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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADAMTS1
Full Name:
A disintegrin and metalloproteinase with thrombospondin motifs 1 precursor
Alias:
A disintegrin and metalloproteinase with thrombospondin motifs 1; A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1; ADAM metallopeptidase with thrombospondin type 1 motif, 1; ADAM-TS 1; ADAM-TS1; ADAMTS-1; ATS1; C3-C5; KIAA1346; METH1; METH-1
Type:
Protease; EC 3.4.24.-
Mass (Da):
105360
Number AA:
UniProt ID:
Q9UHI8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008201
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007229
GO:0008285
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
F
G
R
R
K
L
G
S
D
M
G
N
A
E
R
Site 2
S27
N
A
E
R
A
P
G
S
R
S
F
G
P
V
P
Site 3
S29
E
R
A
P
G
S
R
S
F
G
P
V
P
T
L
Site 4
S54
S
D
A
L
G
R
P
S
E
E
D
E
E
L
V
Site 5
T73
E
R
A
P
G
H
G
T
T
R
L
R
L
H
A
Site 6
S93
D
L
E
L
R
P
D
S
S
F
L
A
P
G
F
Site 7
S94
L
E
L
R
P
D
S
S
F
L
A
P
G
F
T
Site 8
T101
S
F
L
A
P
G
F
T
L
Q
N
V
G
R
K
Site 9
S109
L
Q
N
V
G
R
K
S
G
S
E
T
P
L
P
Site 10
S111
N
V
G
R
K
S
G
S
E
T
P
L
P
E
T
Site 11
T113
G
R
K
S
G
S
E
T
P
L
P
E
T
D
L
Site 12
T118
S
E
T
P
L
P
E
T
D
L
A
H
C
F
Y
Site 13
T128
A
H
C
F
Y
S
G
T
V
N
G
D
P
S
S
Site 14
T170
A
A
S
E
R
L
A
T
A
A
P
G
E
K
P
Site 15
T208
V
D
D
E
P
R
P
T
G
K
A
E
T
E
D
Site 16
T220
T
E
D
E
D
E
G
T
E
G
E
D
E
G
A
Site 17
S230
E
D
E
G
A
Q
W
S
P
Q
D
P
A
L
Q
Site 18
S247
G
Q
P
T
G
T
G
S
I
R
K
K
R
F
V
Site 19
S255
I
R
K
K
R
F
V
S
S
H
R
Y
V
E
T
Site 20
S256
R
K
K
R
F
V
S
S
H
R
Y
V
E
T
M
Site 21
S269
T
M
L
V
A
D
Q
S
M
A
E
F
H
G
S
Site 22
S276
S
M
A
E
F
H
G
S
G
L
K
H
Y
L
L
Site 23
Y293
F
S
V
A
A
R
L
Y
K
H
P
S
I
R
N
Site 24
S297
A
R
L
Y
K
H
P
S
I
R
N
S
V
S
L
Site 25
S301
K
H
P
S
I
R
N
S
V
S
L
V
V
V
K
Site 26
S323
Q
K
G
P
E
V
T
S
N
A
A
L
T
L
R
Site 27
S343
Q
K
Q
H
N
P
P
S
D
R
D
A
E
H
Y
Site 28
Y350
S
D
R
D
A
E
H
Y
D
T
A
I
L
F
T
Site 29
T352
R
D
A
E
H
Y
D
T
A
I
L
F
T
R
Q
Site 30
S364
T
R
Q
D
L
C
G
S
Q
T
C
D
T
L
G
Site 31
T366
Q
D
L
C
G
S
Q
T
C
D
T
L
G
M
A
Site 32
S384
T
V
C
D
P
S
R
S
C
S
V
I
E
D
D
Site 33
S386
C
D
P
S
R
S
C
S
V
I
E
D
D
G
L
Site 34
T398
D
G
L
Q
A
A
F
T
T
A
H
E
L
G
H
Site 35
S419
D
D
A
K
Q
C
A
S
L
N
G
V
N
Q
D
Site 36
S435
H
M
M
A
S
M
L
S
N
L
D
H
S
Q
P
Site 37
S440
M
L
S
N
L
D
H
S
Q
P
W
S
P
C
S
Site 38
Y482
G
D
L
P
G
T
S
Y
D
A
N
R
Q
C
Q
Site 39
T491
A
N
R
Q
C
Q
F
T
F
G
E
D
S
K
H
Site 40
S507
P
D
A
A
S
T
C
S
T
L
W
C
T
G
T
Site 41
T508
D
A
A
S
T
C
S
T
L
W
C
T
G
T
S
Site 42
T549
N
G
K
C
V
N
K
T
D
R
K
H
F
D
T
Site 43
T556
T
D
R
K
H
F
D
T
P
F
H
G
S
W
G
Site 44
T574
P
W
G
D
C
S
R
T
C
G
G
G
V
Q
Y
Site 45
Y581
T
C
G
G
G
V
Q
Y
T
M
R
E
C
D
N
Site 46
T582
C
G
G
G
V
Q
Y
T
M
R
E
C
D
N
P
Site 47
Y597
V
P
K
N
G
G
K
Y
C
E
G
K
R
V
R
Site 48
Y605
C
E
G
K
R
V
R
Y
R
S
C
N
L
E
D
Site 49
S607
G
K
R
V
R
Y
R
S
C
N
L
E
D
C
P
Site 50
S633
C
E
A
H
N
E
F
S
K
A
S
F
G
S
G
Site 51
S636
H
N
E
F
S
K
A
S
F
G
S
G
P
A
V
Site 52
Y649
A
V
E
W
I
P
K
Y
A
G
V
S
P
K
D
Site 53
S653
I
P
K
Y
A
G
V
S
P
K
D
R
C
K
L
Site 54
T681
Q
P
K
V
V
D
G
T
P
C
S
P
D
S
T
Site 55
S687
G
T
P
C
S
P
D
S
T
S
V
C
V
Q
G
Site 56
T688
T
P
C
S
P
D
S
T
S
V
C
V
Q
G
Q
Site 57
S689
P
C
S
P
D
S
T
S
V
C
V
Q
G
Q
C
Site 58
S722
G
V
C
G
G
N
G
S
T
C
K
K
I
S
G
Site 59
S728
G
S
T
C
K
K
I
S
G
S
V
T
S
A
K
Site 60
S730
T
C
K
K
I
S
G
S
V
T
S
A
K
P
G
Site 61
T732
K
K
I
S
G
S
V
T
S
A
K
P
G
Y
H
Site 62
S733
K
I
S
G
S
V
T
S
A
K
P
G
Y
H
D
Site 63
T743
P
G
Y
H
D
I
I
T
I
P
T
G
A
T
N
Site 64
S761
K
Q
R
N
Q
R
G
S
R
N
N
G
S
F
L
Site 65
S766
R
G
S
R
N
N
G
S
F
L
A
I
K
A
A
Site 66
T776
A
I
K
A
A
D
G
T
Y
I
L
N
G
D
Y
Site 67
Y777
I
K
A
A
D
G
T
Y
I
L
N
G
D
Y
T
Site 68
Y783
T
Y
I
L
N
G
D
Y
T
L
S
T
L
E
Q
Site 69
T784
Y
I
L
N
G
D
Y
T
L
S
T
L
E
Q
D
Site 70
T787
N
G
D
Y
T
L
S
T
L
E
Q
D
I
M
Y
Site 71
Y794
T
L
E
Q
D
I
M
Y
K
G
V
V
L
R
Y
Site 72
S805
V
L
R
Y
S
G
S
S
A
A
L
E
R
I
R
Site 73
S813
A
A
L
E
R
I
R
S
F
S
P
L
K
E
P
Site 74
S815
L
E
R
I
R
S
F
S
P
L
K
E
P
L
T
Site 75
Y838
A
L
R
P
K
I
K
Y
T
Y
F
V
K
K
K
Site 76
Y840
R
P
K
I
K
Y
T
Y
F
V
K
K
K
K
E
Site 77
S848
F
V
K
K
K
K
E
S
F
N
A
I
P
T
F
Site 78
S890
D
I
N
G
Q
P
A
S
E
C
A
K
E
V
K
Site 79
S900
A
K
E
V
K
P
A
S
T
R
P
C
A
D
H
Site 80
S921
L
G
E
W
S
S
C
S
K
T
C
G
K
G
Y
Site 81
T923
E
W
S
S
C
S
K
T
C
G
K
G
Y
K
K
Site 82
Y928
S
K
T
C
G
K
G
Y
K
K
R
S
L
K
C
Site 83
S932
G
K
G
Y
K
K
R
S
L
K
C
L
S
H
D
Site 84
S937
K
R
S
L
K
C
L
S
H
D
G
G
V
L
S
Site 85
S944
S
H
D
G
G
V
L
S
H
E
S
C
D
P
L
Site 86
S947
G
G
V
L
S
H
E
S
C
D
P
L
K
K
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation