
Q
E
S
K
K
M
P
V
A
G
Site 7
T62
G
K
A
N
K
D
R
T
E
D
K
Q
D
G
M
Site 8
S73
Q
D
G
M
P
G
R
S
W
A
S
K
R
V
S
Site 9
S76
M
P
G
R
S
W
A
S
K
R
V
S
E
S
V
Site 10
S80
S
W
A
S
K
R
V
S
E
S
V
K
A
L
L
Site 11
S82
A
S
K
R
V
S
E
S
V
K
A
L
L
L
K
Site 12
Y108
K
V
G
K
A
H
V
Y
C
E
G
N
D
V
Y
Site 13
Y115
Y
C
E
G
N
D
V
Y
D
V
M
L
N
Q
T
Site 14
Y131
L
Q
F
N
N
N
K
Y
Y
L
I
Q
L
L
E
Site 15
Y132
Q
F
N
N
N
K
Y
Y
L
I
Q
L
L
E
D
Site 16
S161
V
G
K
M
G
Q
H
S
L
V
A
C
S
G
N
Site 17
T184
Q
K
K
F
L
D
K
T
K
N
N
W
E
D
R
Site 18
Y201
F
E
K
V
P
G
K
Y
D
M
L
Q
M
D
Y
Site 19
Y208
Y
D
M
L
Q
M
D
Y
A
T
N
T
Q
D
E
Site 20
S223
E
E
T
K
K
E
E
S
L
K
S
P
L
K
P
Site 21
S226
K
K
E
E
S
L
K
S
P
L
K
P
E
S
Q
Site 22
S232
K
S
P
L
K
P
E
S
Q
L
D
L
R
V
Q
Site 23
Y260
E
M
M
M
E
M
K
Y
N
T
K
K
A
P
L
Site 24
T271
K
A
P
L
G
K
L
T
V
A
Q
I
K
A
G
Site 25
Y306
M
E
A
C
N
E
F
Y
T
R
I
P
H
D
F
Site 26
T317
P
H
D
F
G
L
R
T
P
P
L
I
R
T
Q
Site 27
T349
I
A
I
K
L
V
K
T
E
L
Q
S
P
E
H
Site 28
S353
L
V
K
T
E
L
Q
S
P
E
H
P
L
D
Q
Site 29
Y362
E
H
P
L
D
Q
H
Y
R
N
L
H
C
A
L
Site 30
S376
L
R
P
L
D
H
E
S
Y
E
F
K
V
I
S
Site 31
Y377
R
P
L
D
H
E
S
Y
E
F
K
V
I
S
Q
Site 32
S383
S
Y
E
F
K
V
I
S
Q
Y
L
Q
S
T
H
Site 33
Y385
E
F
K
V
I
S
Q
Y
L
Q
S
T
H
A
P
Site 34
S388
V
I
S
Q
Y
L
Q
S
T
H
A
P
T
H
S
Site 35
T389
I
S
Q
Y
L
Q
S
T
H
A
P
T
H
S
D
Site 36
Y397
H
A
P
T
H
S
D
Y
T
M
T
L
L
D
L
Site 37
S430
R
M
L
L
W
H
G
S
R
M
S
N
W
V
G
Site 38
T453
A
P
P
E
A
P
I
T
G
Y
M
F
G
K
G
Site 39
Y455
P
E
A
P
I
T
G
Y
M
F
G
K
G
I
Y
Site 40
Y462
Y
M
F
G
K
G
I
Y
F
A
D
M
S
S
K
Site 41
S470
F
A
D
M
S
S
K
S
A
N
Y
C
F
A
S
Site 42
S514
G
L
L
Q
G
K
H
S
T
K
G
L
G
K
M
Site 43
T530
P
S
S
A
H
F
V
T
L
N
G
S
T
V
P
Site 44
T544
P
L
G
P
A
S
D
T
G
I
L
N
P
D
G
Site 45
Y552
G
I
L
N
P
D
G
Y
T
L
N
Y
N
E
Y
Site 46
Y556
P
D
G
Y
T
L
N
Y
N
E
Y
I
V
Y
N
Site 47
Y559
Y
T
L
N
Y
N
E
Y
I
V
Y
N
P
N
Q
Site 48
Y562
N
Y
N
E
Y
I
V
Y
N
P
N
Q
V
R
M
Site 49
Y571
P
N
Q
V
R
M
R
Y
L
L
K
V
Q
F
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation