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Updated November 2019
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Protein Info
Short Name:
MLH3
Full Name:
DNA mismatch repair protein Mlh3
Alias:
MutL 3
Type:
DNA repair
Mass (Da):
163710
Number AA:
UniProt ID:
Q9UHC1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0030983
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006298
GO:0007131
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
R
S
G
L
A
I
S
S
L
G
Q
C
V
E
E
Site 2
S63
D
N
G
F
G
M
G
S
D
D
V
E
K
V
G
Site 3
Y73
V
E
K
V
G
N
R
Y
F
T
S
K
C
H
S
Site 4
T75
K
V
G
N
R
Y
F
T
S
K
C
H
S
V
Q
Site 5
S80
Y
F
T
S
K
C
H
S
V
Q
D
L
E
N
P
Site 6
Y90
D
L
E
N
P
R
F
Y
G
F
R
G
E
A
L
Site 7
T119
K
K
N
R
T
M
K
T
F
V
K
L
F
Q
S
Site 8
T138
K
A
C
E
A
D
V
T
R
A
S
A
G
T
T
Site 9
Y153
V
T
V
Y
N
L
F
Y
Q
L
P
V
R
R
K
Site 10
S179
R
Q
R
I
E
A
L
S
L
M
H
P
S
I
S
Site 11
S186
S
L
M
H
P
S
I
S
F
S
L
R
N
D
V
Site 12
S188
M
H
P
S
I
S
F
S
L
R
N
D
V
S
G
Site 13
T204
M
V
L
Q
L
P
K
T
K
D
V
C
S
R
F
Site 14
Y215
C
S
R
F
C
Q
I
Y
G
L
G
K
S
Q
K
Site 15
S220
Q
I
Y
G
L
G
K
S
Q
K
L
R
E
I
S
Site 16
S227
S
Q
K
L
R
E
I
S
F
K
Y
K
E
F
E
Site 17
Y230
L
R
E
I
S
F
K
Y
K
E
F
E
L
S
G
Site 18
S236
K
Y
K
E
F
E
L
S
G
Y
I
S
S
E
A
Site 19
Y238
K
E
F
E
L
S
G
Y
I
S
S
E
A
H
Y
Site 20
S240
F
E
L
S
G
Y
I
S
S
E
A
H
Y
N
K
Site 21
S241
E
L
S
G
Y
I
S
S
E
A
H
Y
N
K
N
Site 22
Y245
Y
I
S
S
E
A
H
Y
N
K
N
M
Q
F
L
Site 23
T262
N
K
R
L
V
L
R
T
K
L
H
K
L
I
D
Site 24
S276
D
F
L
L
R
K
E
S
I
I
C
K
P
K
N
Site 25
S287
K
P
K
N
G
P
T
S
R
Q
M
N
S
S
L
Site 26
S293
T
S
R
Q
M
N
S
S
L
R
H
R
S
T
P
Site 27
S298
N
S
S
L
R
H
R
S
T
P
E
L
Y
G
I
Site 28
T299
S
S
L
R
H
R
S
T
P
E
L
Y
G
I
Y
Site 29
S358
E
K
L
F
V
E
L
S
G
E
D
I
K
E
F
Site 30
S366
G
E
D
I
K
E
F
S
E
D
N
G
F
S
L
Site 31
S372
F
S
E
D
N
G
F
S
L
F
D
A
T
L
Q
Site 32
T377
G
F
S
L
F
D
A
T
L
Q
K
R
V
T
S
Site 33
T383
A
T
L
Q
K
R
V
T
S
D
E
R
S
N
F
Site 34
S384
T
L
Q
K
R
V
T
S
D
E
R
S
N
F
Q
Site 35
S388
R
V
T
S
D
E
R
S
N
F
Q
E
A
C
N
Site 36
Y401
C
N
N
I
L
D
S
Y
E
M
F
N
L
Q
S
Site 37
T415
S
K
A
V
K
R
K
T
T
A
E
N
V
N
T
Site 38
T416
K
A
V
K
R
K
T
T
A
E
N
V
N
T
Q
Site 39
T422
T
T
A
E
N
V
N
T
Q
S
S
R
D
S
E
Site 40
S424
A
E
N
V
N
T
Q
S
S
R
D
S
E
A
T
Site 41
S425
E
N
V
N
T
Q
S
S
R
D
S
E
A
T
R
Site 42
S428
N
T
Q
S
S
R
D
S
E
A
T
R
K
N
T
Site 43
T435
S
E
A
T
R
K
N
T
N
D
A
F
L
Y
I
Site 44
Y441
N
T
N
D
A
F
L
Y
I
Y
E
S
G
G
P
Site 45
Y443
N
D
A
F
L
Y
I
Y
E
S
G
G
P
G
H
Site 46
S445
A
F
L
Y
I
Y
E
S
G
G
P
G
H
S
K
Site 47
S451
E
S
G
G
P
G
H
S
K
M
T
E
P
S
L
Site 48
S457
H
S
K
M
T
E
P
S
L
Q
N
K
D
S
S
Site 49
S463
P
S
L
Q
N
K
D
S
S
C
S
E
S
K
M
Site 50
S464
S
L
Q
N
K
D
S
S
C
S
E
S
K
M
L
Site 51
S466
Q
N
K
D
S
S
C
S
E
S
K
M
L
E
Q
Site 52
S468
K
D
S
S
C
S
E
S
K
M
L
E
Q
E
T
Site 53
T475
S
K
M
L
E
Q
E
T
I
V
A
S
E
A
G
Site 54
S490
E
N
E
K
H
K
K
S
F
L
E
H
S
S
L
Site 55
S495
K
K
S
F
L
E
H
S
S
L
E
N
P
C
G
Site 56
S496
K
S
F
L
E
H
S
S
L
E
N
P
C
G
T
Site 57
S510
T
S
L
E
M
F
L
S
P
F
Q
T
P
C
H
Site 58
T514
M
F
L
S
P
F
Q
T
P
C
H
F
E
E
S
Site 59
T558
P
K
R
F
K
D
A
T
E
V
G
C
Q
P
L
Site 60
S588
K
E
K
K
K
E
S
S
N
C
G
R
R
N
V
Site 61
Y598
G
R
R
N
V
F
S
Y
G
R
V
K
L
C
S
Site 62
T606
G
R
V
K
L
C
S
T
G
F
I
T
H
V
V
Site 63
T610
L
C
S
T
G
F
I
T
H
V
V
Q
N
E
K
Site 64
S620
V
Q
N
E
K
T
K
S
T
E
T
E
H
S
F
Site 65
S626
K
S
T
E
T
E
H
S
F
K
N
Y
V
R
P
Site 66
Y630
T
E
H
S
F
K
N
Y
V
R
P
G
P
T
R
Site 67
T641
G
P
T
R
A
Q
E
T
F
G
N
R
T
R
H
Site 68
S649
F
G
N
R
T
R
H
S
V
E
T
P
D
I
K
Site 69
T652
R
T
R
H
S
V
E
T
P
D
I
K
D
L
A
Site 70
S660
P
D
I
K
D
L
A
S
T
L
S
K
E
S
G
Site 71
T661
D
I
K
D
L
A
S
T
L
S
K
E
S
G
Q
Site 72
S663
K
D
L
A
S
T
L
S
K
E
S
G
Q
L
P
Site 73
Y681
N
C
R
T
N
I
S
Y
G
L
E
N
E
P
T
Site 74
T688
Y
G
L
E
N
E
P
T
A
T
Y
T
M
F
S
Site 75
T690
L
E
N
E
P
T
A
T
Y
T
M
F
S
A
F
Site 76
Y691
E
N
E
P
T
A
T
Y
T
M
F
S
A
F
Q
Site 77
S704
F
Q
E
G
S
K
K
S
Q
T
D
C
I
L
S
Site 78
T706
E
G
S
K
K
S
Q
T
D
C
I
L
S
D
T
Site 79
S711
S
Q
T
D
C
I
L
S
D
T
S
P
S
F
P
Site 80
T713
T
D
C
I
L
S
D
T
S
P
S
F
P
W
Y
Site 81
S714
D
C
I
L
S
D
T
S
P
S
F
P
W
Y
R
Site 82
S716
I
L
S
D
T
S
P
S
F
P
W
Y
R
H
V
Site 83
Y720
T
S
P
S
F
P
W
Y
R
H
V
S
N
D
S
Site 84
S724
F
P
W
Y
R
H
V
S
N
D
S
R
K
T
D
Site 85
T730
V
S
N
D
S
R
K
T
D
K
L
I
G
F
S
Site 86
S746
P
I
V
R
K
K
L
S
L
S
S
Q
L
G
S
Site 87
S748
V
R
K
K
L
S
L
S
S
Q
L
G
S
L
E
Site 88
S749
R
K
K
L
S
L
S
S
Q
L
G
S
L
E
K
Site 89
S753
S
L
S
S
Q
L
G
S
L
E
K
F
K
R
Q
Site 90
Y761
L
E
K
F
K
R
Q
Y
G
K
V
E
N
P
L
Site 91
T770
K
V
E
N
P
L
D
T
E
V
E
E
S
N
G
Site 92
S775
L
D
T
E
V
E
E
S
N
G
V
T
T
N
L
Site 93
T779
V
E
E
S
N
G
V
T
T
N
L
S
L
Q
V
Site 94
S783
N
G
V
T
T
N
L
S
L
Q
V
E
P
D
I
Site 95
S801
D
K
N
R
L
E
N
S
D
V
C
K
I
T
T
Site 96
T808
S
D
V
C
K
I
T
T
M
E
H
S
D
S
D
Site 97
S812
K
I
T
T
M
E
H
S
D
S
D
S
S
C
Q
Site 98
S814
T
T
M
E
H
S
D
S
D
S
S
C
Q
P
A
Site 99
S816
M
E
H
S
D
S
D
S
S
C
Q
P
A
S
H
Site 100
S817
E
H
S
D
S
D
S
S
C
Q
P
A
S
H
I
Site 101
S822
D
S
S
C
Q
P
A
S
H
I
L
D
S
E
K
Site 102
S827
P
A
S
H
I
L
D
S
E
K
F
P
F
S
K
Site 103
S833
D
S
E
K
F
P
F
S
K
D
E
D
C
L
E
Site 104
S845
C
L
E
Q
Q
M
P
S
L
R
E
S
P
M
T
Site 105
S849
Q
M
P
S
L
R
E
S
P
M
T
L
K
E
L
Site 106
T852
S
L
R
E
S
P
M
T
L
K
E
L
S
L
F
Site 107
S869
K
P
L
D
L
E
K
S
S
E
S
L
A
S
K
Site 108
S870
P
L
D
L
E
K
S
S
E
S
L
A
S
K
L
Site 109
S872
D
L
E
K
S
S
E
S
L
A
S
K
L
S
R
Site 110
S875
K
S
S
E
S
L
A
S
K
L
S
R
L
K
G
Site 111
S878
E
S
L
A
S
K
L
S
R
L
K
G
S
E
R
Site 112
S883
K
L
S
R
L
K
G
S
E
R
E
T
Q
T
M
Site 113
T887
L
K
G
S
E
R
E
T
Q
T
M
G
M
M
S
Site 114
S902
R
F
N
E
L
P
N
S
D
S
S
R
K
D
S
Site 115
S904
N
E
L
P
N
S
D
S
S
R
K
D
S
K
L
Site 116
S905
E
L
P
N
S
D
S
S
R
K
D
S
K
L
C
Site 117
S909
S
D
S
S
R
K
D
S
K
L
C
S
V
L
T
Site 118
S913
R
K
D
S
K
L
C
S
V
L
T
Q
D
F
C
Site 119
S938
E
N
G
V
I
P
T
S
D
S
A
T
Q
D
N
Site 120
S940
G
V
I
P
T
S
D
S
A
T
Q
D
N
S
F
Site 121
T942
I
P
T
S
D
S
A
T
Q
D
N
S
F
N
K
Site 122
S946
D
S
A
T
Q
D
N
S
F
N
K
N
S
K
T
Site 123
S951
D
N
S
F
N
K
N
S
K
T
H
S
N
S
N
Site 124
T953
S
F
N
K
N
S
K
T
H
S
N
S
N
T
T
Site 125
S955
N
K
N
S
K
T
H
S
N
S
N
T
T
E
N
Site 126
T959
K
T
H
S
N
S
N
T
T
E
N
C
V
I
S
Site 127
S977
L
V
L
P
Y
N
N
S
K
V
T
G
K
D
S
Site 128
S984
S
K
V
T
G
K
D
S
D
V
L
I
R
A
S
Site 129
S991
S
D
V
L
I
R
A
S
E
Q
Q
I
G
S
L
Site 130
S997
A
S
E
Q
Q
I
G
S
L
D
S
P
S
G
M
Site 131
S1000
Q
Q
I
G
S
L
D
S
P
S
G
M
L
M
N
Site 132
T1013
M
N
P
V
E
D
A
T
G
D
Q
N
G
I
C
Site 133
S1032
E
S
K
A
R
A
C
S
E
T
E
E
S
N
T
Site 134
T1034
K
A
R
A
C
S
E
T
E
E
S
N
T
C
C
Site 135
T1066
N
K
M
T
G
L
S
T
F
I
A
P
T
E
D
Site 136
S1095
D
V
V
L
E
N
G
S
Q
Y
R
C
Q
P
F
Site 137
T1119
P
R
A
R
A
E
R
T
V
M
R
Q
D
N
R
Site 138
T1128
M
R
Q
D
N
R
D
T
V
D
D
T
V
S
S
Site 139
T1132
N
R
D
T
V
D
D
T
V
S
S
E
S
L
Q
Site 140
S1134
D
T
V
D
D
T
V
S
S
E
S
L
Q
S
L
Site 141
S1135
T
V
D
D
T
V
S
S
E
S
L
Q
S
L
F
Site 142
S1137
D
D
T
V
S
S
E
S
L
Q
S
L
F
S
E
Site 143
S1140
V
S
S
E
S
L
Q
S
L
F
S
E
W
D
N
Site 144
S1143
E
S
L
Q
S
L
F
S
E
W
D
N
P
V
F
Site 145
Y1153
D
N
P
V
F
A
R
Y
P
E
V
A
V
D
V
Site 146
S1167
V
S
S
G
Q
A
E
S
L
A
V
K
I
H
N
Site 147
Y1177
V
K
I
H
N
I
L
Y
P
Y
R
F
T
K
G
Site 148
T1208
A
C
L
M
S
T
K
T
E
E
N
G
E
A
G
Site 149
Y1241
E
Q
L
I
I
D
S
Y
E
K
Q
Q
A
Q
G
Site 150
S1249
E
K
Q
Q
A
Q
G
S
G
R
K
K
L
L
S
Site 151
S1256
S
G
R
K
K
L
L
S
S
T
L
I
P
P
L
Site 152
S1257
G
R
K
K
L
L
S
S
T
L
I
P
P
L
E
Site 153
T1258
R
K
K
L
L
S
S
T
L
I
P
P
L
E
I
Site 154
T1266
L
I
P
P
L
E
I
T
V
T
E
E
Q
R
R
Site 155
T1268
P
P
L
E
I
T
V
T
E
E
Q
R
R
L
L
Site 156
Y1278
Q
R
R
L
L
W
C
Y
H
K
N
L
E
D
L
Site 157
S1321
N
E
L
R
R
G
R
S
T
V
T
K
S
I
V
Site 158
T1322
E
L
R
R
G
R
S
T
V
T
K
S
I
V
E
Site 159
S1326
G
R
S
T
V
T
K
S
I
V
E
E
F
I
R
Site 160
T1341
E
Q
L
E
L
L
Q
T
T
G
G
I
Q
G
T
Site 161
S1373
I
K
F
N
D
G
L
S
L
Q
E
S
C
R
L
Site 162
S1399
Q
C
A
H
G
R
P
S
M
L
P
L
A
D
I
Site 163
S1442
A
E
C
D
T
R
Q
S
L
Q
Q
S
M
P
P
Site 164
S1446
T
R
Q
S
L
Q
Q
S
M
P
P
C
E
P
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation