PhosphoNET

           
Protein Info 
   
Short Name:  MED13
Full Name:  Mediator of RNA polymerase II transcription subunit 13
Alias:  Activator-recruited cofactor 250 kDa; ARC250; DRIP 250; DRIP250; KIAA0593; Mediator 13; Mediator complex subunit 13; Mediator of RNA polymerase II transcription 13; T240; THRAP1; Thyroid hormone receptor associated protein 1; Thyroid hormone receptor-associated 240 kDa; TR240; TRAP240; Vitamin D3 receptor-interacting
Type:  Receptor, nuclear
Mass (Da):  239318
Number AA:  2174
UniProt ID:  Q9UHV7
International Prot ID:  IPI00021388
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0016592     Uniprot OncoNet
Molecular Function:  GO:0016455  GO:0030374  GO:0004872 PhosphoSite+ KinaseNET
Biological Process:  GO:0030521  GO:0045944  GO:0006367 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1Y33TGIKWKKYVWQGPTS
Site 2S55TEEDPILSSFSRCLK
Site 3S56EEDPILSSFSRCLKA
Site 4Y99LTLFTMTYQKKKMEC
Site 5S157DEKPINKSEHLSCSF
Site 6S163KSEHLSCSFTFFLHG
Site 7T165EHLSCSFTFFLHGDS
Site 8Y187INQHQPVYLLSEEHI
Site 9S190HQPVYLLSEEHITLA
Site 10T195LLSEEHITLAQQSNS
Site 11S200HITLAQQSNSPFQVI
Site 12S227QAFKMSDSATKKLIG
Site 13T229FKMSDSATKKLIGEW
Site 14S250SCCLKEMSEEKQEDM
Site 15S263DMDWEDDSLAAVEVL
Site 16T292VPQSDIPTPSPVGST
Site 17S294QSDIPTPSPVGSTHC
Site 18S298PTPSPVGSTHCSSSC
Site 19T299TPSPVGSTHCSSSCL
Site 20S303VGSTHCSSSCLGVHQ
Site 21S304GSTHCSSSCLGVHQV
Site 22S314GVHQVPASTRDPAMS
Site 23S321STRDPAMSSVTLTPP
Site 24S322TRDPAMSSVTLTPPT
Site 25T324DPAMSSVTLTPPTSP
Site 26T326AMSSVTLTPPTSPEE
Site 27T329SVTLTPPTSPEEVQT
Site 28S330VTLTPPTSPEEVQTV
Site 29T336TSPEEVQTVDPQSVQ
Site 30S349VQKWVKFSSVSDGFN
Site 31S350QKWVKFSSVSDGFNS
Site 32S357SVSDGFNSDSTSHHG
Site 33S359SDGFNSDSTSHHGGK
Site 34T360DGFNSDSTSHHGGKI
Site 35S361GFNSDSTSHHGGKIP
Site 36Y394RAQNKRKYSASSGGL
Site 37S395AQNKRKYSASSGGLC
Site 38S397NKRKYSASSGGLCEE
Site 39S434LRHKNLKSRNAGQQG
Site 40S445GQQGQAPSLGQQQQI
Site 41T458QILPKHKTNEKQEKS
Site 42T474KPQKRPLTPFHHRVS
Site 43S481TPFHHRVSVSDDVGM
Site 44S483FHHRVSVSDDVGMDA
Site 45S492DVGMDADSASQRLVI
Site 46S494GMDADSASQRLVISA
Site 47S500ASQRLVISAPDSQVR
Site 48S504LVISAPDSQVRFSNI
Site 49S509PDSQVRFSNIRTNDV
Site 50T519RTNDVAKTPQMHGTE
Site 51S530HGTEMANSPQPPPLS
Site 52S537SPQPPPLSPHPCDVV
Site 53T549DVVDEGVTKTPSTPQ
Site 54T551VDEGVTKTPSTPQSQ
Site 55S553EGVTKTPSTPQSQHF
Site 56T554GVTKTPSTPQSQHFY
Site 57S557KTPSTPQSQHFYQMP
Site 58Y561TPQSQHFYQMPTPDP
Site 59T565QHFYQMPTPDPLVPS
Site 60S572TPDPLVPSKPMEDRI
Site 61S581PMEDRIDSLSQSFPP
Site 62S583EDRIDSLSQSFPPQY
Site 63S585RIDSLSQSFPPQYQE
Site 64Y590SQSFPPQYQEAVEPT
Site 65Y617EANIAWKYYKFPKKK
Site 66Y618ANIAWKYYKFPKKKD
Site 67Y675SDELVQQYQIKNQCL
Site 68S683QIKNQCLSAIASDAE
Site 69S687QCLSAIASDAEQEPK
Site 70Y698QEPKIDPYAFVEGDE
Site 71S718DKKDRQNSEREAGKK
Site 72S733HKVEDGTSSVTVLSH
Site 73S734KVEDGTSSVTVLSHE
Site 74T736EDGTSSVTVLSHEED
Site 75S739TSSVTVLSHEEDAMS
Site 76S746SHEEDAMSLFSPSIK
Site 77S749EDAMSLFSPSIKQDA
Site 78T760KQDAPRPTSHARPPS
Site 79S761QDAPRPTSHARPPST
Site 80S767TSHARPPSTSLIYDS
Site 81S769HARPPSTSLIYDSDL
Site 82T781SDLAVSYTDLDNLFN
Site 83S789DLDNLFNSDEDELTP
Site 84T795NSDEDELTPGSKKSA
Site 85S798EDELTPGSKKSANGS
Site 86S801LTPGSKKSANGSDDK
Site 87S805SKKSANGSDDKASCK
Site 88S810NGSDDKASCKESKTG
Site 89S814DKASCKESKTGNLDP
Site 90T827DPLSCISTADLHKMY
Site 91Y834TADLHKMYPTPPSLE
Site 92T836DLHKMYPTPPSLEQH
Site 93S839KMYPTPPSLEQHIMG
Site 94S848EQHIMGFSPMNMNNK
Site 95S859MNNKEYGSMDTTPGG
Site 96T862KEYGSMDTTPGGTVL
Site 97T863EYGSMDTTPGGTVLE
Site 98T867MDTTPGGTVLEGNSS
Site 99S874TVLEGNSSSIGAQFK
Site 100S890EVDEGFCSPKPSEIK
Site 101S894GFCSPKPSEIKDFSY
Site 102S900PSEIKDFSYVYKPEN
Site 103Y901SEIKDFSYVYKPENC
Site 104T922SMFAPLKTLPSQYLP
Site 105S925APLKTLPSQYLPPIK
Site 106Y927LKTLPSQYLPPIKLP
Site 107Y939KLPEECIYRQSWTVG
Site 108S956ELLSSGPSMPFIKEG
Site 109S966FIKEGDGSNMDQEYG
Site 110Y972GSNMDQEYGTAYTPQ
Site 111T977QEYGTAYTPQTHTSF
Site 112T980GTAYTPQTHTSFGMP
Site 113S983YTPQTHTSFGMPPSS
Site 114S989TSFGMPPSSAPPSNS
Site 115S990SFGMPPSSAPPSNSG
Site 116S994PPSSAPPSNSGAGIL
Site 117S996SSAPPSNSGAGILPS
Site 118S1003SGAGILPSPSTPRFP
Site 119S1005AGILPSPSTPRFPTP
Site 120T1006GILPSPSTPRFPTPR
Site 121T1011PSTPRFPTPRTPRTP
Site 122T1014PRFPTPRTPRTPRTP
Site 123T1017PTPRTPRTPRTPRGA
Site 124T1020RTPRTPRTPRGAGGP
Site 125S1029RGAGGPASAQGSVKY
Site 126S1033GPASAQGSVKYENSD
Site 127Y1036SAQGSVKYENSDLYS
Site 128S1039GSVKYENSDLYSPAS
Site 129Y1042KYENSDLYSPASTPS
Site 130S1043YENSDLYSPASTPST
Site 131S1046SDLYSPASTPSTCRP
Site 132T1047DLYSPASTPSTCRPL
Site 133S1049YSPASTPSTCRPLNS
Site 134T1050SPASTPSTCRPLNSV
Site 135S1056STCRPLNSVEPATVP
Site 136Y1110KGADVGVYIPDPTQE
Site 137T1115GVYIPDPTQEAQYRC
Site 138Y1120DPTQEAQYRCTCGFS
Site 139S1138NRKFGNNSGLFLEDE
Site 140T1153LDIIGRNTDCGKEAE
Site 141T1169RFEALRATSAEHVNG
Site 142S1170FEALRATSAEHVNGG
Site 143S1201DQCTNLFSPFGAADQ
Site 144S1214DQDPFPKSGVISNWV
Site 145S1218FPKSGVISNWVRVEE
Site 146Y1233RDCCNDCYLALEHGR
Site 147S1247RQFMDNMSGGKVDEA
Site 148S1258VDEALVKSSCLHPWS
Site 149S1275NDVSMQCSQDILRML
Site 150T1298DAIQKKRTVRPWGVQ
Site 151S1321HKMAGRGSYGTDESP
Site 152Y1322KMAGRGSYGTDESPE
Site 153T1324AGRGSYGTDESPEPL
Site 154S1327GSYGTDESPEPLPIP
Site 155Y1363ERLMLEPYGSQRDIA
Site 156S1365LMLEPYGSQRDIAYV
Site 157Y1371GSQRDIAYVVLCPEN
Site 158T1393KSFFRDLTAIYESCR
Site 159Y1396FRDLTAIYESCRLGQ
Site 160S1398DLTAIYESCRLGQHR
Site 161S1408LGQHRPVSRLLTDGI
Site 162S1420DGIMRVGSTASKKLS
Site 163T1421GIMRVGSTASKKLSE
Site 164S1423MRVGSTASKKLSEKL
Site 165S1427STASKKLSEKLVAEW
Site 166S1436KLVAEWFSQAADGNN
Site 167Y1452AFSKLKLYAQVCRYD
Site 168Y1463CRYDLGPYLASLPLD
Site 169S1484PNLVAPTSQSLITPP
Site 170T1489PTSQSLITPPQMTNT
Site 171T1501TNTGNANTPSATLAS
Site 172S1503TGNANTPSATLASAA
Site 173T1534ATANSTLTTASTSSS
Site 174T1535TANSTLTTASTSSSS
Site 175S1537NSTLTTASTSSSSSS
Site 176T1538STLTTASTSSSSSSN
Site 177S1539TLTTASTSSSSSSNL
Site 178S1540LTTASTSSSSSSNLN
Site 179S1541TTASTSSSSSSNLNS
Site 180S1542TASTSSSSSSNLNSG
Site 181S1543ASTSSSSSSNLNSGV
Site 182S1544STSSSSSSNLNSGVS
Site 183S1548SSSSNLNSGVSSNKL
Site 184S1551SNLNSGVSSNKLPSF
Site 185S1552NLNSGVSSNKLPSFP
Site 186S1557VSSNKLPSFPPFGSM
Site 187S1563PSFPPFGSMNSNAAG
Site 188S1566PPFGSMNSNAAGSMS
Site 189S1573SNAAGSMSTQANTVQ
Site 190T1578SMSTQANTVQSGQLG
Site 191T1594QQTSALQTAGISGES
Site 192S1598ALQTAGISGESSSLP
Site 193S1602AGISGESSSLPTQPH
Site 194S1603GISGESSSLPTQPHP
Site 195T1606GESSSLPTQPHPDVS
Site 196S1613TQPHPDVSESTMDRD
Site 197T1626RDKVGIPTDGDSHAV
Site 198S1630GIPTDGDSHAVTYPP
Site 199T1634DGDSHAVTYPPAIVV
Site 200T1648VYIIDPFTYENTDES
Site 201S1655TYENTDESTNSSSVW
Site 202T1656YENTDESTNSSSVWT
Site 203S1658NTDESTNSSSVWTLG
Site 204S1659TDESTNSSSVWTLGL
Site 205S1660DESTNSSSVWTLGLL
Site 206S1683TLPPHIKSTVSVQII
Site 207T1684LPPHIKSTVSVQIIP
Site 208S1686PHIKSTVSVQIIPCQ
Site 209Y1694VQIIPCQYLLQPVKH
Site 210Y1707KHEDREIYPQHLKSL
Site 211S1717HLKSLAFSAFTQCRR
Site 212T1720SLAFSAFTQCRRPLP
Site 213T1728QCRRPLPTSTNVKTL
Site 214S1729CRRPLPTSTNVKTLT
Site 215T1730RRPLPTSTNVKTLTG
Site 216T1734PTSTNVKTLTGFGPG
Site 217T1746GPGLAMETALRSPDR
Site 218S1750AMETALRSPDRPECI
Site 219T1774APVKDKQTELGETFG
Site 220T1779KQTELGETFGEAGQK
Site 221S1833NRARRKKSSARKFGL
Site 222S1834RARRKKSSARKFGLQ
Site 223S1877HGELKDWSCLLSRRN
Site 224S1881KDWSCLLSRRNLQSL
Site 225S1887LSRRNLQSLSKRLKD
Site 226S1889RRNLQSLSKRLKDMC
Site 227S1934PDSVSTGSVFGRSTT
Site 228T1940GSVFGRSTTLNMQTS
Site 229T1941SVFGRSTTLNMQTSQ
Site 230S1947TTLNMQTSQLNTPQD
Site 231T1951MQTSQLNTPQDTSCT
Site 232T1977QVASATYTTENLDLA
Site 233T2003GIFDLLDTGDDLDPD
Site 234S2018IINILPASPTGSPVH
Site 235T2020NILPASPTGSPVHSP
Site 236S2022LPASPTGSPVHSPGS
Site 237S2026PTGSPVHSPGSHYPH
Site 238S2029SPVHSPGSHYPHGGD
Site 239Y2031VHSPGSHYPHGGDAG
Site 240S2042GDAGKGQSTDRLLST
Site 241T2043DAGKGQSTDRLLSTE
Site 242S2048QSTDRLLSTEPHEEV
Site 243T2049STDRLLSTEPHEEVP
Site 244Y2090SACPQAQYQCPLFLK
Site 245S2109LHVPSVQSDELLHSK
Site 246S2115QSDELLHSKHSHPLD
Site 247S2118ELLHSKHSHPLDSNQ
Site 248S2123KHSHPLDSNQTSDVL
Site 249S2127PLDSNQTSDVLRFVL
Site 250T2149WLTCDPATQDRRSCL
Site 251S2154PATQDRRSCLPIHFV
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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