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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PUF60
Full Name:
Poly(U)-binding-splicing factor PUF60
Alias:
60 kDa poly(U)-binding-splicing factor; FBP interacting repressor; FBP-interacting repressor; FIR; Poly-U binding splicing factor 60KDa; Pyrimidine tract binding splicing factor; Ro ribonucleoprotein binding protein 1; Ro-binding protein 1; RoBP1; RoBPI; Siah binding protein 1; Siah binding protein 1, FBP interacting repressor, pyrimidine tract binding splicing factor, Ro ribonucleoprotein-binding protein 1; SIAHBP1
Type:
Transcription, coactivator/corepressor
Mass (Da):
59875
Number AA:
559
UniProt ID:
Q9UHX1
International Prot ID:
IPI00856076
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0019907
GO:0030529
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003676
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T3
_
_
_
_
_
M
A
T
A
T
I
A
L
Q
V
Site 2
T5
_
_
_
M
A
T
A
T
I
A
L
Q
V
N
G
Site 3
S18
N
G
Q
Q
G
G
G
S
E
P
A
A
A
A
A
Site 4
S41
K
P
P
Q
G
T
D
S
I
K
M
E
N
G
Q
Site 5
S49
I
K
M
E
N
G
Q
S
T
A
A
K
L
G
L
Site 6
T60
K
L
G
L
P
P
L
T
P
E
Q
Q
E
A
L
Site 7
Y73
A
L
Q
K
A
K
K
Y
A
M
E
Q
S
I
K
Site 8
S112
M
G
F
G
D
P
L
S
P
L
Q
S
M
A
A
Site 9
S116
D
P
L
S
P
L
Q
S
M
A
A
Q
R
Q
R
Site 10
Y137
R
V
Y
V
G
S
I
Y
Y
E
L
G
E
D
T
Site 11
T144
Y
Y
E
L
G
E
D
T
I
R
Q
A
F
A
P
Site 12
S157
A
P
F
G
P
I
K
S
I
D
M
S
W
D
S
Site 13
S161
P
I
K
S
I
D
M
S
W
D
S
V
T
M
K
Site 14
Y177
K
G
F
A
F
V
E
Y
E
V
P
E
A
A
Q
Site 15
S192
L
A
L
E
Q
M
N
S
V
M
L
G
G
R
N
Site 16
S206
N
I
K
V
G
R
P
S
N
I
G
Q
A
Q
P
Site 17
Y229
A
R
A
F
N
R
I
Y
V
A
S
V
H
Q
D
Site 18
S232
F
N
R
I
Y
V
A
S
V
H
Q
D
L
S
D
Site 19
S238
A
S
V
H
Q
D
L
S
D
D
D
I
K
S
V
Site 20
S244
L
S
D
D
D
I
K
S
V
F
E
A
F
G
K
Site 21
S254
E
A
F
G
K
I
K
S
C
T
L
A
R
D
P
Site 22
T256
F
G
K
I
K
S
C
T
L
A
R
D
P
T
T
Site 23
T262
C
T
L
A
R
D
P
T
T
G
K
H
K
G
Y
Site 24
T263
T
L
A
R
D
P
T
T
G
K
H
K
G
Y
G
Site 25
Y274
K
G
Y
G
F
I
E
Y
E
K
A
Q
S
S
Q
Site 26
S280
E
Y
E
K
A
Q
S
S
Q
D
A
V
S
S
M
Site 27
S286
S
S
Q
D
A
V
S
S
M
N
L
F
D
L
G
Site 28
T311
T
P
P
M
P
L
L
T
P
A
T
P
G
G
L
Site 29
T314
M
P
L
L
T
P
A
T
P
G
G
L
P
P
A
Site 30
S406
V
V
N
P
I
L
A
S
P
P
T
L
G
L
L
Site 31
S428
E
E
E
L
F
P
E
S
E
R
P
E
M
L
S
Site 32
S435
S
E
R
P
E
M
L
S
E
Q
E
H
M
S
I
Site 33
S441
L
S
E
Q
E
H
M
S
I
S
G
S
S
A
R
Site 34
S443
E
Q
E
H
M
S
I
S
G
S
S
A
R
H
M
Site 35
S445
E
H
M
S
I
S
G
S
S
A
R
H
M
V
M
Site 36
S461
K
L
L
R
K
Q
E
S
T
V
M
V
L
R
N
Site 37
T462
L
L
R
K
Q
E
S
T
V
M
V
L
R
N
M
Site 38
T484
D
D
L
E
G
E
V
T
E
E
C
G
K
F
G
Site 39
Y499
A
V
N
R
V
I
I
Y
Q
E
K
Q
G
E
E
Site 40
S555
D
Q
E
R
F
D
N
S
D
L
S
A
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation