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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LCMT1
Full Name:
Leucine carboxyl methyltransferase 1
Alias:
CGI-68; LCMT; PPMT1; Protein phosphatase methyltransferase 1; Protein-leucine O-methyltransferase
Type:
EC 2.1.1.-; Amino Acid Metabolism - histidine; Methyltransferase; Other Amino Acids Metabolism - selenoamino acid; Lipid Metabolism - androgen and estrogen; Amino Acid Metabolism - tyrosine
Mass (Da):
38380
Number AA:
UniProt ID:
Q9UIC8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003880
GO:0008757
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006481
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
T
R
Q
R
E
S
S
I
T
S
C
C
S
Site 2
S9
A
T
R
Q
R
E
S
S
I
T
S
C
C
S
T
Site 3
T11
R
Q
R
E
S
S
I
T
S
C
C
S
T
S
S
Site 4
S12
Q
R
E
S
S
I
T
S
C
C
S
T
S
S
C
Site 5
S15
S
S
I
T
S
C
C
S
T
S
S
C
D
A
D
Site 6
T16
S
I
T
S
C
C
S
T
S
S
C
D
A
D
D
Site 7
S18
T
S
C
C
S
T
S
S
C
D
A
D
D
E
G
Site 8
T29
D
D
E
G
V
R
G
T
C
E
D
A
S
L
C
Site 9
S34
R
G
T
C
E
D
A
S
L
C
K
R
F
A
V
Site 10
S58
I
Q
H
F
V
R
L
S
K
E
R
K
A
P
E
Site 11
Y70
A
P
E
I
N
R
G
Y
F
A
R
V
H
G
V
Site 12
T103
N
L
G
A
G
M
D
T
T
F
W
R
L
K
D
Site 13
T104
L
G
A
G
M
D
T
T
F
W
R
L
K
D
E
Site 14
Y118
E
D
L
L
P
S
K
Y
F
E
V
D
F
P
M
Site 15
S141
I
K
C
K
P
P
L
S
S
P
I
L
E
L
H
Site 16
S142
K
C
K
P
P
L
S
S
P
I
L
E
L
H
S
Site 17
T152
L
E
L
H
S
E
D
T
L
Q
M
D
G
H
I
Site 18
S176
G
A
D
L
R
D
L
S
E
L
E
E
K
L
K
Site 19
Y228
E
R
A
M
F
I
N
Y
E
Q
V
N
M
G
D
Site 20
S260
A
G
V
E
T
C
K
S
L
E
S
Q
K
E
R
Site 21
S263
E
T
C
K
S
L
E
S
Q
K
E
R
L
L
S
Site 22
S270
S
Q
K
E
R
L
L
S
N
G
W
E
T
A
S
Site 23
S277
S
N
G
W
E
T
A
S
A
V
D
M
M
E
L
Site 24
Y285
A
V
D
M
M
E
L
Y
N
R
L
P
R
A
E
Site 25
S294
R
L
P
R
A
E
V
S
R
I
E
S
L
E
F
Site 26
S298
A
E
V
S
R
I
E
S
L
E
F
L
D
E
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation