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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NPC1L1
Full Name:
Alias:
Type:
Mass (Da):
148698
Number AA:
1359
UniProt ID:
Q9UHC9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T25
L
A
Q
S
E
P
Y
T
T
I
H
Q
P
G
Y
Site 2
T26
A
Q
S
E
P
Y
T
T
I
H
Q
P
G
Y
C
Site 3
Y36
Q
P
G
Y
C
A
F
Y
D
E
C
G
K
N
P
Site 4
S46
C
G
K
N
P
E
L
S
G
S
L
M
T
L
S
Site 5
S48
K
N
P
E
L
S
G
S
L
M
T
L
S
N
V
Site 6
S59
L
S
N
V
S
C
L
S
N
T
P
A
R
K
I
Site 7
T61
N
V
S
C
L
S
N
T
P
A
R
K
I
T
G
Site 8
T67
N
T
P
A
R
K
I
T
G
D
H
L
I
L
L
Site 9
Y82
Q
K
I
C
P
R
L
Y
T
G
P
N
T
Q
A
Site 10
T83
K
I
C
P
R
L
Y
T
G
P
N
T
Q
A
C
Site 11
T87
R
L
Y
T
G
P
N
T
Q
A
C
C
S
A
K
Site 12
S134
N
T
C
S
P
N
Q
S
L
F
I
N
V
T
R
Site 13
S168
Q
H
S
F
A
E
Q
S
Y
D
S
C
S
R
V
Site 14
Y169
H
S
F
A
E
Q
S
Y
D
S
C
S
R
V
R
Site 15
S171
F
A
E
Q
S
Y
D
S
C
S
R
V
R
V
P
Site 16
S173
E
Q
S
Y
D
S
C
S
R
V
R
V
P
A
A
Site 17
S274
A
R
P
Q
A
L
D
S
T
F
Y
L
G
Q
M
Site 18
T275
R
P
Q
A
L
D
S
T
F
Y
L
G
Q
M
P
Site 19
Y277
Q
A
L
D
S
T
F
Y
L
G
Q
M
P
G
S
Site 20
S314
V
A
P
A
R
D
K
S
K
M
V
D
P
K
K
Site 21
S324
V
D
P
K
K
G
T
S
L
S
D
K
L
S
F
Site 22
S326
P
K
K
G
T
S
L
S
D
K
L
S
F
S
T
Site 23
S330
T
S
L
S
D
K
L
S
F
S
T
H
T
L
L
Site 24
S332
L
S
D
K
L
S
F
S
T
H
T
L
L
G
Q
Site 25
S384
T
D
P
V
E
L
W
S
A
P
N
S
Q
A
R
Site 26
S388
E
L
W
S
A
P
N
S
Q
A
R
S
E
K
A
Site 27
S392
A
P
N
S
Q
A
R
S
E
K
A
F
H
D
Q
Site 28
T413
R
T
N
Q
V
I
L
T
A
P
N
R
S
S
Y
Site 29
S419
L
T
A
P
N
R
S
S
Y
R
Y
D
S
L
L
Site 30
Y420
T
A
P
N
R
S
S
Y
R
Y
D
S
L
L
L
Site 31
Y422
P
N
R
S
S
Y
R
Y
D
S
L
L
L
G
P
Site 32
S424
R
S
S
Y
R
Y
D
S
L
L
L
G
P
K
N
Site 33
S433
L
L
G
P
K
N
F
S
G
I
L
D
L
D
L
Site 34
S458
L
R
H
L
Q
V
W
S
P
E
A
Q
R
N
I
Site 35
S466
P
E
A
Q
R
N
I
S
L
Q
D
I
C
Y
A
Site 36
Y472
I
S
L
Q
D
I
C
Y
A
P
L
N
P
D
N
Site 37
Y483
N
P
D
N
T
S
L
Y
D
C
C
I
N
S
L
Site 38
Y493
C
I
N
S
L
L
Q
Y
F
Q
N
N
R
T
L
Site 39
Y524
D
W
K
D
H
F
L
Y
C
A
N
A
P
L
T
Site 40
Y564
G
G
Y
K
G
K
D
Y
S
E
A
E
A
L
I
Site 41
S565
G
Y
K
G
K
D
Y
S
E
A
E
A
L
I
M
Site 42
Y579
M
T
F
S
L
N
N
Y
P
A
G
D
P
R
L
Site 43
S620
V
T
F
M
A
E
R
S
L
E
D
E
I
N
R
Site 44
T628
L
E
D
E
I
N
R
T
T
A
E
D
L
P
I
Site 45
T629
E
D
E
I
N
R
T
T
A
E
D
L
P
I
F
Site 46
S658
L
G
S
Y
S
S
W
S
R
V
M
V
D
S
K
Site 47
S796
S
A
F
V
A
L
L
S
L
D
S
K
R
Q
E
Site 48
S799
V
A
L
L
S
L
D
S
K
R
Q
E
A
S
R
Site 49
Y886
K
D
S
Y
L
L
D
Y
F
L
F
L
N
R
Y
Site 50
Y908
Y
F
V
T
T
L
G
Y
N
F
S
S
E
A
G
Site 51
S911
T
T
L
G
Y
N
F
S
S
E
A
G
M
N
A
Site 52
S912
T
L
G
Y
N
F
S
S
E
A
G
M
N
A
I
Site 53
Y936
S
F
T
Q
K
I
Q
Y
A
T
E
F
P
E
Q
Site 54
S944
A
T
E
F
P
E
Q
S
Y
L
A
I
P
A
S
Site 55
Y970
P
S
S
C
C
R
L
Y
I
S
G
P
N
K
D
Site 56
T983
K
D
K
F
C
P
S
T
V
N
S
L
N
C
L
Site 57
S1000
C
M
S
I
T
M
G
S
V
R
P
S
V
E
Q
Site 58
S1004
T
M
G
S
V
R
P
S
V
E
Q
F
H
K
Y
Site 59
Y1011
S
V
E
Q
F
H
K
Y
L
P
W
F
L
N
D
Site 60
S1033
K
G
G
L
A
A
Y
S
T
S
V
N
L
T
S
Site 61
T1034
G
G
L
A
A
Y
S
T
S
V
N
L
T
S
D
Site 62
S1035
G
L
A
A
Y
S
T
S
V
N
L
T
S
D
G
Site 63
T1039
Y
S
T
S
V
N
L
T
S
D
G
Q
V
L
D
Site 64
Y1057
I
L
S
P
R
L
E
Y
S
G
T
I
S
A
H
Site 65
S1058
L
S
P
R
L
E
Y
S
G
T
I
S
A
H
C
Site 66
T1060
P
R
L
E
Y
S
G
T
I
S
A
H
C
N
L
Site 67
S1074
L
Y
L
L
D
S
A
S
R
F
M
A
Y
H
K
Site 68
Y1079
S
A
S
R
F
M
A
Y
H
K
P
L
K
N
S
Site 69
S1086
Y
H
K
P
L
K
N
S
Q
D
Y
T
E
A
L
Site 70
Y1089
P
L
K
N
S
Q
D
Y
T
E
A
L
R
A
A
Site 71
T1090
L
K
N
S
Q
D
Y
T
E
A
L
R
A
A
R
Site 72
T1113
D
L
R
K
V
P
G
T
D
P
A
F
E
V
F
Site 73
Y1132
T
N
V
F
Y
E
Q
Y
L
T
I
L
P
E
G
Site 74
S1219
I
T
R
S
F
A
I
S
T
K
P
T
W
L
E
Site 75
T1232
L
E
R
A
K
E
A
T
I
S
M
G
S
A
V
Site 76
S1324
A
S
C
P
N
H
P
S
R
V
S
T
A
D
N
Site 77
S1327
P
N
H
P
S
R
V
S
T
A
D
N
I
Y
V
Site 78
T1328
N
H
P
S
R
V
S
T
A
D
N
I
Y
V
N
Site 79
Y1333
V
S
T
A
D
N
I
Y
V
N
H
S
F
E
G
Site 80
S1337
D
N
I
Y
V
N
H
S
F
E
G
S
I
K
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation