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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HMG2L1
Full Name:
HMG domain-containing protein 4
Alias:
High mobility group 2-like 1; HM2L1; HMG box domain containing 4; HMGBCG; Protein HMGBCG; THC211630
Type:
DNA binding protein
Mass (Da):
65712
Number AA:
601
UniProt ID:
Q9UGU5
International Prot ID:
IPI00455982
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000785
GO:0005634
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006355
GO:0006810
GO:0007034
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
D
C
F
D
G
D
H
T
F
E
D
I
G
L
A
Site 2
S29
I
G
L
A
A
G
R
S
Q
R
E
K
K
R
S
Site 3
S36
S
Q
R
E
K
K
R
S
Y
K
D
F
L
R
E
Site 4
Y37
Q
R
E
K
K
R
S
Y
K
D
F
L
R
E
E
Site 5
S54
I
A
A
Q
V
R
N
S
S
K
K
K
L
K
D
Site 6
S55
A
A
Q
V
R
N
S
S
K
K
K
L
K
D
S
Site 7
S62
S
K
K
K
L
K
D
S
E
L
Y
F
L
G
T
Site 8
Y65
K
L
K
D
S
E
L
Y
F
L
G
T
D
T
H
Site 9
T69
S
E
L
Y
F
L
G
T
D
T
H
K
K
K
R
Site 10
S79
H
K
K
K
R
K
H
S
S
D
D
Y
Y
Y
G
Site 11
S80
K
K
K
R
K
H
S
S
D
D
Y
Y
Y
G
D
Site 12
Y83
R
K
H
S
S
D
D
Y
Y
Y
G
D
I
S
S
Site 13
Y84
K
H
S
S
D
D
Y
Y
Y
G
D
I
S
S
L
Site 14
Y85
H
S
S
D
D
Y
Y
Y
G
D
I
S
S
L
E
Site 15
S89
D
Y
Y
Y
G
D
I
S
S
L
E
S
S
Q
K
Site 16
S90
Y
Y
Y
G
D
I
S
S
L
E
S
S
Q
K
K
Site 17
S93
G
D
I
S
S
L
E
S
S
Q
K
K
K
K
K
Site 18
S94
D
I
S
S
L
E
S
S
Q
K
K
K
K
K
S
Site 19
S101
S
Q
K
K
K
K
K
S
S
P
Q
S
T
D
T
Site 20
S102
Q
K
K
K
K
K
S
S
P
Q
S
T
D
T
A
Site 21
S105
K
K
K
S
S
P
Q
S
T
D
T
A
M
D
L
Site 22
T106
K
K
S
S
P
Q
S
T
D
T
A
M
D
L
L
Site 23
T108
S
S
P
Q
S
T
D
T
A
M
D
L
L
K
A
Site 24
S124
T
S
P
L
A
A
G
S
K
P
S
K
K
T
G
Site 25
T130
G
S
K
P
S
K
K
T
G
E
K
S
S
G
S
Site 26
S134
S
K
K
T
G
E
K
S
S
G
S
S
S
H
S
Site 27
S135
K
K
T
G
E
K
S
S
G
S
S
S
H
S
E
Site 28
S137
T
G
E
K
S
S
G
S
S
S
H
S
E
S
K
Site 29
S138
G
E
K
S
S
G
S
S
S
H
S
E
S
K
K
Site 30
S139
E
K
S
S
G
S
S
S
H
S
E
S
K
K
E
Site 31
S141
S
S
G
S
S
S
H
S
E
S
K
K
E
H
H
Site 32
S143
G
S
S
S
H
S
E
S
K
K
E
H
H
R
K
Site 33
S153
E
H
H
R
K
K
V
S
G
S
S
G
E
L
P
Site 34
S155
H
R
K
K
V
S
G
S
S
G
E
L
P
L
E
Site 35
S166
L
P
L
E
D
G
G
S
H
K
S
K
K
M
K
Site 36
S169
E
D
G
G
S
H
K
S
K
K
M
K
P
L
Y
Site 37
Y176
S
K
K
M
K
P
L
Y
V
N
T
E
T
L
T
Site 38
T183
Y
V
N
T
E
T
L
T
L
R
E
P
D
G
L
Site 39
S197
L
K
M
K
L
I
L
S
P
K
E
K
G
S
S
Site 40
S204
S
P
K
E
K
G
S
S
S
V
D
E
E
S
F
Site 41
S205
P
K
E
K
G
S
S
S
V
D
E
E
S
F
Q
Site 42
S210
S
S
S
V
D
E
E
S
F
Q
Y
P
S
Q
Q
Site 43
Y213
V
D
E
E
S
F
Q
Y
P
S
Q
Q
A
T
V
Site 44
S215
E
E
S
F
Q
Y
P
S
Q
Q
A
T
V
K
K
Site 45
T219
Q
Y
P
S
Q
Q
A
T
V
K
K
S
S
K
K
Site 46
S223
Q
Q
A
T
V
K
K
S
S
K
K
S
A
R
D
Site 47
S227
V
K
K
S
S
K
K
S
A
R
D
E
Q
G
A
Site 48
S243
L
L
G
H
E
L
Q
S
F
L
K
T
A
R
K
Site 49
T247
E
L
Q
S
F
L
K
T
A
R
K
K
H
K
S
Site 50
S254
T
A
R
K
K
H
K
S
S
S
D
A
H
S
S
Site 51
S255
A
R
K
K
H
K
S
S
S
D
A
H
S
S
P
Site 52
S256
R
K
K
H
K
S
S
S
D
A
H
S
S
P
G
Site 53
S260
K
S
S
S
D
A
H
S
S
P
G
P
E
G
C
Site 54
S261
S
S
S
D
A
H
S
S
P
G
P
E
G
C
G
Site 55
S269
P
G
P
E
G
C
G
S
D
A
S
Q
F
A
E
Site 56
S272
E
G
C
G
S
D
A
S
Q
F
A
E
S
H
S
Site 57
S279
S
Q
F
A
E
S
H
S
A
N
L
D
L
S
G
Site 58
S294
L
E
P
I
L
V
E
S
D
S
S
S
G
G
E
Site 59
S296
P
I
L
V
E
S
D
S
S
S
G
G
E
L
E
Site 60
S297
I
L
V
E
S
D
S
S
S
G
G
E
L
E
A
Site 61
S298
L
V
E
S
D
S
S
S
G
G
E
L
E
A
G
Site 62
S312
G
E
L
V
I
D
D
S
Y
R
E
I
K
K
K
Site 63
Y313
E
L
V
I
D
D
S
Y
R
E
I
K
K
K
K
Site 64
S322
E
I
K
K
K
K
K
S
K
K
S
K
K
K
K
Site 65
S325
K
K
K
K
S
K
K
S
K
K
K
K
D
K
E
Site 66
S340
K
H
K
E
K
R
H
S
K
S
K
R
S
L
G
Site 67
S342
K
E
K
R
H
S
K
S
K
R
S
L
G
L
S
Site 68
S345
R
H
S
K
S
K
R
S
L
G
L
S
A
V
P
Site 69
T383
L
P
L
P
G
L
H
T
D
G
H
S
E
K
K
Site 70
S387
G
L
H
T
D
G
H
S
E
K
K
K
K
K
E
Site 71
Y414
K
K
K
N
M
S
A
Y
Q
V
F
C
K
E
Y
Site 72
Y462
I
W
K
Q
K
A
Q
Y
L
Q
H
K
Q
N
K
Site 73
S480
T
T
V
K
R
K
A
S
S
S
E
G
S
M
K
Site 74
S481
T
V
K
R
K
A
S
S
S
E
G
S
M
K
V
Site 75
S482
V
K
R
K
A
S
S
S
E
G
S
M
K
V
K
Site 76
S485
K
A
S
S
S
E
G
S
M
K
V
K
A
S
S
Site 77
S492
S
M
K
V
K
A
S
S
V
G
V
L
S
P
Q
Site 78
S497
A
S
S
V
G
V
L
S
P
Q
K
K
S
P
P
Site 79
S502
V
L
S
P
Q
K
K
S
P
P
T
T
M
L
L
Site 80
T505
P
Q
K
K
S
P
P
T
T
M
L
L
P
A
S
Site 81
T506
Q
K
K
S
P
P
T
T
M
L
L
P
A
S
P
Site 82
S512
T
T
M
L
L
P
A
S
P
A
K
A
P
E
T
Site 83
S556
V
A
V
S
G
S
L
S
V
L
L
D
S
I
I
Site 84
S561
S
L
S
V
L
L
D
S
I
I
C
A
L
G
P
Site 85
S588
G
C
P
K
Q
V
L
S
N
T
L
D
N
I
A
Site 86
T590
P
K
Q
V
L
S
N
T
L
D
N
I
A
Y
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation