KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
DACH1
Full Name:
Dachshund homolog 1
Alias:
DACH; FLJ10138
Type:
Mass (Da):
78562
Number AA:
758
UniProt ID:
Q9UI36
International Prot ID:
IPI00039808
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
P
A
A
L
I
P
P
T
Q
L
V
P
P
Q
P
Site 2
S21
V
P
P
Q
P
P
I
S
T
S
A
S
S
S
G
Site 3
T22
P
P
Q
P
P
I
S
T
S
A
S
S
S
G
T
Site 4
S23
P
Q
P
P
I
S
T
S
A
S
S
S
G
T
T
Site 5
S25
P
P
I
S
T
S
A
S
S
S
G
T
T
T
S
Site 6
S27
I
S
T
S
A
S
S
S
G
T
T
T
S
T
S
Site 7
T29
T
S
A
S
S
S
G
T
T
T
S
T
S
S
A
Site 8
T30
S
A
S
S
S
G
T
T
T
S
T
S
S
A
T
Site 9
T31
A
S
S
S
G
T
T
T
S
T
S
S
A
T
S
Site 10
S32
S
S
S
G
T
T
T
S
T
S
S
A
T
S
S
Site 11
T33
S
S
G
T
T
T
S
T
S
S
A
T
S
S
P
Site 12
S34
S
G
T
T
T
S
T
S
S
A
T
S
S
P
A
Site 13
S35
G
T
T
T
S
T
S
S
A
T
S
S
P
A
P
Site 14
T37
T
T
S
T
S
S
A
T
S
S
P
A
P
S
I
Site 15
S38
T
S
T
S
S
A
T
S
S
P
A
P
S
I
G
Site 16
S39
S
T
S
S
A
T
S
S
P
A
P
S
I
G
P
Site 17
S43
A
T
S
S
P
A
P
S
I
G
P
P
A
S
S
Site 18
S49
P
S
I
G
P
P
A
S
S
G
P
T
L
F
R
Site 19
S50
S
I
G
P
P
A
S
S
G
P
T
L
F
R
P
Site 20
T53
P
P
A
S
S
G
P
T
L
F
R
P
E
P
I
Site 21
S82
G
G
G
G
G
G
G
S
G
G
G
G
G
S
S
Site 22
S88
G
S
G
G
G
G
G
S
S
G
N
G
G
G
G
Site 23
S89
S
G
G
G
G
G
S
S
G
N
G
G
G
G
G
Site 24
S102
G
G
G
G
G
G
G
S
N
C
N
P
N
L
A
Site 25
S112
N
P
N
L
A
A
A
S
N
G
S
G
G
G
G
Site 26
T132
G
G
G
V
A
S
S
T
P
I
N
A
S
T
G
Site 27
S137
S
S
T
P
I
N
A
S
T
G
S
S
S
S
S
Site 28
T138
S
T
P
I
N
A
S
T
G
S
S
S
S
S
S
Site 29
S140
P
I
N
A
S
T
G
S
S
S
S
S
S
S
S
Site 30
S141
I
N
A
S
T
G
S
S
S
S
S
S
S
S
S
Site 31
S142
N
A
S
T
G
S
S
S
S
S
S
S
S
S
S
Site 32
S143
A
S
T
G
S
S
S
S
S
S
S
S
S
S
S
Site 33
S144
S
T
G
S
S
S
S
S
S
S
S
S
S
S
S
Site 34
S145
T
G
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 35
S146
G
S
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 36
S147
S
S
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 37
S157
S
S
S
S
S
S
S
S
S
S
S
S
S
S
C
Site 38
S158
S
S
S
S
S
S
S
S
S
S
S
S
S
C
G
Site 39
S159
S
S
S
S
S
S
S
S
S
S
S
S
C
G
P
Site 40
S160
S
S
S
S
S
S
S
S
S
S
S
C
G
P
L
Site 41
S161
S
S
S
S
S
S
S
S
S
S
C
G
P
L
P
Site 42
S162
S
S
S
S
S
S
S
S
S
C
G
P
L
P
G
Site 43
S163
S
S
S
S
S
S
S
S
C
G
P
L
P
G
K
Site 44
Y173
P
L
P
G
K
P
V
Y
S
T
P
S
P
V
E
Site 45
S174
L
P
G
K
P
V
Y
S
T
P
S
P
V
E
N
Site 46
T175
P
G
K
P
V
Y
S
T
P
S
P
V
E
N
T
Site 47
S177
K
P
V
Y
S
T
P
S
P
V
E
N
T
P
Q
Site 48
T182
T
P
S
P
V
E
N
T
P
Q
N
N
E
C
K
Site 49
T228
H
L
V
G
G
L
H
T
V
Y
T
K
L
K
R
Site 50
Y230
V
G
G
L
H
T
V
Y
T
K
L
K
R
L
E
Site 51
T231
G
G
L
H
T
V
Y
T
K
L
K
R
L
E
I
Site 52
S268
V
N
R
C
K
L
I
S
R
K
D
F
E
T
L
Site 53
T274
I
S
R
K
D
F
E
T
L
Y
N
D
C
T
N
Site 54
Y276
R
K
D
F
E
T
L
Y
N
D
C
T
N
A
S
Site 55
T280
E
T
L
Y
N
D
C
T
N
A
S
S
R
P
G
Site 56
S284
N
D
C
T
N
A
S
S
R
P
G
R
P
P
K
Site 57
T293
P
G
R
P
P
K
R
T
Q
S
V
T
S
P
E
Site 58
S295
R
P
P
K
R
T
Q
S
V
T
S
P
E
N
S
Site 59
T297
P
K
R
T
Q
S
V
T
S
P
E
N
S
H
I
Site 60
S298
K
R
T
Q
S
V
T
S
P
E
N
S
H
I
M
Site 61
S302
S
V
T
S
P
E
N
S
H
I
M
P
H
S
V
Site 62
S308
N
S
H
I
M
P
H
S
V
P
G
L
M
S
P
Site 63
S373
S
E
N
G
D
M
N
S
S
V
G
S
S
D
G
Site 64
S374
E
N
G
D
M
N
S
S
V
G
S
S
D
G
S
Site 65
S377
D
M
N
S
S
V
G
S
S
D
G
S
W
D
K
Site 66
S378
M
N
S
S
V
G
S
S
D
G
S
W
D
K
E
Site 67
S381
S
V
G
S
S
D
G
S
W
D
K
E
T
L
P
Site 68
T386
D
G
S
W
D
K
E
T
L
P
S
S
P
S
Q
Site 69
S389
W
D
K
E
T
L
P
S
S
P
S
Q
G
P
Q
Site 70
S390
D
K
E
T
L
P
S
S
P
S
Q
G
P
Q
A
Site 71
S392
E
T
L
P
S
S
P
S
Q
G
P
Q
A
S
I
Site 72
S398
P
S
Q
G
P
Q
A
S
I
T
H
P
R
M
P
Site 73
T400
Q
G
P
Q
A
S
I
T
H
P
R
M
P
G
A
Site 74
S409
P
R
M
P
G
A
R
S
L
P
L
S
H
P
L
Site 75
S413
G
A
R
S
L
P
L
S
H
P
L
N
H
L
Q
Site 76
S474
A
A
A
A
Q
V
Q
S
P
P
S
R
V
E
T
Site 77
S477
A
Q
V
Q
S
P
P
S
R
V
E
T
S
V
I
Site 78
T481
S
P
P
S
R
V
E
T
S
V
I
K
E
R
V
Site 79
S491
I
K
E
R
V
P
D
S
P
S
P
A
P
S
L
Site 80
S493
E
R
V
P
D
S
P
S
P
A
P
S
L
E
E
Site 81
S497
D
S
P
S
P
A
P
S
L
E
E
G
R
R
P
Site 82
S506
E
E
G
R
R
P
G
S
H
P
S
S
H
R
S
Site 83
S509
R
R
P
G
S
H
P
S
S
H
R
S
S
S
V
Site 84
S510
R
P
G
S
H
P
S
S
H
R
S
S
S
V
S
Site 85
S513
S
H
P
S
S
H
R
S
S
S
V
S
S
S
P
Site 86
S514
H
P
S
S
H
R
S
S
S
V
S
S
S
P
A
Site 87
S515
P
S
S
H
R
S
S
S
V
S
S
S
P
A
R
Site 88
S517
S
H
R
S
S
S
V
S
S
S
P
A
R
T
E
Site 89
S518
H
R
S
S
S
V
S
S
S
P
A
R
T
E
S
Site 90
S519
R
S
S
S
V
S
S
S
P
A
R
T
E
S
S
Site 91
T523
V
S
S
S
P
A
R
T
E
S
S
S
D
R
I
Site 92
S525
S
S
P
A
R
T
E
S
S
S
D
R
I
P
V
Site 93
S526
S
P
A
R
T
E
S
S
S
D
R
I
P
V
H
Site 94
S527
P
A
R
T
E
S
S
S
D
R
I
P
V
H
Q
Site 95
T578
M
H
I
E
K
D
E
T
P
L
S
T
P
T
A
Site 96
S581
E
K
D
E
T
P
L
S
T
P
T
A
R
D
S
Site 97
T582
K
D
E
T
P
L
S
T
P
T
A
R
D
S
L
Site 98
T584
E
T
P
L
S
T
P
T
A
R
D
S
L
D
K
Site 99
S588
S
T
P
T
A
R
D
S
L
D
K
L
S
L
T
Site 100
S593
R
D
S
L
D
K
L
S
L
T
G
H
G
Q
P
Site 101
T595
S
L
D
K
L
S
L
T
G
H
G
Q
P
L
P
Site 102
S607
P
L
P
P
G
F
P
S
P
F
L
F
P
D
G
Site 103
T663
R
E
R
E
L
R
E
T
L
E
K
Q
L
A
M
Site 104
S715
Q
T
L
K
Q
A
A
S
T
D
S
L
R
V
L
Site 105
S718
K
Q
A
A
S
T
D
S
L
R
V
L
N
D
S
Site 106
S725
S
L
R
V
L
N
D
S
L
T
P
E
I
E
A
Site 107
T727
R
V
L
N
D
S
L
T
P
E
I
E
A
D
R
Site 108
S735
P
E
I
E
A
D
R
S
G
G
R
T
D
A
E
Site 109
T739
A
D
R
S
G
G
R
T
D
A
E
R
T
I
Q
Site 110
Y751
T
I
Q
D
G
R
L
Y
L
K
T
T
V
M
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation