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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DMGDH
Full Name:
Alias:
ME2GLYDH
Type:
Mass (Da):
96811
Number AA:
866
UniProt ID:
Q9UI17
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
R
S
C
P
L
Q
G
S
P
G
R
P
R
S
V
Site 2
S28
G
S
P
G
R
P
R
S
V
C
G
R
E
G
E
Site 3
S41
G
E
E
K
P
P
L
S
A
E
T
Q
W
K
D
Site 4
T52
Q
W
K
D
R
A
E
T
V
I
I
G
G
G
C
Site 5
Y110
I
N
L
K
K
I
H
Y
D
S
I
K
L
Y
E
Site 6
Y116
H
Y
D
S
I
K
L
Y
E
K
L
E
E
E
T
Site 7
S134
V
G
F
H
Q
P
G
S
I
R
L
A
T
T
P
Site 8
T139
P
G
S
I
R
L
A
T
T
P
V
R
V
D
E
Site 9
T140
G
S
I
R
L
A
T
T
P
V
R
V
D
E
F
Site 10
Y149
V
R
V
D
E
F
K
Y
Q
M
T
R
T
G
W
Site 11
Y186
N
K
V
L
A
G
L
Y
N
P
G
D
G
H
I
Site 12
Y215
K
C
G
A
L
L
K
Y
P
A
P
V
T
S
L
Site 13
T220
L
K
Y
P
A
P
V
T
S
L
K
A
R
S
D
Site 14
S221
K
Y
P
A
P
V
T
S
L
K
A
R
S
D
G
Site 15
T229
L
K
A
R
S
D
G
T
W
D
V
E
T
P
Q
Site 16
T234
D
G
T
W
D
V
E
T
P
Q
G
S
M
R
A
Site 17
S238
D
V
E
T
P
Q
G
S
M
R
A
N
R
I
V
Site 18
S297
V
L
R
D
L
E
G
S
Y
Y
L
R
Q
E
R
Site 19
Y299
R
D
L
E
G
S
Y
Y
L
R
Q
E
R
D
G
Site 20
Y312
D
G
L
L
F
G
P
Y
E
S
Q
E
K
M
K
Site 21
S314
L
L
F
G
P
Y
E
S
Q
E
K
M
K
V
Q
Site 22
S323
E
K
M
K
V
Q
D
S
W
V
T
N
G
V
P
Site 23
S340
F
G
K
E
L
F
E
S
D
L
D
R
I
M
E
Site 24
T373
N
V
V
N
G
P
I
T
Y
S
P
D
I
L
P
Site 25
Y374
V
V
N
G
P
I
T
Y
S
P
D
I
L
P
M
Site 26
Y391
P
H
Q
G
V
R
N
Y
W
V
A
I
G
F
G
Site 27
Y410
H
A
G
G
V
G
K
Y
L
S
D
W
I
L
H
Site 28
S412
G
G
V
G
K
Y
L
S
D
W
I
L
H
G
E
Site 29
T436
P
N
R
Y
G
K
W
T
T
T
Q
Y
T
E
A
Site 30
S448
T
E
A
K
A
R
E
S
Y
G
F
N
N
I
V
Site 31
Y449
E
A
K
A
R
E
S
Y
G
F
N
N
I
V
G
Site 32
Y457
G
F
N
N
I
V
G
Y
P
K
E
E
R
F
A
Site 33
T468
E
R
F
A
G
R
P
T
Q
R
V
S
G
L
Y
Site 34
S472
G
R
P
T
Q
R
V
S
G
L
Y
Q
R
L
E
Site 35
Y475
T
Q
R
V
S
G
L
Y
Q
R
L
E
S
K
C
Site 36
S480
G
L
Y
Q
R
L
E
S
K
C
S
M
G
F
H
Site 37
T503
F
Y
K
P
G
Q
D
T
Q
Y
R
P
S
F
R
Site 38
Y505
K
P
G
Q
D
T
Q
Y
R
P
S
F
R
R
T
Site 39
T512
Y
R
P
S
F
R
R
T
N
W
F
E
P
V
G
Site 40
S547
F
N
I
K
G
Q
D
S
I
R
L
L
D
H
L
Site 41
S568
K
V
G
F
T
N
I
S
H
M
L
T
P
K
G
Site 42
T572
T
N
I
S
H
M
L
T
P
K
G
R
V
Y
A
Site 43
Y578
L
T
P
K
G
R
V
Y
A
E
L
T
V
S
H
Site 44
T582
G
R
V
Y
A
E
L
T
V
S
H
Q
S
P
G
Site 45
S584
V
Y
A
E
L
T
V
S
H
Q
S
P
G
E
F
Site 46
S597
E
F
L
L
I
T
G
S
G
S
E
L
H
D
L
Site 47
S599
L
L
I
T
G
S
G
S
E
L
H
D
L
R
W
Site 48
T645
R
K
V
L
Q
K
L
T
P
E
D
L
S
D
D
Site 49
S650
K
L
T
P
E
D
L
S
D
D
V
F
K
F
L
Site 50
S661
F
K
F
L
Q
T
K
S
L
K
V
S
N
I
P
Site 51
Y685
G
E
L
G
W
E
L
Y
H
R
R
E
D
S
V
Site 52
S691
L
Y
H
R
R
E
D
S
V
A
L
Y
D
A
I
Site 53
Y695
R
E
D
S
V
A
L
Y
D
A
I
M
N
A
G
Site 54
T712
E
G
I
D
N
F
G
T
Y
A
M
N
A
L
R
Site 55
Y744
P
L
E
A
G
L
E
Y
F
V
K
L
N
K
P
Site 56
T776
K
R
R
L
V
C
L
T
L
A
T
D
D
V
D
Site 57
Y792
E
G
N
E
S
I
W
Y
N
G
K
V
V
G
N
Site 58
T800
N
G
K
V
V
G
N
T
T
S
G
S
Y
S
Y
Site 59
S802
K
V
V
G
N
T
T
S
G
S
Y
S
Y
S
I
Site 60
S804
V
G
N
T
T
S
G
S
Y
S
Y
S
I
Q
K
Site 61
S806
N
T
T
S
G
S
Y
S
Y
S
I
Q
K
S
L
Site 62
S808
T
S
G
S
Y
S
Y
S
I
Q
K
S
L
A
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation