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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SIX4
Full Name:
Homeobox protein SIX4
Alias:
AREC3; homeobox SIX4
Type:
Uncharacterized
Mass (Da):
80832
Number AA:
760
UniProt ID:
Q9UIU6
International Prot ID:
IPI00006525
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0009653
GO:0007275
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
S
S
S
S
P
T
G
Q
I
Site 2
S5
_
_
_
M
S
S
S
S
P
T
G
Q
I
A
S
Site 3
T7
_
M
S
S
S
S
P
T
G
Q
I
A
S
A
A
Site 4
S12
S
P
T
G
Q
I
A
S
A
A
D
I
K
Q
E
Site 5
S26
E
N
G
M
E
S
A
S
E
G
Q
E
A
H
R
Site 6
S88
A
D
Q
V
Q
L
H
S
E
L
L
G
R
H
H
Site 7
S139
F
L
W
S
L
P
Q
S
D
L
L
R
G
N
E
Site 8
S147
D
L
L
R
G
N
E
S
L
L
K
A
R
A
L
Site 9
Y166
Q
G
I
Y
P
E
L
Y
S
I
L
E
S
H
S
Site 10
S167
G
I
Y
P
E
L
Y
S
I
L
E
S
H
S
F
Site 11
S171
E
L
Y
S
I
L
E
S
H
S
F
E
S
A
N
Site 12
S173
Y
S
I
L
E
S
H
S
F
E
S
A
N
H
P
Site 13
Y187
P
L
L
Q
Q
L
W
Y
K
A
R
Y
T
E
A
Site 14
T192
L
W
Y
K
A
R
Y
T
E
A
E
R
A
R
G
Site 15
Y208
P
L
G
A
V
D
K
Y
R
L
R
R
K
F
P
Site 16
T219
R
K
F
P
L
P
R
T
I
W
D
G
E
E
T
Site 17
Y228
W
D
G
E
E
T
V
Y
C
F
K
E
K
S
R
Site 18
S234
V
Y
C
F
K
E
K
S
R
N
A
L
K
E
L
Site 19
Y247
E
L
Y
K
Q
N
R
Y
P
S
P
A
E
K
R
Site 20
S249
Y
K
Q
N
R
Y
P
S
P
A
E
K
R
H
L
Site 21
T265
K
I
T
G
L
S
L
T
Q
V
S
N
W
F
K
Site 22
S282
R
Q
R
D
R
N
P
S
E
T
Q
S
K
S
E
Site 23
T284
R
D
R
N
P
S
E
T
Q
S
K
S
E
S
D
Site 24
S286
R
N
P
S
E
T
Q
S
K
S
E
S
D
G
N
Site 25
S288
P
S
E
T
Q
S
K
S
E
S
D
G
N
P
S
Site 26
S290
E
T
Q
S
K
S
E
S
D
G
N
P
S
T
E
Site 27
S295
S
E
S
D
G
N
P
S
T
E
D
E
S
S
K
Site 28
T296
E
S
D
G
N
P
S
T
E
D
E
S
S
K
G
Site 29
S301
P
S
T
E
D
E
S
S
K
G
H
E
D
L
S
Site 30
S308
S
K
G
H
E
D
L
S
P
H
P
L
S
S
S
Site 31
S313
D
L
S
P
H
P
L
S
S
S
S
D
G
I
T
Site 32
S314
L
S
P
H
P
L
S
S
S
S
D
G
I
T
N
Site 33
S315
S
P
H
P
L
S
S
S
S
D
G
I
T
N
L
Site 34
S316
P
H
P
L
S
S
S
S
D
G
I
T
N
L
S
Site 35
T320
S
S
S
S
D
G
I
T
N
L
S
L
S
S
H
Site 36
S323
S
D
G
I
T
N
L
S
L
S
S
H
M
E
P
Site 37
S325
G
I
T
N
L
S
L
S
S
H
M
E
P
V
Y
Site 38
Y332
S
S
H
M
E
P
V
Y
M
Q
Q
I
G
N
A
Site 39
S368
P
V
F
L
N
G
N
S
F
I
Q
G
P
S
G
Site 40
T386
N
G
L
N
V
G
N
T
Q
A
V
A
L
N
P
Site 41
S398
L
N
P
P
K
M
S
S
N
I
V
S
N
G
I
Site 42
S402
K
M
S
S
N
I
V
S
N
G
I
S
M
T
D
Site 43
S415
T
D
I
L
G
S
T
S
Q
D
V
K
E
F
K
Site 44
S426
K
E
F
K
V
L
Q
S
S
A
N
S
A
T
T
Site 45
S430
V
L
Q
S
S
A
N
S
A
T
T
T
S
Y
S
Site 46
T433
S
S
A
N
S
A
T
T
T
S
Y
S
P
S
V
Site 47
T434
S
A
N
S
A
T
T
T
S
Y
S
P
S
V
P
Site 48
S435
A
N
S
A
T
T
T
S
Y
S
P
S
V
P
V
Site 49
S437
S
A
T
T
T
S
Y
S
P
S
V
P
V
S
F
Site 50
S439
T
T
T
S
Y
S
P
S
V
P
V
S
F
P
G
Site 51
S450
S
F
P
G
L
I
P
S
T
E
V
K
R
E
G
Site 52
T451
F
P
G
L
I
P
S
T
E
V
K
R
E
G
I
Site 53
T460
V
K
R
E
G
I
Q
T
V
A
S
Q
D
G
G
Site 54
S463
E
G
I
Q
T
V
A
S
Q
D
G
G
S
V
V
Site 55
S493
I
P
N
S
G
A
N
S
Q
F
L
N
G
S
I
Site 56
S499
N
S
Q
F
L
N
G
S
I
G
F
S
P
L
Q
Site 57
S520
A
A
S
Q
G
N
I
S
V
S
S
S
T
S
D
Site 58
S522
S
Q
G
N
I
S
V
S
S
S
T
S
D
G
S
Site 59
S523
Q
G
N
I
S
V
S
S
S
T
S
D
G
S
T
Site 60
S524
G
N
I
S
V
S
S
S
T
S
D
G
S
T
F
Site 61
S526
I
S
V
S
S
S
T
S
D
G
S
T
F
T
S
Site 62
S529
S
S
S
T
S
D
G
S
T
F
T
S
E
S
T
Site 63
T530
S
S
T
S
D
G
S
T
F
T
S
E
S
T
T
Site 64
S533
S
D
G
S
T
F
T
S
E
S
T
T
V
Q
Q
Site 65
T537
T
F
T
S
E
S
T
T
V
Q
Q
G
K
V
F
Site 66
S566
N
T
G
Q
T
I
G
S
V
K
Q
E
G
L
E
Site 67
S575
K
Q
E
G
L
E
R
S
L
V
F
S
Q
L
M
Site 68
S595
A
Q
V
N
A
N
L
S
S
E
N
I
S
G
S
Site 69
S596
Q
V
N
A
N
L
S
S
E
N
I
S
G
S
G
Site 70
S600
N
L
S
S
E
N
I
S
G
S
G
L
H
P
L
Site 71
S602
S
S
E
N
I
S
G
S
G
L
H
P
L
A
S
Site 72
T617
S
L
V
N
V
S
P
T
H
N
F
S
L
S
P
Site 73
S623
P
T
H
N
F
S
L
S
P
S
T
L
L
N
P
Site 74
S625
H
N
F
S
L
S
P
S
T
L
L
N
P
T
E
Site 75
S640
L
N
R
D
I
A
D
S
Q
P
M
S
A
P
V
Site 76
S644
I
A
D
S
Q
P
M
S
A
P
V
A
S
K
S
Site 77
S651
S
A
P
V
A
S
K
S
T
V
T
S
V
S
N
Site 78
T652
A
P
V
A
S
K
S
T
V
T
S
V
S
N
T
Site 79
S655
A
S
K
S
T
V
T
S
V
S
N
T
N
Y
A
Site 80
T659
T
V
T
S
V
S
N
T
N
Y
A
T
L
Q
N
Site 81
Y661
T
S
V
S
N
T
N
Y
A
T
L
Q
N
C
S
Site 82
T691
A
L
G
E
I
V
P
T
A
E
D
Q
V
G
H
Site 83
S700
E
D
Q
V
G
H
P
S
P
A
V
H
Q
D
F
Site 84
S717
E
H
R
L
V
L
Q
S
V
A
N
M
K
E
N
Site 85
S727
N
M
K
E
N
F
L
S
N
S
E
S
K
A
T
Site 86
S729
K
E
N
F
L
S
N
S
E
S
K
A
T
S
S
Site 87
S731
N
F
L
S
N
S
E
S
K
A
T
S
S
L
M
Site 88
T734
S
N
S
E
S
K
A
T
S
S
L
M
M
L
D
Site 89
S735
N
S
E
S
K
A
T
S
S
L
M
M
L
D
S
Site 90
S736
S
E
S
K
A
T
S
S
L
M
M
L
D
S
K
Site 91
S742
S
S
L
M
M
L
D
S
K
S
K
Y
V
L
D
Site 92
Y746
M
L
D
S
K
S
K
Y
V
L
D
G
M
V
D
Site 93
T761
T
V
C
E
D
L
E
T
D
K
K
E
L
A
K
Site 94
T771
K
E
L
A
K
L
Q
T
V
Q
L
D
E
D
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation