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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHL3
Full Name:
Alias:
Type:
Mass (Da):
64970
Number AA:
587
UniProt ID:
Q9UH77
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
E
G
E
S
V
K
L
S
S
Q
T
L
I
Q
A
Site 2
S10
G
E
S
V
K
L
S
S
Q
T
L
I
Q
A
G
Site 3
T12
S
V
K
L
S
S
Q
T
L
I
Q
A
G
D
D
Site 4
T27
E
K
N
Q
R
T
I
T
V
N
P
A
H
M
G
Site 5
S84
A
M
F
T
G
D
M
S
E
S
K
A
K
K
I
Site 6
S86
F
T
G
D
M
S
E
S
K
A
K
K
I
E
I
Site 7
T100
I
K
D
V
D
G
Q
T
L
S
K
L
I
D
Y
Site 8
S102
D
V
D
G
Q
T
L
S
K
L
I
D
Y
I
Y
Site 9
T116
Y
T
A
E
I
E
V
T
E
E
N
V
Q
V
L
Site 10
T163
R
A
F
A
D
V
H
T
C
T
D
L
L
Q
Q
Site 11
T206
L
I
S
S
D
K
L
T
V
S
S
E
E
K
V
Site 12
S208
S
S
D
K
L
T
V
S
S
E
E
K
V
F
E
Site 13
S209
S
D
K
L
T
V
S
S
E
E
K
V
F
E
A
Site 14
Y223
A
V
I
S
W
I
N
Y
E
K
E
T
R
L
E
Site 15
Y248
L
P
L
L
P
R
D
Y
L
V
Q
T
V
E
E
Site 16
T252
P
R
D
Y
L
V
Q
T
V
E
E
E
A
L
I
Site 17
T291
L
L
I
K
N
P
R
T
K
P
R
T
P
V
S
Site 18
T295
N
P
R
T
K
P
R
T
P
V
S
L
P
K
V
Site 19
S316
Q
A
P
K
A
I
R
S
V
E
C
Y
D
F
E
Site 20
Y320
A
I
R
S
V
E
C
Y
D
F
E
E
D
R
W
Site 21
S335
D
Q
I
A
E
L
P
S
R
R
C
R
A
G
V
Site 22
T363
N
G
S
L
R
V
R
T
V
D
V
Y
D
G
V
Site 23
Y367
R
V
R
T
V
D
V
Y
D
G
V
K
D
Q
W
Site 24
T375
D
G
V
K
D
Q
W
T
S
I
A
S
M
Q
E
Site 25
S385
A
S
M
Q
E
R
R
S
T
L
G
A
A
V
L
Site 26
T386
S
M
Q
E
R
R
S
T
L
G
A
A
V
L
N
Site 27
S410
D
G
S
T
G
L
A
S
V
E
A
Y
S
Y
K
Site 28
Y416
A
S
V
E
A
Y
S
Y
K
T
N
E
W
F
F
Site 29
S433
P
M
N
T
R
R
S
S
V
G
V
G
V
V
E
Site 30
S453
V
G
G
Y
D
G
A
S
R
Q
C
L
S
T
V
Site 31
S458
G
A
S
R
Q
C
L
S
T
V
E
Q
Y
N
P
Site 32
T459
A
S
R
Q
C
L
S
T
V
E
Q
Y
N
P
A
Site 33
Y472
P
A
T
N
E
W
I
Y
V
A
D
M
S
T
R
Site 34
S477
W
I
Y
V
A
D
M
S
T
R
R
S
G
A
G
Site 35
T478
I
Y
V
A
D
M
S
T
R
R
S
G
A
G
V
Site 36
S481
A
D
M
S
T
R
R
S
G
A
G
V
G
V
L
Site 37
Y493
G
V
L
S
G
Q
L
Y
A
T
G
G
H
D
G
Site 38
S506
D
G
P
L
V
R
K
S
V
E
V
Y
D
P
G
Site 39
Y510
V
R
K
S
V
E
V
Y
D
P
G
T
N
T
W
Site 40
T514
V
E
V
Y
D
P
G
T
N
T
W
K
Q
V
A
Site 41
S553
D
G
S
C
N
L
A
S
V
E
Y
Y
N
P
V
Site 42
Y556
C
N
L
A
S
V
E
Y
Y
N
P
V
T
D
K
Site 43
Y557
N
L
A
S
V
E
Y
Y
N
P
V
T
D
K
W
Site 44
T561
V
E
Y
Y
N
P
V
T
D
K
W
T
L
L
P
Site 45
T565
N
P
V
T
D
K
W
T
L
L
P
T
N
M
S
Site 46
S572
T
L
L
P
T
N
M
S
T
G
R
S
Y
A
G
Site 47
T573
L
L
P
T
N
M
S
T
G
R
S
Y
A
G
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation