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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RAPGEFL1
Full Name:
Alias:
Link guanine nucleotide exchange factor II
Type:
Mass (Da):
73265
Number AA:
662
UniProt ID:
Q9UHV5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
K
F
L
K
K
Q
T
S
Q
L
A
G
R
T
V
Site 2
T19
T
S
Q
L
A
G
R
T
V
A
G
G
P
G
G
Site 3
S30
G
P
G
G
G
L
G
S
C
G
G
P
G
G
G
Site 4
S52
G
P
A
G
G
Q
R
S
L
Q
R
R
Q
S
V
Site 5
S58
R
S
L
Q
R
R
Q
S
V
S
R
L
L
L
P
Site 6
S60
L
Q
R
R
Q
S
V
S
R
L
L
L
P
A
F
Site 7
S97
G
V
A
E
E
P
G
S
G
G
P
C
W
L
Q
Site 8
S122
G
G
G
G
P
L
R
S
P
S
S
Y
S
S
D
Site 9
S124
G
G
P
L
R
S
P
S
S
Y
S
S
D
E
L
Site 10
S125
G
P
L
R
S
P
S
S
Y
S
S
D
E
L
S
Site 11
Y126
P
L
R
S
P
S
S
Y
S
S
D
E
L
S
P
Site 12
S127
L
R
S
P
S
S
Y
S
S
D
E
L
S
P
G
Site 13
S128
R
S
P
S
S
Y
S
S
D
E
L
S
P
G
E
Site 14
S132
S
Y
S
S
D
E
L
S
P
G
E
P
L
T
S
Site 15
T138
L
S
P
G
E
P
L
T
S
P
P
W
A
P
L
Site 16
S139
S
P
G
E
P
L
T
S
P
P
W
A
P
L
G
Site 17
S173
A
T
R
D
S
A
A
S
D
I
L
L
D
D
I
Site 18
Y230
L
L
H
F
L
D
T
Y
Q
G
L
L
Q
E
E
Site 19
S256
L
L
I
M
K
D
E
S
L
Y
Q
G
L
R
E
Site 20
T265
Y
Q
G
L
R
E
D
T
L
R
L
H
Q
L
V
Site 21
T274
R
L
H
Q
L
V
E
T
V
E
L
K
I
P
E
Site 22
S287
P
E
E
N
Q
P
P
S
K
Q
V
K
P
L
F
Site 23
S302
R
H
F
R
R
I
D
S
C
L
Q
T
R
V
A
Site 24
T306
R
I
D
S
C
L
Q
T
R
V
A
F
R
G
S
Site 25
S313
T
R
V
A
F
R
G
S
D
E
I
F
C
R
V
Site 26
Y321
D
E
I
F
C
R
V
Y
M
P
D
H
S
Y
V
Site 27
S326
R
V
Y
M
P
D
H
S
Y
V
T
I
R
S
R
Site 28
Y327
V
Y
M
P
D
H
S
Y
V
T
I
R
S
R
L
Site 29
T329
M
P
D
H
S
Y
V
T
I
R
S
R
L
S
A
Site 30
S332
H
S
Y
V
T
I
R
S
R
L
S
A
S
V
Q
Site 31
S337
I
R
S
R
L
S
A
S
V
Q
D
I
L
G
S
Site 32
S344
S
V
Q
D
I
L
G
S
V
T
E
K
L
Q
Y
Site 33
Y351
S
V
T
E
K
L
Q
Y
S
E
E
P
A
G
R
Site 34
S352
V
T
E
K
L
Q
Y
S
E
E
P
A
G
R
E
Site 35
S414
L
P
E
E
I
Q
V
S
P
G
D
T
E
I
H
Site 36
T418
I
Q
V
S
P
G
D
T
E
I
H
R
V
E
P
Site 37
Y451
H
E
L
E
F
V
D
Y
V
F
H
G
E
R
G
Site 38
T462
G
E
R
G
R
R
E
T
A
N
L
E
L
L
L
Site 39
T476
L
Q
R
C
S
E
V
T
H
W
V
A
T
E
V
Site 40
S528
G
L
D
N
A
A
V
S
R
L
R
L
T
W
E
Site 41
T533
A
V
S
R
L
R
L
T
W
E
K
L
P
G
K
Site 42
S560
D
P
C
R
N
H
K
S
Y
R
E
V
I
S
K
Site 43
Y561
P
C
R
N
H
K
S
Y
R
E
V
I
S
K
M
Site 44
S566
K
S
Y
R
E
V
I
S
K
M
K
P
P
V
I
Site 45
T584
P
L
I
L
K
D
L
T
F
L
H
E
G
S
K
Site 46
S605
V
N
I
E
K
L
H
S
V
A
E
K
V
R
T
Site 47
T612
S
V
A
E
K
V
R
T
I
R
K
Y
R
S
R
Site 48
Y616
K
V
R
T
I
R
K
Y
R
S
R
P
L
C
L
Site 49
S628
L
C
L
D
M
E
A
S
P
N
H
L
Q
T
K
Site 50
Y637
N
H
L
Q
T
K
A
Y
V
R
Q
F
Q
V
I
Site 51
S654
Q
N
L
L
F
E
L
S
Y
K
L
E
A
N
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation