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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GLS2
Full Name:
Alias:
L-glutaminase;L-glutamine amidohydrolase
Type:
Mass (Da):
66323
Number AA:
602
UniProt ID:
Q9UI32
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
K
A
L
Q
K
A
L
S
R
A
G
S
H
C
G
Site 2
S16
K
A
L
S
R
A
G
S
H
C
G
R
G
G
W
Site 3
S27
R
G
G
W
G
H
P
S
R
S
P
L
L
G
G
Site 4
S29
G
W
G
H
P
S
R
S
P
L
L
G
G
G
V
Site 5
S41
G
G
V
R
H
H
L
S
E
A
A
A
Q
G
R
Site 6
T50
A
A
A
Q
G
R
E
T
P
H
S
H
Q
P
Q
Site 7
S53
Q
G
R
E
T
P
H
S
H
Q
P
Q
H
Q
D
Site 8
S63
P
Q
H
Q
D
H
D
S
S
E
S
G
M
L
S
Site 9
S64
Q
H
Q
D
H
D
S
S
E
S
G
M
L
S
R
Site 10
S66
Q
D
H
D
S
S
E
S
G
M
L
S
R
L
G
Site 11
Y78
R
L
G
D
L
L
F
Y
T
I
A
E
G
Q
E
Site 12
T79
L
G
D
L
L
F
Y
T
I
A
E
G
Q
E
R
Site 13
S104
K
A
T
G
L
Q
T
S
D
P
R
L
R
D
C
Site 14
S122
M
H
R
V
V
Q
E
S
S
S
G
G
L
L
D
Site 15
T145
S
S
N
I
V
L
L
T
Q
A
F
R
K
K
F
Site 16
S189
Y
I
P
Q
L
A
K
S
N
P
D
L
W
G
V
Site 17
T200
L
W
G
V
S
L
C
T
V
D
G
Q
R
H
S
Site 18
S207
T
V
D
G
Q
R
H
S
V
G
H
T
K
I
P
Site 19
T211
Q
R
H
S
V
G
H
T
K
I
P
F
C
L
Q
Site 20
Y237
I
S
T
L
G
T
D
Y
V
H
K
F
V
G
K
Site 21
S247
K
F
V
G
K
E
P
S
G
L
R
Y
N
K
L
Site 22
Y251
K
E
P
S
G
L
R
Y
N
K
L
S
L
N
E
Site 23
S255
G
L
R
Y
N
K
L
S
L
N
E
E
G
I
P
Site 24
Y294
K
F
D
F
V
L
Q
Y
L
N
K
M
A
G
N
Site 25
Y303
N
K
M
A
G
N
E
Y
M
G
F
S
N
A
T
Site 26
T310
Y
M
G
F
S
N
A
T
F
Q
S
E
K
E
T
Site 27
Y322
K
E
T
G
D
R
N
Y
A
I
G
Y
Y
L
K
Site 28
Y327
R
N
Y
A
I
G
Y
Y
L
K
E
K
K
C
F
Site 29
S382
I
T
G
E
S
V
L
S
A
E
A
V
R
N
T
Site 30
T389
S
A
E
A
V
R
N
T
L
S
L
M
H
S
C
Site 31
S444
P
L
D
K
L
G
N
S
H
R
G
T
S
F
C
Site 32
T448
L
G
N
S
H
R
G
T
S
F
C
Q
K
L
V
Site 33
S449
G
N
S
H
R
G
T
S
F
C
Q
K
L
V
S
Site 34
Y463
S
L
F
N
F
H
N
Y
D
N
L
R
H
C
A
Site 35
S508
A
L
R
R
F
A
L
S
A
M
D
M
E
Q
K
Site 36
Y517
M
D
M
E
Q
K
D
Y
D
S
R
T
A
L
H
Site 37
S519
M
E
Q
K
D
Y
D
S
R
T
A
L
H
V
A
Site 38
Y575
V
V
K
L
L
Q
D
Y
Q
D
S
Y
T
L
S
Site 39
S578
L
L
Q
D
Y
Q
D
S
Y
T
L
S
E
T
Q
Site 40
Y579
L
Q
D
Y
Q
D
S
Y
T
L
S
E
T
Q
A
Site 41
T580
Q
D
Y
Q
D
S
Y
T
L
S
E
T
Q
A
E
Site 42
S582
Y
Q
D
S
Y
T
L
S
E
T
Q
A
E
A
A
Site 43
S594
E
A
A
A
E
A
L
S
K
E
N
L
E
S
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation