PhosphoNET

           
Protein Info 
   
Short Name:  AFF4
Full Name:  ISOFORM 1 OF AF4/FMR2 FAMILY MEMBER 4.
Alias:  AF4/FMR2 family member 4: ALL1-fused gene from chromosome 5q31: Major CDK9 elongation factor-associated protein: AF4/FMR2 family member 4: ALL1-fused gene from chromosome 5q31: Major CDK9 elongation factor-associated protein; ALL1-fused gene from chromosome 5q31
Type:  Transcription protein
Mass (Da):  127459
Number AA:  1163
UniProt ID:  Q9UHB7
International Prot ID:  IPI00004344
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005634  GO:0043226  GO:0043227 Uniprot OncoNet
Molecular Function:  GO:0003700  GO:0003677  GO:0003700 PhosphoSite+ KinaseNET
Biological Process:  GO:0045449  GO:0006366  GO:0006351 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S31GEDAFPPSSPLFAEP
Site 2S32EDAFPPSSPLFAEPY
Site 3Y39SPLFAEPYKVTSKED
Site 4S43AEPYKVTSKEDKLSS
Site 5S49TSKEDKLSSRIQSML
Site 6S50SKEDKLSSRIQSMLG
Site 7S54KLSSRIQSMLGNYDE
Site 8S85PKPTVPPSADEKSNP
Site 9S90PPSADEKSNPNFFEQ
Site 10S102FEQRHGGSHQSSKWT
Site 11S105RHGGSHQSSKWTPVG
Site 12S106HGGSHQSSKWTPVGP
Site 13T109SHQSSKWTPVGPAPS
Site 14S116TPVGPAPSTSQSQKR
Site 15T117PVGPAPSTSQSQKRS
Site 16S118VGPAPSTSQSQKRSS
Site 17S120PAPSTSQSQKRSSGL
Site 18S124TSQSQKRSSGLQSGH
Site 19S125SQSQKRSSGLQSGHS
Site 20S129KRSSGLQSGHSSQRT
Site 21S132SGLQSGHSSQRTSAG
Site 22S133GLQSGHSSQRTSAGS
Site 23T136SGHSSQRTSAGSSSG
Site 24S137GHSSQRTSAGSSSGT
Site 25S140SQRTSAGSSSGTNSS
Site 26S141QRTSAGSSSGTNSSG
Site 27S142RTSAGSSSGTNSSGQ
Site 28T144SAGSSSGTNSSGQRH
Site 29S146GSSSGTNSSGQRHDR
Site 30S147SSSGTNSSGQRHDRE
Site 31S155GQRHDRESYNNSGSS
Site 32Y156QRHDRESYNNSGSSS
Site 33S159DRESYNNSGSSSRKK
Site 34S161ESYNNSGSSSRKKGQ
Site 35S162SYNNSGSSSRKKGQH
Site 36S163YNNSGSSSRKKGQHG
Site 37S171RKKGQHGSEHSKSRS
Site 38S174GQHGSEHSKSRSSSP
Site 39S176HGSEHSKSRSSSPGK
Site 40S178SEHSKSRSSSPGKPQ
Site 41S179EHSKSRSSSPGKPQA
Site 42S180HSKSRSSSPGKPQAV
Site 43S188PGKPQAVSSLNSSHS
Site 44S189GKPQAVSSLNSSHSR
Site 45S192QAVSSLNSSHSRSHG
Site 46S193AVSSLNSSHSRSHGN
Site 47S195SSLNSSHSRSHGNDH
Site 48S197LNSSHSRSHGNDHHS
Site 49S204SHGNDHHSKEHQRSK
Site 50S210HSKEHQRSKSPRDPD
Site 51S212KEHQRSKSPRDPDAN
Site 52S222DPDANWDSPSRVPFS
Site 53S224DANWDSPSRVPFSSG
Site 54S229SPSRVPFSSGQHSTQ
Site 55S230PSRVPFSSGQHSTQS
Site 56S234PFSSGQHSTQSFPPS
Site 57T235FSSGQHSTQSFPPSL
Site 58S237SGQHSTQSFPPSLMS
Site 59S241STQSFPPSLMSKSNS
Site 60S244SFPPSLMSKSNSMLQ
Site 61S246PPSLMSKSNSMLQKP
Site 62S248SLMSKSNSMLQKPTA
Site 63Y256MLQKPTAYVRPMDGQ
Site 64S265RPMDGQESMEPKLSS
Site 65S271ESMEPKLSSEHYSSQ
Site 66S272SMEPKLSSEHYSSQS
Site 67Y275PKLSSEHYSSQSHGN
Site 68S276KLSSEHYSSQSHGNS
Site 69S277LSSEHYSSQSHGNSM
Site 70S279SEHYSSQSHGNSMTE
Site 71S283SSQSHGNSMTELKPS
Site 72T285QSHGNSMTELKPSSK
Site 73S290SMTELKPSSKAHLTK
Site 74S291MTELKPSSKAHLTKL
Site 75T296PSSKAHLTKLKIPSQ
Site 76S302LTKLKIPSQPLDASA
Site 77S308PSQPLDASASGDVSC
Site 78S310QPLDASASGDVSCVD
Site 79S314ASASGDVSCVDEILK
Site 80S326ILKEMTHSWPPPLTA
Site 81T332HSWPPPLTAIHTPCK
Site 82T336PPLTAIHTPCKTEPS
Site 83T340AIHTPCKTEPSKFPF
Site 84S343TPCKTEPSKFPFPTK
Site 85T349PSKFPFPTKESQQSN
Site 86S355PTKESQQSNFGTGEQ
Site 87T359SQQSNFGTGEQKRYN
Site 88Y365GTGEQKRYNPSKTSN
Site 89T370KRYNPSKTSNGHQSK
Site 90S371RYNPSKTSNGHQSKS
Site 91S378SNGHQSKSMLKDDLK
Site 92S387LKDDLKLSSSEDSDG
Site 93S388KDDLKLSSSEDSDGE
Site 94S389DDLKLSSSEDSDGEQ
Site 95S392KLSSSEDSDGEQDCD
Site 96T401GEQDCDKTMPRSTPG
Site 97S405CDKTMPRSTPGSNSE
Site 98T406DKTMPRSTPGSNSEP
Site 99S409MPRSTPGSNSEPSHH
Site 100S411RSTPGSNSEPSHHNS
Site 101S414PGSNSEPSHHNSEGA
Site 102S418SEPSHHNSEGADNSR
Site 103S424NSEGADNSRDDSSSH
Site 104S428ADNSRDDSSSHSGSE
Site 105S429DNSRDDSSSHSGSES
Site 106S430NSRDDSSSHSGSESS
Site 107S432RDDSSSHSGSESSSG
Site 108S434DSSSHSGSESSSGSD
Site 109S436SSHSGSESSSGSDSE
Site 110S437SHSGSESSSGSDSES
Site 111S438HSGSESSSGSDSESE
Site 112S440GSESSSGSDSESESS
Site 113S442ESSSGSDSESESSSS
Site 114S444SSGSDSESESSSSDS
Site 115S446GSDSESESSSSDSEA
Site 116S447SDSESESSSSDSEAN
Site 117S448DSESESSSSDSEANE
Site 118S449SESESSSSDSEANEP
Site 119S451SESSSSDSEANEPSQ
Site 120S457DSEANEPSQSASPEP
Site 121S459EANEPSQSASPEPEP
Site 122S461NEPSQSASPEPEPPP
Site 123T469PEPEPPPTNKWQLDN
Site 124S487KVNPHKVSPASSVDS
Site 125S490PHKVSPASSVDSNIP
Site 126S491HKVSPASSVDSNIPS
Site 127S494SPASSVDSNIPSSQG
Site 128S498SVDSNIPSSQGYKKE
Site 129S499VDSNIPSSQGYKKEG
Site 130Y502NIPSSQGYKKEGREQ
Site 131S514REQGTGNSYTDTSGP
Site 132Y515EQGTGNSYTDTSGPK
Site 133T516QGTGNSYTDTSGPKE
Site 134T518TGNSYTDTSGPKETS
Site 135S519GNSYTDTSGPKETSS
Site 136S526SGPKETSSATPGRDS
Site 137T528PKETSSATPGRDSKT
Site 138S533SATPGRDSKTIQKGS
Site 139T535TPGRDSKTIQKGSES
Site 140S540SKTIQKGSESGRGRQ
Site 141S542TIQKGSESGRGRQKS
Site 142S549SGRGRQKSPAQSDST
Site 143S553RQKSPAQSDSTTQRR
Site 144S555KSPAQSDSTTQRRTV
Site 145T556SPAQSDSTTQRRTVG
Site 146T557PAQSDSTTQRRTVGK
Site 147T561DSTTQRRTVGKKQPK
Site 148S586RGGLKIESETPVDLA
Site 149T588GLKIESETPVDLASS
Site 150S594ETPVDLASSMPSSRH
Site 151S595TPVDLASSMPSSRHK
Site 152S598DLASSMPSSRHKAAT
Site 153S599LASSMPSSRHKAATK
Site 154T605SSRHKAATKGSRKPN
Site 155S617KPNIKKESKSSPRPT
Site 156S619NIKKESKSSPRPTAE
Site 157S620IKKESKSSPRPTAEK
Site 158T624SKSSPRPTAEKKKYK
Site 159Y630PTAEKKKYKSTSKSS
Site 160S632AEKKKYKSTSKSSQK
Site 161S634KKKYKSTSKSSQKSR
Site 162S636KYKSTSKSSQKSREI
Site 163S640TSKSSQKSREIIETD
Site 164T646KSREIIETDTSSSDS
Site 165T648REIIETDTSSSDSDE
Site 166S649EIIETDTSSSDSDES
Site 167S651IETDTSSSDSDESES
Site 168S653TDTSSSDSDESESLP
Site 169S656SSSDSDESESLPPSS
Site 170S658SDSDESESLPPSSQT
Site 171S662ESESLPPSSQTPKYP
Site 172S663SESLPPSSQTPKYPE
Site 173T665SLPPSSQTPKYPESN
Site 174Y668PSSQTPKYPESNRTP
Site 175S671QTPKYPESNRTPVKP
Site 176T674KYPESNRTPVKPSSV
Site 177S679NRTPVKPSSVEEEDS
Site 178S680RTPVKPSSVEEEDSF
Site 179S686SSVEEEDSFFRQRMF
Site 180S694FFRQRMFSPMEEKEL
Site 181S703MEEKELLSPLSEPDD
Site 182S706KELLSPLSEPDDRYP
Site 183Y712LSEPDDRYPLIVKID
Site 184T724KIDLNLLTRIPGKPY
Site 185Y731TRIPGKPYKETEPPK
Site 186T734PGKPYKETEPPKGEK
Site 187S757REAQKQASEKVSNKG
Site 188S761KQASEKVSNKGKRKH
Site 189S777NEDDNRASESKKPKT
Site 190S779DDNRASESKKPKTED
Site 191T784SESKKPKTEDKNSAG
Site 192S789PKTEDKNSAGHKPSS
Site 193S795NSAGHKPSSNRESSK
Site 194S796SAGHKPSSNRESSKQ
Site 195S800KPSSNRESSKQSAAK
Site 196S801PSSNRESSKQSAAKE
Site 197S804NRESSKQSAAKEKDL
Site 198S814KEKDLLPSPAGPVPS
Site 199S821SPAGPVPSKDPKTEH
Site 200T826VPSKDPKTEHGSRKR
Site 201T834EHGSRKRTISQSSSL
Site 202S836GSRKRTISQSSSLKS
Site 203S838RKRTISQSSSLKSSS
Site 204S839KRTISQSSSLKSSSN
Site 205S840RTISQSSSLKSSSNS
Site 206S843SQSSSLKSSSNSNKE
Site 207S844QSSSLKSSSNSNKET
Site 208S845SSSLKSSSNSNKETS
Site 209S847SLKSSSNSNKETSGS
Site 210T851SSNSNKETSGSSKNS
Site 211S852SNSNKETSGSSKNSS
Site 212S854SNKETSGSSKNSSST
Site 213S855NKETSGSSKNSSSTS
Site 214S858TSGSSKNSSSTSKQK
Site 215S859SGSSKNSSSTSKQKK
Site 216S860GSSKNSSSTSKQKKT
Site 217S862SKNSSSTSKQKKTEG
Site 218T867STSKQKKTEGKTSSS
Site 219T871QKKTEGKTSSSSKEV
Site 220S872KKTEGKTSSSSKEVK
Site 221S873KTEGKTSSSSKEVKE
Site 222S875EGKTSSSSKEVKEKA
Site 223S884EVKEKAPSSSSNCPP
Site 224S885VKEKAPSSSSNCPPS
Site 225S886KEKAPSSSSNCPPSA
Site 226S887EKAPSSSSNCPPSAP
Site 227S892SSSNCPPSAPTLDSS
Site 228T895NCPPSAPTLDSSKPR
Site 229S898PSAPTLDSSKPRRTK
Site 230S899SAPTLDSSKPRRTKL
Site 231T904DSSKPRRTKLVFDDR
Site 232Y913LVFDDRNYSADHYLQ
Site 233S914VFDDRNYSADHYLQE
Site 234Y918RNYSADHYLQEAKKL
Site 235S933KHNADALSDRFEKAV
Site 236Y941DRFEKAVYYLDAVVS
Site 237S963LEKNAQESKSPFPMY
Site 238S965KNAQESKSPFPMYSE
Site 239Y970SKSPFPMYSETVDLI
Site 240S971KSPFPMYSETVDLIK
Site 241T973PFPMYSETVDLIKYT
Site 242Y979ETVDLIKYTMKLKNY
Site 243Y986YTMKLKNYLAPDATA
Site 244T1027NALKYSKTLTEHLKN
Site 245T1029LKYSKTLTEHLKNSY
Site 246S1035LTEHLKNSYNNSQAP
Site 247S1039LKNSYNNSQAPSPGL
Site 248S1043YNNSQAPSPGLGSKA
Site 249S1048APSPGLGSKAVGMPS
Site 250S1055SKAVGMPSPVSPKLS
Site 251S1058VGMPSPVSPKLSPGN
Site 252S1062SPVSPKLSPGNSGNY
Site 253S1066PKLSPGNSGNYSSGA
Site 254Y1069SPGNSGNYSSGASSA
Site 255S1070PGNSGNYSSGASSAS
Site 256S1071GNSGNYSSGASSASA
Site 257S1074GNYSSGASSASASGS
Site 258S1075NYSSGASSASASGSS
Site 259S1077SSGASSASASGSSVT
Site 260S1081SSASASGSSVTIPQK
Site 261Y1105QVTSNFLYATEIWDQ
Site 262S1117WDQAEQLSKEQKEFF
Site 263Y1147IMTDLVRYTRQGLHW
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


2019 Kinexus Bioinformatics Corporation