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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IHPK2
Full Name:
Inositol hexakisphosphate kinase 2
Alias:
EC 2.7.4.21; InsP6 kinase 2; IP6K2; P(i)-uptake stimulator; PiUS
Type:
Kinase (non-protein)
Mass (Da):
49186
Number AA:
426
UniProt ID:
Q9UHH9
International Prot ID:
Isoform1 - IPI00426289
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008440
PhosphoSite+
KinaseNET
Biological Process:
GO:0030308
GO:0046854
GO:0043065
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y52
V
P
R
E
H
Q
F
Y
E
T
L
P
A
E
M
Site 2
T63
P
A
E
M
R
K
F
T
P
Q
Y
K
G
V
V
Site 3
Y66
M
R
K
F
T
P
Q
Y
K
G
V
V
S
V
R
Site 4
S71
P
Q
Y
K
G
V
V
S
V
R
F
E
E
D
E
Site 5
Y87
R
N
L
C
L
I
A
Y
P
L
K
G
D
H
G
Site 6
S102
I
V
D
I
V
D
N
S
D
C
E
P
K
S
K
Site 7
S108
N
S
D
C
E
P
K
S
K
L
L
R
W
T
T
Site 8
T114
K
S
K
L
L
R
W
T
T
N
K
K
H
H
V
Site 9
T115
S
K
L
L
R
W
T
T
N
K
K
H
H
V
L
Site 10
T127
H
V
L
E
T
E
K
T
P
K
D
W
V
R
Q
Site 11
S143
R
K
E
E
K
M
K
S
H
K
L
E
E
E
F
Site 12
Y160
L
K
K
S
E
V
L
Y
Y
T
V
E
K
K
G
Site 13
Y161
K
K
S
E
V
L
Y
Y
T
V
E
K
K
G
N
Site 14
T162
K
S
E
V
L
Y
Y
T
V
E
K
K
G
N
I
Site 15
S171
E
K
K
G
N
I
S
S
Q
L
K
H
Y
N
P
Site 16
Y176
I
S
S
Q
L
K
H
Y
N
P
W
S
M
K
C
Site 17
Y201
N
A
K
H
R
N
Q
Y
K
F
I
L
L
E
N
Site 18
Y213
L
E
N
L
T
S
R
Y
E
V
P
C
V
L
D
Site 19
S233
R
Q
H
G
D
D
A
S
E
E
K
A
A
N
Q
Site 20
S247
Q
I
R
K
C
Q
Q
S
T
S
A
V
I
G
V
Site 21
S249
R
K
C
Q
Q
S
T
S
A
V
I
G
V
R
V
Site 22
Y262
R
V
C
G
M
Q
V
Y
Q
A
G
S
G
Q
L
Site 23
Y275
Q
L
M
F
M
N
K
Y
H
G
R
K
L
S
V
Site 24
S281
K
Y
H
G
R
K
L
S
V
Q
G
F
K
E
A
Site 25
Y298
Q
F
F
H
N
G
R
Y
L
R
R
E
L
L
G
Site 26
S323
A
V
L
E
R
Q
E
S
Y
R
F
Y
S
S
S
Site 27
Y324
V
L
E
R
Q
E
S
Y
R
F
Y
S
S
S
L
Site 28
Y327
R
Q
E
S
Y
R
F
Y
S
S
S
L
L
V
I
Site 29
S328
Q
E
S
Y
R
F
Y
S
S
S
L
L
V
I
Y
Site 30
S330
S
Y
R
F
Y
S
S
S
L
L
V
I
Y
D
G
Site 31
Y335
S
S
S
L
L
V
I
Y
D
G
K
E
R
P
E
Site 32
S347
R
P
E
V
V
L
D
S
D
A
E
D
L
E
D
Site 33
S356
A
E
D
L
E
D
L
S
E
E
S
A
D
E
S
Site 34
S359
L
E
D
L
S
E
E
S
A
D
E
S
A
G
A
Site 35
S363
S
E
E
S
A
D
E
S
A
G
A
Y
A
Y
K
Site 36
Y367
A
D
E
S
A
G
A
Y
A
Y
K
P
I
G
A
Site 37
S376
Y
K
P
I
G
A
S
S
V
D
V
R
M
I
D
Site 38
Y392
A
H
T
T
C
R
L
Y
G
E
D
T
V
V
H
Site 39
T396
C
R
L
Y
G
E
D
T
V
V
H
E
G
Q
D
Site 40
Y406
H
E
G
Q
D
A
G
Y
I
F
G
L
Q
S
L
Site 41
T418
Q
S
L
I
D
I
V
T
E
I
S
E
E
S
G
Site 42
S421
I
D
I
V
T
E
I
S
E
E
S
G
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation