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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MKRN1
Full Name:
Makorin 1
Alias:
Makorin ring finger protein 1; Makorin, RING finger protein 61, RNF61; Makorin, ring finger protein, 1; Makorin-1; RING finger protein 61; RNF61
Type:
Uncharacterized protein
Mass (Da):
53349
Number AA:
482
UniProt ID:
Q9UHC7
International Prot ID:
IPI00033350
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
A
E
A
A
T
P
G
T
T
A
T
T
Site 2
S48
A
G
G
G
G
G
G
S
D
G
S
G
G
G
W
Site 3
S51
G
G
G
G
S
D
G
S
G
G
G
W
T
K
Q
Site 4
S78
E
G
D
N
C
R
Y
S
H
D
L
S
D
S
P
Site 5
S82
C
R
Y
S
H
D
L
S
D
S
P
Y
S
V
V
Site 6
S84
Y
S
H
D
L
S
D
S
P
Y
S
V
V
C
K
Site 7
Y86
H
D
L
S
D
S
P
Y
S
V
V
C
K
Y
F
Site 8
S87
D
L
S
D
S
P
Y
S
V
V
C
K
Y
F
Q
Site 9
Y100
F
Q
R
G
Y
C
I
Y
G
D
R
C
R
Y
E
Site 10
Y106
I
Y
G
D
R
C
R
Y
E
H
S
K
P
L
K
Site 11
T120
K
Q
E
E
A
T
A
T
E
L
T
T
K
S
S
Site 12
T123
E
A
T
A
T
E
L
T
T
K
S
S
L
A
A
Site 13
S126
A
T
E
L
T
T
K
S
S
L
A
A
S
S
S
Site 14
S127
T
E
L
T
T
K
S
S
L
A
A
S
S
S
L
Site 15
S154
G
E
A
E
S
R
N
S
N
F
A
T
V
G
A
Site 16
T158
S
R
N
S
N
F
A
T
V
G
A
G
S
E
D
Site 17
Y178
E
F
V
P
G
Q
P
Y
C
G
R
T
A
P
S
Site 18
T187
G
R
T
A
P
S
C
T
E
A
P
L
Q
G
S
Site 19
S194
T
E
A
P
L
Q
G
S
V
T
K
E
E
S
E
Site 20
T196
A
P
L
Q
G
S
V
T
K
E
E
S
E
K
E
Site 21
S200
G
S
V
T
K
E
E
S
E
K
E
Q
T
A
V
Site 22
T205
E
E
S
E
K
E
Q
T
A
V
E
T
K
K
Q
Site 23
Y216
T
K
K
Q
L
C
P
Y
A
A
V
G
E
C
R
Site 24
Y230
R
Y
G
E
N
C
V
Y
L
H
G
D
S
C
D
Site 25
S270
H
E
K
D
M
E
L
S
F
A
V
Q
R
S
K
Site 26
Y289
G
I
C
M
E
V
V
Y
E
K
A
N
P
S
E
Site 27
S295
V
Y
E
K
A
N
P
S
E
R
R
F
G
I
L
Site 28
Y309
L
S
N
C
N
H
T
Y
C
L
K
C
I
R
K
Site 29
S325
R
S
A
K
Q
F
E
S
K
I
I
K
S
C
P
Site 30
S330
F
E
S
K
I
I
K
S
C
P
E
C
R
I
T
Site 31
S338
C
P
E
C
R
I
T
S
N
F
V
I
P
S
E
Site 32
Y361
K
Q
K
L
I
L
K
Y
K
E
A
M
S
N
K
Site 33
Y372
M
S
N
K
A
C
R
Y
F
D
E
G
R
G
S
Site 34
Y388
P
F
G
G
N
C
F
Y
K
H
A
Y
P
D
G
Site 35
Y392
N
C
F
Y
K
H
A
Y
P
D
G
R
R
E
E
Site 36
T407
P
Q
R
Q
K
V
G
T
S
S
R
Y
R
A
Q
Site 37
S408
Q
R
Q
K
V
G
T
S
S
R
Y
R
A
Q
R
Site 38
S409
R
Q
K
V
G
T
S
S
R
Y
R
A
Q
R
R
Site 39
Y411
K
V
G
T
S
S
R
Y
R
A
Q
R
R
N
H
Site 40
S429
L
I
E
E
R
E
N
S
N
P
F
D
N
D
E
Site 41
T441
N
D
E
E
E
V
V
T
F
E
L
G
E
M
L
Site 42
T461
A
G
G
D
D
E
L
T
D
S
E
D
E
W
D
Site 43
S463
G
D
D
E
L
T
D
S
E
D
E
W
D
L
F
Site 44
Y478
H
D
E
L
E
D
F
Y
D
L
D
L
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation